A method includes collecting used dialysis fluid in a container and combining the dialysis fluid with an acid to lower the pH value of the used dialysis fluid.
This disclosure relates to medical fluid pumping systems and related devices and methods. In some aspects, a blood treatment system includes a user interface; a processor in communication with the user interface and configured to perform operations including: presenting instructions on the user interface, the instructions pertaining to at least one modality of a set of modalities, wherein the set of modalities include hemodialysis (HD), hemofiltration (HF), and hemodiafiltration (HDF), wherein the instructions pertain to a component of a blood treatment machine of the blood treatment system; receiving information associated with the component of the blood treatment machine; and eliminating modalities from the set of modalities to determine a modality of the blood treatment machine based on the received information.
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
3.
DETECTING AND MONITORING OXYGEN-RELATED EVENTS IN HEMODIALYSIS PATIENTS
The present teachings include analyzing oxygen saturation levels sensed during a hemodialysis treatment for a patient to determine whether the patient has a medical condition based on hypoxemia, apnea, or the like experienced during the treatment. To this end, the present teachings may include the use of a machine-learning algorithm trained to identify a presence of a high-frequency intermittent pattern that would be formed in a plot of the oxygen saturation levels, e.g., to determine a severity of respiratory instability experienced. The present teaching may also or instead include a time-series analysis including at least one of: (i) calculating recurrence-based quantification, such as, but not limited to, recurrence rate, determinism, and laminarity; (ii) calculating the optimal recurrence threshold based on maximum variations of the system's determinism and degree of predictability; and (iii) calculating complexity-based measures such as permutation entropy. Such analyses may be used to detect, inter-alia, sleep apnea syndrome.
An extracorporeal blood treatment device and a method are provided for removing a secondary membrane formed on a semipermeable membrane of a dialyzer during an extracorporeal blood treatment. The extracorporeal blood treatment device operates in a first operating mode in which a dialysate outlet valve is open such that dialysate flows through a dialyzer feed line, through a dialysate chamber, and into and through a dialyzer discharge line. The extracorporeal blood treatment device operates in a second operating mode to remove the secondary membrane from the semipermeable membrane. During the second operating mode, the dialysate outlet valve is closed for a duration of time such that dialysate is prevented from flowing through the dialyzer discharge line. A backflush procedure results wherein a volume of dialysate passes from the dialysate chamber through the semipermeable membrane and into the blood chamber.
The present invention relates to a method to make polymeric membranes that are preferably useful in dialysis, wherein the method conducts at least one membrane-forming step and/or post-forming processing step with the use of sonication. Polymeric membrane, such as polymeric hollow fiber membrane, having improved one or properties are further described.
A mechanical lift includes a housing defining a series of vertical adjustment notches, an adjustment block disposed within the housing, a hook extending from the adjustment block and configured to support a hanging load, a stopper supported by the adjustment block and movable between retracted and extended positions, and a spring disposed within the housing and exerting an upward force against the adjustment block to mechanically lift the adjustment block and the hook extending therefrom from a first vertical position at a first notch of the series of vertical adjustment notches to a second notch of the series of vertical adjustment notches when the stopper is in the retracted position. In the retracted position, the stopper is disengaged from the housing. In the extended position, the stopper is engaged with a selected notch to lock a vertical position of the adjustment block and the hook extending therefrom.
In one aspect, a medical device includes: a housing; a plurality of attachment points disposed on a face of the housing and configured to hold a medical fluid tubing system; a lighting system disposed at or below the face of the housing; and a processor configured to control the lighting system to (a) visually indicate the locations of the attachment points and (b) in response to a feedback signal indicating whether or not the medical fluid tubing system is attached to at least one of the attachment points, alter the visual indication of the lighting system.
G16H 20/60 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to nutrition control, e.g. diets
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
G16H 70/20 - ICT specially adapted for the handling or processing of medical references relating to practices or guidelines
8.
MEDICAL FLUID CASSETTE LEAK DETECTION METHODS AND DEVICES
This disclosure relates to medical fluid cassette leak detection methods and devices. In some implementations, a method of detecting micro-leaks in a medical fluid cassette, the method includes decreasing a pressure between a vacuum reservoir of a medical treatment machine and a membrane of the medical fluid cassette when the medical fluid cassette is coupled to the medical treatment machine; measuring, using a flow meter, a rate of net fluid flow between the vacuum reservoir and the membrane of the medical fluid cassette; determining that the rate of net fluid flow between the vacuum reservoir and the membrane of the medical fluid cassette is above a threshold value; and in response to determining that the rate of net fluid flow is above the threshold value, causing the medical treatment machine to take a particular action.
A system and method for measuring edema, at home, is provided, along with a measuring pattern for use therewith. The system includes a computing system that has an imaging device, a processor, a memory, and a wireless transmitter. The computing system is configured to capture edema data of a patient and send the data to a remote doctor. The pattern can be incorporated into a flexible sheet substrate that can be placed over a portion of a patient's skin. By pressing the flexible sheet substrate into the patient, a depression is formed and the pattern is distorted. The imaging device captures an image of the depression and the distorted pattern. The computing system processes the image and determines a depth of the depression based on the distortion of the pattern.
A circuit for measuring the conductivity of a medical fluid, the circuit comprising: a data collecting cell through which a medical fluid is configured to flow; an input voltage source that provides an input voltage to the data collecting cell; a voltage measurement unit configured to measure the input voltage and an output voltage of the data collecting cell; and a switch in communication with the voltage measurement unit, the switch configured to switch between a first state in which the voltage measurement unit is configured to measure the input voltage and a second state in which the voltage measurement unit is configured to measure the output voltage of the data collecting cell.
G01N 27/04 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
G01N 27/08 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a liquid which is flowing continuously
11.
MANAGING COMMUNICATIONS WITH A CONNECTED HEALTH SYSTEM
A medical system, comprising: a medical machine; and a gateway device configured to communicate with the medical machine to allow access to a network, the gateway device comprising a data allowance and limitation unit that is configured to limit communication between the medical machine and the network when the data allowance and limitation unit is in an open state, wherein the data allowance and limitation unit is placed in the open state when a plannable system event occurs, and wherein, while in the open state, the data allowance and limitation unit is placed in a closed state when an unplanned event occurs, thereby providing less limited communication between the medical machine and the network compared to the open state.
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
H04M 1/14 - Supports for sets, e.g. incorporating armrests with resilient means to eliminate extraneous vibrations
A hollow fiber membrane and methods of making the hollow fiber membrane are described. The membrane includes a hydrophobic polymer such as polysulfone, a hydrophilic polymer such as polyvinylpyrrolidone (PVP), and a fluropolymer additive, and optionally a stabilizer, for instance, to stabilize the fluoropolymer additive in the membrane, particularly during conditioning or E-beam sterilization or both. Further conditioning improvements to membrane manufacturing are disclosed. The membrane may be incorporated into a dialysis filter for use in hemodialysis and related applications. The membrane has improved hemocompatibility, charge stability, or middle molecule clearance compared to conventional membranes. Also disclosed is a method of evaluating membrane charge stability.
B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
Dialysis systems for operating dialysis machines (e.g., peritoneal dialysis machines) for conducting dialysis treatments are disclosed. The dialysis system may include a spent dialysate container for receiving spent dialysate from a patient. In use, the spent dialysate containers are arranged and configured to provide one or more mechanical advantages to ease disposal of the spent dialysate. For example, the spent dialysate container may receive the spent dialysate from the patient and enable the patient or caregiver to dispose of the spent dialysate without requiring the patient or caregiver to lift bags of spent dialysate or incorporate lengthy drain lines. The spent dialysate container may include a reservoir to receive the spent dialysate, wheels to enable the patient or caregiver to transport the reservoir, mechanisms to facilitate disposal of the spent dialysate from the reservoir, a nozzle to dispose of the spent dialysate, and/or a disinfectant to disinfect the drain.
Techniques and apparatuses for determining an estimated cardiac output for a patient during dialysis treatment are described. In one embodiment, for example, an apparatus may include a memory and logic coupled to the memory. The logic may be configured to determine an upper body oxygen consumption for a patient, determine, during a dialysis process: a hemoglobin concentration and a venous oxygen saturation measured via an optical blood monitor operably coupled to an extracorporeal circuit of a dialysis system performing the dialysis process,; an arterial oxygen saturation measured via a pulse oximeter operably coupled to the extracorporeal circuit; an arterial-venous oxygen content difference based on the arterial oxygen saturation and the venous oxygen saturation; and an upper body blood flow (UBBF) as (upper body oxygen consumption)/(arterial-venous oxygen content difference), and determine a treatment recommendation based on the upper body blood flow. Other embodiments are described.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/02 - Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
A61B 5/029 - Measuring blood output from the heart, e.g. minute volume
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
Collection filter devices configured to filter peritoneal dialysis (PD) effluent draining from a patient during a PD process for collecting target materials, such as human cells, microorganisms, and/or other components from PD effluent. For instance, a filter device may be configured to be installed in-line in a drain circuit of a PD system using conventional tubing. The captured materials may be analyzed or otherwise processed to determine health characteristics of a patient and/or to capture stem cells.
A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
16.
SPECIMEN COLLECTION AND STORAGE FOR POOL TESTING AND SIMILAR
The present teachings generally include devices, systems, kits, and methods for collecting, storing, and transporting specimens, e.g., in the context of pool testing. For example, the present teachings may include a compound swab featuring a first swab and a second swab, where the first swab can be detached for pool testing and the second swab can be preserved for testing based on results of the pool test. The present teachings may also or instead include a container having a separator structurally configured to separate swabs of a compound swab. Further, the present teachings may include a swab having a suction enhancer to promote the capture of a specimen on a collection tip thereof. The present teachings may also or instead include a receptacle that can house a plurality of swabs and sever at least a portion of the collections tips thereof, e.g., for pool testing.
A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
A61B 10/02 - Instruments for taking cell samples or for biopsy
The present teachings generally include parabiotic dialysis systems and techniques. For example, the present disclosure includes parabiotic liver dialysis, e.g., for use in settings with limited resources. To this end, a parabiotic liver dialysis system may include a device having a semipermeable membrane with an average pore size that allows for the passage of albumin therethrough. In such a system, a first extracorporeal circuit may connect the device to the vascular system of a first animal (e.g., a liver patient), and a second extracorporeal circuit may connect the device to the vascular system of a second animal (e.g., a human with normal liver function), where the exchange of albumin therebetween is facilitated through the device. The present disclosure also includes various safety measures for parabiotic dialysis systems and techniques, such as biometric verification systems and techniques.
A61M 1/34 - Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration, diafiltration
A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
B01D 61/00 - Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
18.
SYSTEM AND METHOD FOR DETECTING VENOUS NEEDLE DISLODGEMENT
In one aspect, a method and system for detecting a change in fluid dynamics of a fluid flowing through an extra-corporeal circuit is disclosed, which includes establishing an acoustic wave resonance across a transverse dimension of at least a portion of a line associated with the extra-corporeal circuit through which the fluid flows, monitoring a phase signal of the resonant acoustic wave, and identifying occurrence of a change in fluid dynamics of the flowing fluid when the observed phase signal of the resonant acoustic wave indicates a deviation from the expected fluid flow signature. The change in fluid dynamics can be used to indicate a venous needle dislodgement event.
G01S 5/18 - Position-fixing by co-ordinating two or more direction or position-line determinations; Position-fixing by co-ordinating two or more distance determinations using ultrasonic, sonic, or infrasonic waves
19.
ADMINISTERING DIALYSIS TREATMENT USING A HYBRID AUTOMATED PERITONEAL DIALYSIS SYSTEM
A dialysis machine (e.g., a peritoneal dialysis (PD) machine) can include a control unit configured to operate in a hybrid automated mode during a PD treatment. A processor in the control unit is configured to engage a pump during a fill phase of the PD cycle. The volume of fluid (e.g., dialysate) transferred to a patient line during the fill phase is monitored. After a dwell period, the pump is disengaged at the start of a drain phase of the PD cycle. Disengaging the pump can include: configuring valves of a disposable cassette to bypass the pump chambers of a disposable cassette; activating a bypass valve to shunt the patient line to a drain line; or moving a roller assembly of a peristaltic pump. The fluid transferred from the patient line to the drain line is monitored during the drain phase of the PD cycle..
A61M 60/113 - Extracorporeal pumps, i.e. the blood being pumped outside the patient’s body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
In one aspect, a method for optimizing a therapy for osteoporosis is disclosed, which comprises (a) generating in silico a plurality of virtual patients, wherein each of the virtual patients comprises a mathematical construct for modeling progression of osteoporosis via simulation of bone remodeling, said mathematical construct comprising a plurality of dynamic mathematical relations defining time-dependent evolution of at least one of a cell density variable or concentration variable associated with any of pre-osteoblasts, osteoblasts, preosteoclasts, osteoclasts, osteocytes, a bone resorption signal, sclerostin, estrogen, bone density and bone mineral content and employs a processor to determine time-variation of at least one of bone mineral density and bone mineral fraction based on at least a portion of said time- dependent variables, (b) applying a simulated therapy to said plurality of virtual patients, and (c) using said virtual patients to determine an effect of said simulated therapy on progression of osteoporosis.
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
21.
BLOOD TREATMENT SYSTEMS AND RELATED COMPONENTS AND METHODS
This disclosure relates to a blood treatment system including a blood treatment machine, a dialyzer configured to be coupled to the blood treatment machine, a blood line having a first end configured to be connected to the dialyzer and a second end configured to be connected to a needle for insertion into a patient, and one or more sensors operable to transmit, to the blood treatment machine, data related to tension along the blood line. The blood treatment machine is configured to take action in response to the data received from the one or more sensors.
A hemodialysis system includes: a hemodialysis machine configured to provide hemodialysis treatment to a patient, wherein the hemodialysis treatment includes circulating extracorporeal blood of the patient through an extracorporeal blood circuit; a first oxygen saturation sensor device configured to measure oxygen saturation corresponding to the extracorporeal blood of the patient in the extracorporeal blood circuit; a second oxygen saturation sensor device configured to measure oxygen saturation corresponding to blood flowing within the patient; and at least one controller configured to determine one or more oxygen saturation phase shift (OSPS) values or one or more transcutaneous travel time values corresponding to the patient based on oxygen saturation measurements from the first oxygen saturation sensor device and the second oxygen saturation sensor device.
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/1459 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
23.
SYSTEM FOR ASSESSING AND MITIGATING POTENTIAL SPREAD OF INFECTIOUS DISEASE AMONG DIALYSIS PATIENTS
A method for mitigating the spread of infectious diseases among dialysis patients is provided. The method comprises: receiving, by a prediction system and from a medical facility, individual treatment data indicating dialysis treatment information associated with a patient undergoing dialysis treatment; receiving, by the prediction system and from a blood testing laboratory, individual lab data indicating blood analysis information associated with the patient; determining, by the prediction system, disease analysis results for the patient based on inputting the individual treatment data and the individual lab data into a disease prediction machine learning (ML) model, wherein the disease analysis results indicate a likelihood of the patient being infected with a contagious disease; and providing, by the prediction system and to the medical facility, instructions indicating one or more responsive actions based on the disease analysis results.
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 50/80 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for detecting, monitoring or modelling epidemics or pandemics, e.g. flu
24.
BLOOD MONITORING SYSTEM FOR DETERMINING A CALIBRATED HEMOGLOBIN CONCENTRATION VALUE FOR A PATIENT BASED ON PATIENT-SPECIFIC MEAN CORPUSCULAR HEMOGLOBIN CONCENTRATION DATA
A hemodialysis system includes a hemodialysis machine and a blood monitoring system. The hemodialysis machine is configured to provide hemodialysis treatment to a patient, wherein the hemodialysis treatment includes circulating extracorporeal blood of the patient through an extracorporeal blood circuit. The blood monitoring system includes: a sensor device configured to measure a hematocrit value corresponding to the extracorporeal blood of the patient in the extracorporeal blood circuit; and at least one controller. The blood monitoring system is configured to communicate with an electronic health records (EHR) system over a communications network to obtain patient-specific mean corpuscular hemoglobin concentration (MCHC) data for the patient. The at least one controller is configured to determine a hemoglobin concentration value corresponding to the extracorporeal blood for the patient in the extracorporeal blood circuit using the measured hematocrit value and the patient-specific MCHC data for the patient.
A system for determining individualized dialysis prescriptions is provided. The system comprises a prescription recommendation server and an on-demand dialysis machine. The prescription recommendation server is configured to: receive, from a prescriber computing device, patient information associated with a new patient; determine, based on the patient information, an individualized dialysis prescription for the new patient, wherein the individualized dialysis prescription indicates a particular patient cluster associated with the new patient; and transmit, to an on-demand dialysis machine, the individualized dialysis prescription for the new patient. The on-demand dialysis machine is configured to: receive, from the prescription recommendation server, the individualized dialysis prescription for the new patient; and perform a dialysis treatment on the new patient based on the individualized dialysis prescription.
methods, apparatuses, and systems for determining a peritoneal transport status of a patient based on mass analyzing low volumes of peritoneal dialysis (PD) effluent to generate patient information that may be evaluated using PD effluent fingerprints to determine peritoneal transport characteristics of the patient are described. For example, in one embodiment, a method of determining a transport status of a dialysis patient may include obtaining a volume of peritoneal dialysis (PD) effluent of the dialysis patient, generating patient information via mass analysis of the volume of PD effluent, and determining patient profile information based on evaluating the patient information with a profile library, the patient profile information comprising a peritoneal transport status classification. Other embodiments are described.
Systems, methods, and/or apparatuses may be operative to perform a dialysis process that includes a displacer infusion process. In one embodiment, a method for determining a displacer compound may include constructing a plurality of target protein quantitative structure-activity relationship (QSAR) models, one for each of the plurality of binding sites, analyzing a set of candidate compounds using the plurality of QSAR models to determine a set of at least one potential compound with an affinity for binding to each of the plurality of binding sites, and selecting at least one displacer compound from the set of at least one potential compound. Other embodiments are described.
G16B 15/30 - Drug targeting using structural data; Docking or binding prediction
G16B 5/00 - ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
The disclosed arterial chambers for hemodialysis may include a cap with a blood inlet port for conveying an intended patient's blood into the arterial chamber, an auxiliary port configured to provide fluid access to the arterial chamber, and a needleless access port configured to couple to a needleless syringe. The needleless access port may be configured for administering a substance to an interior of the arterial chamber from the needleless syringe and/or for withdrawing blood from the interior of the arterial chamber into the needleless syringe. Various tubing sets, hemodialysis systems, and other components, systems, and methods are also disclosed.
An apparatus used in analyzing spent dialysate includes at least a first surface configured to accommodate a dialysate drain bag in a first predetermined position, and at least a second surface configured to accommodate a dialysate analysis device in a second predetermined position, such that when the dialysate drain bag is in the first predetermined position and the dialysate analysis device is in the second predetermined position, a light sensor of the dialysate analysis device is positioned to sense light passing through the dialysate drain bag.
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
A system for monitoring percentage change in blood volume (?BV%) during dialysis treatment includes a sensor device configured to obtain hematocrit (Hct)-related measurements based on detecting light which has passed through extracorporeal blood of a patient undergoing the dialysis treatment; one or more controllers configured to: determine Hct values based on the Hct-related measurements obtained by the sensor device; determine ?BV% values based on the determined Hct values; and generate a GUI having a ?BV% plot based on the determined ?BV% values; and a display device having a display configured to display the GUI having the ?BV% plot. Zone indicators are provided on the display to distinguish between a first zone corresponding to a first ?BV% profile, a second zone corresponding to a second ?BV% profile, and a third zone corresponding to a third ?BV% profile.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
Methods to treat anemia are provided whereby an erythropoietin stimulating agent (ESA) and an iron supplement are administered by a wearable device, based on patient parameters sensed by the wearable device. The method can involve monitoring patient parameters and dosing an ESA and an iron supplement in real-time, via the wearable device.
A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
A61B 5/021 - Measuring pressure in heart or blood vessels
A computer-implemented medical system is provided. The system includes a docking station and a mobile machine. The system is configured to perform operations comprising: receiving, by the mobile machine and from a user, a request to transport the mobile machine to a target location to perform a medical treatment; automatically navigating the mobile machine to the target location; performing, by the mobile machine, the medical treatment on a patient; determining, by the mobile machine, that the medical treatment is completed and the mobile machine is disconnected from the patient; automatically navigating the mobile machine to a stationary docking station of the medical system; and determining that the mobile machine is connected to the docking station through one or more connectors, and in response, receiving, by the mobile machine, at least one of an electrical charge, a refill of one or more supplies, a cleaning, or a drain of waste.
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
A dialysis system, such as a hemodialysis system, includes a flow chamber. The flow chamber includes: a tube section having a first end and a second end, a tube section longitudinal axis extending between the first end and the second end, the tube section having an inner wall and outer wall; and a helical flow path disposed in the inner wall of the tube section, the helical flow path extending along at least a portion of the tube section longitudinal axis.
Techniques for real-time intradialytic hypotension (IDH) prediction are disclosed. A system obtains historical hemodialysis treatment data that is segmented into sets of machine learning training data based on temporal proximities to IDH events and trains a machine learning model to predict IDH events based on the sets of machine learning training data.
A61B 5/02 - Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
A61M 1/34 - Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration, diafiltration
35.
AN INJECTION PORT FOR CONNECTING WITH A MEDICAL FLUID CONTAINER AND METHODS FOR THE PRODUCTION OF SAME
The present invention relates to an injection port for connecting with a container, such as a medical fluid container. The injection port includes a barrel, a septum, and a cap, which are sequentially formed via a three-shot injection molding process. The present invention further relates to an assembly that includes the injection port connected to a container. Further, the present invention relates to a method of making the injection port utilizing a three-shot injection molding process.
In one aspect, a system includes a blood treatment machine; a dialyzer configured to be coupled to the blood treatment machine, the dialyzer including a dialyzer housing defining a blood inlet and a blood outlet; a bundle of hollow fibers within an interior of the dialyzer housing; a pumping device drivable to force blood received from the blood inlet through lumens of the bundle of hollow fibers and out the blood outlet; a dialysate inlet port in fluid communication with a dialysate flow path that includes space in the interior of the dialyzer housing between the bundle of hollow fibers; and a dialysate outlet port in fluid communication with the dialysate flow path. The system further includes a fluid conditioning system configured to (i) prepare and supply fresh dialysate to the dialyzer via the dialysate inlet port, and (ii) receive spent dialysate from the dialyzer via the dialysate outlet port, recycle the spent dialysate, and supply the recycled dialysate to the dialyzer via the dialysate inlet port.
A dialyzer housing manufacturing system includes a molding device configured to mold a dialyzer housing, and a tool coupled to a robotic arm and configured to retrieve the dialyzer housing from the molding device after the dialyzer housing is molded. The tool includes a frame, a first suction cup connected to a first portion of the frame, and a second suction cup connected to a second portion of the frame, the second suction cup being oriented about 70 degrees to about 110 degrees relative to the first suction cup.
A sorbent canister utilized when performing a dialysis treatment during hemodialysis (HD) or peritoneal dialysis (PD) is provided. The sorbent canister includes inlet and outlet ports that include a threaded interface for connection to inlet and outlet tubes for circulation of dialysate through the sorbent canister. Upon disconnection from a dialysis machine, a pressure relief cap can be threaded onto the threaded interface to seal the fluid in the sorbent canister while allowing for off-gases to be expelled when a pressure within the sorbent canister exceeds a threshold pressure, thereby preventing a rupture in the canister body. In one embodiment, the pressure relief cap includes a deformable insert with a hole formed therein that is closed in an uncompressed state and opened in a compressed state. In another embodiment, the pressure relief cap includes a diaphragm that mates with a feature of the inlet or outlet port.
A systems is provided herein to evaluate health of a patient. The system includes one or more testing modules configured to receive examination data related to at least one of gripping power, vision health, or hearing strength of a user; one or more pumps configured to provide fluid to or receive fluid from the user's body and analyze the fluid to determine one or more contents included in the fluid; a data processor unit configured to analyze the received examination data to determine whether the user is at risk of a health problem, and a communication unit capable of communicating information to a computing system. In response to determining that the user is at risk of the health problem, the data processor requests the communication unit to notify a health care provider about the risk. Corresponding methods and non-transitory computer readable medium are also disclosed.
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
A61B 3/00 - Apparatus for testing the eyes; Instruments for examining the eyes
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
Dialyzer systems can consolidate multiple technologies and functionalities of blood treatment systems in a significantly integrated fashion. For example, this disclosure describes dialyzer systems that include a magnetically driven and magnetically levitating pump rotor integrated into the dialyzer. Such a dialyzer can be used with treatment modules that include a magnetic field-generating pump drive unit. In some embodiments, the dialyzers include pressure sensor chambers with flexible membranes with which corresponding pressure transducers of the treatment modules can interface to detect arterial and/or venous pressures.
Dialyzer systems can consolidate multiple technologies and functionalities of blood treatment systems in a significantly integrated fashion. For example, this disclosure describes dialyzer systems that include a magnetically driven and magnetically levitating pump rotor integrated into the dialyzer. Such a dialyzer can be used with treatment modules that include a magnetic field-generating pump drive unit. In some embodiments, the dialyzers include pressure sensor chambers with flexible membranes with which corresponding pressure transducers of the treatment modules can interface to detect arterial and/or venous pressures.
A61M 60/113 - Extracorporeal pumps, i.e. the blood being pumped outside the patient’s body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
42.
PISTON ASSEMBLY INCLUDING LEAK DETECTION IN A DIALYSIS MACHINE
Dialysis systems and methods for operating dialysis machines (e.g., peritoneal dialysis machines) for conducting dialysis treatments are disclosed. The dialysis system may include a dialysis machine for transferring dialysate to a patient from a dialysate source. The dialysate may flow from the dialysate source through a cartridge or cassette (e.g., a disposable cartridge or cassette) positionable within the dialysis machine. The dialysis machine includes a piston for pumping fluid (e.g., dialysate) from the cassette to the patient. In various embodiments, during use, the piston is arranged and configured to contact, compress, etc. a membrane defining one or more fluid chambers in the cassette. In one embodiment, the piston includes a sensor for detecting a leak at the interface between the piston and the membrane. The sensor may be a capacitive sensor.
G01M 3/16 - Investigating fluid tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using electric detection means
43.
MEASURING FLUID FLOW ASSOCIATED WITH A DIALYSIS MACHINE
A dialysis machine (e.g., a peritoneal dialysis (PD) machine) can include a control unit configured to monitor an amount of fluid withdrawn from a heater bag line during a PD treatment. A processor in the control unit is configured to operate a first pump to draw fluid into a first pump chamber and measure a first fluid volume in the first pump chamber. The processor is further configured to operate the first pump and a second pump to transfer fluid from the first pump chamber to a second pump chamber, measure a second fluid volume in the second pump chamber, and determine a measured fluid volume for a single pump cycle based on the first fluid volume and the second fluid volume. The first fluid volume is correlated to the second fluid volume and, therefore, the multiple independent measurements increase an accuracy of the fluid volume measurement.
A dialysis access site system may operate to generate a treatment recommendation for treating a condition of an access site based on an image of the access site. The dialysis access site system may an apparatus having at least one processor and a memory coupled to the at least one processor. The memory may include instructions that, when executed by the at least one processor, may cause the at least one processor to receive an access site image comprising an image of a dialysis access site of a patient, determine access site information for the dialysis access site based on at least one access site feature determined from the access site image, the access site information indicating a condition of the dialysis access site, and determine a treatment recommendation for the dialysis access site based on the access site information.
Techniques for vascular access identification and validation are disclosed. The techniques include: directly or indirectly acquiring an acquired value for a parameter that is a function of oxygen saturation (S02) of a sample of blood in or obtained from a vascular access device (VAD) disposed in a subject; performing an evaluation of the acquired value at least by comparing the acquired value with one or more reference values; and responsive to the evaluation of the acquired value, assigning an identity classification to the VAD, wherein the identity classification is one of a central venous catheter (CVC), an arteriovenous access device (AVA), or another class of VAD.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/02 - Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
A61B 5/0215 - Measuring pressure in heart or blood vessels by means inserted into the body
A61B 5/1459 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
A medical device includes a plurality of electromechanical components and a control unit, coupled to the electromechanical components, that actuates the electromechanical components. For each of the electromechanical components, the control unit maintains a count of a number of times a respective one of the electromechanical components is actuated and/or a run time duration of the respective one of the electromechanical components. The medical device also includes a table having observed values for each of the electromechanical components, where a maintenance alert is provided for at least one of the electromechanical components in response to the count and/or the run time for the at least one of the electromechanical components exceeding a corresponding maintenance limit for the electromechanical component. The maintenance limits are independent for different ones of the electromechanical components. The medical device may be a dialysis machine.
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
A fluid conduit includes a first portion having a first porosity, a second portion disposed immediately adjacent to the first portion, the second portion having a second porosity that is greater than the first porosity, and a third portion of the fluid conduit disposed immediately adjacent to the second portion, the third portion having a third porosity that is less than the second porosity. Each of the first portion, the second portion, and the third portion may be integrally formed as a single, continuous piece defining the fluid conduit.
Techniques for monitoring fluid volumes during peritoneal analysis include: computing lower abdominal fluid volumes, continuously during a dwell time of a peritoneal dialysis treatment, based at least on bioimpedance data from electrodes positioned on a patient's upper thighs; and computing intraperitoneal volumes, continuously during the dwell time of the peritoneal dialysis treatment, based at least on bioimpedance data from the electrodes positioned on the patient's upper thighs and electrodes positioned on the patient's torso.
A61M 1/00 - Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
This disclosure relates to dialysis systems and methods. In some implementations, a dialysis system includes a dialysis machine with a fluid line and a drain line, a blood line set configured to be connected to the dialysis machine, and a drain apparatus coupled to the dialysis machine. The drain apparatus includes a chamber configured to receive an end of a patient line of the blood line set, an inlet line, an outlet line, and a valve. The inlet line has a first end configured to be coupled to the chamber and a second end configured to be coupled to the fluid line of the dialysis machine. The outlet line has a first end configured to be coupled to the chamber and a second end configured to be coupled to the drain line of the dialysis machine. The valve is configured to control flow of fluid through the outlet line.
Techniques and apparatus for de-priming processes are described. For example, in one embodiment, an apparatus may include at least one processor and a memory coupled to the at least one processor, the memory may include instructions that, when executed by the processor, may cause the at least one processor to determine a priming volume of a primer fluid infused into a priming system associated with the patient during a priming phase of the dialysis treatment, cause an ultrafiltration rate of an ultrafiltration pump of the dialysis machine in fluid communication with the patient to be changed from a treatment ultrafiltration rate to a de-priming ultrafiltration rate to remove the priming volume over a de-priming time period, and cause, after the de-priming time period, the ultrafiltration rate of the ultrafiltration pump to be changed back the treatment ultrafiltration rate. Other embodiments are described.
A dialysis system may include a dialysis machine (e.g., a hemodialysis (HD) machine or a peritoneal dialysis (PD) machine) that is configured to communicate with a secure access card having onboard biometric processing capabilities and using a wireless connection established according to a wireless communication protocol. Implementations of the wireless connection may include a short-range wireless technology protocol, such as, for example, Near Field Communication (NFC), WiFi and/or Bluetooth technology protocols. The secure access card may include biometric security features, such as a biometric sensor and/or a biometric verification module, to provide and control secure biometric access to the dialysis machine when the secure access card is brought into proximity of the dialysis machine.
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
G06F 21/32 - User authentication using biometric data, e.g. fingerprints, iris scans or voiceprints
This disclosure relates to method that comprises sensing properties of a urine sample of a patient using a biomarker sensor to generate raw urine data. The method further includes transmitting the raw urine data to a processor, using the processor to generate processed urine data from the raw urine data, and transmitting the processed urine data to a computing device.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 20/00 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers
A61B 5/1172 - Identification of persons based on the shapes or appearances of their bodies or parts thereof using fingerprinting
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
Dialysis systems and methods for operating dialysis machines (e.g., peritoneal dialysis machines) for conducting dialysis treatments are disclosed. The dialysis system may include a dialysis machine for transferring dialysate to a patient from a dialysate source. The dialysate may flow from the dialysate source through a cartridge or cassette (e.g., a disposable cartridge or cassette) positionable within the dialysis machine. The cassette includes a fluid flow channel. The dialysis machine includes a heating chamber for in-line heating of the dialysate in the fluid flow channel. The fluid flow channel is arranged and configured to provide turbulent flow of the dialysate through the fluid flow channel to provide increased heat transfer from the heating chamber to the dialysate.
Computer code embedded in an electronic component (e.g., a processor, a sensor, etc.) of a medical device, such as a dialysis machine, can be authenticated by comparing a metadata signature derived from the computer code of the electronic component to a key derived from a pre-authenticated code associated with the electronic component. The metadata signature can be derived by running an error-check/error-correct algorithm (e.g., SHA256) on the computer code of the electronic component. A use of the metadata signature enables detection of any unauthorized changes to the computer code as compared to the pre-authenticated code.
G06F 21/62 - Protecting access to data via a platform, e.g. using keys or access control rules
H04L 9/32 - Arrangements for secret or secure communications; Network security protocols including means for verifying the identity or authority of a user of the system
An assembly comprises a manifold configured to couple to a medical fluid cassette and a multi-lumen tube comprising a plurality of lumens within an outer wall of the multi-lumen tube. The manifold has a plurality of fluid connection ports and can be connected to the multi-lumen tube (e.g., via an adapter).
A dialysis system may include a dialysis machine (e.g., a peritoneal dialysis machine) having a fluid system for delivering fluid (e.g., dialysate) to a patient. The dialysis machine may include at least one processor and a memory coupled to the at least one processor, the memory comprising instructions that, when executed by the processor, may cause the at least one processor to determine volume information for a fluid system of a dialysis machine, wherein the volume information may comprise a patient line volume and an accuracy adjustment volume, and to determine a priming volume to prime the fluid system with a fluid based on the volume information. Other embodiments are described.
A device for detecting potential health issues includes a retinal scanner configured to capture retinal data of the user, a blood pressure sensor configured to capture blood pressure data of the user, an alert module configured to alert the user of a potential health risk, and at least one processor communicatively coupled to the retinal scanner, the blood pressure sensor, and the alert module.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
A61B 5/021 - Measuring pressure in heart or blood vessels
A sorbent cartridge device includes an ion-exchange material containing zirconium phosphate and no more than about 0.1 mg of leachable phosphate ions per about 1 g of the ion-exchange material. In one example, the cartridge also includes a phosphate-adsorbing material containing zirconium oxide. In this example, the weight ratio between zirconium phosphate and zirconium oxide in the cartridge is from about 10:1 to about 40:1. The zirconium phosphate may be alkaline zirconium phosphate prepared by a process including the following steps: (i) drying acid zirconium phosphate to obtain a dry acid zirconium phosphate; (ii) combining the dry acid zirconium phosphate with an aqueous solution to obtain an aqueous slurry; and (iii) combining the slurry with an alkali hydroxide to obtain the alkaline zirconium phosphate. During step (ii), any free phosphate ions in the dry acid zirconium phosphate leach out into the aqueous phase of the slurry.
B01J 20/06 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group
A dialysis system has a module with a dialyzer configured to remove one or more substances from a dialysis solution as it passes through a dialyzer. The module has a fluid line, a sorbent cartridge, and a sodium control system adapted to actively alter a sodium concentration of dialysis solution passing through the fluid line as the dialysis solution exits the sorbent cartridge. The sodium control system has a conductivity sensor that sends a signal indicating the conductivity of the dialysis solution as the dialysis solution exits the sorbent cartridge, the conductivity meter being in communication with the sodium control system, a processor configured to receive the signal from the conductivity sensor, compare the conductivity signal to a threshold value lower than a prescription value, and cause the sodium control system to stop actively altering the sodium concentration if the signal is greater than the threshold value.
In some embodiments, a medical system includes a dialysis machine having at least one outer surface to be disinfected at a given location, at least one disinfection sensor connected to the dialysis machine at the given location, the disinfection sensor including two or more electrode in fluid contact with the outside surface of the dialysis machine, and a conductivity sensor component in electrical contact with the two or more electrodes, the conductivity sensor component configured to send an electrical signal indicating a conductivity of a liquid on an outside surface of the dialysis machine and in contact with the two or more electrodes, a processor configured to receive the electrical signal and thereby determine a disinfection status of the given location, and a user interface configured to indicate the disinfection status of the given location.
A spectroscopic detection system includes a sensor configured to reflect light of a first wavelength associated with a presence of a reference substance on the sensor and configured to reflect light of a second wavelength associated with a presence of a monitored substance on the sensor, wherein the monitored substance flows to the sensor from a circulating fluid. The spectroscopic detection system further includes a detector that has first and second channels for respectively receiving the light of the first and second wavelengths reflected from the sensor and one or more processors in electrical communication with the detector and configured to identify an excess condition of the monitored substance with respect to the circulating fluid based on a ratio of a second amount of the light of the second wavelength received at the detector to a first amount of the light of the first wavelength received at the detector.
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
A dialysis machine (e.g., a peritoneal dialysis (PD) machine) can include a patient line that provides dialysate solution to a patient and removes effluent dialysate from the patient through a catheter. During a drain phase of a PD treatment, an occlusion can occur at different locations in the patient line and/or catheter. A pressure sensor can detect a change in pressure of the fluid at the proximal end of the patient line to infer a potential occlusion in the patient line. Prior to setting an alarm to alert the patient of the blockage in the patient line, operating parameters of the PD machine can be changed to attempt to correct the issue. In an embodiment, the pump mechanism can be cycled at a reduced speed or a reduced rate in order to confirm the occlusion or attempt to alleviate the low fluid flow condition before the alarm is set.
A device for measuring conductivity of a fluid. The device including a chamber and at least two electrodes. The chamber includes an inlet, an outlet, an upper surface, and a lower surface that runs separate from the upper surface. The fluid enters the chamber through the inlet and flows out of the chamber through the outlet. Moving along a length of the chamber from the inlet to the outlet or from the outlet to the inlet, a distance between the upper surface and the lower surface changes in at least one dimension of the chamber. The two electrodes are configured to measure electrical voltage in the fluid that enters the chamber through the inlet and flows out of the chamber through the outlet.
A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
G01N 27/06 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a liquid
Tubing protectors, systems including tubing protection, and methods for protecting tubing, are disclosed, such as for protecting tubing connected between a patient and a dialysis machine (e.g., peritoneal dialysis machine) during a dialysis treatment. A tubing protector (200; 300) may include a tubing sheath (205) attachable to a patient. The sheath may include a first portion (220) for receiving and protecting a length of tubing (120) extendible in the sheath, such as to minimize collapse, kinking, blockage, or combinations thereof, along the length of the tubing. A second portion (225) may comprise a flexible material and enclose the first portion. The first portion may comprise a resilient material, which allows for movement in the sheath and has a strength to allow for reorientation of the tubing, while withstanding deformation of the tubing along the length. The first portion may be a coil, a plurality of rings, a woven mesh, or a solid tube, or combinations thereof.
In the present disclosure, a blood treatment machine includes a user interface configured to display information, a transceiver configured to send and receive signals, a controller configured to process input signals received by the transceiver and display information on the user interface, one or more pumps, and a first door. The first door has a closed configuration in which the door covers the one or more pumps and an open configuration in which the one or more pumps are accessible by a user. The blood treatment machine further includes at least a portion of a keyboard mounted on the door, the keyboard being configured to transmit signals to the transceiver of the machine.
A61M 1/34 - Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration, diafiltration
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
The described technology may include processes to model acid-base homeostasis in normal patients and under acid-base disorder conditions. In one embodiment, a method may include an acid-base homeostasis analysis. The method may include, via a processor of a computing device: providing a physiological acid-base model configured to model acid-base homeostasis of a virtual patient, the physiological acid-base model to: determine a plurality of operating parameters for an HCO3/CO2 buffering system having renal and pulmonary regulatory mechanisms, determine acid-base information comprising a bicarbonate concentration, a carbon dioxide concentration, and a free hydrogen ions concentration via simulating the HCO3/CO2 buffering system, and determine predicted patient information based on the acid-base information. Other embodiments are described.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 50/00 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
67.
REMOTE COMMUNICATION WITH MULTIPLE DIALYSIS MACHINES
A remote control device may be used to wirelessly control functions of one or more dialysis machines, e.g. in a clinic environment and without requiring direct contact with the dialysis machines. Components of the remote control device may include control interfaces, e.g. buttons, for controlling and adjusting functions of a medical device, such as a dialysis machine, including, for example, volume control, blood pump control blood flow rate control and/or adjusting the level in the venous drip chamber, among other control features. Display of the remote control device may include one or more screens that may display information of one or more dialysis machines, patients undergoing dialysis treatment, and/or alarms or alerts of one or more of the dialysis machines. In an implementation, ultrasonic communication is used to wirelessly exchange information and commands between the remote control device and the one or more dialysis machines.
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
H03J 9/04 - Remote-control of tuned circuits; Combined remote-control of tuning and other functions, e.g. brightness, amplification using ultrasonic, sonic or infrasonic waves
H04B 11/00 - Transmission systems employing ultrasonic, sonic or infrasonic waves
A method for adjustment of a dialysate during dialysis for a patient is provided. A patient undergoing a dialysis treatment, e.g., a hemodialysis (HD) treatment, can experience multiple physiological changes during the treatment. These can include change in blood volume as well as change in concentration of blood electrolytes. Blood electrolytes when taken out of their desired ranges can result in one or more health risks. The disclosure provides a way of avoiding those health risks by adjusting composition of dialysate during dialysis treatment such that blood electrolytes are maintained within their desired ranges.
Systems and methods for generating anonymized acoustic fingerprints. For a predetermined time interval, raw audio data associated with an environment can be captured and processed. Based on the captured raw audio data, a plurality of discrete data elements can be generated.
G10L 25/51 - Speech or voice analysis techniques not restricted to a single one of groups specially adapted for particular use for comparison or discrimination
G06F 21/62 - Protecting access to data via a platform, e.g. using keys or access control rules
Augmented reality-based training and troubleshooting for medical devices. An electronic mobile device can be equipped with an AR application that, when executed, causes the electronic mobile device to provide augmented reality-based training on how to set up, or perform maintenance on, one or more components of a medical device. The AR application, when executed, can also cause the electronic mobile device to provide augmented reality-based troubleshooting for one or more components of a medical device.
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
71.
SYSTEMS AND METHODS FOR ESTIMATING ULTRAFILTRATION RATES
Systems and methods for estimating the post-treatment ultrafiltration rate of a patient are provided. A medical device can be configured to determine an estimated post-treatment ultrafiltration rate based on one or more values associated with a patient prepared to undergo treatment with the medical device. The medical device can also be configured to compare the estimated post-treatment ultrafiltration rate with one or more threshold values. The medical device can be configured to have an alert module, which can be activated when the estimated post-treatment ultrafiltration rate exceeds the one or more threshold values.
A technique for determining skin sodium content using bioimpedance spectroscopy includes applying a current at a predetermined frequency to skin of a subject, measuring a voltage across the skin of the subject produced by the current, determining a resistance across the skin of the subject at the predetermined frequency using the measured voltage, and determining skin sodium content using the measured voltage.
Constraining adaptive optimizations of a state of an operation module of a medical device includes determining if a new state has at least one operational parameter that is outside a constraint that has been provided to the medical device in a non-repudiable manner, accepting the new state if no operational parameters are outside any of the constraints, and reverting the medical device to a previous valid state if at least one operational parameter is outside at least one of the constraints. The adaptive optimizations may be provided using artificial intelligence along with relevant inputs thereto. The medical device may be a dialysis system. Constraint data may be provided to the medical device along with a one-way hash value of the constraint data using, for example, a SHA 256 hash. The one-way hash value may be digitally signed using a private key that is part of a public/private key pair.
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
A method of preparing a medical fluid with a medical fluid generating machine includes receiving, at the medical fluid generating machine, a container to be filled with the medical fluid, receiving, at a processor, instructions to prepare the medical fluid, the instructions including an identification a medical fluid type from among a plurality of medical fluids and a desired volume of the medical fluid, preparing the medical fluid according to the received instructions, testing the prepared medical fluid to ensure that one or more characteristics of the prepared medical fluid is within an acceptable range, filling the container with the prepared fluid and labelling the container with information about the medical fluid, the information including the identification of the medical fluid type within the filled container, and an expiration date of the fluid.
Embodiments of the disclosure provide a method for determining beginning blood volume of a patient during dialysis (e.g., hemodialysis). Ultrafiltration rates are determined at different time stamps during dialysis by obtaining a blood flowrate measurement and hematocrit measurements at input port and output port of a dialyzer connected to the patient. The flowrate and hematocrit measurements are used to determine fluid removed from the patient during dialysis. The ultrafiltration rates and fluid removed from the patient are used to determine the beginning blood volume of the patient.
FRESENIUS MEDICAL CARE DEUTSCHLAND, GMBH (Germany)
Inventor
Fuertinger, Doris H.
Kotanko, Peter
Rogg, Sabrina
Abstract
Systems, methods, and/or apparatuses may be operative to perform a dialysis process using RBV-based UF control. Embodiments may include methods operative to receive RBV target information comprising population-based dialysis data of real patient outcomes of a patient population associated with the patient, determine an RBV value of a patient during the dialysis process, and determine UF information to control a UF pump of the dialysis device to maintain the RBV value within a target RBV range defined by the RBV target information. Other embodiments are described.
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
In one aspect, a dialysis fluid cassette includes an inlet fluid line, multiple outlet fluid lines, and a valve including an actuation feature by which the valve can be rotated to fluidly communicate the inlet fluid line with a selected fluid line of the multiple outlet fluid lines.
A sorbent cartridge device and a dialysis system comprising a dialysate generation machine dialysate generation machine, a pump adapted to move fluid through the dialysate generation machine, and a sorbent cartridge are described. The sorbent cartridge device fluidically connected to the dialysate generation machine. The sorbent cartridge device includes a housing defining a housing interior, a fluid coupling attached to the housing and configured to fluidically connect at least one fluid line to the housing interior, a baffle attached to a bottom of the housing interior and fluidically connected to the housing interior, the baffle configured to direct fluid flow entering the baffle radially and circumferentially, and a fluid accumulation module attached at the top of the housing and fluidically connected to the housing interior, the fluid accumulation module configured to direct fluid flow entering the fluid accumulation module from a bottom surface of the fluid accumulation module towards a center port of the module.
A method and system for determining a patient's risk of developing an infection is disclosed. In one embodiment, the system and method includes extracting patient data from one or more databases corresponding to a pool of patients receiving treatment; using one or more predictive models with the extracted patient data to generate, for each of the patients in the pool of patients, a respective patient risk score for developing an infection within a selected time period; generating a report including at least a portion of the identified subset of the pool of patients and their respective patient risk scores; and transmitting the report to one or more health care facilities, the one or more health care facilities further identifying one or more patients from the portion of the identified subset of the pool of patients for interventional treatment, consultation, training, or combinations thereof.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
80.
DIALYSATE BAG HEATER TRAY FOR PERITONEAL DIALYSIS SYSTEMS
In one aspect, a peritoneal dialysis system (100) includes a tray (116) for supporting a bag (124) that can receive dialysate from a source (122) of dialysate, multiple force sensors (218) disposed adjacent a portion (202) of the tray (116) that is in contact with the bag (124) when the bag (124) is supported by the tray (116), and one or more processors configured to receive data from the multiple force sensors (218) and to determine, based on the data, an amount of dialysate contained in the bag (124).
A61M 5/44 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests having means for cooling or heating the devices or media
81.
BLOOD TREATMENT MACHINE WITH BLOOD PRESSURE MEASUREMENT NOTIFICATION
A system for blood treatment that includes a blood treatment machine. The blood treatment machine includes a receiver, a user interface configured to display information related to the blood pressure data received by the receiver, and a controller. The controller is configured to generate a notification to notify a user of an upcoming blood pressure measurement before the blood pressure measurement occurs. The blood treatment machine also includes a blood pressure monitoring device connected to the blood treatment machine. The blood pressure monitoring device is configured to send signals containing blood pressure information to the receiver of the blood treatment machine.
The disclosure relates to a dialysis machine that comprises a dialyzer, a fluid source, a first line connected to the fluid source, and a container containing bicarbonate. The container connects to the first line and the fluid flows from the fluid source, through the first line, to the container. The dialysis machine further includes a second line connected to the container, a flow rate sensor connected to at least one of the lines, a pressure sensor configured for detecting fluid pressure of the container, a display, and a data processing apparatus. The data processing apparatus is configured to receive signals from the flow rate sensor and the pressure sensor. The data processing apparatus is configured to calculate a size of the container based on the received signals.
A sensor assembly measures characteristics of a fluid entering or exiting a patient via a catheter. The sensor assembly includes a flow tube that accepts the fluid at a first end thereof expels the fluid at a second end thereof, a plurality of sensors disposed about the flow tube, the sensors including at least one temperature sensor that measures temperature of the fluid and at least one pressure sensor that measures pressure of the fluid, and a connector that connects the sensor assembly to the catheter. The sensors may also include a clarity sensor, a conductivity sensor, a flow sensor, and/or an air detector. The sensor assembly may also include a wireless communication device that provides wireless communication. The sensor assembly may communicate with a dialysis machine via a network. The dialysis machine may be a peritoneal dialysis machine.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
84.
AUTOMATIC PRIMING AND SCHEDULING FOR DIALYSIS SYSTEMS
A method including automatically performing at least one integrity test on a dialysis machine after powering on the dialysis machine, wherein the at least one integrity test is selected from the group consisting of a battery test, a dialysate conductivity test, and a dialysate temperature test. The method also includes presenting, on a display of the dialysis machine, a first set of instructions for priming the dialysis machine after completing the at least one integrity test.
An intelligent support assembly, for example, a mobile support assembly (e.g., cart) for a dialysis machine (e.g., a peritoneal dialysis cycler), and methods for performing dialysis treatment using such an assembly. The intelligent support assembly may be configured to determine one or more properties relating to a dialysis treatment being performed on a patient using the dialysis machine, and to control one or more actions that affect the dialysis treatment based at least in part on the determined one or more properties. The cart may be configured to receive information corresponding to the one or more properties from, and transmit such information to, the dialysis machine, network access devices, sensor devices, and other devices. The controlled actions may include adjusting a height of dialysis solution or other items relative to a height of the patient, and moving the cart relative to the location of the patient.
A method and system for identifying an undocumented comorbidity condition in a patient. In one embodiment, the method includes extracting patient data from one or more databases corresponding to a pool of patients receiving treatment; using one or more predictive models with the extracted patient data to generate, for each of the patients in the pool of patients, a respective patient risk score for having an undocumented comorbidity condition; identifying a subset of the pool of patients having a respective patient risk score that is higher than a predetermined threshold value; and based on the identified subset of the pool of patients, identifying one or more patients for additional evaluation, additional review, or combinations thereof.
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
87.
FIBER-OPTIC CLOT DETECTOR WITH AN ULTRASONIC CLOT NEUTRALIZER
A method and system for detecting and neutralizing blood clots during dialysis (e.g., hemodialysis) is provided. A fiber-optic sensor is provided in a hemodialysis machine to detect vibration of blood cells, and the hemodialysis machine can be configured to prevent blood clotting by sounding an alarm, agitating the blood cells, infusing saline, raising temperature and/or infusing heparin.
Medical fluid tubing described herein is configured to be advantageously tolerant of kinking and/or crushing. That is, the tubing is configured such that even if the tubing is kinked or fully compressed at least some portion of the lumen defined by the tubing will remain open, and some fluid will continue to flow through the tubing. Such kink and compression tolerant medical tubing can be advantageously used in association with medical fluid pumping systems (e.g., peritoneal dialysis systems and the like). In some examples, the tubing described herein is used in conjunction with, or as a part of, a medical fluid cassette that interfaces with such medical fluid pumping systems.
A multi-purpose cap adapted to fit onto fluid ports of different sizes and configurations of medical devices used for purifying or concentrating biological samples, wherein the cap is adapted to press fit onto diverse fluid ports on dialyzers and other blood treatment devices.
A method and system for determining a functionality level of dialysis patients for assessing parameters and timing of care. In one embodiment, the method includes extracting patient data from one or databases corresponding to a pool of patients having end stage renal disease (ESRD); using a predictive model with the extracted patient data to generate, for each of the patients in the pool of patients, a respective patient functional status score; identifying a subset of the pool of patients having a respective patient functional status score that is lower than a predetermined threshold value and/or a patient functional status score that is trending downwards; and based on the identified subset of the pool of patients, providing one or more treatment plans, wherein the treatment plans include at least one of (a) commencing one of an interventional treatment plan, or (b) commencing palliative and/or hospice care, or (c) combinations thereof.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 20/00 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
A dialysis system includes a dialysis machine, a drain line configured to be connected to the dialysis machine to direct waste fluid from the dialysis machine to a drain, and a plug device configured to be inserted into and secured to an opening of the drain. The plug device is connectable to the drain line to allow the waste fluid to be directed from the dialysis machine, through the drain line, through the plug device, and into the drain.
A peritoneal dialysis (PD) fluid line set includes a fluid line configured to carry spent dialysate to a drain receptacle and a chemical testing device disposed along the fluid line. The chemical testing device is configured to detect a presence of a substance in the spent dialysate as the spent dialysate flows past the chemical testing device, and the chemical testing device is configured to provide a visual indicator of the presence of the substance in the spent dialysate.
A system and method for determining patient hospitalization risk and treating patients is disclosed. The system and method may include extracting patient data from one or databases corresponding to a pool of patients having end stage renal disease; using a predictive model with the extracted patient data to generate, for each of the patients, a respective expected probability for hospitalization within a predetermined time period; identifying a subset of patients having respective expected probabilities that are higher than other patients in the pool of patients; identifying, for each patient, at least one factor from the patient data that increased the expected probability of hospitalization; and based on the identified factors, determining and executing clinical interventions to lower the probability of hospitalization within the subset of the pool of patients.
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
94.
WETNESS DETECTION WITH BIOMETRIC SENSOR DEVICE FOR USE IN BLOOD TREATMENT
A device that allows for patient identification comprising a housing, a biometric sensor, coupled to the housing. the biometric sensor is configured to detect a biometric feature of a patient. The device further comprises a signal transmitter configured to transmit data related to the detected biometric feature to a medical treatment machine for carrying out a medical treatment on the patient. The patient identification device is configured to be secured to the patient during the dialysis treatment.
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
G16H 10/65 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records stored on portable record carriers, e.g. on smartcards, RFID tags or CD
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
A system includes a dialyzer having a blood side and a dialysate side, a first extracorporeal circuit including one or more first fluid connectors for connecting the blood side of the dialyzer to the vascular system of a kidney patient, a second extracorporeal circuit including one or more second fluid connectors for connecting the dialysate side of the dialyzer to the vascular system of a healthy animal, a first pump in fluid communication with at least one of the first and second extracorporeal circuits, and a driver mechanically coupled to the first pump, where the driver is configured to drive the first pump using energy from an energy source.
Closed-loop dialysis systems and methods of operating a closed-loop dialysis system are provided. One method involves determining, at the closed-loop dialysis system, an initial ultrafiltration rate and setting, by the closed-loop dialysis system, an ultrafiltration pump of a dialysis system to the determined ultrafiltation rate. The method also involves obtaining a regression set by repeating steps including measuring a total change in blood volume, setting, by the closed loop dialysis system, the ultrafiltration pump to a minimum pump rate for a rebound duration, and measuring a rebound change in blood volume. The method also involves updating, by the closed loop dialysis system, the ultrafiltration rate using the regression set and updating the regression set.
Closed-loop dialysis systems and methods of operating a closed-loop dialysis system are provided. One method involves determining, at the closed-loop dialysis system, an initial ultrafiltration rate and setting, by the closed-loop dialysis system, an ultrafiltration pump of a dialysis system to the determined ultrafiltration rate. The method also involves obtaining a regression set by repeating steps including measuring a total change in blood volume, setting, by the closed loop dialysis system, the ultrafiltration pump to a minimum pump rate for a rebound duration, and measuring a rebound change in blood volume. The method also involves updating, by the closed loop dialysis system, the ultrafiltration rate using the regression set and updating the regression set.
An article configured to warm and monitor a patient during a dialysis treatment, the article includes one or more heating elements. The article also includes one or more sensors configured to monitor a condition of the patient during the dialysis treatment. The article also includes a fabric portion configured to receive the one or more heating elements and the one or more sensors and position the one or more heating elements and the one or more sensors on the patient during treatment. The article also includes a transmitter configured to transmit information from the one or more sensors to a dialysis machine and an electrical connector configured to provide power to at least one of the one or more heating elements and the one or more sensors.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/02 - Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
A61B 5/022 - Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skin; Ophthaldynamometers
A drip chamber is provided that includes a hollow body and a nucleation column extending into the interior of the hollow body. The nucleation column can be formed with, or treated by a treatment to include, microfeatures or other surface properties that provide nucleation sites for the nucleation and amalgamation of microbubbles. The drip chamber can include a bubble catcher in the bottom of the hollow body and the nucleation column can extend from the bubble catcher into the interior of the hollow body. Methods of making such drip chambers are also provided.
Techniques and apparatuses for access recirculation of a patient during dialysis treatment are described. In one embodiment, for example, an apparatus may include at least one memory, and logic coupled to the at least one memory. The logic may be configured to determine a first hemoglobin concentration for a dialysis system, determine a change in an ultrafiltration rate, determine a second hemoglobin concentration modified due to the change in the ultrafiltration rate based on a dialysis system model of the dialysis system, and determine an access recirculation value for the dialysis system. Other embodiments are described.
patents
