A tactile sensor utilizes a magnet embedded in an elastomer and a magnetometer for measuring a strength of a magnetic field emitted by the magnet. The elastomer may include two layers, with a first layer having a lower modulus than the second layer. When two layers are used, the magnet can be positioned at an interface between the layers. The use of a softer outer layer increases the sensitivity of the sensor. Sensitivity can be further increased by including features or a pattern of features on the surface of the elastomer. The features, which can be similar to fingerprints on a human hand, are adapted to provide vibrational information caused by the surface roughness of a material. The sensor provides material characterization and can be used to identify the material in contact with the sensor. The sensor can be fabricated using molding techniques.
2.
PROCESS MAPPING FOR ADDITIVE MANUFACTURING USING MELT POOL TOPOLOGICAL FEATURES
Methods and systems are for generating a process map for forming a structure, the process map usable for controlling additive manufacturing with the structure. The methods and systems are configured for obtaining a value of at least one process parameter for controlling thermo-fluid dynamics of the structure for melting material; heating, in accordance with the value of the at least one process parameter, the structure; obtaining a high-speed imaging of a melt pool; determining changes in a topological shape of the melt pool from the imaging; determining an absence or a presence of a defect in the structure representing whether the material is successful added to the structure; and generating a process map that correlates the value of the at least one process parameter to the absence or the presence of the defect in the structure.
Provided are systems, methods, and apparatuses for passive light interferometry. A system includes a mirror, a first sensor arranged to capture light from a light source reflected by the mirror, a controller in communication with the first sensor, the controller configured to cause rotation of the mirror based on movement of the light, an interferometer arranged in an optical path of the light source reflected by the mirror, and a beam splitter arranged in an optical path between the mirror and the interferometer.
G01N 21/35 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
4.
SYSTEM AND METHOD FOR NAVIGATING AND INTERACTING VIA CONVERSATION
A system and method can be used by blind and low-vision users to navigate and interact in an environment using conversational speech. The system and method integrate object detection, spatial anchors, and conversation to support both independent navigation and interaction. Object detection can be accomplished by capturing data from sensors on an electronic device carried by the user. Spatial anchors can include information relevant to requests from the user. The use of conversational speech permits an exchange of information that is not cognitively overwhelming.
Cationic compounds and methods of making and using same. A cationic compound comprises one or more norborenyl group(s) and one or more cationic group(s). The cationic groups(s) is/are chosen from phosphonium groups, imidazolium groups, cyclic ammonium groups, and the like, and any combination thereof. The cationic group(s) is/are independently covalently linked or covalently linked via a linking group to the norbornene ring of a norborenyl group. In various examples, one or more cationic compound(s) is/are used as a monomer or monomers in a polymerization, such as, for example, a direct insertion polymerization or the like, to form a cationic polymer. In various examples, an anionic exchange membrane, which may be used in a device, such as, for example, in a sensor, an actuator, an energy-storage device, or an energy-generating device, or the like, comprising one or more cationic polymer(s).
C07D 295/02 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
6.
PRIORITIZING CANDIDATE CELL TYPE-SPECIFIC ENHANCERS THROUGH COMPARATIVE GENOMICS
Materials and methods for labeling and isolating particular cell types from mixed cell populations are provided herein. Also provided herein are methods for generating data representing a synthetic genetic sequence configured for labeling at least one cell type by causing expression of a marker in the at least one cell type.
The invention relates to a method (100) for embedding at least one application (20) into a real-time environment, the real-time environment being provided by a memory-programmable controller (31), and the method having the following steps: - receiving (101) the at least one application (20), said at least one application (20) being received as an intermediate representation, - providing (102) a sandbox (80) for the at least one received application (20), and - running (103) the at least one application (21), which is run in the sandbox, wherein the step of running (103) the application is carried out on the basis of an interpretation of the at least one application (21) run in the sandbox using a virtualization runtime (35) of the real-time environment. The intermediate representation is expanded by the runtime (35) in order to provide at least one real-time and/or security function for the at least one application (21) run in the sandbox.
G06F 21/53 - Monitoring users, programs or devices to maintain the integrity of platforms, e.g. of processors, firmware or operating systems during program execution, e.g. stack integrity, buffer overflow or preventing unwanted data erasure by executing in a restricted environment, e.g. sandbox or secure virtual machine
G06F 21/54 - Monitoring users, programs or devices to maintain the integrity of platforms, e.g. of processors, firmware or operating systems during program execution, e.g. stack integrity, buffer overflow or preventing unwanted data erasure by adding security routines or objects to programs
Provided is a system, method, and apparatus for steering light. The system includes a medium arranged in a path of at least one light beam and at least one controller configured to steer the at least one light beam by modulating a sonic waveform in the medium.
G02B 1/06 - Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of fluids in transparent cells
B06B 1/06 - Processes or apparatus for generating mechanical vibrations of infrasonic, sonic or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction
B06B 1/20 - Processes or apparatus for generating mechanical vibrations of infrasonic, sonic or ultrasonic frequency making use of a vibrating fluid
G01H 9/00 - Measuring mechanical vibrations or ultrasonic, sonic or infrasonic waves by using radiation-sensitive means, e.g. optical means
Disclosed herein is a formalized programming framework using memory compartmentalization and other properties of certified compilers to provide that security guarantees verified at the source level also hold on the compiled code. A trusted execution environment formulated as a collection of objects that access separate memory locations and conform to a public interface.
G06F 21/57 - Certifying or maintaining trusted computer platforms, e.g. secure boots or power-downs, version controls, system software checks, secure updates or assessing vulnerabilities
G06F 9/30 - Arrangements for executing machine instructions, e.g. instruction decode
G06F 9/448 - Execution paradigms, e.g. implementations of programming paradigms
G06F 11/36 - Preventing errors by testing or debugging of software
Disclosed herein is a novel system that enables focus tunability with spatial selectivity, in which the lens appears to have different focal lengths over different parts of the display. This is achieved with an improved and modified version of a Lohmann lens that enables spatial selectivity, while replacing mechanical motion with optical translation using a phase spatial light modulator.
G02F 1/015 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour based on semiconductor elements with at least one potential jump barrier, e.g. PN, PIN junction
G06F 3/048 - Interaction techniques based on graphical user interfaces [GUI]
12.
SYSTEM AND METHOD FOR TRAINING A SUBJECT TO SELF-REGULATE NEURAL VARIABILITY
Disclosed herein is a system and method for training a subject to self-regulate neural variability. The system and method implements a prefrontal cortex brain-computer interface (BCI) and a method that allows subjects to use neurofeedback to produce a desired neural activity by regulation of their arousal levels to stabilize their neural activity across a timescale of seconds or minutes. The system comprises a prefrontal cortex brain-computer interface (BCI) to train subjects to use neurofeedback to produce desired neural activity. Subjects used the disclosed system and method, which includes BCI feedback, to self-regulate their arousal levels and successfully stabilize their neural activity.
Provided herein is a method of mounting tissue or cell sample for microscopic analysis, a kit for the preparation of a microscope slide assembly, and microscope slide assemblies. The tissue or cell samples can be expanded tissue or cell samples embedded in a swelled polymer.
Disclosed herein is a system and method for controlling a high-density storage system comprising a plurality of layers, each layer comprising a plurality of rows for storing a plurality of coupled totes and one or more carriers located on opposite ends of each layer, each carrier being multiple rows wide, each carrier capable of retrieving totes from a row in the layer, depositing a tote into a row in the layer and shifting totes from one row to another within the layer.
Disclosed herein is a mobile high-density storage system comprising a storage structure deployed in a mobile container, for example, a tractor-trailer or a delivery van. The mobile storage structure optimizes the arrangement of totes within the structure while mobile such that the totes required for the next delivery are able to be easily accessed, for example, by moving the totes required for the next delivery to a location near and open end of the mobile container. In some embodiments, the mobile storage structure may interface with a storage structure deployed in a warehouse to automatically transfer totes from the mobile storage structure to the stationary storage structure.
Disclosed herein are various configurations of a high-density storage system comprising a plurality of layers, each layer comprising a plurality of rows for storing a plurality of coupled totes and one or more robotic carriers located on opposite ends of each layer, each carrier being multiple rows wide, each carrier capable of retrieving totes from a row in the layer, depositing a tote into a row or oral in a layer and shifting totes from one row to another within the layer.
B65G 35/06 - Mechanical conveyors not otherwise provided for comprising a load-carrier moving along a path, e.g. a closed path, and adapted to be engaged by any one of a series of traction elements spaced along the path
B65G 1/133 - Storage devices mechanical with article supports or holders movable in a closed circuit to facilitate insertion or removal of articles the circuit being confined in a horizontal plane
B65G 1/137 - Storage devices mechanical with arrangements or automatic control means for selecting which articles are to be removed
G06Q 10/087 - Inventory or stock management, e.g. order filling, procurement or balancing against orders
17.
SYSTEM AND METHOD FOR LOCAL PORE DETECTION IN LASER POWDER BED FUSION ADDITIVE MANUFACTURING
HONEYWELL FEDERAL MANUFACTURING & TECHNOLOGIES, LLC (USA)
Inventor
Sun, Tao
Ren, Zhongshu
Chen, Lianyi
Rollett, Anthony
Choi, Ann
Abstract
In one aspect, the disclosure relates to detection of pore defects in laser powder bed fusion additive manufacturing. A convolutional neural network is trained based upon a training data set. The training data set can be generated using simulations or experiments performed on a metal sample by capturing side-view x-ray imagery as well as top-view thermal imagery of the metal sample as it is formed with a laser. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
B22F 10/28 - Powder bed fusion, e.g. selective laser melting [SLM] or electron beam melting [EBM]
B29C 64/153 - Processes of additive manufacturing using only solid materials using layers of powder being selectively joined, e.g. by selective laser sintering or melting
B22F 3/105 - Sintering only by using electric current, laser radiation or plasma
G01N 29/44 - Processing the detected response signal
18.
SYSTEM AND METHOD FOR DESIGNING STIMULI FOR NEUROMODULATION
Disclosed herein is a novel pseudoinverse estimation system and method that adapts regression techniques to directly estimate one or more pseudoinverses of a neuromodulation pathway, thereby circumventing the need of inverting an estimated forward model. This is accomplished by the learning of a restricted domain that restricts the potential stimuli required to produce a desired neuro response.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G06F 18/213 - Feature extraction, e.g. by transforming the feature space; Summarisation; Mappings, e.g. subspace methods
G06F 18/2415 - Classification techniques relating to the classification model, e.g. parametric or non-parametric approaches based on parametric or probabilistic models, e.g. based on likelihood ratio or false acceptance rate versus a false rejection rate
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
19.
PROFILING NEWLY-SYNTHESIZED GLYCOPROTEINS AS MOLECULAR SIGNATURES OF INJURY IN DONOR ORGANS
Disclosed herein is a novel method for improving transductive fine-tuning for few-shot learning using margin-based uncertainty weighting and probability regularization. Margin-based uncertainty is designed to assign low loss weights for wrongly predicted samples and high loss weights for the correct ones. Probability regularization provides for the probability of each testing sample being adjusted by a scale vector, which quantifies the difference between the class marginal distribution and the uniform.
Disclosed herein is a method for skeleton-based action recognition using handcrafted features. The input of the model is keypoint data of one or more skeletons from the frames of a video clip. Several histogram features are used to describe the spatial and temporal patterns of the corresponding body. These features are concatenated and sent to a linear classifier to predict the category of the actions.
Additive manufacturing methods, additive manufacturing systems, and products thereof are provided. The method comprises depositing a bioink into a support material based on a first computer model of an object, thereby forming a first portion of an object in the support material. The bioink comprises cells. The method comprises depositing a structure material into the support material based on the first computer model of an object, thereby forming a first portion of a scaffold for the object. The structure material is different from the bioink and the structure material comprises a polymer. The method comprises repeating the depositing of the bioink and the structure material as necessary to additively form the object and the scaffold within the object.
B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
B33Y 80/00 - Products made by additive manufacturing
23.
PHOSPHORAMIDITE CONJUGATES AND METHODS OF FORMING SYNTHETIC OLIGONUCLEOTIDES THEREFROM
A method of synthesizing a polynucleotide composition includes performing a synthesis of the polynucleotide composition via phosphoramidite chemistry, solid-phase supported synthesis, to create polynucleotide chain. During at least one cycle of the synthesis, coupling an RDRP-phophoramidite reagent in a growing chain of the polynucleotide composition. The RDRP -phophoramidite reagent, includes a phosphoramidite compound conjugated to an RDRP initiator or a chain transfer agent for RDRP via a moiety comprising a protected hydroxyl group. A hydroxyl protecting group of the protected hydroxyl group is stable to polynucleotide synthesis conditions.
B01J 19/00 - Chemical, physical or physico-chemical processes in general; Their relevant apparatus
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
C40B 50/08 - Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
24.
POST-SYNTHETIC MODIFICATION OF POLYNUCLEOTIDES VIA ACYLATION REAGENTS
A method of modifying a polynucleotide includes reacting the polynucleotide with one or more molecules of an acylating reagent. The acylating reagent includes an acylating compound conjugated to (i) an initiator compound for reversible deactivation radical polymerization; (ii) a chain transfer agent for reversible deactivation radical polymerization or (iii) a compound comprising a polymerizable group to form a modified polynucleotide.
C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
Disclosed herein is a system and method implementing a processing and detection pipeline to detect spreading depolarization waves in a brain occurring after a traumatic brain injury. The method relies solely on EEG data collected by a standard EEG machine.
Disclosed herein is a novel method for modelling and simulating urban solar harvesting by modeling the components of solar radiation using a modelling framework with modules related to view factors, transmittance, beam and diffuse shadow modeling, heat transfer equilibrium, and a virtual environment that emulates urban infrastructure and receives weather and radiation data as inputs. Also disclosed herein are various approaches for modelling diffuse shadows, which are a component of the integrated modelling framework. The various modules are integrated and optimized to compose several versions of modeling and simulation tools, which can estimate the temperature, power, and energy output of dense groups of freely-defined dynamic solar harvesting surfaces in urban and other intricate scenarios characterized by high three-dimensionality.
Disclosed herein is a co-designed compiler and CGRA architecture that achieves both high programmability and extreme energy efficiency. The architecture includes a rich set of control-flow operators that support arbitrary control flow and memory access on the CGRA fabric. The architecture is able to realize both energy and area savings over prior art implementations by offloading most control operations into a programmable on-chip network where they can re-use existing network switches.
Disclosed herein is a high-density storage system comprising a plurality of layers, each layer comprising a plurality of rows for storing a plurality of coupled totes and one or more carriers located on opposite ends of each layer, each carrier being multiple rows wide, each carrier capable of retrieving totes from a row in the layer, depositing a tote into a row or oral in a layer and shifting totes from one row to another within the layer.
B65G 1/06 - Storage devices mechanical with means for presenting articles for removal at predetermined position or level
B65G 1/137 - Storage devices mechanical with arrangements or automatic control means for selecting which articles are to be removed
B65G 41/00 - Supporting frames or bases for conveyors as a whole, e.g. transportable conveyor frames
B65D 21/028 - Containers specially shaped, or provided with fittings or attachments, to facilitate nesting, stacking, or joining together for stacking containers lying on their sides, or for joining containers side-by-side, by means which are lateral with respect to the normal orientation of the containers with interconnecting means forming part of the containers, e.g. dovetails, snap connectors or hook elements
B65G 1/00 - Storing articles, individually or in orderly arrangement, in warehouses or magazines
B65G 1/16 - Special arrangements of articles in storage spaces
B65G 47/90 - Devices for picking-up and depositing articles or materials
29.
BIODEGRADABLE HYDROGEL ACTUATOR WITH SHAPE MORPHING CAPABILITY FOR SOFT ROBOTICS AND METHODS OF FABRICATION
A morphing, biologically-derived actuator can be used with soft robotics in a marine environment. The actuator is fabricated using a modified hydrogel additive manufacturing printing process, where the printed structure is exposed to various concentrations of crosslinking initiator to ensure a water-tight seal between adjacent printed layers. The actuator fabricated using the disclosed process is suitable for marine use and is safe for marine animals and is biodegradable.
B25J 19/00 - Accessories fitted to manipulators, e.g. for monitoring, for viewing; Safety devices combined with or specially adapted for use in connection with manipulators
B32B 27/28 - Layered products essentially comprising synthetic resin comprising copolymers of synthetic resins not wholly covered by any one of the following subgroups
B32B 27/08 - Layered products essentially comprising synthetic resin as the main or only constituent of a layer next to another layer of a specific substance of synthetic resin of a different kind
30.
METHOD FOR PRODUCTION OF VIRUS-LIKE PARTICLES FOR GENE DELIVERY
Methods for production of gene-delivery vectors suitable for animal models and humans using a bacteria/mammalian dual-expression plasmid, wherein the virus-like particles may be massively produced via heterologous expression in bacteria. Also provided are methods of increasing virus-like particle transduction efficiency and methods of directed evolution.
A capacitive sensor system is adapted for use as a wearable sensor and is capable of measuring the muscle activity of a user. The sensor system monitors the change in distance between an electrode and the user's skin, where the change is caused by the changing muscle cross-sectional area or muscle bulging. A musculoskeletal model is used to validate the capacitance measurement with the muscle cross-sectional area from gold-standard marker-based motion capture along with gold-standard measurements of muscle excitation, and muscle contraction force. The sensor can be used in real-world settings to assist with gait rehabilitation, among other uses.
A clinical decision support system and method for patients with pulmonary arterial hypertension is disclosed herein. The system may comprise a processor to process instructions to execute one or more pulmonary arterial hypertension risk algorithms configured to generate a risk score value associated with a patient surviving within a given time period. The system may comprise a means for input and output, wherein input variable data may be received and a set of risk score values may be displayed. A method for operating the clinical decision support system is also disclosed.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/02 - Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
33.
METHOD AND SYSTEM TO IDENTIFY NATURAL PRODUCTS FROM MASS SPECTROMETRY AND GENOMICS DATA
A method and system is for receiving data representing gene clusters, the gene clusters including one or more genes configured to encode one or more polypeptides or other small molecules; accessing a machine learning model, the machine learning model being trained with a training dataset that associates the gene clusters to structures of one or more small molecules represented in the data; applying the machine learning model to the data representing the gene clusters; identifying, based on applying the machine learning model, one or more monomers associated with at least one gene cluster represented in the data; and determining a structure for a natural product including the one or more monomers.
A needle for mass spectrometry having a solid shaft and a first end with a tip having a radius of curvature of less than 1500 nm, wherein the tip is distal from a second end of the needle, wherein the second end is configured to accept an electrical potential, and wherein the tip provides an ionization region when the electrical potential is applied. Methods of manufacturing a needle having a radius of curvature of less than 1500 nm. Methods and systems including at least one needle of the present disclosure for qualitative and/or quantitative analysis.
Disclosed herein is a nanostructured composite thermal interface and a method for fabricating the interface. The interface consists of a metal foil having arrays of metal nanowires disposed on either side thereof. An adhesive polymer is interspersed within the nanowires in each array and serves as a binder to adhere the interface to the surfaces of target objects, for example, a CPU and a heat sink.
Disclosed herein is a method for fabricating a nanowire array on an uneven or curved surface. A pliable, porous scaffold is used to hold a liquid electrolyte, creating s semi-solid electrolyte that is used to transfer pressure to a template disposed on the target surface to cause the template to conform to and bond with the target surface to substantially eliminate the gap therebetween, such that a robust and controllable growth of the nanowire array can be realized.
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
A61K 47/28 - Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
An oxygenation system producing oxygen for therapeutic cells housed in an implanted or external device, the oxygenation system comprising a first electrode comprising a first material layer stack and a catalyst film of a high surface area or catalyst particles on which at least one catalyst for electrocatalytic oxygen evolution reaction is disposed; and a second electrode comprising a second material stack.
Disclosed herein is a method for optimizing electrode placement that directly exploits the thresholding phenomenon of neurons. The method employs a loss function which only becomes non-zero when the electric field is above a user- specified threshold in the cancel region, thereby allowing for fields which can have significant non-zero current in the cancel region, but still provide more focused neural activation.
A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
Provided is a system and method for holographic light curtains. A system includes a holographic projector configured to project a holographic image, a rolling-shutter camera arranged to receive light from the holographic image, and at least one processor in communication with the rolling-shutter camera, the at least one processor programmed or configured to: determine an intensity of the light received from the holographic image; and detect a disturbance in a space of the holographic image based on a change in the intensity.
Disclosed herein are devices comprising stretchable interdigitated electrode arrays and methods for fabricating the devices. The devices are capable of acting as elongation sensors by sensing a change in the capacitance of the device as the distance between the interdigitated fingers changes when the device is elongated or compressed. The device may be coupled to other devices such as to be able to sense elongation or compression of the coupled device. The interdigitated fingers of the device are supported by a substrate and may be fabricated using traditional microfabrication techniques.
G01B 7/16 - Measuring arrangements characterised by the use of electric or magnetic techniques for measuring the deformation in a solid, e.g. by resistance strain gauge
G01B 1/00 - Measuring instruments characterised by the selection of material therefor
Disclosed herein is a novel design of an instrumented cochlear implant, wherein the electrode array portion of the implant is provided with a microfabricated thin-film sensing array comprising one or more sensors to detect various features of the electrode array during insertion and to provide feedback to the surgeon during implantation. The sensing array collects intraoperative information on the state of the electrode array during insertion.
Disclosed herein is an artificial intelligence-based system and method for detecting possible danger in a scene contain one or more people. Individual people are detected and it is determined if one of the person's limbs is in a threatening position and if the hand of the person is holding a weapon. The system uses neural networks to detect people and weapons and classifiers to determine a probability of danger, based on the evaluation of the position and state of the limbs of the person.
Disclosed herein is a system for analyzing data extracted from an instrumented cochlear implant, wherein the electrode array portion of the implant is provided with a microfabricated thin-film sensing array comprising one or more sensors to detect various features of the electrode array during insertion and to provide feedback to the surgeon during implantation. Preferred embodiments of the system utilize one or more trained machine learning models to extract features from the raw data received from the sensing array and can perform a pose estimation of the electrode array and recommend next surgical actions to increase the probability of a positive clinical outcome.
Disclosed herein is a cochlear implant surgery simulator and training system. The system comprises a 3D model of a scala tympani upon which a surgeon performs practice insertions an the electrode array of a cochlear implant, wherein the electrode array is instrumented with one or more thin-film sensors disposed along a length of the electrode array, enabling real-time collection of force and position data. The system further comprises a feedback system for analyzing data collected from the instrumented electrode array and deriving scoring metrics regarding the surgeon's insertion technique.
Disclosed herein is a system and method for implementing object detection and identification, regardless of the orientation of the object. The product detection and recognition method and system disclosed herein comprises capturing views of each object from different angles from a plurality of cameras and fusing the result of a matching process to identify the object as one of a plurality of objects enrolled in an object database.
A method of detecting bacteria. An example aspect is configured to: provide at least one peptide comprising the amino acid sequence as set forth in any one of SEQ ID NOS: 1-46; attach a label to the at least one peptide to form a labeled peptide; add the labeled peptide to an aqueous sample; and detect a qualitative or quantitative signal in the aqueous sample, the signal indicating a presence of at least one gram-positive or at least one gram-negative bacteria. A peptide capable of binding to at least one cell wall carbohydrate ligand on a cell wall surface of at least one bacteria, the peptide having an amino acid sequence as set forth in any one of SEQ ID NOS: 1-46.
Disclosed herein is a system and method to provide secured I/O channels for multiple types of I/O devices to isolated applications, on-demand. The invention enables composition of different I/O kernels and, as such, eliminates developer effort required to re-implement and re-verify new I/O kernels to protect multiple types of I/O devices.
G06F 9/455 - Emulation; Interpretation; Software simulation, e.g. virtualisation or emulation of application or operating system execution engines
G06F 21/53 - Monitoring users, programs or devices to maintain the integrity of platforms, e.g. of processors, firmware or operating systems during program execution, e.g. stack integrity, buffer overflow or preventing unwanted data erasure by executing in a restricted environment, e.g. sandbox or secure virtual machine
G06F 21/57 - Certifying or maintaining trusted computer platforms, e.g. secure boots or power-downs, version controls, system software checks, secure updates or assessing vulnerabilities
49.
SCALABLE FABRICATION OF MICRODEVICES FROM METALS, CERAMICS, AND POLYMERS
A method for manufacturing a structure having at least one microscale feature includes mixing a powdered material with a binder to yield a slurry, shaping the slurry to yield a green device, and sintering the green device to yield the structure.
B22F 3/00 - Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sintering; Apparatus specially adapted therefor
C04B 35/00 - Shaped ceramic products characterised by their composition; Ceramic compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
C04B 35/622 - Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
C04B 35/626 - Preparing or treating the powders individually or as batches
B29C 33/38 - SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING - Details thereof or accessories therefor characterised by the material or the manufacturing process
B29C 33/42 - SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING - Details thereof or accessories therefor characterised by the shape of the moulding surface, e.g. ribs or grooves
B81C 1/00 - Manufacture or treatment of devices or systems in or on a substrate
50.
SYSTEM FOR ROBOTIC CHARACTERIZATION OF IMPACTED SITES
A mobile testing and evaluation vehicle can include a body and a mobility feature disposed on the body, where the mobility feature is configured to move the body with respect to a zone of interest. The mobile testing and evaluation vehicle can also include a sensor device configured to obtain a measurement of a parameter associated with a sample in the zone of interest. The mobile testing and evaluation vehicle can further include a controller that is configured to receive the measurement, evaluate the sample based on the measurement, and evaluate the zone of interest based on evaluating the sample.
A method, system, and computer program product for designing reconfigurable kinematic devices. An example aspect is configured to: model two rigid stages of the device, assign at least one degree of freedom to at least one kinematic mode of the device; design at least one flexural rod; place at least one tunable flexure; assign a thickness to the at least one flexural rod; add mechanical details; and modularize the device for printing. A kinematic device configured to provide haptic feedback or motion control having at least two rigid stages, at least one kinematic mode, at least one flexural rod, and at least one tunable flexure.
G06F 30/15 - Vehicle, aircraft or watercraft design
G06F 30/17 - Mechanical parametric or variational design
G06F 30/12 - Geometric CAD characterised by design entry means specially adapted for CAD, e.g. graphical user interfaces [GUI] specially adapted for CAD
G06F 30/20 - Design optimisation, verification or simulation
52.
SYSTEM, METHOD, AND COMPUTER PROGRAM PRODUCT FOR GENERATING MODIFIED LIGHT EMISSIONS
Provided are systems, methods, and computer program products for generating modified light emissions. The system includes at least one signal receiver arranged on a vehicle, at least one sensor arranged on the vehicle, at least one lighting system arranged on the vehicle, and at least one processor in communication with the at least one signal receiver, the at least one sensor, and the at least one lighting system, the at least one processor configured to: receive a first signal with the at least one signal receiver; receive sensor data from the at least one sensor; determine lighting data based on the first signal; generate a modified light emission by geometrically transforming the lighting pattern based on the sensor data; and control the at least one lighting system to output the modified light emission.
B60Q 1/14 - Arrangement of optical signalling or lighting devices, the mounting or supporting thereof or circuits therefor the devices being primarily intended to illuminate the way ahead or to illuminate other areas of way or environments the devices being headlights having dimming means
B60Q 1/46 - Arrangement of optical signalling or lighting devices, the mounting or supporting thereof or circuits therefor the devices being primarily intended to indicate the vehicle, or parts thereof, or to give signals, to other traffic for giving flashing caution signals during drive, other than signalling change of direction, e.g. flashing the headlights
B60R 11/04 - Mounting of cameras operative during drive; Arrangement of controls thereof relative to the vehicle
53.
MEDICAL PATCH FOR CONTROLLED DELIVERY OF WOUND HEALING FACTORS AND THERAPIES
The present disclosure is directed a medical device applied as patch to a wound to promote healing. Engineered cells are disposed in the device that can secrete wound healing factors in response to light utilizing optogenetics. Biomaterials can be formed as needles into which cells can be loaded. Biosensors can also be included to facilitate multi-point mapping of the wound healing process. Another feature is an electrical stimulator to enhance cell proliferation and differentiation, further enhancing wound repair.
Stretchable and flexible thermoelectric devices may generally include a substrate having an array of semiconductors in electrical communication via a plurality of liquid metal interconnects, and coated on at least a portion thereof with opposing liquid crystal elastomer layers. The liquid crystal elastomer layers may be reaction products of a reaction mixture of a mesogenic group, a spacer, a crosslinker, and a photoinitiator. The liquid crystal elastomer layers may alternately heat and cool to achieve cyclical bending actuation when voltage is applied to the thermoelectric device. Methods of making and using the thermoelectric devices are also described.
H10N 10/856 - Thermoelectric active materials comprising organic compositions
H10N 10/13 - Thermoelectric devices comprising a junction of dissimilar materials, i.e. devices exhibiting Seebeck or Peltier effects operating with only the Peltier or Seebeck effects characterised by the heat-exchanging means at the junction
F03G 7/06 - Mechanical-power-producing mechanisms, not otherwise provided for or using energy sources not otherwise provided for using expansion or contraction of bodies due to heating, cooling, moistening, drying, or the like
H01L 25/00 - Assemblies consisting of a plurality of individual semiconductor or other solid state devices
Methods of controlling a computing system based on wiggling and/or other types of continuous multidirectional gesturing. In some embodiments, the methods monitor user gesturing for the occurrence of a recognizable item-action gesture that a user has made without having provided any other input to the computing system and then take one or more actions in response to recognizing the item-action gesture. In some embodiments, the actions include identifying one or more on-display item underlying the item-action gesture, duplicating the identified item(s) to one or more target locations, and adding one or more visual indicia to the identified on-display item(s), among other things. In some embodiments, a user can append an item-action gesture with one or more action extensions that each cause the computing system to take one or more additional actions concerning the identified on-display item(s). Software for performing one or more of the disclosed methodologies is also disclosed.
G06F 3/0488 - Interaction techniques based on graphical user interfaces [GUI] using specific features provided by the input device, e.g. functions controlled by the rotation of a mouse with dual sensing arrangements, or of the nature of the input device, e.g. tap gestures based on pressure sensed by a digitiser using a touch-screen or digitiser, e.g. input of commands through traced gestures
G06F 3/0484 - Interaction techniques based on graphical user interfaces [GUI] for the control of specific functions or operations, e.g. selecting or manipulating an object, an image or a displayed text element, setting a parameter value or selecting a range
Provided are systems, methods, and computer program products for optical vibration sensing. The system includes a first visual sensor, a second visual sensor, and at least one processor in communication with the first visual sensor and the second visual sensor, the at least one processor configured to: capture at least one first image comprising at least one light on at least one object with the first visual sensor, capture at least one second image comprising the at least one light on the at least one object with the second visual sensor, and determine a vibration of the at least one object based on the at least one light captured in the at least one first image and the at least one second image.
Provided herein are methods, nucleic acids, transformed yeast cells, and kits useful for rapid and effective multiplexed identification of nanobody binding to a target protein domain.
C40B 30/04 - Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
G01N 33/533 - Production of labelled immunochemicals with fluorescent label
Provided herein is a method of detecting or quantifying a microbe, such as a virion or bacteria cell, in a biological sample by agglutination with a yeast cell expressing on its surface a fusion protein including an anchor, a nanobody peptide, and a fluorogen-activating peptide. Also provided herein are yeast cells comprising a gene for expressing the fusion protein and a kit comprising the yeast cells.
Disclosed herein is a system and method for generating complex, concave polygonal bonding boxes which tightly cover the most representative faces of retail products having arbitrary poses. The polygonal bounding boxes do not include unnecessary background information or miss parts of the objects, as would the axis-aligned or rotated bounding boxes produced by prior art detectors. A simple projection transformation can correct the pose of products for downstream tasks.
G06T 7/70 - Determining position or orientation of objects or cameras
G06V 10/44 - Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersections; Connectivity analysis, e.g. of connected components
60.
3D-PRINTED MICRO-SUPERCAPACITORS AND METHODS FOR FABRICATING THE SAME
Three-dimensional micro-supercapacitors and methods for fabrication of micro- supercapacitors are provided. A micro-supercapacitor embodiment includes a three- dimensional electrode with self-supporting layers of two-dimensional nanomaterial. A method embodiment includes using non-contact 3D printing to generate a micro- supercapacitor, including a three-dimensional electrode having self-supporting two- dimensional nanomaterial.
Systems, apparatuses and methods for automated perineal care are provided. A system embodiment includes a user support element, a sensor configured to measure a cleanliness state of a user, a cleaning element configured to clean a user perineal area, and a controller configured to command operation of the cleaning element based on the sensor. An apparatus embodiment includes a containment structure, a sensor, a cleaning element assembly including a drive, actuator and a nozzle, and a controller configured to control the cleaning element assembly based on the sensor. A method embodiment includes positioning a user into a perineal cleaning position, scanning the user with a sensor, determining a cleanliness status, and activating a cleaning element based on the cleanliness status.
A system, method, and computer program product for predicting properties of electrolytes in a liquid electrolyte mixture independent of empirical fitting from experimentally measured properties. An example aspect is configured to: validate at least one molecular force field, prepare a liquid electrolyte mixture corresponding to the at least one molecular force field, perform molecular dynamic simulations of the electrolyte mixture, obtain simulated molecular dynamic trajectories from the molecular dynamic simulations, and perform molecular structure analysis to predict ionic conductivity, ion pairing properties, solubility properties, and/or other thermodynamic properties of the liquid electrolyte mixture.
G16C 10/00 - Computational theoretical chemistry, i.e. ICT specially adapted for theoretical aspects of quantum chemistry, molecular mechanics, molecular dynamics or the like
G16C 60/00 - Computational materials science, i.e. ICT specially adapted for investigating the physical or chemical properties of materials or phenomena associated with their design, synthesis, processing, characterisation or utilisation
G06F 3/00 - Input arrangements for transferring data to be processed into a form capable of being handled by the computer; Output arrangements for transferring data from processing unit to output unit, e.g. interface arrangements
63.
SYSTEMS AND METHODS FOR VERIFYING TRAIN CONTROLLERS
Disclosed herein is a system and method for formally verifying the safety of the Federal Railroad Administration freight train kinematics model with all its relevant forces and parameters, including track slope and curvature, airbrake propagation, and resistive forces as computed by the Davis equation.
G06F 30/27 - Design optimisation, verification or simulation using machine learning, e.g. artificial intelligence, neural networks, support vector machines [SVM] or training a model
G06F 11/14 - Error detection or correction of the data by redundancy in operation, e.g. by using different operation sequences leading to the same result
B61C 17/12 - Control gear; Arrangements for controlling locomotives from remote points in the train or when operating in multiple units
G06F 11/34 - Recording or statistical evaluation of computer activity, e.g. of down time, of input/output operation
64.
INTERACTIVE SYSTEM USING SPEECH RECOGNITION AND DIGITAL MEDIA
A system for interactive system using speech recognition and digital media is described. The system uses automated speech recognition and recognizes interactions from users to execute digital media items. The interactions are based on behavior of the user. The user is given a prompt. If the student responds to a prompt correctly, the student is rewarded with an animation. Otherwise the user experience continues without a reward. The system recognizes natural language responses for interactions of the user. The media item is dynamically generated as the user interacts with the digital media item.
The present disclosure is directed to simple, scalable methods of forming colloidal MXene dispersions in nonpolar organic solvents with long term stability.
A hybrid graphene material includes a functional group to expand the use of graphene in various applications. The hybrid material may include a substrate, such as silicon nanowires, where the graphene is fabricated on the surface of the substrate with an out-of-plane topography. Functional groups can be added to the graphene and affect the electrical, chemical, or photo characteristics of the hybrid material.
Provided herein are engineered lipid-bound vesicles for cytosolic delivery of an exogenous secreted, cell surface receptor-binding signaling molecule. Also provided herein are methods of making and using the engineered lipid-bound vesicles, and devices comprising the lipid-bound vesicles.
A61P 19/08 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
B22F 12/00 - Apparatus or devices specially adapted for additive manufacturing; Auxiliary means for additive manufacturing; Combinations of additive manufacturing apparatus or devices with other processing apparatus or devices
B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
68.
SYSTEM AND METHOD FOR MATERIAL MODELLING AND DESIGN USING DIFFERENTIABLE MODELS
Disclosed herein is a framework for the modeling and design of materials based on differentiable programming, where the models can be trained by gradient-based optimization. Within this framework, all the components are differentiable and can be seamlessly integrated and unified with deep learning. The framework can design and optimize materials for a variety of applications.
G16C 60/00 - Computational materials science, i.e. ICT specially adapted for investigating the physical or chemical properties of materials or phenomena associated with their design, synthesis, processing, characterisation or utilisation
G16C 20/30 - Prediction of properties of chemical compounds, compositions or mixtures
G16C 20/70 - Machine learning, data mining or chemometrics
G06N 7/00 - Computing arrangements based on specific mathematical models
69.
FREEFORM FABRICATION OF THREE-DIMENSIONAL STRUCTURES USING A DROPLET-ON-DEMAND PROCESS WITH CONTINUOUS AND FREQUENCY MODULATED MATERIAL DEPOSITION
A method of forming a three-dimensional structure using droplet-based freeform printing is provided. The method includes depositing a structural material through one or more nozzles onto a surface of a substrate by droplet-based freeform printing, such as inkjet printing, to form one or more three-dimensional structures comprising a smooth surface and one or more cross-sectional dimensions. The structural material undergoes a liquid-to-solid transition after deposition of the structural material, and the one or more cross-sectional dimensions are controlled by a droplet ejection frequency. A method of fabricating a matrix including a three-dimensional structure including forming a negative three-dimensional template using droplet-based freeform printing, depositing, such as casting, a matrix material over the negative three-dimensional template and at least a portion of the surface of the substrate and solidifying the matrix material to form a matrix comprising the one or more three-dimensional structures of the negative template is also provided.
B29C 33/52 - SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING - Details thereof or accessories therefor with means for, or specially constructed to facilitate, the removal of articles, e.g. of undercut articles soluble or fusible
B29C 39/02 - Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor for making articles of definite length, i.e. discrete articles
B33Y 80/00 - Products made by additive manufacturing
Disclosed herein is a method for defining a model of a trusted loT security gateway architecture based on a microhypervisor, wherein evaluation of the model provides a guarantee that the correct security protections are applied to each loT device's network traffic at all times, including when under attack. The models defined in accordance with the method disclosed herein are used to verify security gateway architectures that provide robust trust properties to a broad range of legacy hardware platforms utilizing existing software with a reasonable performance overhead.
Disclosed herein is a system and method for the automatic detection of persons engaged in the open carry of firearms at a venue. The system and method comprise strategically placed cameras at the venue which are connected to edge devices which extract frames from video generated by the cameras. The video frames are sent to a server for analysis by an AI/ML model trained to detect firearms and, specifically, to detect persons carrying firearms. If a person wielding a firearm is detected in any image, an alert is raised and local authorities are automatically contacted. The system is designed to run continuously such as to be able to quickly detect a person in a venue carrying a firearm.
A tactile interaction device uses a plurality of shape-changing tactile elements that are driven by electro-osmotic flow of a fluid. An electric filed applied to a pumping membrane by two electrodes is responsible for inducing a flow of the liquid. Multiple tactile elements can be used on the device to permit localized tactile feedback to a user. The device is adapted to be in contact with the user's skin, such as a finger or hand.
The present disclosure relates to structures and methods of use of textiles for protection, and more particularly, relates to single layer knitted structures that can be worn as garments to block mosquito bites. The knit structures of the present embodiments can include single layer structures having a unique geometric combination of yarn properties and textiles to block mosquito bites in a single, comfortable layer of fabric. The knit structures can include one or more controllable parameters that can be adjusted to increase and/or decrease the bite blocking ability of the knit structure.
A01M 29/34 - Scaring or repelling devices, e.g. bird-scaring apparatus preventing or obstructing access or passage, e.g. by means of barriers, spikes, cords, obstacles or sprinkled water specially adapted for insects
A01M 29/30 - Scaring or repelling devices, e.g. bird-scaring apparatus preventing or obstructing access or passage, e.g. by means of barriers, spikes, cords, obstacles or sprinkled water
D04B 1/00 - Weft knitting processes for the production of fabrics or articles not dependent on the use of particular machines; Fabrics or articles defined by such processes
D04B 1/24 - Weft knitting processes for the production of fabrics or articles not dependent on the use of particular machines; Fabrics or articles defined by such processes specially adapted for knitting goods of particular configuration wearing apparel
D04B 1/14 - Other fabrics or articles characterised primarily by the use of particular thread materials
74.
SCALABLE MANUFACTURING OF MICRONEEDLE ARRAYS USING AUTOMATED HIGH-THROUGHPUT MANUFACTURING SYSTEMS AND HIGH-CAPACITY MOLDING
A manufacturing method for making a plurality of microneedle arrays (MNAs) includes: dispensing a polymer resin into a plurality of wells of at least one mold by an automated dispenser comprising at least one dispensing nozzle; centrifuging the at least one mold to distribute the dispensed polymer resin within the plurality of wells of the at least one mold; curing, solidifying, and/or drying the polymer resin within the plurality of wells of the at least one mold; and removing individual molded MNA parts from the at least one mold with at least one electromechanical mover controlled by at least one computer processor. A mold for making a plurality of the MNAs and a high-throughput manufacturing system for making the MNAs using the mold are also provided.
A61M 5/32 - Syringes - Details - Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
A61K 9/00 - Medicinal preparations characterised by special physical form
75.
METHODS FOR ENGINEERING AND USE OF CILIATED ORGANOIDS HAVING NATIVE-LIKE, APICAL-OUT POLARITY
Disclosed herein is a system and method for implementing a personalized ultrasound neuromodulation system and methods with neural sensing of personalized electrophysiological data, guiding ultrasound targeting and dosage using such personalized data. Specific ultrasound transducer solutions are provided for various neural targets that enable the low-intensity focused ultrasound to modulate the central nervous system and peripheral nervous systems to treat a variety of neurological and mental disorders. A portable ultrasound console device, a wearable guiding apparatus and a compact solution for effectively and safely enabling point-of-care neuromodulation, e.g., home healthcare, are provided. Further methods for ultrasound waveform customization are also described to improve effectiveness of ultrasound neuromodulation.
Disclosed herein is a system and method implementing a trusted loT security gateway architecture, based on a microhypervisor, that provides a guarantee that the correct security protections are applied to each loT device's network traffic at all times, including when under attack. The disclosed architecture provides robust trust properties to a broad range of legacy hardware platforms utilizing existing software with a reasonable performance overhead.
G06F 21/57 - Certifying or maintaining trusted computer platforms, e.g. secure boots or power-downs, version controls, system software checks, secure updates or assessing vulnerabilities
G06F 21/71 - Protecting specific internal or peripheral components, in which the protection of a component leads to protection of the entire computer to assure secure computing or processing of information
H04W 84/18 - Self-organising networks, e.g. ad hoc networks or sensor networks
78.
METHODS FOR FABRICATING AIRWAY ORGANOIDS WITH NATIVE-LIKE, APICAL-OUT POLARITY
A method of fabricating an apical-out airway organoid is accomplished by using a culture medium substantially free of an extracellular matrix material. Mature apical-out airway organoids containing exterior-facing cilia can be induced into rotation when surrounded by a matrix material, such as Matrigel®. A process for quantifying the apical-out airway organoid rotation can be used to measure cilia motility.
Lipid-containing particles and drug products containing the lipid-containing particles are provided. Methods of local and systemic delivery of therapeutic agents to, and through, mucosa, such as intestinal mucosa, are provided.
C08G 65/332 - Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides or esters thereof
80.
SYSTEM AND METHOD IMPLEMENTING A BATTERY AVIONICS SYSTEM FOR ELECTRIC-POWERED AIRCRAFT
Disclosed herein is a system and method implementing a battery avionics system for integrating battery monitoring, control, and management functions with an avionics system of an aircraft. The system uses a model implementing a battery pack digital twin, which is a continuous simulation of the operation of the battery pack within the aircraft, receives data regarding the battery pack generated by the digital twin model and provides optimized parameters to the battery avionics system. The system enables high precision, cell-level resolution control of the battery pack. The system estimates the state of charge, state of health, state of safety, and state of function of the cells and the battery pack as a whole and uses this information to manage the battery pack, given a particular flight profile of the aircraft.
B64D 27/24 - Aircraft characterised by the type or position of power plant using steam, electricity, or spring force
B60L 58/21 - Methods or circuit arrangements for monitoring or controlling batteries or fuel cells, specially adapted for electric vehicles for monitoring or controlling batteries of two or more battery modules having the same nominal voltage
81.
DIRECT DRIVE END-EFFECTORS WITH PARALLEL KINEMATICS
A gripper includes at least one movable finger. Each movable finger includes a first motor, a second motor, a first motor link having a first end coupled to a rotor of the first motor, a second motor link having a first end coupled to a rotor of the second motor, a finger link having a first end in pivotal connection with a second end of the second motor link and a gripper pad, and a connecting link having a first end in pivotal connection with a second end of the first motor link and a second end in pivotal connection with the finger link. The gripper further includes at least one controller programmed or configured to actuate the first motor and the second motor of each of the at least one movable finger.
invitro in vivo in vivo. Extracellular matrix materials, such as collagen, are functionalized with chemicals that are complimentary to ligands disposed on the surface of the extracellular vesicle. In one example embodiment, collagen is functionalized with dibenzocyclooctyne and the extracellular vesicle is functionalized with an azide tag. The extracellular vesicle is immobilized within the collagen through a click reaction involving the dibenzocyclooctyne and the azide tag.
Disclosed herein is a system and method for selecting a battery for a particular application, for example, batteries used in portable electronics, electric vehicles, satellites, etc. The method uses an end-to-end differentiable modeling approach that allows the selection of batteries directly from the parameters of the battery and a specification of the particular application for which the batteries are being selected.
G01R 31/36 - Arrangements for testing, measuring or monitoring the electrical condition of accumulators or electric batteries, e.g. capacity or state of charge [SoC]
Disclosed herein is a system and method implementing an automated, generalizable model for tracking cortical spreading depressions using EEG. The model comprises convolutional neural networks and graph neural networks to leverage both the spatial and the temporal properties of CSDs in the detection. The trained model is generalizable to different head models such that it can be applied to new patients without re-training. Further, the model is scalable to different densities of EEG electrodes, even when trained on a specific electride density.
Lipid-containing particles and formulations containing the lipid-containing particles are provided. Methods of delivery of therapeutic agents to the pancreas using the lipid-containing particles are provided.
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
86.
SYSTEM, METHOD, AND COMPUTER PROGRAM PRODUCT FOR EXTRACTING FEATURES FROM IMAGING BIOMARKERS WITH MACHINE-LEARNING MODELS
Provided are systems, methods, and computer program products for extracting features from imaging biomarkers with machine-learning models. The method includes training a first artificial intelligence (AI) model based on first training data including images labeled with imaging biomarkers, the first AI model trained to identify a plurality of imaging biomarker features in at least one image, training a second AI model based on second training data including sets of imaging biomarker features associated with task-specific labels, the second AI model trained to identify at least one task-specific feature based at least partially on a set of imaging biomarker features, processing at least one input image with the first AI model to generate a first AI model output, and processing the first AI model output with the second AI model to generate a second AI model output.
Methods for assisting one or more users in organizing content-items, such as location information (e.g., URLs) for online information resources (e.g., webpages) and clips taken from information resources, accessed via content-access software, such as one or more web browsers, using a content item-bundle primitive that allows users to create, build, manipulate, and/or populate their own content-item bundles according to their information investigation and collection desires/needs. In some embodiments, the methods include automatically bundling content items into suggested content-item bundles based on learned relationships among various content items. In some embodiments, the methods can be implemented to provide bundle-based task managers that allow users to not only organize their content items but also define tasks and/or projects rooted in the content-item-bundle primitive. Further embodiments are disclosed, as is software for executing disclosed methods.
A method and apparatus for degrading a hypodermal tissue scaffold involves exposing the scaffold to a low-intensity focused ultrasonic beam such as to burst gas vesicles trapped in the silk fibroin from which scaffold is constructed. The rate of degradation van be controlled using ultrasonic beams of varying intensities. In one embodiment, the ultrasonic beams are administered trans-dermally to a hypodermal scaffold.
Disclosed herein is a system providing a mixed reality combination system that pairs augmented reality technology and an inertial measurement unit sensor with 3D printed objects such that user motions tracked by the inertial measurement unit as the user interacts with the 3D printed object is reflected in a virtual environment display of dynamic 3D imagery and augmented reality imagery.
Disclosed herein is a system and method for augmenting data by generating a plurality of pose-altered images of an item from one or more 2D images of the item and using the augmented data to train a train a feature extractor. In other aspects of the invention, the trained feature extractor is used to enroll features extracted from images of new products in a library database of known products or to identify images of unknown products by matching features of an image of the unknown product with features stored in the library database.
A method of manufacturing a porous part includes controlled freeze casting of a slurry. After freezing, a solvent in the slurry is removed by sublimation and the remaining material is sintered to form the porous part. Spatial and temporal control of thermal conditions at the boundary and inside of the mold can be controlled to create parts with controlled porosity, including size, distribution, and directionality of the pores. Porous parts with near-net-shape from ceramics, metals, polymers and other materials and their combinations can be created.
B22F 1/107 - Metallic powder containing lubricating or binding agents; Metallic powder containing organic material containing organic material comprising solvents, e.g. for slip casting
B22F 3/00 - Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sintering; Apparatus specially adapted therefor
B22F 3/22 - Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sintering; Apparatus specially adapted therefor for producing castings from a slip
B28B 1/00 - Producing shaped articles from the material
B29C 39/00 - Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor
Disclosed herein is a system and method for performing pose-correction on images containing objects within a scene, or the entire scene, to compensate for off- centered camera views. The system and method generates a more frontal view of the object or scene by applying planar homography by identifying corner endpoints of the object or the scene and repositioning the corner endpoints to provide a more frontal view. The pose-corrected scene may then be input to an object detector to determine a location of a bounding box of an object-of-interest which would be more accurate than a bounding box from the original off-centered image.
Disclosed herein is a system and method for generating quadrilateral bonding boxes which tightly cover the most representative faces of retail products having arbitrary poses. The quadrilateral boxes do not include unnecessary background information or miss parts of the objects, as would the axis-aligned bounding boxes produced by prior art detectors. A simple projection transformation can correct the pose of products for downstream tasks.
Disclosed herein is a system and method using an equivariant neural network for predicting quantum mechanical charge density. The equivariant neural network serves as a surrogate for the density-functional theory used to calculate a self- consistent field and predicts the central observable charge density, which, in addition to enabling force calculations, can also accelerate DFT itself and compute a full range of chemical properties.
Disclosed herein is a system and method for increasing the confidence of a match between the test image and an image stored in a library database. Features are extracted from the test image and compared to features stored in the image database and, if a match is determined, one or more transformations are performed on the test image to generate pose-altered images. Features are then extracted from the pose-altered images and matched with pose-altered images in the database. The scores for the subsequent matchings can be aggregated to determine an overall probability of a match between the test image in an image in the library database.
G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
G06K 9/46 - Extraction of features or characteristics of the image
G06K 9/64 - Methods or arrangements for recognition using electronic means using simultaneous comparisons or correlations of the image signals with a plurality of references, e.g. resistor matrix
96.
LASER-BASED FAST MICROMANUFACTURING OF TEST DEVICE FOR RAPID DETECTION OF PATHOGENS
A photonic crystal for detection of an analyte includes: a first layer including a first material with a first refractive index; a second layer over the first layer and including a second material with a second refractive index that is higher than the first refractive index; where the second layer includes a hole, the hole including: a first diameter from an outer surface of the second layer to a first hole depth; a second diameter from the first hole depth to a second hole depth; where the first diameter is larger than the second diameter; and a member of a binding pair with the analyte linked to a surface of the hole.
G01N 21/00 - Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
G01N 21/17 - Systems in which incident light is modified in accordance with the properties of the material investigated
G01N 21/25 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
G01N 21/35 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
97.
SYSTEM, METHOD, AND COMPUTER PROGRAM PRODUCT FOR SEGMENTING AN IMAGE
Provided are systems, methods, and computer program products for segmenting an image. A method includes segmenting each image in a sequence of images including a needle into a needle and at least one needle artifact based on processing each image with a first machine-learning model trained with a plurality of hard labels for a plurality of images, resulting in a plurality of hard-labeled images, transforming each hard-labeled image of the plurality of hard-labeled images into a soft-labeled image including pixel values corresponding to an effect of the at least one needle artifact, resulting in a plurality of soft-labeled images, and segmenting at least one image of the sequence of images based on processing the at least one image with a second machine-learning model trained at least partially with the plurality of soft-labeled images.
Provided are methods including the steps of receiving, with at least one computing device, an image of a portion of a subject, assigning; with the at least one computing device and based on a machine-learning model, a label to one or more pixels of the image to generate a diagnostically segmented image; and classifying, with the at least one computing device and based on a machine-learning model, the diagnostically segmented image and the one or more pixels into at least one class to generate a classified image, wherein the classified image includes a classification label indicating a clinical assessment of the portion of the subject and wherein the one or more pixels include a clinical label indicating a diagnosis of a portion of a subject contained within each pixel, based on the diagnostically segmented image having labels assigned to each pixel of the segmented image.
Provided is a system, method, and computer program product for training a machine-learning model. The method includes labeling each object of a plurality of objects with a probabilistic confidence label including a probability classification score for each class of at least two classes, resulting in a plurality of probabilistic confidence labels associated with the plurality of objects, and training, with at least one computing device, the machine-learning model based on the plurality of objects and the plurality of probabilistic confidence labels.
Provided is a system, method, and computer program product for tracking a needle. The method includes determining a visibility of the needle being inserted into a subject in an image of a sequence of images, in response to determining that the visibility satisfies a visibility threshold, detecting a location of the needle based on at least one first algorithm and a detected curvature of the needle, in response to determining that the visibility does not satisfy the visibility threshold, detecting the location of the needle being inserted based on at least one second algorithm, and tracking the location of the needle in the sequence of images based on locations detected with the at least one first algorithm and the at least one second algorithm.
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