System for managing a patient's glucose level including a glucose sensor to generate raw data signals for measurements of the patient's glucose level. The system further includes sensor electronics operatively coupled to the glucose sensor. The sensor electronics have a memory storing one or more predetermined characteristics associated with the sensor electronics. The sensor electronics are in electronic communication with the glucose sensor. The system further includes a receiving device and external devices, wherein the external devices include a first disposable device and a second disposable device. Each external device is configured for wireless communication with both the receiving device and the sensor electronics. The system enables the transfer of sensor context information from the first disposable device to the second disposable device.
Embodiments described herein include an analyte monitoring device. The analyte monitoring device generates sensor data indicative of an analyte level measured by an analyte sensor transcutaneously positioned in contact with a bodily fluid of the subject. The analyte monitoring device initializes a communication module using an advertisement scanning related instruction set, wherein the advertisement scanning related instruction set is a subset of a communications protocol startup instruction set including the advertisement scanning related instruction set and a non-advertisement scanning related instruction set. The analyte monitoring device issues one or more advertising packets and receives a connection request from a receiving device. The analyte monitoring device completes initialization of the communication module using the non-advertisement scanning related instruction set. The analyte monitoring device selects a subset of the sensor data, prepares a data packet comprising the subset of the sensor data, and transmits the data packet to the receiving device.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
H04W 4/80 - Services using short range communication, e.g. near-field communication [NFC], radio-frequency identification [RFID] or low energy communication
H04L 67/00 - Network arrangements or protocols for supporting network services or applications
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
3.
MOBILE APPLICATION UPDATES FOR ANALYTE DATA RECEIVING DEVICES
Embodiments described herein include a method and system for updating a data receiving device for an analyte sensor by a computing device. The method includes receiving, by the computing device, an application update package including an update for an application installed on the computing device and a software or firmware update for the data receiving device. The application and the software or firmware are configured to communicate with or process data from the analyte sensor. The method includes establishing, by the computing device, a short-range wireless communication session with the data receiving device. The method includes transmitting, by the computing device, the software or firmware update for the data receiving device to the data receiving device through the short-range wireless communication session with the data receiving device. The method includes receiving, by the computing device, confirmation of installation of the software or firmware update by the data receiving device.
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
4.
ADAPTIVE SENSOR SENSITIVITY FOR ANALYTE MONITORING SYSTEMS
Embodiments described herein include a device and a computer program product. The device includes one or more processors, an analyte sensor, a temperature sensor, a communication module, and memories. The processors are configured to generate external temperature of the analyte sensor measured by the temperature sensor corresponding to a first time, to calculate a sensitivity adjustment of the sensor based on the temperature data, to add the sensitivity adjustment corresponding to the first time to a total sensitivity adjustment, and to determine whether the first time is below a predetermined time threshold, and if so, to generate external temperature data corresponding to a second time and to calculate an interval between the second time and the first time. The processors are further configured to determine if the first time is equal to the predetermined time threshold, and if so, to store the total sensitivity adjustment in an OTP memory.
A software library for providing a uniform framework for various applications or third-party applications access to sensor data. The system further includes a sensor control module and a remote management module. The sensor control module includes logic for communicating with the sensors and receiving sensor data and to communicate that sensor data to the remote management module or various applications. The sensor control module may include a user interface that may display a banner containing numerous components. The content of the banner may differ depending on the host application. The system may further include a host application that incorporates the banner.
A medical device communication system with a modular design to communicate with different types of medical devices, such as physiological sensors. The modular design is implemented using an extensible software library that provides a uniform framework for various applications or third party applications access to medical device data. The modular design also allows for regulated and unregulated portions of the system to be integrated into the system while allowing each portion to be updated separately. The regulated portion of the system may include components, such as sensors and the software library, that are subject to regulatory approval while the unregulated portion may include applications that are not subject to regulatory approval. Thus, the system enables a third party application developer to avoid having to submit the application to a regulatory agency for an application making use of the sensor data.
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
H04W 12/069 - Authentication using certificates or pre-shared keys
Embodiments described herein include a sensor control device configured for secure over-the-air (OTA) programming. Embodiments include a sensor control device that includes one or more processors, an analyte sensor, a communication module, and a memory. The memory includes a first set of storage blocks that are in a non-programmable state and a second set of blocks that are in a programmable state. The processors are configured to receive, using the communication module, instructions to write marking data to the memory to mark a first storage block from the first set of storage blocks as inaccessible and to write program data to a second storage block from the second set of storage blocks, causing the second storage block to be placed into the non-programmable state. The program data written to the second storage block includes instructions that cause the processors to process analyte data received from the analyte sensor.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G06F 17/00 - Digital computing or data processing equipment or methods, specially adapted for specific functions
G11C 17/00 - Read-only memories programmable only once; Semi-permanent stores, e.g. manually-replaceable information cards
8.
SYSTEMS, DEVICES, AND METHODS FOR ANALYTE MONITORING
Disclosed herein are various embodiments of sensor applicator assemblies for delivering sensor control devices, wherein the embodiments include features for improving the longevity of the sensor applicator or sensor control device, as well as reducing the likelihood of mechanical failure of certain components. Some embodiments include, for example, a pull-tab coupled with the sensor or battery, an adhesive liner for the sensor control device, one or more magnets for retaining the sensor control device in the sensor carrier, and a leaf spring retraction mechanism.
A method can include receiving, using one or more processors, a first record including a first data associated with a personal identification from a first database, receiving, using the one or more processors, a second record including a second data associated with a user identification from a second database, pairing, using the one or more processors, the first data and the second data based upon a shared data item contained in the first record and the second record, and displaying, using one or more processors, a report based upon the first data and the second data.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
Systems, devices and methods are provided for incorporating a medication delivery device into an integrated management system. The integrated management system may be an integrated diabetes management system and may include a glucose monitor, a connected insulin pen, and software. The integrated management system may produce a plurality of reports that may include data related to analyte levels (e.g., glucose levels) and medication delivered (e.g., insulin delivered).
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
11.
SYSTEMS, DEVICES, AND METHODS RELATING TO MEDICATION DOSE GUIDANCE
Systems, devices and methods are provided for determining a medication dose for a patient or user. The dose determination can account for recent and/or historical analyte levels of the patient or user. The dose determination can also take into account other information about the patient or user, such as physiological information, dietary information, activity, and/or behavior. Many different dose determination embodiments are set forth, pertaining to a wide array of different aspects of the system or environment in which the embodiments can be implemented. Systems, devices and methods are provided for displaying information related to glucose levels, including a time in range display and a graph of analyte levels containing an identification of a pattern type of a segment of the day.
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
Digital and graphical user interfaces for third party analyte monitoring applications are provided. For example, disclosed herein are various embodiments of methods, systems, and interfaces for connection interfaces, alarm notification settings interfaces, and logbook interfaces in a third party analyte monitoring application. In addition, various embodiments of interface enhancements are described, including enhanced visibility mode and interfaces for setting up a third party analyte monitoring application, among other embodiments.
Systems are provided for an in vivo ketone sensor having a distal portion configured for placement in contact with an interstitial fluid of a user and a proximal portion including a working electrode, a sensing layer with P-hydroxybutyrate dehydrogenase, and a membrane layer configured to limit transport of one or more biomolecules. The in vivo ketone sensor is configured to generate signals at the working electrode corresponding to an amount of ketone in the interstitial fluid. Further, the systems includes a sensor control unit having at least one contact in electrical communication with the proximal portion of the sensor, which is configured to receive the generated signals, and convert the generated signals to ketone concentration data using a sensitivity associated with the in vivo ketone sensor. Also included is a transmitter configured to communicate ketone concentration data to a remote device.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/1468 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using enzyme electrodes, e.g. with immobilised oxidase
A medical sensor includes an application-specific integrated circuit (ASIC), medical hardware, and a communication module. The ASIC is communicatively coupled to the medical hardware and communication module. The ASIC is configured to receive measurement signals from the medical hardware and provide the measurement signals to the communication module. The communication module is configured to process the measurement signal into measurement results and transmit the measurement results to a remove device. The communication module includes an application layer for processing the measurement signals and a link layer for transmitting the measurement results. The ASIC is configured to detect that a voltage supplied to the ASIC is below a threshold level and determine an amount of time that the voltage has been below the threshold level. The ASIC is further configured to respond to the voltage supplied to the ASIC being below a threshold level based on the determined amount of time.
The present disclosure provides therapeutic compositions and methods for delivering a therapeutic agent in close proximity to an analyte sensor. In certain embodiments, the present disclosure provides analyte sensors including one or more therapeutic agents, e.g, covalently-bound therapeutic agents. In certain embodiments, the present disclosure further provides therapeutic releasing compositions and methods of delivering such therapeutic releasing compositions.
The present disclosure provides an analyte sensor for use in detecting various analytes. In certain embodiments, an analyte-responsive active area of a presently disclosed analyte sensor includes two or more enzyme systems for detecting the analyte. The present disclosure further provides methods for detecting various analytes using the disclosed analyte sensors.
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
Sensor control device for analyte monitoring comprising electronics housing having shell defining top surface and mount defining bottom surface of the electronics housing. Adhesive patch coupled to the bottom surface defines central opening, and includes first layer facing the mount and second layer facing skin of user. The first layer has first aperture, second layer has second aperture, and the first aperture and second aperture align with central opening along vertical axis of the sensor control device. First layer or second layer includes laser cut slots or laser cut holes configured for drainage of fluid or breathability of skin.
An analyte measurement device including an electronics housing including a shell having an upper surface with a first aperture defined therein; a mount mated to the shell and having an underside with a second aperture defined therein aligned with the first aperture; a collar disposed between the shell and the mount and including: a third aperture aligned with the first aperture and the second aperture, and a plurality of tabs on an outer periphery of the collar; a circuit board disposed within the electronics housing and including a plurality of electronic modules, wherein the circuit board is mounted within the electronics housing on the plurality of tabs on the outer periphery; and an analyte sensor including a tail portion extending through the first aperture and the second aperture and configured to measure an analyte level and a flag portion including a plurality of electrical contacts coupled with the circuit board, and a neck portion interconnecting the tail portion and the flag portion. An assembly for delivery of an analyte sensor is also disclosed.
Analyte sensor comprises an electrode layer having an elongate body comprising a proximal end and a distal end. The electrode layer includes a first active working electrode area, a second electrode portion, and at least one gap electrically separating the first active working electrode portion and the second electrode portion. The first active working electrode area comprises at least one sensing spot with at least one analyte responsive enzyme disposed thereupon. Additional analyte sensors disclosed.
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using enzyme electrodes, e.g. with immobilised oxidase
A61B 5/1468 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means
20.
NAD(P) DEPOT FOR NAD(P)-DEPENDENT ENZYME-BASED SENSORS
The present disclosure provides analyte sensors including one or more NAD(P)-dependent enzymes and an internal supply of NAD(P) for the detection of an analyte. The present disclosure further provides methods of using such analyte sensors for detecting one or more analytes present in a biological sample of a subject, and methods of manufacturing said analyte sensors.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using enzyme electrodes, e.g. with immobilised oxidase
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
Apparatus, methods, and systems for detecting alcohol concentrations of an individual, such as an in vivo alcohol concentrations of an individual. The system can include an analyte sensor and a reader. The reader can receive a signal from the analyte sensor. The reader can determine blood alcohol concentration, in part, based on the received signal from the analyte sensor. The reader can also detect an adverse condition of the analyte sensor, and/or output an indication based on the detected adverse condition.
Apparatus, methods, and systems for detecting alcohol concentrations of an individual, such as an in vivo alcohol concentrations of an individual. The blood alcohol concentration can be determined based on the peak signal width of the signal received from an analyte sensor.
Systems, devices and methods are provided for inserting at least a portion of an in vivo analyte sensor for sensing an analyte level in a bodily fluid of a subject. A sensor insertion component may include a small diameter needle disposed at an angle of about 7 to about 10 degrees to a skin normal insertion force vector with a flexible elongate sensor and sharpened tip supported by a U-shaped protector along an intermediate portion. Advancing the needle into the subject along the vector causes stretching of the skin around the needle, allowing entry of the sensor tip into the body. A bump may be provided on a distal portion of the sensor for engagement by the U-shaped protector and transmission of an insertion force to the sensor tip.
The present disclosure provides an analyte sensor for use in detecting ketones. In certain embodiments, a ketones-responsive active site of a presently disclosed analyte sensor includes an enzyme system comprising ?-hydroxybutyrate dehydrogenase and NADH oxidase disposed on a surface of a platinum working electrode. The present disclosure further provides methods for detecting ketones using the disclosed analyte sensors.
The present disclosure provides redox mediators having two tridentate ligands and analyte sensors comprising such redox mediators. The present disclosure further provides methods of using such analyte sensors for detecting one or more analytes present in a biological sample of a subject.
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
26.
SYSTEMS, DEVICES, AND METHODS FOR ANALYTE MONITORING
Applicator including a housing; a sensor carrier coupled to the housing, and including a first lock interface; a sheath, slidably coupled to the housing, the sheath including a first lock arm having an attached distal end and a free proximal end, the free proximal end including a first lock arm interface disposed on an inner surface of the first lock arm and a first sharp edge disposed on an outer surface of the first lock arm; and a cap threadably coupled to the housing, the cap including an inner surface having a first plurality of crush ribs. The inner surface of the cap is configured to urge the first lock arm inwardly such that the first lock arm interface engages the first lock interface; and the first sharp edge is configured to engage the first plurality of crush ribs during a shock event.
Improved digital interfaces, graphical user interfaces, and alarms for analyte monitoring systems are provided. For example, disclosed herein are various embodiments of methods, systems, and interfaces for signal loss condition determination, Time-in-Ranges interfaces, GMI metrics, urgent low glucose alarms, alarm suppression features, alarm setup interfaces, and alarm unavailability detection features. In addition, various embodiments of interfaces for alarm logging and compatibility checking of an analyte monitoring software application are described. Also, various embodiments of interface enhancements are described, including an enhanced visibility mode, a voice accessibility mode, additional interfaces relating to user privacy, as well as caregiver alarms, among other embodiments.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/1468 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means
28.
SYSTEM, APPARATUS, AND DEVICES FOR ANALYTE MONITORING
A system, apparatus, or device that includes an analyte sensor for monitoring analyte levels. The system, apparatus, or device can include a printed circuit board configured to monitor an analyte level, and a battery connected to the printed circuit board and configured to power the printed circuit board. The system, apparatus, or device can also include a connector connected to the printed circuit board and configured to establish an electrical connection between and analyte sensor and the printed circuit board, and a processor connected to the printed circuit board and configured to process data associated with the monitored analyte level. In addition, the system, apparatus, or device, can include an antenna for transmitting the monitored analyte level resting on a plurality of risers. The risers can extend from a surface of the printed circuit board by a fixed distance.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/1468 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
29.
SYSTEMS, DEVICES, AND METHODS FOR AN ANALYTE SENSOR
A method includes assembling a sensor subassembly that includes a sensor, a sensor mount, a collar, a sharp, and a sensor cap. The method includes loading a sensor in a sensor mount; dispensing adhesive into a mount channel of the sensor mount; clamping a collar to the sensor mount; and curing the adhesive to fix the collar to the sensor mount. The method can also include inserting a sharp into the sensor mount over the sensor an attaching a sensor cap to the sensor and sensor sharp to provide a sealed sensor subassembly. Methods of assembling an on-body sensor puck assembly and an applicator assembly, and a sensor including a tail, a flag, and a neck that interconnects the tail and the flag and methods of configuring a sensor are also disclosed.
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
30.
SECURED COMMUNICATIONS IN MEDICAL MONITORING SYSTEMS
In one embodiment, a method for secured communication between a medical sensor and a computing device includes receiving, by the medical sensor, an authentication request from the computing device. The method includes generating, based on values provided in the authentication request, a challenge-response message for the computing device. The method includes receiving, from the computing device, a responsive challenge-response message. The method includes verifying that the responsive challenge-response message includes an expected value and corresponds to an expected format. The method includes, in response to verifying the responsive challenge-response message, sending a sensor secret value to the computing device.
G06F 12/14 - Protection against unauthorised use of memory
G06F 13/14 - Handling requests for interconnection or transfer
H04L 9/00 - Arrangements for secret or secure communications; Network security protocols
H04L 9/32 - Arrangements for secret or secure communications; Network security protocols including means for verifying the identity or authority of a user of the system
31.
SYSTEMS, DEVICES, AND METHODS FOR ANALYTE SENSOR APPLICATORS
An assembly and method for delivery of an analyte sensor including a reusable applicator having a proximal portion and a distal portion are disclosed. The reusable applicator can include a housing, a sensor carrier configured a sensor carrier configured to releasably receive a first analyte sensor, a sharp carrier configured to releasably receive a sharp module and movable between the proximal portion of the reusable applicator and the distal portion of the reusable applicator for delivery of the first analyte sensor from the reusable applicator, and a reset tool configured to reset the reusable applicator for delivery of another analyte sensor.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/1459 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
32.
SYSTEMS, DEVICES, AND METHODS FOR ANALYTE SENSOR INSERTION
An assembly and method for delivery of an analyte sensor including a reusable applicator having a proximal portion and a distal portion are disclosed. The reusable applicator can include a housing, a sensor carrier configured to releasably receive the first analyte sensor, a sharp carrier configured to releasably receive a sharp module, and an actuator movable relative to the housing. The actuator can include three positions: a first position with the sensor carrier and the sharp carrier are at the proximal portion of the reusable applicator, a second position with the sensor carrier and the sharp carrier are at the distal portion of the reusable applicator for delivery of the first analyte sensor, and a third position with the sensor carrier at the distal portion of the reusable applicator and the sharp carrier at the proximal portion of the reusable applicator after delivery of the first analyte sensor from the reusable applicator, wherein the first position, the second position, and the third position are different, and wherein the actuator is configured to be returned from the third position to the first position for delivery of another analyte sensor.
An interactive graphical user interface associates information configured for interactive display and input, including patient identifying information for each patient in a patient list, a medication schedule for the each patient, and a treatment assessment worksheet comprising a display indicating the medical monitoring data for the each patient. The worksheet enables comparing monitoring results over different periods of time and development of treatment plans.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
34.
ANALYTE SENSORS FEATURING ENHANCEMENTS FOR DECREASING INTERFERENT SIGNAL
Analyte sensors are being increasingly employed for monitoring various analytes in vivo. Analyte sensors may feature enhancements to address signals obtained from interferent species. Some analyte sensors may comprise a working electrode comprising an active area disposed thereon and electrode asperities laser planed therefrom. Some analyte sensors may comprise an interferent-reactant species incorporated therewith. Some analyte sensors may comprise an interferent scrubbing electrode. Combinations of these enhancements may additionally be employed.
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using enzyme electrodes, e.g. with immobilised oxidase
A61B 5/1468 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means
35.
SYSTEMS, DEVICES, AND METHODS FOR MEAL INFORMATION COLLECTION, MEAL ASSESSMENT, AND ANALYTE DATA CORRELATION
Systems, devices, and methods for detecting, measuring and classifying meals for an individual based on analyte measurements. These results and related information can be presented to the individual to show the individual which meals are causing the most severe analyte response. These results can be organized and categorized based on preselected criteria or previous meals and results so as to organize and present the results in a format with reference to glucose as the monitored analyte. Various embodiments disclosed herein relate to methods, systems, and software applications intended to engage an individual by providing direct and timely feedback regarding the individual's meal-related glycemic response.
G16H 20/60 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to nutrition control, e.g. diets
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
36.
ANALYTE SENSORS FEATURING A REDUCED-AREA WORKING ELECTRODE FOR DECREASING INTERFERENT SIGNAL
Analyte sensors are being increasingly employed for monitoring various analytes in vivo. Analyte sensors may feature enhancements to address signals obtained from interferent species. Some analyte sensors may comprise a working electrode having sensing portion and an exposed electrode portion, wherein the sensing portion comprises an active area having an analyte-responsive enzyme disposed thereupon and the exposed electrode portion comprises no active area. The exposed electrode portion and the sensing portion may be present in a ratio of and about 1:10 to about 10:1.
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using enzyme electrodes, e.g. with immobilised oxidase
A61B 5/1468 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means
37.
ANALYTE SENSORS FEATURING WORKING ELECTRODE ASPERITY PLANING FOR DECREASING INTERFERENT SIGNAL
Analyte sensors are being increasingly employed for monitoring various analytes in vivo. Analyte sensors may feature enhancements to address signals obtained from interferent species. Some analyte sensors may comprise an analyte sensor comprising a working electrode comprising an active area disposed thereon and electrode asperities laser planed therefrom, the active area comprising an analyte-responsive enzyme. Methods include laser singulating a working electrode, the working electrode comprising an active area disposed thereupon and electrode asperities, the active area comprising an analyte-responsive enzyme, and laser.
Various embodiments of systems, devices and methods for improving the accuracy of an analyte sensor and for detecting sensor fault conditions are disclosed. According to some embodiments, these systems, devices, and methods can utilize a first data collected by a glucose sensor and a second data collected by a secondary sensing element. In some embodiments, the secondary sensing element can be one of a lactate sensing element, a ketone sensing element, or a heart rate monitor, among others.
Analyte sensors are being increasingly employed for monitoring various analytes in vivo. Analyte sensors configured to monitor multiple analytes are also in development. Sufficient sensitivity for low-abundance analytes and multiple analytes having differing membrane permeability values may complicate analyte detection in some cases. Analyte sensors may feature enhancements to address one or both of these issues. Some analyte sensors may comprise a carbon working electrode comprising a dielectric substrate, one or more apertures extending through the dielectric substrate and filled with a carbon conductor pillar, a carbon conductor coating on a first face of the dielectric substrate in direct contact with each carbon conductor pillar, and one or more active areas on a second face of the dielectric substrate in electrical communication with the carbon conductor pillars. Photopolymerized mass transport limiting membranes may be used in combination with such carbon working electrodes or with other working electrode types.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using enzyme electrodes, e.g. with immobilised oxidase
Improved graphical user and digital interfaces for analyte monitoring systems are provided. For example, disclosed herein are various embodiments of GUIs including Time-in-Ranges, Analyte Level/Trend Alert, and sensor usage interfaces. In addition, various embodiments of digital interfaces are described, including methods for data backfilling, expired or failed sensor transmissions, merging data from multiple devices in an analyte monitoring system, transitioning a previously activated analyte sensor to a new reader device, and autonomous sensor system alarms, among other embodiments.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
41.
SYSTEMS, DEVICES, AND METHODS FOR DOSING PATTERN MANAGEMENT
Systems, devices, and methods for identifying and managing medication dosage patterns to assist in decisions for administration at, e.g., the time a meal is being consumed, are described. The application can include a new mealtime insulin dose-decisioning feature that is accessible through or in conjunction with an analyte monitoring application. Using retrospective analyte and medication dosing data only, the dosing pattern management application can display patterns in past dose administrations to facilitate easy and better dose decisions for diabetics on a regimen of multiple daily injections.
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
42.
ANALYTE SENSORS AND SENSING METHODS FOR DETECTING INHIBITORS OF DIAPHORASE
Analyte sensors featuring an enzyme system comprising diaphorase and a NAD-dependent dehydrogenase may be utilized to detect inhibitors of diaphorase, provided that the transfer of electrons to a working electrode is rate-limiting with respect to the diaphorase. Such analyte sensors may comprise a sensor tail comprising at least a first working electrode, a first active area disposed upon a surface of the first working electrode, and an analyte-permeable membrane overcoating at least the first active area. The enzyme system comprises NAD, reduced NAD, or any combination thereof; a NAD-dependent dehydrogenase, such as NAD-dependent glucose dehydrogenase; and diaphorase. Inhibitors of diaphorase that may be detected include, for example, warfarin, dicoumarol, and similar compounds. A second active area may be present to facilitate detection of an analyte differing from the inhibitor of diaphorase.
A method of treatment of a type 2 diabetic patient includes selecting a type 2 diabetic patient having a predetermined comorbidity for treatment, initiating a continuous glucose monitor regimen for the selected type 2 diabetic patient, wherein after six months of initiation of the continuous glucose monitor regimen, a rate of hospitalization for a predetermined diagnostic category of the selected patient having the predetermined comorbidity is reduced by at least 12% relative to an average rate of hospitalization for the predetermined diagnostic category of selected patients having the predetermined comorbidity without the continuous glucose monitor regimen.
Improved graphical user interfaces for analyte monitoring systems are provided herein. In particular, disclosed herein are various embodiments of Time-in-Ranges interfaces and Analyte Level/Trend Alert interfaces.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/1468 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means
G01N 33/487 - Physical analysis of biological material of liquid biological material
A sensor control device and methods of making them are described. The sensor control device includes an electronics housing and a plug assembly. The electronics housing includes an upper shell matable to a lower mount having a skin-facing surface. The plug assembly is coupled to the electronics housing and includes a sensor module that has a sensor and a sharp module having a sharp. The plug assembly includes a base having a skin-facing surface and a plug portion comprising a lumen therethrough. At least a portion of a surface of the electronics housing or the plug assembly comprises an antimicrobial agent. The antimicrobial agent may be a metal and/or a metal oxide.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/1459 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
46.
SENSOR ARRAY SYSTEMS AND METHODS FOR DETECTING MULTIPLE ANALYTES
Multiple analytes may be dysregulated singularly or concurrently in certain physiological conditions and may be advantageously assayed together using analyte sensors capable of detecting multiple analytes. Certain analyte sensors capable of the detection of multiple analytes may include first and second working electrodes, analyte-responsive active areas disposed on each of the working electrodes, and reference and counter electrodes. Analyte sensors that include multiple working electrodes but do not include reference and counter electrodes can also be used in conjunction with another sensor that contains reference and counter electrodes, such that these electrodes are shared.
Analyte sensors responsive at low working electrode potentials may comprise an active area upon a surface of a working electrode, wherein the active area comprises a polymer, a redox mediator covalently bonded to the polymer, and at least one analyte-responsive enzyme covalently bonded to the polymer. A specific redox mediator responsive at low potential may have a structure of (I) wherein G is a linking group covalently bonding the redox mediator to the polymer. A mass transport limiting membrane permeable to the analyte may overcoat the active area. In some sensor configurations, the mass transport limiting membrane may comprise a membrane polymer crosslinked with a branched crosslinker comprising three or more crosslinkable groups, such as polyethylene glycol tetraglycidyl ether.
Physiological parameters that related to the kinetics of red blood cell hemoglobin glycation, red blood cell elimination, and red blood cell generation within the body of a subject can be used, for example, to calculate a more reliable calculated HbA1c (cHbA1c), adjusted HbA1c (aHbA1c), and/or a personalized target glucose range, among other things, for subject-personalized diagnoses, treatments, and/or monitoring protocols. Such physiological parameters may be determined using a model that considers cross-membrane glucose transport and glycation.
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
49.
METHODS, DEVICES, AND SYSTEMS FOR PHYSIOLOGICAL PARAMETER ANALYSIS
A method for deriving physiological parameters may include: measuring a glucose level of a subject over time; measuring a HbA1c of individual red blood cells in a sample comprising a plurality of red blood cells; deriving a measured cellular HbA1c distribution of the sample; and calculating at least one physiological parameter selected from the group consisting of (a) a red blood cell elimination constant (kage), (b) a red blood cell glycation rate constant (kgly), and/or (c) an apparent glycation constant (K) based on the measured cellular HbA1c distribution and the glucose levels of the subject over time.
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
50.
SYSTEMS, DEVICES, AND METHODS FOR SENSOR COMMUNICATIONS
Systems, methods, and devices for improved sensor communications in an analyte monitoring system are provided. In some embodiments, a first remote device can be configured establish a first wireless communication link with a sensor control device. The first remote device can then transmit sensor context information to a second remote device and deactivate the first wireless communication link. Subsequently, the second remote device can establish a second wireless communication link with the sensor control device by using the sensor context information.
Compositions of matter, methods, devices, systems and apparatus for detecting analytes are disclosed including, for example, protein switches and their use in an in vivo sensor. The protein switch can be used to determine a level of an analyte that is diagnostic for health and/or well-being of a subject.
Apparatus, methods, and systems for detecting alcohol concentrations of an individual, and in particular in vivo alcohol concentrations of an individual. Alcohol sensing compositions include at least one alcohol-responsive active area comprising a concerted enzyme system having at least a first enzyme and second enzyme capable of acting in concert to facilitate the detection of alcohol. At least one of the enzymes in the concerted enzyme system is a ketoreductase.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using enzyme electrodes, e.g. with immobilised oxidase
53.
SYSTEMS, DEVICES, AND METHODS RELATING TO MEDICATION DOSE GUIDANCE
Systems, devices and methods are provided for determining a medication dose for a patient or user. The dose determination can account for recent and/or historical analyte levels of the patient or user. The dose determination can also take into account other information about the patient or user, such as physiological information, dietary information, activity, and/or behavior. Many different dose determination embodiments are set forth, pertaining to a wide array of different aspects of the system or environment in which the embodiments can be implemented.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
A61B 5/022 - Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skin; Ophthaldynamometers
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
54.
SYSTEMS, DEVICES, AND METHODS FOR HANDLING WIRELESS COMMUNICATIONS IN AN ANALYTE MONITORING ENVIRONMENT
Example embodiments of systems, devices, and methods are described for communication in an analyte monitoring system in accordance with an applicable communication protocol. A first device of the system may transmit a command to a second device of the system and the second device may encounter a processing delay in preparing data responsive to the command. The second device may transmit dummy data to the first device in order to maintain compliance with the communication protocol until such time that the second device is ready to transmit data responsive to the command. Numerous different embodiments for incorporating and/or accommodating the presence of dummy data in a communication hierarchy are provided.
H04W 4/38 - Services specially adapted for particular environments, situations or purposes for collecting sensor information
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
H04W 4/80 - Services using short range communication, e.g. near-field communication [NFC], radio-frequency identification [RFID] or low energy communication
H04W 12/033 - Protecting confidentiality, e.g. by encryption of the user plane, e.g. user’s traffic
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
55.
ANALYTE SENSORS AND SENSING METHODS FEATURING DUAL DETECTION OF GLUCOSE AND KETONES
Glucose and ketones may be dysregulated singularly or concurrently in certain physiological conditions and may be advantageously assayed together using an analyte sensor capable of detecting both analytes. Certain analyte sensors capable of dual detection may comprise a first working electrode and a second working electrode, a ketones-responsive active area disposed upon a surface of the first working electrode, a glucose-responsive active area comprising a glucose-responsive enzyme disposed upon a surface of the second working electrode, a membrane having a first portion overcoating the ketones-responsive active area and a second portion overcoating the glucose-responsive active area, in which the first portion and the second portion have different compositions. The ketones-responsive active area comprises an enzyme system comprising at least two enzymes that are capable of acting in concert to facilitate detection of ketones.
Multiple enzymes may be present in the active area(s) of an electrochemical sensor to facilitate analysis of analytes. The multiple enzymes may function independently to detect several analytes or in concert to detect a single analyte. One configuration includes a first active area and a second active area, where the first active area has an oxidation-reduction potential that is sufficiently separated from the oxidation-reduction potential of the second active area to allow independent signal production. Some configurations may have an active area overcoated with a multi-component membrane containing two or more different membrane polymers. Sensor configurations having multiple enzymes capable of interacting in concert include those in which a first enzyme converts an analyte into a first product and a second enzyme converts the first product into a second product, thereby generating a signal at a working electrode that is proportional to the analyte concentration.
Creatinine levels may be monitored as a measure of kidney function. Conventionally, blood and/or urine tests are used for this purpose. Analyte sensors capable of monitoring creatinine in vivo may comprise: a sensor tail comprising at least a first working electrode, a creatinine-responsive active area disposed upon a surface of the first working electrode, a first membrane that is permeable to creatinine and overcoats the creatinine-responsive active area, and an oxygen scavenger located upon the sensor tail in proximity to the creatinine-responsive active area. The creatinine-responsive active area comprises a first electron transfer agent, a first polymer, and an enzyme system comprising multiple enzymes, particularly creatinine amidohydrolase, creatine amidohydrolase, and sarcosine oxidase, that are capable of acting in concert to facilitate detection of creatinine. An oxidase enzyme may serve as the oxygen scavenger, particularly glucose oxidase when detecting creatinine in fluids also containing glucose.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using enzyme electrodes, e.g. with immobilised oxidase
58.
ANALYTE SENSORS AND SENSING METHODS FOR DUAL DETECTION OF GLUCOSE AND ETHANOL
Multiple enzymes may be present in one or more active areas of an electrochemical analyte sensor for detecting one or more different analytes. In particular, an analyte sensor may comprise a sensor tail configured for insertion into a tissue and one or more working electrodes having a glucose-responsive active area and an ethanol-responsive active area to detect glucose and ethanol in vivo.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using enzyme electrodes, e.g. with immobilised oxidase
59.
SYSTEMS, DEVICES, AND METHODS FOR IMPROVED MEAL AND THERAPY INTERFACES IN ANALYTE MONITORING SYSTEMS
Various embodiments of systems, devices and methods for identifying meal start and meal peak response candidates are described. The methods include a set of meal start candidates and meal peak response candidates based on user-initiated analyte checks and analyte data from an analyte monitoring system.
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
G16H 20/60 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to nutrition control, e.g. diets
A61J 7/04 - Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
60.
SYSTEMS, DEVICES, AND METHODS FOR ANALYTE SENSOR INSERTION
Systems, devices and methods are provided for inserting at least a portion of an in vivo analyte sensor for sensing an analyte level in a bodily fluid of a subject. In particular, disclosed herein are various embodiments of applicators, and components thereof, designed to reduce trauma to tissue of a sensor insertion site and to increase the likelihood of a successful sensor insertion. Also disclosed are embodiments to ensure structural integrity of a sensor.
A61M 5/32 - Syringes - Details - Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
A61B 17/04 - Surgical instruments, devices or methods, e.g. tourniquets for closing wounds, or holding wounds closed, e.g. surgical staples; Accessories for use therewith for suturing wounds; Holders or packages for needles or suture materials
A61B 17/06 - Needles; Holders or packages for needles or suture materials
A method of calculating at least one physiological parameter using a reticulocyte production index (RPI) value including: measuring a plurality of first glucose levels over a first time period; measuring a first glycated hemoglobin (HbA1c) level corresponding to an end of the first time period; measuring the RPI value; calculating a red blood cell elimination constant (kage) based on the RPI value; and calculating the at least one physiological parameter selected from the group consisting of: a red blood cell glycation rate constant (kgly), a red blood cell generation rate constant (kgen), and an apparent glycation constant (K), based on (1) the plurality of first glucose levels, (2) the first HbA1c level, and (3) the kage. Further, one or more related analyses (e.g., personalized-target glucose range, personalized-target average glucose, cHbA1c, and the like) can be estimated and/or adjusted based on the at least one physiological parameter.
Various embodiments of systems, devices and methods for detecting a sensor fault in an analyte sensor are disclosed. These embodiments utilize analyte metrics and thresholds.
A61B 5/1495 - Calibrating or testing in vivo probes
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
It can be particularly difficult to measure pH in vivo using current electrochemical sensors due to sensor drift and fouling of the sensor surface. Sensors suitable for measuring pH, particularly in vivo, may comprise: a sensor tail comprising a first working electrode, a second working electrode, and at least one other electrode; a first active portion located upon the first working electrode, the first active portion comprising a substance having pH-dependent oxidation-reduction chemistry; and a second active portion located upon the second working electrode, the second active portion comprising a substance having oxidation-reduction chemistry that is substantially invariant with pH. A difference between a first signal from the first active portion and a second signal from the second active portion may be correlated to a pH value for a fluid.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
64.
NEEDLE ASSEMBLIES CONTAINING ORIENTED ACUPUNCTURE NEEDLES AND METHODS FOR PRODUCTION THEREOF
Acupuncture needles may be used for piercing tissue with less trauma than may occur when employing larger gauge needles. However, because acupuncture needles are fabricated and packaged differently than are larger gauge needles, acupuncture needles may be less compatible with certain manufacturing processes. Needle assemblies compatible with manufacturing processes may comprise a continuous support material having a plurality of apertures defined therein, and a first injection molded coupler that surrounds a proximal portion of an acupuncture needle and connects the acupuncture needle to a first location upon the continuous support material, such that the acupuncture needle is held in a pre-determined orientation with respect to a longitudinal axis of the first injection molded coupler. The acupuncture needles in adjacent apertures may also be spaced apart substantially uniformly.
Membranes permeable to an analyte may overlay the active sensing region of a sensor to limit the analyte flux and improve the response linearity of the sensor. Temperature variation of the analyte permeability can be problematic in some instances. Polymeric membrane compositions having limited variation in analyte permeability as a function of temperature may comprise: a polymer backbone comprising one or more side chains that comprise a heterocycle; and an amine-free polyether arm appended, via an alkyl spacer or a hydroxy-functionalized alkyl spacer, to the heterocycle of at least a portion of the one or more side chains.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
C08F 226/06 - Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a heterocyclic ring containing nitrogen
C08G 81/02 - Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers at least one of the polymers being obtained by reactions involving only carbon-to-carbon unsaturated bonds
A system includes a sensor applicator, a sensor control device arranged within the sensor applicator and including an electronics housing and a sensor extending from a bottom of the electronics housing, and a cap coupled to one of the sensor applicator and the sensor control device, wherein the cap is removable prior to deploying the sensor control device from the sensor applicator.
A system includes a sensor applicator, a sensor control device arranged within the sensor applicator and including an electronics housing and a sensor extending from a bottom of the electronics housing, and a cap coupled to one of the sensor applicator and the sensor control device, wherein the cap is removable prior to deploying the sensor control device from the sensor applicator.
A system includes a sensor applicator, a sensor control device arranged within the sensor applicator and including an electronics housing and a sensor extending from a bottom of the electronics housing, and a cap coupled to one of the sensor applicator and the sensor control device, wherein the cap is removable prior to deploying the sensor control device from the sensor applicator.
A system includes a sensor applicator, a sensor control device arranged within the sensor applicator and including an electronics housing and a sensor extending from a bottom of the electronics housing, and a cap coupled to one of the sensor applicator and the sensor control device, wherein the cap is removable prior to deploying the sensor control device from the sensor applicator.
A lactate-responsive enzyme may form the basis for lactate detection and quantification using an electrochemical analyte sensor. Various features may be incorporated within an analyte sensor containing a lactate-responsive enzyme, particularly lactate oxidase, to improve sensitivity and response stability of the analyte sensor. Such analyte sensors may comprise: a working electrode having an active area disposed thereon, and a mass transport limiting membrane overcoating at least the active area upon the working electrode. The active area comprises at least a polymer, an albumin, and a lactate-responsive enzyme that is covalently bonded to the polymer. The mass transport limiting membrane may comprise at least a crosslinked polyvinylpyridine homopolymer or copolymer. The analyte sensors may determine a lactate concentration in a biological fluid, particularly in vivo, which may be correlated to various physiological conditions.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using enzyme electrodes, e.g. with immobilised oxidase
71.
NOTES AND EVENT LOG INFORMATION ASSOCIATED WITH ANALYTE SENSORS
The detection of various analytes within an individual can sometimes be vital for monitoring the condition of their health. Deviation from normal analyte levels can be indicative of a number of physiological conditions. Improved computing devices that allow a user to input data about the sensor user's lifestyle and a user to access an event log associated with an analyte monitoring sensor may be beneficial.
Systems, devices and methods are provided for power-efficient wireless communications between electronic devices. In particular, the embodiments disclosed herein can reduce battery consumption in a transmitting electronic device and enhance data integrity of data received by a receiving electronic device. According to the embodiments, a first electronic device transmits advertising packets according to a wireless communications protocol, wherein the advertising packets contain a first payload data. In response to receiving the advertising packets, a second electronic device can transmit a scan request to the first electronic device which, in turn, terminates the transmission of advertising packets.
H04W 4/38 - Services specially adapted for particular environments, situations or purposes for collecting sensor information
H04W 4/80 - Services using short range communication, e.g. near-field communication [NFC], radio-frequency identification [RFID] or low energy communication
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
73.
SYSTEMS, DEVICES, AND METHODS RELATED TO THE INDIVIDUALIZED CALIBRATION AND/OR MANUFACTURING OF MEDICAL DEVICES
Systems, devices, kits, and methods are provided herein in the form of example embodiments that relate to calibration of medical devices. The medical devices can be sensors adapted to sense a biochemical attribute. The embodiments can be used to determine calibration information specific to an individual medical device. The embodiments can determine the calibration information by reference to one or more parameters obtained during manufacturing of the medical device. The embodiments can also determine the calibration information by reference to in vitro testing of the medical devices. The embodiments also apply to systems incorporating those medical devices in their use in the field. Also described are embodiments of modifications to surfaces of sensor substrates, such as through applied radiation and/or the creation of a well, to aid in the placement and/or sizing of a sensor element on the substrate.
A method for sensing an analyte utilizing a sensor having a working electrode, the method includes providing the working electrode with an analyte-specific enzyme and a redox mediator, providing the working electrode to the analyte, accumulating charge derived from the analyte reacting with the analyte-specific enzyme and the redox mediator for a set period of time, connecting the working electrode to circuit after the set period of time, and measuring the signal from the accumulated charge.
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
C12Q 1/26 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
75.
METHOD AND APPARATUS FOR ANALYTE DETECTION USING AN ELECTROCHEMICAL BIOSENSOR
A method for sensing an analyte utilizing a sensor having a working electrode, the method includes providing the working electrode with an analytc-specitic enzyme and a redox mediator, providing thc working electrode to the analyte, accumulating charge derived from the analyte reacting with the analyte-specific enzyme and the redox mediator for a set period of time, connecting the working electrode to circuit atter the set period of time, and measuring the signal from the accumulated charge.
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
C12Q 1/26 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
76.
SYSTEMS, DEVICES, AND METHODS FOR WELLNESS AND NUTRITION MONITORING AND MANAGEMENT USING ANALYTE DATA
Systems, devices and methods are provided for the monitoring and management of an individual's wellness and nutrition using analyte data from an in vivo analyte sensor. Generally, a sensor control device is provided for wear on the body. The sensor control device can include an in vivo analyte sensor for measuring an analyte level in a bodily fluid, an accelerometer for measuring the physical activity level of the subject, as well as communications circuitry for wirelessly transmitting data to a reader device. Furthermore, disclosed herein are embodiments of various graphical user interfaces for displaying analyte metrics on a reader device, comparing the analyte response of various foods and/or meals, modifying daily nutrient recommendations based on analyte metrics and physical activity level measurements, and other features described herein. Additionally, the embodiments disclosed herein can be used to monitor various types of analytes.
Systems, devices and methods are provided for inserting at least a portion of an in vivo analyte sensor, such as a dermal sensor, for sensing an analyte level in a bodily fluid of a subject. An applicator is positioned against a skin surface and a force is applied to the applicator causing at least a portion of a sharp and an in vivo analyte sensor to be positioned in the body of the subject. In particular, disclosed herein are embodiments of applicators designed to prevent premature sharp withdrawal and/or reduce the likelihood of improper sensor insertion. Also disclosed are embodiments of applicators including sharp modules having an angled sharp which can be configured to create an insertion path for a sensor.
Method, device and system for providing consistent and reliable glucose response information to physiological changes and/or activities are provided to improve glycemic control and health management. Embodiments of the method include determining a correlation between an overnight glucose level and an activity metric, comprising receiving activity metric information and overnight glucose level information over a predetermined time period; categorizing the overnight glucose level information with or without significant activity metrics into first and second sets; determining a correlation for the first set and the activity metric; and determining, using the determined correlation, an impact of a measured level of the activity metric on overnight glucose level.
Systems, devices, and methods are provided that allow detection of episodes in analyte measurement, prompting a patient to self-report possible causes for the episodes. Correlation of possible causes with detected episodes assists patient behavior modification to reduce the occurrence of episodes.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G06F 30/20 - Design optimisation, verification or simulation
80.
STABILIZED LACTATE RESPONSIVE ENZYMES, ELECTRODES AND SENSORS, AND METHODS FOR MAKING AND USING THE SAME
Embodiments of the present disclosure relate to stabilized lactate oxidase compositions, and electrodes, sensors and systems that include the same. Also provided are methods for making the compositions and for detecting and/or measuring lactate in vivo with stable lactate enzyme compositions.
C12N 9/08 - Oxidoreductases (1.), e.g. luciferase acting on hydrogen peroxide as acceptor (1.11)
C12N 11/02 - Enzymes or microbial cells immobilised on or in an organic carrier
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
C12Q 1/26 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
C12Q 1/30 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving catalase
81.
COMPACT MEDICAL DEVICE INSERTERS AND RELATED SYSTEMS AND METHODS
Compact medical device inserters, systems incorporating the same, and related methods of use are described. The inserters can include a housing, a sharp support, a sharp body, and a shroud, and can apply a sensor control device to a recipient with a sensor implanted in the recipient's body. The shroud can extend from the sensor control device in a position that covers or protects the sensor and a sharp, and can be retracted by pressure placed upon the inserter against the recipient's body to cause the sharp and sensor to penetrate the body, after which the sharp can be automatically withdrawn with the aid of a biasing element.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
82.
SYSTEMS, DEVICES, AND METHODS FOR REVISING OR SUPPLEMENTING ROM-BASED RF COMMANDS
Systems, devices, and methods are provided that enable the revision of RF command handling software stored in ROM, and that enable to supplementation of RF command handling software stored in ROM. Examples of the systems, devices, and methods make use of a lookup data structure stored within writable non-volatile memory.
G06F 3/06 - Digital input from, or digital output to, record carriers
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
G06F 13/16 - Handling requests for interconnection or transfer for access to memory bus
Methods, computers, and systems used to improve accuracy of analyte level measurement of an in vivo positioned analyte sensor are disclosed herein. The methods, computers, and systems disclosed herein may be used to provide a calibrated analyte level. Specific embodiments relate to methods, computers, and systems for improving accuracy of glucose measurement of an in vivo positioned glucose sensor.
Methods, computers, and systems used to improve accuracy of analyte level measurement of an in vivo positioned analyte sensor are disclosed herein. The methods, computers, and systems disclosed herein may be used to provide a calibrated analyte level. Specific embodiments relate to methods, computers, and systems for improving accuracy of glucose measurement of an in vivo positioned glucose sensor.
A61B 5/1495 - Calibrating or testing in vivo probes
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
85.
SELF-POWERED ANALYTE SENSOR AND DEVICES USING THE SAME
A61B 5/1459 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
86.
APPLICATION INTERFACE AND DISPLAY CONTROL IN AN ANALYTE MONITORING ENVIRONMENT
Systems, devices, and methods are provided for the control of interfacing between applications that facilitate the monitoring of diabetes running on a mobile device, including the authentication of a third party user interface application by a sensor interface application. Control of the display of current analyte levels and critical events is also provided.
An application program stored in a ROM includes a function lookup data structure in which functions called by the application program have identifiers and memory addresses at which the function is located and can be executed. Upon startup, the function lookup data structure is copied to a RAM as a revised lookup data structure and is compared to a revision lookup data structure also written to that RAM or elsewhere. If the revision lookup data structure contains replacement functions having the same function identifiers but new memory addresses, these new memory addresses are written over the existing addresses in the revised lookup data structure for those replacement functions. The application program refers to the revised lookup data structure to find and execute the functions; thus the original application program on the ROM can continue to be used with revised functions.
A power supply control circuit for a portable electronic device is capable of connecting and disconnecting a power supply with respect to an electrical load of the device. The power supply control circuit offers a relatively quick transition time and low leakage current, making the control circuit particularly suitable for applications that require the power supply to remain connected to the electrical load at all times.
H02J 13/00 - Circuit arrangements for providing remote indication of network conditions, e.g. an instantaneous record of the open or closed condition of each circuitbreaker in the network; Circuit arrangements for providing remote control of switching means in a power distribution network, e.g. switching in and out of current consumers by using a pulse code signal carried by the network
89.
SYSTEMS, DEVICES, AND METHODS FOR ENERGY EFFICIENT ELECTRICAL DEVICE ACTIVATION
Systems, devices, and methods are provided for changing the power state of a sensor control device in an in vivo analyte monitoring system in various manners, such as through the use of external stimuli (light, magnetics) and RF transmissions.
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/1459 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
90.
SYSTEM AND METHOD TO MANAGE DIABETES BASED ON GLUCOSE MEDIAN, GLUCOSE VARIABILITY, AND HYPOGLYCEMIC RISK
A system and method provides a glucose report for determining glycemic risk based on an ambulatory glucose profile of glucose data over a time period, a glucose control assessment based on median and variability of glucose, and indicators of high glucose variability. Time of day periods are shown at which glucose levels can be seen. A median glucose goal and a low glucose line provide coupled with glucose variability provide a view into effects that raising or lowering the median goal would have. Likelihood of low glucose, median glucose compared to goal, and variability of glucose below median provide probabilities based on glucose data. Patterns can be seen and provide guidance for treatment.
G01N 33/66 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
91.
MEDICAL DEVICE DATA PROCESSING AND COMMUNICATION METHODS AND SYSTEMS
Methods and devices to monitor an analyte in body fluid are provided. Embodiments include continuous or discrete acquisition of analyte related data from a transcutaneously positioned in vivo analyte sensor automatically or upon request from a user. The detection and/or monitoring of glucose levels or other analytes, such as lactate, oxygen, A1C, or the like, in certain individuals is vitally important to their health. For example, the monitoring of glucose is particularly important to individuals with diabetes.
A system and method to provide guidance for diabetes therapy includes determining glycemic risks based on an analysis of glucose data. The analysis includes visualization of a glucose median, the variability of glucose in a patient, and the risk of hypoglycemia. An Advanced Daily Patterns report includes a visualization of an ambulatory glucose profile and a glucose control measure. The glucose control measure provides a highly visible and understandable display of the glucose condition of a patient visually expressed in the categories of low glucose, median glucose, and glucose variability.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
93.
ANALYSIS OF GLUCOSE MEDIAN, VARIABILITY, AND HYPOGLYCEMIA RISK FOR THERAPY GUIDANCE
A system and method to provide guidance for diabetes therapy includes determining glycemic risks based on an analysis of glucose data. The analysis includes visualization of a glucose median, the variability of glucose in a patient, and the risk of hypoglycemia. An Advanced Daily Patterns report includes a visualization of an ambulatory glucose profile and a glucose control measure. The glucose control measure provides a highly visible and understandable display of the glucose condition of a patient visually expressed in the categories of low glucose, median glucose, and glucose variability.
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers
94.
METHOD AND APPARATUS FOR DETERMINING MEDICATION DOSE INFORMATION
Methods, devices, and kits are provided for determining a recommended insulin dose to be administered to user based upon analyte data determined by an analyte sensor.
Devices associated with on-body analyte sensor units are disclosed. These devices include any of packaging and/or loading systems, applicators and elements of the on-body sensor units themselves. Also, various approaches to connecting electrochemical analyte sensors to and/or within associated on-body analyte sensor units are disclosed. The connector approaches variously involve the use of unique sensor and ancillary element arrangements to facilitate assembly of separate electronics assemblies and sensor elements that are kept apart until the end user brings them together.
Devices associated with on-body analyte sensor units are disclosed. These devices include any of packaging and/or loading systems, applicators and elements of the on-body sensor units themselves. Also, various approaches to connecting electrochemical analyte sensors to and/or within associated on-body analyte sensor units are disclosed. The connector approaches variously involve the use of unique sensor and ancillary element arrangements to facilitate assembly of separate electronics assemblies and sensor elements that are kept apart until the end user brings them together.
Devices associated with on-body analyte sensor units are disclosed. These devices include any of packaging and/or loading systems, applicators and elements of the on-body sensor units themselves. Also, various approaches to connecting electrochemical analyte sensors to and/or within associated on-body analyte sensor units are disclosed. The connector approaches variously involve the use of unique sensor and ancillary element arrangements to facilitate assembly of separate electronics assemblies and sensor elements that are kept apart until the end user brings them together.
Devices associated with on-body analyte sensor units are disclosed. These devices include any of packaging and/or loading systems, applicators and elements of the on-body sensor units themselves. Also, various approaches to connecting electrochemical analyte sensors to and/or within associated on-body analyte sensor units are disclosed. The connector approaches variously involve the use of unique sensor and ancillary element arrangements to facilitate assembly of separate electronics assemblies and sensor elements that are kept apart until the end user brings them together.
Methods and devices for providing application specific integrated circuit architecture for a two electrode analyte sensor or a three electrode analyte sensor are provided. Systems and kits employing the same are also provided.
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
100.
METHODS, DEVICES AND SYSTEMS FOR ANALYTE MONITORING MANAGEMENT
Methods of analyte monitoring management are provided. The methods include indicating on a user interface a plurality of analyte management procedures available for user-selection, where the plurality of analyte management procedures relate to analyte management parameters. Embodiments include receiving an indication to initiate a first procedure of the plurality of analyte management procedures, where the first procedure is for determining a first analyte management parameter. The methods may further include outputting user-instructions associated with the first procedure; receiving analyte measurement data for the first procedure; estimating the first analyte management parameter based on the analyte measurement data; calculating a degree of certainty for the estimation of the first analyte management parameter; and, initiating an action in response to an event associated with a status of the estimation of the first analyte management parameter or the degree of certainty. Analyte monitoring devices and systems implementing the methods are also provided.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 20/00 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
G16H 80/00 - ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
patents
