UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (USA)
CARNEGIE MELLON UNIVERSITY (USA)
Inventor
Capogrosso, Marco
Weber, Douglas John
Verma, Nikhil
Gerszten, Peter C.
Pirondini, Elvira
Sorensen, Erynn
Carranza Urquizo, Erick Fabrizio
Fisher, Lee
Powell, Marc
Abstract
Disclosed herein are methods for treating impairment of a limb in a subject. Particular methods comprise applying a therapeutically effective amount of an electrical stimulus to dorsal roots, dorsal rootlets, or dorsal root ganglia, of sensory neurons innervating the limb of the subject, wherein the impairment is a motor impairment and/or a proprioception impairment due to neurological disorder or injury, the electrical stimulus is applied with one or more electrodes controlled by a neurostimulator, and the one or more electrodes are implanted in the epidural space at the dorsolateral aspect of the spinal cord and proximate to the dorsal roots or dorsal rootlets of the sensory neurons innervating the limb of the subject, or the one or more electrodes are implanted proximate to dorsal root ganglia of sensory neurons innervating the limb of the subject.
Disclosed herein is a system and method implementing a trusted loT security gateway architecture, based on a microhypervisor, that provides a guarantee that the correct security protections are applied to each loT device's network traffic at all times, including when under attack. The disclosed architecture provides robust trust properties to a broad range of legacy hardware platforms utilizing existing software with a reasonable performance overhead.
G06F 21/57 - Certifying or maintaining trusted computer platforms, e.g. secure boots or power-downs, version controls, system software checks, secure updates or assessing vulnerabilities
G06F 21/71 - Protecting specific internal or peripheral components, in which the protection of a component leads to protection of the entire computer to assure secure computing or processing of information
Disclosed herein is a method for defining a model of a trusted loT security gateway architecture based on a microhypervisor, wherein evaluation of the model provides a guarantee that the correct security protections are applied to each loT device's network traffic at all times, including when under attack. The models defined in accordance with the method disclosed herein are used to verify security gateway architectures that provide robust trust properties to a broad range of legacy hardware platforms utilizing existing software with a reasonable performance overhead.
Provided is a method of training a machine-learning-based artificial intelligence (AI) model to handle diverse types of motions occurring during image acquisition, including capturing image data including motion between an imaging device and tissue, modifying the captured image data, resulting in modified image data, by at least one of: altering an amount of time between any two frames; removing a subsequence of frames from the captured image data; and adding a subsequence of one or more new frames to the captured image data, and training a machine-learning-based AI model based on the modified image data. Other systems and methods are also described.
Disclosed herein are systems and methods for processing ash. For example, in certain embodiments, the method comprises dissolving at least a portion of ash in acid. In some embodiments, the acid is produced in a reactor. In some embodiments, dissolving at least a portion of ash in acid produces refined silica (SiO2) (e.g., amorphous silica, substantially pure silica, and/or a substantial amount of silica). According to certain embodiments, the ash can be further processed (e.g., using electro winning, pH- based precipitation, and/or electrorefining) to obtain other components instead of or in addition to refined silica.
In some aspects, the present disclosure pertains to methods for the electrochemical production of calcium silicate compounds in an electrochemical cell that comprises (a) a Ca-based electrode that comprises calcium metal or an inorganic calcium material, (b) an SiOx-based electrode that comprises a SiOx material, where x ranges from 1 to 2, and (c) a liquid electrolyte disposed between the Ca-based electrode and the SiOx-based electrode. In these methods, the electrochemical cell is operated under conditions such that calcium cations are produced at the Ca-based electrode and one or more calcium silicate (Ca-Si-oxide) compounds are produced at the SiOx-based electrode. In other aspects, the present disclosure pertains to systems for the electrochemical production of calcium silicate compounds.
A method and system for additive manufacturing are provided herein. The method comprises depositing a structure material, by a nozzle (810), into a support material (808) by applying to the structure material such that the structure material flows through the nozzle. The structure material comprises a polymer and a rheological modifier. Depositing of the structure material is repeated as necessary to create an object (814). The support material is at least partially removed from object. In various examples, the method comprises varying a print parameter from a first portion of the object to a second portion of the object, moving the nozzle away from a previously deposited layer of the object when repositioning for deposition of a subsequent layer of the object, or a combination thereof.
B29C 64/40 - Structures for supporting 3D objects during manufacture and intended to be sacrificed after completion thereof
B33Y 50/02 - Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
B29C 64/118 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
B29C 64/393 - Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
8.
SYSTEM AND METHOD FOR ANALYZING MEDICAL IMAGES BASED ON SPATIO-TEMPORAL DATA
Provided is a system, method, and computer program product for analyzing spatio-temporal medical images using an artificial neural network. The method includes capturing a series of medical images of a patient, the series of medical images comprising visual movement of at least one entity, tracking time-varying spatial data associated with the at least one entity based on the visual movement, generating spatio-temporal data by correlating the time-varying spatial data with the series of medical images, and analyzing the series of medical images based on an artificial neural network comprising a plurality of layers, one or more layers of the plurality of layers each combining features from at least three different scales, at least one layer of the plurality of layers of the artificial neural network configured to learn spatio-temporal relationships based on the spatio-temporal data.
9.
SYSTEM AND METHOD FOR POSITIONING AN AQUATIC VESSEL
An aquatic vessel, illustratively a pontoon boat including a thruster system is disclosed. The aquatic vessel executes a process to automatically position the aquatic vessel relative to a target location such as a mooring implement. Exemplary mooring implements include a dock, a slip, or a lift.
A system and method for controlling a vehicle platform, the system comprising on onboard controller and an off-board controller that work together to provide autonomous navigation in fields or similar areas where the vehicle is deployed, perception for obstacle detection and avoidance, and a user interface for user/ vehicle interaction and control.
G05D 1/243 - Means capturing signals occurring naturally from the environment, e.g. ambient optical, acoustic, gravitational or magnetic signals (using passive navigation aids external to the vehicle G05D 1/244;using signals from positioning sensors located off-board the vehicle G05D 1/249)
UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (USA)
Inventor
Mathai, Tejas Sudharshan
Galeotti, John
Gorantla, Vijay Saradhi
Abstract
Provided is a system, method, and computer program product for segmenting vessels in an ultrasound image. The method includes detecting edges of a vessel in the ultrasound image; detecting a vessel contour of the vessel in the ultrasound image based on the detected edges and a distance regularized level set evolution; and tracking the vessel contour with a Kalman Filter.
Methods for creating semolina flour-based shape-changing food from a multi-layered dough with at least one grooved surface. The dough layers have difference compositions including natural, staple and edible ingredients. The dough is exposed to stimuli during dehydration (e.g., baking) or hydration (e.g., boiling) processes.
Provided is a system, method, and computer program product for creating a deep-learning model for processing image data. The method includes establishing dense connections between each layer of a plurality of layers of a convolutional neural network (CNN) and a plurality of preceding layers of the CNN, downsampling an input of each downsampling layer of a plurality of downsampling layers in a first branch of the CNN, and upsampling an input of each upsampling layer of a plurality of upsampling layers in a second branch of the CNN by convolving the input.
Provided are methods for labeling ultrasound data. The method may include training a convolutional neural network (CNN) based on ultrasound data. The ultrasound data may include ultrasonic waveform data (e.g., radio frequency (RF) waveform data). An RF input of each downsampling layer of a plurality of downsampling layers in the CNN may be downsampled. The RF input may include RF waveform data for an ultrasound. Tissues in the ultrasound may be segmented based on an output of the CNN. A system is also disclosed.
Systems, methods, and computer program products are provided for removing noise and/or artifacts from an image. The method includes training a generative adversarial network (GAN) based on a plurality of images, the plurality of images comprising at least one undesired element comprising at least one of the following: noise, speckle patterns, artifacts, or any combination thereof, and generating a modified image based on processing an image of an eye or other object with the GAN to remove the at least one undesired element from the image that is above an outer surface of the eye or other object.
A high-density storage system for goods is described in which totes carrying the goods are storage in a storage structure and stored and retrieved by robotic carriers. The carriers move laterally and/or longitudinally along the exterior of the support structure and retrieve totes from the interior of the structure by manipulating rows of coupled totes. Totes at the ends of rows are quickly removed and stored in another row until the desired tote appears at the end of the row, at which point the carrier proceeds with the tote to the exit point of the storage system. Storing totes is also a quick action by pushing them into any row. As a tote is pushed into the row, it will automatically couple with a tote inside the row that it comes into contact with.
B65D 21/028 - Containers specially shaped, or provided with fittings or attachments, to facilitate nesting, stacking, or joining together for stacking containers lying on their sides, or for joining containers side-by-side, by means which are lateral with respect to the normal orientation of the containers with interconnecting means forming part of the containers, e.g. dovetails, snap connectors or hook elements
17.
AGILE DEPTH SENSING USING TRIANGULATION LIGHT CURTAINS
A method to dynamically and adaptively sample the depths of a scene using the principle of triangulation light curtains is described. The approach directly detects the presence or absence of obstacles (or scene points) at specified 3D lines in a scene by sampling the scene. The scene can be sampled sparsely, non-uniformly, or densely at specified regions. The depth sampling can be varied in real-time, enabling quick object discovery or detailed exploration of areas of interest. Once an object is discovered in the scene, adaptive light curtains comprising dense sampling of a region of the scene containing the object, can be used to better define the position, shape and size of the discovered object.
G01B 11/25 - Measuring arrangements characterised by the use of optical techniques for measuring contours or curvatures by projecting a pattern, e.g. moiré fringes, on the object
G01S 17/48 - Active triangulation systems, i.e. using the transmission and reflection of electromagnetic waves other than radio waves
G01S 17/89 - Lidar systems, specially adapted for specific applications for mapping or imaging
G01V 8/00 - Prospecting or detecting by optical means
SHANGHAI HANSHI INFORMATION TECHNOLOGY CO., LTD. (China)
Inventor
Skaff, Sarjoun
Savvides, Marios
Ahmed, Uzair
Nallamothu, Sreena
Tao, Ran
Mohan, Nikhil
Abstract
An automated inventory monitoring system includes an image capture module able to create an image of an aisle of a retail store. Images of products labels are identified in the image and classified as shelf labels or peg labels. For shelf labels, an area of the shelf is defined and associated with the shelf label. Images of products are identified in the image and products on the shelf within an area associated with a shelf label are associated with the shelf label. Products located below a peg label are associated with the peg label. Based on the association between labels and products, out-of-stock products, plugs and spread may be detected and reported to the staff of the retail store.
G06Q 10/087 - Inventory or stock management, e.g. order filling, procurement or balancing against orders
G06V 10/22 - Image preprocessing by selection of a specific region containing or referencing a pattern; Locating or processing of specific regions to guide the detection or recognition
A system for outputting a visual representation of a brain of a patient is configured to receive sensor data representing a behavior of a region of the brain of the patient. The system retrieves mapping data that maps a prediction value to the region. The prediction value is indicative of an effect on a behavior of the patient responsive to a treatment of the region, the mapping data being indexed to a patient identifier. The system receives, responsive to an application of a stimulation to the region, sensor data representing behavior of the region. The system executes a model that updates, based on the sensor data, the prediction value for the region. The system updates, responsive to executing the model, the mapping data by including the updated prediction value in the mapping data. The system outputs a visual representation of the updated mapping data comprising the updated prediction value.
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
Described herein are divalent nucleobases that each binds two nucleic acid strands, matched or mismatched when incorporated into a nucleic acid or nucleic acid analog backbone, such as in a ?-peptide nucleic acid (?PNA). Also provided are genetic recognition reagents comprising one or more of the divalent nucleobases and a nucleic acid or nucleic acid analog backbone, such as a ?PNA backbone. Uses for the divalent nucleobases and monomers and genetic recognition reagents containing the divalent nucleobases also are provided.
Various systems and process for fabricating customized medical devices via the freeform reversible embedding of suspended hydrogels process are disclosed. The mechanical properties of the fabricated objects can be controlled according to the manner or orientation in which the structure material is deposited into the support material and the three- dimensional movement of the extruder assembly. Further, the dimensions of the fabricated objects can be validated by adding a contrast agent to the structure material, obtaining a three-dimensional reconstruction of the fabricated object, and then comparing the three- dimensional reconstruction to the computer model upon which the fabricated object is based. These and other techniques are described herein.
B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
B33Y 70/00 - Materials specially adapted for additive manufacturing
B33Y 80/00 - Products made by additive manufacturing
B29C 64/386 - Data acquisition or data processing for additive manufacturing
A61L 27/00 - Materials for prostheses or for coating prostheses
Embodiments described herein are generally directed to a device that monitors for the presence of objects passing through or impinging on a virtual shell near the device, referred to herein as a light curtain, which is created by rapidly rotating a line sensor and a line laser in synchrony. The boundaries of the light curtain are defined by a sweeping line defined by the intersection of the sensing and illumination planes.
G01B 11/25 - Measuring arrangements characterised by the use of optical techniques for measuring contours or curvatures by projecting a pattern, e.g. moiré fringes, on the object
A method of training a deep neural network, such as would be used in facial recognition, includes training the deep neural network to normalize feature vectors to a learned value representing the radius of a multi-dimensional hypersphere using a convex augmentation of the primary loss function.
Described herein are genetic recognition reagents comprising terminal aromatic moieties that bind specifically to a template nucleic acid and concatenate. Also provided are methods of using the genetic recognition reagents, e.g., to treat or diagnose a repeat expansion disorder, such as DM1.
C07D 239/47 - One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
C07D 239/54 - Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
C07D 251/16 - Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
Genetic recognition reagents comprising bivalent nucleobases are provided that bind two strands of nucleic acid, such as an expanded repeat sequence associated with an expanded repeat disease. In one example the expanded repeat disease is a polyQ disease, such as Huntington's disease. Methods of use of the reagents are provided, including a method of binding nucleic acid, such as an expanded repeat sequence associated with an expanded repeat disease, a method of identifying the presence of a nucleic acid comprising an expanded repeat, and a method of treating an expanded repeat disease are provided.
This document describes systems and method of embedded printing for additive manufacturing. A print material is printed into a support material. The print material and the support material each have a fluid phase and a solid phase. The print material transitions from the fluid phase to the solid phase based on a fluid-fluid interaction with the support material. One or more parameters of the support material can be adjusted to cause a diffusion rate of the print material into the support material during the fluid-fluid interaction to be less than a threshold value. Multiple print materials can be printed into the support material simultaneously.
B29C 64/165 - Processes of additive manufacturing using a combination of solid and fluid materials, e.g. a powder selectively bound by a liquid binder, catalyst, inhibitor or energy absorber
B29C 64/124 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified
B29C 64/40 - Structures for supporting 3D objects during manufacture and intended to be sacrificed after completion thereof
THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (Canada)
Inventor
Narasimhan, Srinivasa
Achar, Supreeth
Kutulakos, Kiriakos
Bartels, Joseph
Whittaker, William
Abstract
Energy-efficient epipolar imaging is applied to the ToF domain to significantly expand the versatility of ToF sensors. The described system exhibits 15+ m range outdoors in bright sunlight; robustness to global transport effects such as specular and diffuse inter-reflections; interference-free 3D imaging in the presence of many ToF sensors, even when they are all operating at the same optical wavelength and modulation frequency; and blur- and distortion-free 3D video in the presence of severe camera shake. The described embodiments are broadly applicable in consumer and robotics domains.
RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (USA)
UNIVERSITY OF STRATHCLYDE (United Kingdom)
CARNEGIE MELLON UNIVERSITY (USA)
Inventor
Ulijn, Rein V.
Lampel, Ayala
Tuttle, Tell
Scott, Gary
Mcphee, Scott
Bettinger, Christopher
Abstract
A self-assembling peptide is provided that is enzymatically oxidized to form a polymeric pigment. The monomeric peptide has three amino acids (tyrosine (Y), one phenylalanine (F), and one aspartic acid (D) or one lysine (K)) and, following self-assembly and treatment with a tyrosinase enzyme oxidizes and polymerizes into a material with predetermined properties.
C07K 1/107 - General processes for the preparation of peptides by chemical modification of precursor peptides
C07K 5/087 - Tripeptides the side chain of the first amino acid containing carbocyclic rings, e.g. Phe, Tyr
C07K 5/09 - Tripeptides the side chain of the first amino acid containing more amino groups than carboxyl groups, or derivatives thereof, e.g. Lys, Arg
C07K 5/093 - Tripeptides the side chain of the first amino acid containing more carboxyl groups than amino groups, or derivatives thereof, e.g. Asp, Glu, Asn
Described herein are divalent nucleobases that each binds two nucleic acid strands, matched or mismatched when incorporated into a nucleic acid or nucleic acid analog backbone, such as in a ?-peptide nucleic acid (?PNA). Also provided are genetic recognition reagents comprising one or more of the divalent nucleobases and a nucleic acid or nucleic acid analog backbone, such as a ?PNA backbone. Uses for the divalent nucleobases and monomers and genetic recognition reagents containing the divalent nucleobases also are provided.
C07D 239/47 - One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
C07D 239/54 - Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
C07D 251/16 - Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
C07D 475/08 - Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
C07K 14/00 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
In a preferred embodiment, there is provided a compound comprising a macrocyclic tetradentate ligand of the structure wherein D is a nitrogen atom; each X is (i) H, deuterium, (ii) Li, Na, K, alkali metals, (iii) alkaline earth metals, transition metals, rare earth metals, (iv) or is unoccupied with the resulting negative charge being balanced by a nonbonded countercation; and Yi, Y2, Y3 and Y4 are each independently selected from the group consisting of wherein every D is directly attached to at least one E, and E is S(=Q)2, S(=Q)R'2, S(=Q), P(=Q)R', PR'3 or C=Q, where Q is oxygen or NR', wherein at least one E in at least one Y is more stable towards nucleophilic attack than C=Q and is S(=Q)2, S(=Q)R'2, or S(=Q), and is directly attached to one D.
UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (USA)
CARNEGIE MELLON UNIVERSITY (USA)
MISSISSIPPI STATE UNIVERSITY (USA)
Inventor
Madhani, Shalv
Frankowski, Brian Joseph
Federspiel, William J.
Burgreen, Gregory
Antaki, James F.
Abstract
An extracorporeal system for lung assist includes a housing which includes a blood flow inlet in fluid connection with a pressurizing stator compartment, a fiber bundle compartment in fluid connection with the pressurizing stator compartment via a flow channel within the housing, and a blood flow outlet in fluid connection with the fiber bundle compartment. An impeller is rotatably positioned within the pressurizing compartment for pressurizing blood entering the pressurizing stator compartment from the blood flow inlet. The system further includes a fiber bundle positioned within the fiber bundle compartment. The fiber bundle includes a plurality of hollow gas permeable fibers. The plurality of hollow gas permeable fibers is adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers. The plurality of hollow gas permeable fibers is positioned such that blood flows around the plurality of hollow gas permeable fibers when flowing through the fiber bundle compartment. The plurality of hollow gas permeable fibers extend generally perpendicular to the direction of bulk flow of blood through the fiber bundle compartment from the flow channel to the blood flow outlet. The system further includes a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers and a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers.
A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
A61M 60/113 - Extracorporeal pumps, i.e. the blood being pumped outside the patient’s body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
A61M 60/216 - Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (USA)
Inventor
Falo, Louis D., Jr.
Erdos, Geza
Ozdoganlar, O. Burak
Abstract
A method of forming a microneedle array can include forming a microneedle array having one or more chemotherapeutic agents. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more chemotherapeutic agents can be present in a higher concentration in the plurality of microneedles than in the base portion.
The invention disclosed herein describes a supervised autonomy system designed to precisely model, inspect and process the surfaces of complex three-dimensional objects. The current application context for this system is laser coating removal of aircraft, but this invention is suitable for use in a wide variety of applications that require close, precise positioning and maneuvering of an inspection or processing tool over the entire surface of a physical object. For example, this system, in addition to laser coating removal, could also apply new coatings, perform fine-grained or gross inspection tasks, deliver and/or use manufacturing process tools or instruments, and/or verify the results of other manufacturing processes such as but not limited to welding, riveting, or the placement of various surface markings or fixtures.
B25J 19/00 - Accessories fitted to manipulators, e.g. for monitoring, for viewing; Safety devices combined with or specially adapted for use in connection with manipulators
G01N 21/25 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
G01N 27/90 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables for investigating the presence of flaws using eddy currents
G01S 17/89 - Lidar systems, specially adapted for specific applications for mapping or imaging
An expandable valved conduit for pediatric right ventricular outflow tract (RVOT) reconstruction is disclosed. The valved conduit may provide long-term patency and resistance to thrombosis and stenosis. The valved conduit may enlarge radially and/or longitudinally to accommodate the growing anatomy of the patient. Further, a method is disclosed for the manufacture of the valved conduit based in part on a plastically deformable biocompatible polymer and a computer-optimized valve design developed for such an expandable valved conduit.
UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (USA)
CARNEGIE MELLON UNIVERSITY (USA)
Inventor
Falo, Louis D., Jr,
Erdos, Geza
Ozdoganlar, O. Burak
Abstract
A method of forming a microneedle array can include forming a microneedle array that has one or more bioactive component. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more bioactive components are present in a higher concentration in the plurality of microneedles than in the base portion.
UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (USA)
CARNEGIE MELLON UNIVERSITY (USA)
Inventor
Falo, Louis D., Jr.
Erdos, Geza
Ozdoganlar, O. Burak
Abstract
A method of forming a microneedle array can include forming a microneedle array that has one or more bioactive component. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more bioactive components are present in a higher concentration in the plurality of microneedles than in the base portion.
A61M 37/00 - Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
37.
A METAL-SEMICONDUCTOR-METAL (MSM) HETEROJUNCTION DIODE
In one aspect, a diode comprises: a semiconductor layer haying a first side and a second side opposite the first side, the semiconductor layer haying a thickness between the first side and the second side, the thickness of the semiconductor layer being based on a mean free path of a charge carrier emitted into the semiconductor layer; a first metal layer deposited on the first side of the semiconductor layer; and a second metal layer deposited on the second side of the semiconductor layer.
H01L 29/167 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only elements of Group IV of the Periodic System in uncombined form further characterised by the doping material
38.
A METAL-SEMICONDUCTOR-METAL (MSM) HETEROJUNCTION DIODE
In one aspect, a diode comprises: a semiconductor layer having a first side and a second side opposite the first side, the semiconductor layer having a thickness between the first side and the second side, the thickness of the semiconductor layer being based on a mean free path of a charge carrier emitted into the semiconductor layer; a first metal layer deposited on the first side of the semiconductor layer; and a second metal layer deposited on the second side of the semiconductor layer.
UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (USA)
Inventor
Yoshida, Masahiro
Bernstein, C. Douglas
Dur, Onur
Pekkan, Kerem
Abstract
Artificial heart valve structures and methods of their fabrication are disclosed. The heart valve structures may be fabricated from a biocompatible polymer and include one or more heart valve leaflet structures incorporated within a conduit. The valve structures may incorporate one or more conduit sinuses, as well as a gap between the lower margin of the valve leaflets and the interior of the conduit. In addition, the valve structures may include one or more valve sinuses created in a space between the valve leaflets and the conduit inner surface. Computational fluid dynamics and mechanical modeling may be used to design the valve leaflets with optimal characteristics. A heart valve structure may also incorporate a biodegradable component to which cells may adhere The incorporated cells may arise from patient cells migrating to the biodegradable component, or the component may be pre-seeded with cells prior to implantation in a patient.
A61L 27/54 - Biologically active materials, e.g. therapeutic substances
A61L 33/00 - Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
A system includes an end effector (110), a robotic wrist (120) for orienting the end effector (110); and a robotic arm (130) for positioning the end effector. The robotic arm (130) is foldable into a stack. The robotic wrist (120) is mounted to a last link of the robotic arm.
B25J 9/04 - Programme-controlled manipulators characterised by movement of the arms, e.g. cartesian co-ordinate type by rotating at least one arm, excluding the head movement itself, e.g. cylindrical co-ordinate type or polar co-ordinate type
B25J 9/06 - Programme-controlled manipulators characterised by multi-articulated arms
41.
METHODS AND APPARATUS FOR MANUFACTURING PLASMA BASED PLASTICS AND BIOPLASTICS PRODUCED THEREFROM
Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.
Compositions and methods for manufacturing polymers are disclosed. Compositions include novel plastics, including films and shaped forms comprising polymer matrices that are biologically compatible and biodegradable. Such plastics may comprise polymers derived from natural sources. Further, such plastics are useful in biological systems for wound repair, implants, stents, drug encapsulation and delivery, and other applications. The disclosed methods comprise mild manufacturing processes such that various additives, such as biologically active proteins, sugars, lipids, and the like may be incorporated into the polymer matrix without subsequent loss of bioactivity during processing. Additionally, methods of manufacture for controlling mechanical properties, such as elasticity, pliancy, and the porosity of such plastics are disclosed.
C08J 9/28 - Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof by elimination of a liquid phase from a macromolecular composition or article, e.g. drying of coagulum
43.
METHOD FOR LABELING IMAGES THROUGH A COMPUTER GAME
A methodology to determine the contents of an image uses an online game that is played by a large number of people at once. Each player may be randomly assigned a partner to form a pair. Partners do not know each other's identity and cannot communicate with one another. Players cannot see what their partners are typing, and the only thing the two partners have in common is an image that they can both see. One object of the game is to have each player type exactly what his or her partner is typing or has already typed. Once both players type the same string of words or letters, they receive a new image (the players are not required to type the string at the same time). The string upon which the two players agree is used as a label for that image. When trying to agree on a word, players may not be able to type certain specific strings of characters or "forbidden words". When humans play the electronic game (online or over the Internet), they help computers determine the contents of images. If played by a large number of people, this game could provide a resource capable, of classifying a vast portion of images on the World Wide Web. Because of the rules governing abstracts, this abstract should not be used to construe the claims.
A63F 13/70 - Game security or game management aspects
A63F 13/45 - Controlling the progress of the video game
A63F 13/795 - Game security or game management aspects involving player-related data, e.g. identities, accounts, preferences or play histories for providing a buddy list
patents
