Abrégé

Novel cyclic peptides, cyclic peptide conjugates and compositions containing them for treating neurological diseases in a subject include an Odorranalectin (OL) sequence or modified OL sequence as a scaffold and a biologically active peptide or protein and/or therapeutic agent conjugated thereto. Methods of treatment of neurological diseases are based on intranasal delivery of a cyclic peptide or cyclic peptide conjugate as described herein. Combinatorial libraries that include a plurality of cyclic peptides have also been developed and can be used to screen for a ligand(s) for a receptor of interest.

Classes IPC  ?

• C07K 5/12 - Peptides cycliques
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 31/4045 - Indole-alkylamines; Leurs amides, p.ex. sérotonine, mélatonine
• A61K 47/64 - Conjugués médicament-peptide, médicament-protéine ou médicament-acide polyaminé, c. à d. l’agent de modification étant un peptide, une protéine ou un acide polyaminé lié par covalence ou complexé à un agent thérapeutiquement actif
• A61K 47/65 - Séquences de liaison, liants ou bras-espaceurs peptidiques, p.ex. séquences de liaison peptidiques vulnérable aux protéases
• A61P 25/04 - Analgésiques centraux, p.ex. opioïdes
• A61P 25/06 - Agents antimigraineux
• A61P 25/16 - Antiparkinsoniens
• A61P 25/18 - Antipsychotiques, c. à. d. neuroleptiques; Médicaments pour le traitement de la manie ou de la schizophrénie
• A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p.ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
• A61P 25/36 - Médicaments pour le traitement des troubles du système nerveux des états d'abus ou de dépendance aux opiacés
• C07K 7/64 - Peptides cycliques ne comportant que des liaisons peptidiques normales

Abrégé

The instant invention relates to seaweed extract compositions, processes for isolation, isolated active agents, and methods of treating disease, disorders and conditions in a subject, including, reactive oxygen species (ROS)-mediated diseases and diseases mediated through the activation of the Nrf2-ARE (antioxidant response element) pathway, including proliferative diseases and disorders, Alzheimer's disease, stroke, and certain diseases and disorders of aging and associated with aging and exposure, by use of the extracts, compounds, and compositions thereof.

Classes IPC  ?

• A61K 36/05 - Chlorophycota ou chlorophyta (algues vertes), p.ex. Chlorella
• A23L 33/105 - Extraits de plantes, leurs doublons artificiels ou leurs dérivés
• A61K 8/34 - Alcools
• A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
• A61K 31/055 - Phénols le noyau aromatique étant substitué par un halogène
• A61K 31/085 - Ethers ou acétals ayant une liaison éther à un carbone cyclique d'un noyau aromatique
• A61K 31/352 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p.ex. fungichromine ayant des cycles à six chaînons avec un oxygène comme seul hétéro-atome d'un cycle condensés avec des carbocycles, p.ex. cannabinols, méthanthéline
• A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p.ex. agents antirhumatismaux; Médicaments anti-inflammatoires non stéroïdiens [AINS]

Abrégé

The disclosure relates to a plant that is tolerant or resistant to species of Ca. Liberibacter. Specifically exemplified are citrus and solanaceous plants. Provided by the disclosure is a modified citrus or solanaceous plant that is resistant or tolerant to Sec-dependent effectors secreted by bacteria. Also provided by the disclosure are methods of modifying a plant genome plant to provide tolerance or resistance to species of Ca. Liberibacter. Still further provided by the disclosure are methods conferring a population of plants with tolerance or resistance to species of Ca. Liberibacter and screening that population for the plants that are tolerant or resistant to species of Ca. Liberibacter.

Classes IPC  ?

• C12N 15/82 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules végétales

Abrégé

Disclosed are method and vectors for the application of POLQ in creating T-DNA free gene editing in plants. The method of simultaneous silencing of POLQ during CRISP/CAS9 gene editing increased the T-DNA free gene edited TO tobacco seedlings ratio. The method impacts the application of CRISPR gene editing technology in vegetatively propagated crops such as fruit trees by preventing the introduction of foreign DNA during gene editing.

Classes IPC  ?

• C12N 15/82 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules végétales
• C12N 5/04 - Cellules ou tissus végétaux
• C12N 9/22 - Ribonucléases
• C12N 15/11 - Fragments d'ADN ou d'ARN; Leurs formes modifiées
• C12Q 1/6895 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les plantes, les champignons ou les algues

Abrégé

A device for multiplexing a wireless charging (WLC) coil for near-field communication (NFC) is provided. The device includes: the WLC coil with a first end, a second end, and a first contact point located between the first end and the second end; a first terminal connected with the first end of the WLC coil; a second terminal connected with the second end of the WLC coil; and a third terminal connected with the first contact point of the WLC coil, where the first terminal of the WLC coil is configured to be a first WLC terminal; the third terminal of the WLC coil is configured to be a first NFC terminal; and the second terminal of the WLC coil is configured to be multiplexed as a second WLC terminal and a second NFC terminal.

Classes IPC  ?

• H02J 50/00 - Circuits ou systèmes pour l'alimentation ou la distribution sans fil d'énergie électrique
• H02J 50/12 - Circuits ou systèmes pour l'alimentation ou la distribution sans fil d'énergie électrique utilisant un couplage inductif du type couplage à résonance
• H04B 5/00 - Systèmes de transmission à induction directe, p.ex. du type à boucle inductive

Abrégé

Various examples are provided related to the application of a kernel neural network (KNN) to the analysis of high dimensional and ultrahigh dimensional data for, e.g., risk prediction. In one embodiment, a method includes training a KNN with a training set to produce a trained KNN model, determining a likelihood of a condition based at least in part upon an output indication of the trained KNN corresponding to one or more phenotypes, identifying treatment or prevention strategy for an individual based at least in part upon the likelihood of the condition. The KNN model includes a plurality of kernels as a plurality of layers to capture complexity between the data with disease phenotypes. The training set of data includes genetic information applied as inputs to the KNN and the phenotype(s), and the output indication is based upon analysis of data comprising genetic information from the individual by the trained KNN.

Classes IPC  ?

• G06N 3/08 - Méthodes d'apprentissage
• G06N 5/022 - Ingénierie de la connaissance; Acquisition de la connaissance

Abrégé

The disclosure provides methods of treating obesity, reducing weight, or preventing weight gain using a combination therapy of GDF15 polypeptide and a myostatin inhibitor (e.g., a myostatin propeptide).

Classes IPC  ?

• C07K 14/495 - Facteur de croissance transformant (TGF)
• A61P 3/04 - Anorexigènes; Médicaments de l'obésité
• C07K 14/47 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• C12N 15/86 - Vecteurs viraux

Abrégé

Embodiments of the present disclosure provide for coaxial nozzles, capsule fabrication systems comprising coaxial nozzles, and methods of capsule fabrication using capsule fabrication systems. In certain embodiments, coaxial nozzle configurations, capsule fabrication systems, and methods as described herein can be used for multi-layered capsule fabrication.

Classes IPC  ?

• A61J 3/07 - Dispositifs ou procédés spécialement conçus pour donner à des produits pharmaceutiques une forme physique déterminée ou une forme propre à leur administration la forme de capsules ou de petits conteneurs similaires à absorber par voie buccale
• A61K 9/48 - Préparations en capsules, p.ex. de gélatine, de chocolat
• B05B 1/30 - Buses, têtes de pulvérisation ou autres dispositifs de sortie, avec ou sans dispositifs auxiliaires tels que valves, moyens de chauffage agencés pour commander un débit, p.ex. à l'aide de conduits de section réglable

Abrégé

The present disclosure describes systems and methods for acquiring structural attributes of a building. One such method comprises acquiring, by one or more cameras of an unmanned aerial vehicle, infrared thermal and visible RGB aerial images of a building; identifying structural components of the building based on an infrared thermal aerial image, wherein a floor structure of the building is identified from a color change in the infrared thermal aerial image between the building and a foundation structure of the building; positioning a bounding box around the floor structure of the building present in the infrared thermal aerial image; and estimating a lowest floor elevation of the building by calculating a lowest floor elevation value based on an amount of image pixels representing a distance between a top of the bounding box and a top of the foundation structure of the building. Other methods and systems are also provided.

Classes IPC  ?

• G06V 20/10 - Scènes terrestres
• G06T 7/12 - Découpage basé sur les bords
• G06V 10/26 - Segmentation de formes dans le champ d’image; Découpage ou fusion d’éléments d’image visant à établir la région de motif, p.ex. techniques de regroupement; Détection d’occlusion

Abrégé

The subject matter described herein is directed to synergistic compositions comprising pyrethrum vapor and a second agent selected from the group consisting of an essential oil and a compound of Formula I. In other embodiments, topical synergistic compositions comprising pyrethrum and an essential oil are described. Additionally described are methods for repelling and controlling arthropods using the synergistic compositions. The subject matter described herein is directed to synergistic compositions comprising pyrethrum vapor and a second agent selected from the group consisting of an essential oil and a compound of Formula I. In other embodiments, topical synergistic compositions comprising pyrethrum and an essential oil are described. Additionally described are methods for repelling and controlling arthropods using the synergistic compositions.

Classes IPC  ?

• A01N 37/08 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant trois liaisons à des hétéro-atomes, avec au plus deux liaisons à un contenant des groupes carboxyliques, ou leurs thio-analogues, liés directement par l'atome de carbone à un cycle cycloaliphatique; Leurs dérivés
• A01N 25/04 - Dispersions ou gels
• A01N 65/06 - Coniferophyta [gymnospermes], p.ex. cyprès
• A01N 65/08 - Magnoliopsida [dicotylédones]
• A01N 65/10 - Apiaceae ou Umbelliferae [famille de la carotte], p.ex. persil, carvi, aneth, livèche, fenouil ou "snakebed" [Cnidium monnieri]
• A01N 65/28 - Myrtaceae [famille du myrte], p.ex. cajeputier ou clou de girofle
• A01N 65/36 - Rutaceae [famille de la rue], p.ex. citron vert, orange, citron, chêne-liège ou clavelier
• A01N 65/44 - Poaceae ou Gramineae [famille des céréales], p.ex. bambou, citronnelle ou verveine des Indes
• A01N 65/48 - Zingiberaceae [famille du gingembre], p.ex. gingembre ou grand galanga
• A01P 7/04 - Insecticides
• A01P 17/00 - Répulsifs des animaux nuisibles

Abrégé

The present disclosure presents systems and methods for building infrastructure and infection prevention data analysis. One such method comprises building contents of an electronic repository of performance metrics related to material pathogen propagation or reduction; assigning, via machine learning, a performance score or grade to a certain infrastructure building material based on the performance metrics associated with the building material; and predicting and outputting, via the machine learning, a risk associated with a building based on its infrastructure building materials, wherein the infrastructure building materials comprises the certain infrastructure building material.

Classes IPC  ?

• G06F 30/27 - Optimisation, vérification ou simulation de l’objet conçu utilisant l’apprentissage automatique, p.ex. l’intelligence artificielle, les réseaux neuronaux, les machines à support de vecteur [MSV] ou l’apprentissage d’un modèle
• G06F 16/951 - Indexation; Techniques d’exploration du Web
• G06F 30/13 - Conception architecturale, p.ex. conception architecturale assistée par ordinateur [CAAO] relative à la conception de bâtiments, de ponts, de paysages, d’usines ou de routes

Abrégé

Compositions and formulations comprising diphenhydramine and lactoferrin for preventing or treating infection by a SARS-CoV-related betacoronavirus are described. Methods of using the compositions and formulations are also described. The methods include administering to a patient at risk of being infected by a SARS-CoV-related betacoronavirus or suffering from SARS-CoV-related betacoronavirus-related illness a composition or formulation comprising diphenhydramine and lactoferrin.

Classes IPC  ?

• A61K 38/40 - Transferrines, p.ex. lactoferrines, ovotransferrines
• A61K 31/137 - Arylalkylamines, p.ex. amphétamine, épinéphrine, salbutamol, éphédrine
• A61K 31/138 - Aryloxyalkylamines, p.ex. propranolol, tamoxifène, phénoxybenzamine
• A61K 31/167 - Amides, p.ex. acides hydroxamiques ayant des cycles aromatiques, p.ex. colchicine, aténolol, progabide ayant l'atome d'azote d'un groupe carboxamide lié directement au cycle aromatique, p.ex. lidocaïne, paracétamol
• A61K 31/426 - 1,3-Thiazoles
• A61K 31/451 - Pipéridines non condensées, p.ex. pipérocaïne ayant un carbocycle lié directement à l'hétérocycle, p.ex glutéthimide, mépéridine, lopéramide, phencyclidine, piminodine
• A61K 31/485 - Dérivés du morphinane, p.ex. morphine, codéine
• A61K 31/625 - Acide salicylique; Ses dérivés  ayant des substituants hétérocycliques, p.ex. 4-salicyloylmorpholine
• A61P 31/14 - Antiviraux pour le traitement des virus ARN

Abrégé

Provided are compositions and methods of treating cell proliferative disorders, especially cancer. Also provided are methods for assessing and monitoring cell proliferative processes and processes for amelioration of cell proliferative disorders, especially cancer.

Classes IPC  ?

• G01N 33/574 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour le cancer
• A61P 35/00 - Agents anticancéreux
• C07D 339/08 - Cycles à six chaînons
• C07D 495/04 - Systèmes condensés en ortho
• C07D 519/00 - Composés hétérocycliques contenant plusieurs systèmes de plusieurs hétérocycles déterminants condensés entre eux ou condensés avec un système carbocyclique commun non prévus dans les groupes ou

Abrégé

Provided herein are modified recombinant adeno-associated virus (rAAV) capsid proteins, such as modified rAAV1, rAAV5, and rAAV6 capsid proteins, rAAV particles comprising such capsid proteins, nucleic acid molecules encoding such capsid proteins, as well as compositions, kits and methods of use thereof.

Classes IPC  ?

• C07K 14/005 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant de virus
• C12N 15/86 - Vecteurs viraux
• C12N 15/861 - Vecteurs adénoviraux

Abrégé

Described are modified T cells overexpressing one or more glucose transporters. Pharmaceutical compositions containing the glucose transporter overexpressing T cells are also described. The glucose transporter overexpressing T cells and pharmaceutical compositions can be used in adoptive cell therapies.

Classes IPC  ?

• A61K 35/17 - Lymphocytes; Lymphocytes B; Lymphocytes T; Cellules tueuses naturelles; Lymphocytes activés par un interféron ou une cytokine
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61P 35/00 - Agents anticancéreux
• C07K 14/705 - Récepteurs; Antigènes de surface cellulaire; Déterminants de surface cellulaire
• C12N 5/0783 - Cellules T; Cellules NK; Progéniteurs de cellules T ou NK

Abrégé

The disclosure relates to macrocyclic peptides and pharmaceutical compositions thereof. The disclosure further relates to pharmaceutical compositions for modulating opioid receptor activity. The macrocyclic tetrapeptides provided herein are useful in treating diseases or disorders relating to the activity of one or more opioid receptors, such as neurological disorders.

Classes IPC  ?

• C07K 5/12 - Peptides cycliques
• A61P 25/04 - Analgésiques centraux, p.ex. opioïdes

Abrégé

The present disclosure provides for cementitious shielding compositions, methods of making the cementitious shielding composition, structures incorporating the concrete cementitious shielding composition, and the like, where the cementitious shielding composition includes elemental boron and/or a boron compound, for example as boron particles. The boron particles can be homogeneously distributed throughout the cementitious shielding composition and can have a largest least dimension of about 100 microns or less. The present disclosure, in some aspects, can reduce or eliminate problems associated with minerals found in concrete aggregates, because those materials are degraded over time by neutron radiation, which leads to disorganized lattice structures, manifested as damage by radiation-induced volumetric expansion (RIVE), and potentially further damage from alkali-silica reaction (ASR).

Classes IPC  ?

• G21F 1/04 - Bétons; Autres matériaux durcis hydrauliquement
• G21C 11/02 - Blindage biologique

Abrégé

A computing entity comprising an intelligent digital memory system and one or more processors communicatively coupled to the intelligent digital memory system is provided. The one or more processors configured to receive one or more storage parameters, determine a store procedure cue neuron search location from candidate ones of a plurality of cue neurons associated with a neural memory network (NoK), insert the input data as a data neuron into the NoK based on the store procedure cue neuron search location, temporally link the data neuron with a location of last insertion, and modify the NoK in a manner of accessibility based on a pattern of a search for the store procedure cue neuron search location.

Classes IPC  ?

• G06N 3/063 - Réalisation physique, c. à d. mise en œuvre matérielle de réseaux neuronaux, de neurones ou de parties de neurone utilisant des moyens électroniques
• G06N 3/0985 - Optimisation d’hyperparamètres; Meta-apprentissage; Apprendre à apprendre

Abrégé

Disclosed are methods and compositions for preventing, treating, and/or ameliorating one or more symptoms of inflammation in a mammal. In particular, viral vectors and medicaments containing them are disclosed, which are useful in the prophylaxis, therapy, or amelioration of symptoms of one or more inflammatory-mediated mammalian diseases, such as age-related macular degeneration (AMD), arthritis, Bechet's disease, Best macular dystrophy, corneal inflammation, diabetic retinopathy, drusen formation, dry AMD, dry eye, geographic atrophy, glaucomaocular neovascularization, Lupus erythematosus, macular degeneration, Mallatia Leventinese and Doyne honeycomb retinal dystrophy, nephritis, ocular hypertension, ocular inflammation, recurrent uveitis, Sorsby fundus dystrophy, vasculitis, vitreoretinopathy, wet AMD, or related disorders. In exemplary methods, administration of a pharmaceutical composition comprising a recombinant viral vector that delivers a secretable and cell-penetrating M013 protein or peptide to a subject in need thereof facilitated treatment of particular human disorders such as AMD, ocular neovascularization, uveitis, and related inflammatory ocular disease.

Classes IPC  ?

• C07K 14/005 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant de virus
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 38/16 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés
• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiques; Thérapie génique
• C12N 7/00 - Virus, p.ex. bactériophages; Compositions les contenant; Leur préparation ou purification
• C12N 15/86 - Vecteurs viraux

Abrégé

Disclosed are various embodiments of memristive devices comprising a number of nodes. Memristive fibers are used to form conductive and memristive paths in the devices. Each memristive fiber may couple one or more nodes to one or more other nodes. In one case, a memristive device includes a first node, a second node, and a memristive fiber. The memristive fiber includes a conductive core and a memristive shell surrounding at least a portion of the conductive core along at least a portion of the memristive fiber. The memristive fiber couples the first node to the second node through a portion of the memristive shell and at least a portion of the conductive core.

Classes IPC  ?

• G06N 3/063 - Réalisation physique, c. à d. mise en œuvre matérielle de réseaux neuronaux, de neurones ou de parties de neurone utilisant des moyens électroniques
• G06N 3/044 - Réseaux récurrents, p.ex. réseaux de Hopfield
• G06N 3/049 - Réseaux neuronaux temporels, p.ex. éléments à retard, neurones oscillants ou entrées impulsionnelles
• G06N 3/065 - Moyens analogiques
• G06N 3/08 - Méthodes d'apprentissage

Abrégé

Provided are embodiments of para-substituted 1,1-dialkyl-4-phenylpiperazin-1-ium iodides advantageous for modulating inflammation that have been synthesized and their electrophysiology activities for α9, α9α10, and α7 nAChRs compared. The para position contained alkyl or aryl amides, or heterocyclic isosteres for the amide, and the alkyl groups were varied at the ammonium piperazine nitrogen to see if compensatory changes in size at this position of the molecule impacted function. The compounds were characterized with two-electrode voltage-clamp measurements on Xenopus oocytes expressing nAChRs. General, the compounds were more potent for α9-containing receptors than for α7, and the majority were either full or strong partial agonists for α9-containing nAChR.

Classes IPC  ?

• C07D 213/56 - Amides
• C07D 263/32 - Composés hétérocycliques contenant des cycles oxazole-1, 3 ou oxazole-1, 3 hydrogéné non condensés avec d'autres cycles comportant deux ou trois liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec uniquement des atomes d'hydrogène, des radicaux hydrocarbonés ou des radicaux hydrocarbonés substitués, liés directement aux atomes de carbone du cycle
• C07D 295/116 - Composés hétérocycliques contenant des cycles polyméthylène imine d'au moins cinq chaînons, des cycles aza-3 bicyclo [3.2.2] nonane, piperazine, morpholine ou thiomorpholine, ne comportant que des atomes d'hydrogène liés directement aux atomes de car avec des radicaux hydrocarbonés substitués liés aux atomes d'azote du cycle substitués par des atomes d'oxygène ou de soufre liés par des liaisons doubles avec les atomes d'azote du cycle et les atomes d'oxygène ou de soufre liés par des liaisons doubles séparés par des carbocycles ou par des chaînes carbonées interrompues par des carbocycles avec les atomes d'oxygène ou de soufre liés par des liaisons doubles étant directement liés à un carbocycle

Abrégé

Provided herein are modified insecticidal proteins comprising an insecticidal protein, wherein the insecticidal protein has been modified to include at least one stink bug gut binding peptide.

Classes IPC  ?

• A01N 63/50 - Enzymes isolées; Protéines isolées
• A01P 7/04 - Insecticides
• C12N 15/82 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules végétales

Abrégé

h A method for using a trained machine learning model to predict risk of incident opioid use disorder (OUD) and/or of N an opioid overdose episode for a subject. The method comprises using at least one computer hardware processor to perform: accessing data associated with the subject, wherein the data comprises values for a plurality of predictors; generating input features for the trained machine learning model from the data; and providing the input features as input to the trained machine learning model to obtain an output indicative of the risk of OUD and/or of the opioid overdose episode for the subject, wherein the trained machine learning model comprises a first plurality of values for a respective first plurality of parameters, the first plurality of values used by the at least one computer hardware processor to obtain the output from the input features.

Classes IPC  ?

• G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
• G16H 20/10 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p.ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p.ex. pour s’assurer de l’administration correcte aux patients
• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p.ex. basé sur des systèmes experts médicaux

Abrégé

Described are CRISPR constructs and systems that can be used to generate brachytic Solanaceae plants rapidly and efficiently. Also described are methods of introducing a brachytic phenotype into a Solanaceae plant having one or more other desired traits using the described CRISPR constructs and systems to generate loss of function mutations in one or more brachytic loci in the plant.

Classes IPC  ?

• C12N 15/82 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules végétales
• C12N 9/22 - Ribonucléases

Abrégé

The disclosure relates to compounds of Formula (I), as well as compositions, methods, uses, and kits comprising the same. The compounds, compositions, methods, uses, and kits provided herein are useful in treating diseases or disorders including cancer, HIV, and angiogenesis-related disorders. The disclosure relates to compounds of Formula (I), as well as compositions, methods, uses, and kits comprising the same. The compounds, compositions, methods, uses, and kits provided herein are useful in treating diseases or disorders including cancer, HIV, and angiogenesis-related disorders.

Classes IPC  ?

• C07J 43/00 - Stéroïdes normaux ayant un hétérocycle contenant de l'azote non condensé ou condensé en spiro avec le squelette du cyclopenta[a]hydrophénanthrène
• A61P 31/18 - Antiviraux pour le traitement des virus ARN du HIV

Abrégé

Various embodiments of the present disclosure provide a framework for obfuscation of a printed circuit board (PCB). In one example, an embodiment provides for generating a plurality of connections interconnecting a plurality of components of the PCB using additive manufacturing, permuting, using a micro electro-mechanical systems (MEMS) device, a first set of connections interconnecting a first component with a second component in the PCB, integrating the MEMS device into the PCB such that the MEMS device covers a second set of connections from an x-ray probe, probing the PCB using x-ray simulation, and iteratively adjusting the permutation of the first set of connections and the integration of the MEMS device using a result of the x-ray simulation to reduce the detectability of the first and second connections based on the result of the x-ray simulation.

Classes IPC  ?

• H05K 3/00 - Appareils ou procédés pour la fabrication de circuits imprimés

Abrégé

Described herein are compositions and methods for waste-to-energy ash in engineered aggregate in road construction.

Classes IPC  ?

• E01C 3/00 - Fondations pour revêtements
• C04B 18/04 - Déchets; Résidus
• C04B 20/02 - Traitement
• C04B 26/26 - Matières bitumineuses, p.ex. goudron, brai
• C04B 28/04 - Ciments Portland
• C08L 95/00 - Compositions contenant des matières bitumeuses, p.ex. asphalte, goudron ou brai

Abrégé

Embodiments of the present disclosure provide for systems for removing contaminants from a leachate, methods of removing contaminants from a leachate, and the like.

Classes IPC  ?

• B01D 61/02 - Osmose inverse; Hyperfiltration
• B01D 61/06 - Récupération d'énergie
• B01D 61/08 - Appareils à cet effet
• C02F 1/44 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par dialyse, osmose ou osmose inverse
• C05C 3/00 - Engrais contenant d'autres sels d'ammonium ou l'ammoniac lui-même, p.ex. ammoniac liquide

Abrégé

Disclosed herein are devices and methods for protecting reconstructed nipples, typically post-surgery. The nipple protector may include a circular base portion and an annular ridge concentrically disposed to define a central aperture. The nipple protector In may further include an adhesive layer disposed on a bottom surface of the base portion for adhering the nipple protector to an area surrounding the reconstructed nipple. The nipple protector is fashioned to allow for direct access to the new nipple, which facilitates application of antibiotic ointments. The nipple protector softly adheres to the skin to provide flexible, adherent, comfortable, and water tolerant usage.

Classes IPC  ?

• A61F 13/14 - Bandages ou pansements; Garnitures absorbantes spécialement conçus pour la cage thoracique ou l'abdomen

Abrégé

The present disclosure provides for compositions, slow-release fertilizer composition, methods of making these compositions, and the like. The present disclosure can be advantageous in some instances since it can achieve multiple goals, where in one aspect, the 5 modified lignin is used to prepare materials with strong adsorption capacity to the heavy metals, and then the material is used to coat fertilizer to prepare controlled-release fertilizer. The application of embodiments of the coated fertilizer in soil not only control the release of nutrients and improve the fertilizer use efficiency, but also effectively adsorb heavy metals in soil and repair the polluted soil.

Classes IPC  ?

• C05G 5/30 - Engrais caractérisés par leur forme en couches ou enrobés, p.ex. enrobages anti-poussière
• C05C 9/00 - Engrais contenant de l'urée ou ses composés

Abrégé

Disclosed herein is a method for treating cancer in a subject that involves administering to the subject a therapeutically effective amount of a composition comprising a polypeptide that comprises an amino acid sequence corresponding to at the C-terminal SUMO-interacting motif (SIM2) of a DAXX protein. The disclosed polypeptide is not a functional DAXX protein but competes with endogenous DAXX for binding to SUMO.

Classes IPC  ?

• A61K 38/04 - Peptides ayant jusqu'à 20 amino-acides dans une séquence entièrement déterminée; Leurs dérivés
• A61K 47/10 - Alcools; Phénols; Leurs sels, p.ex. glycérol; Polyéthylène glycols [PEG]; Poloxamères; Alkyléthers de PEG/POE
• A61K 47/36 - Polysaccharides; Leurs dérivés, p.ex. gommes, amidon, alginate, dextrine, acide hyaluronique, chitosane, inuline, agar-agar ou pectine
• A61P 35/00 - Agents anticancéreux

Abrégé

The present disclosure provide for methods of reforming a hydrocarbon such as methane. In an aspect, when the method is driven via renewable energy (e.g., use of solar energy, wind energy, or other renewable energy) and coupled with zero-energy input product gas separation, this enables the capture of pure CO2 (i.e., carbon sequestration) and carbon-neutral utilization of methane can be achieved. As a result, the present disclosure can provide for a method to reform methane with zero-energy input product gas separation.

Classes IPC  ?

• C01B 32/50 - Anhydride carbonique
• B01J 19/24 - Réacteurs fixes sans élément interne mobile
• B01J 19/32 - Eléments de remplissage en forme de grille ou d'éléments composés de plusieurs pièces pour constituer une unité ou un module dans l'appareil de transfert de chaleur ou de matière
• C01B 5/00 - Eau
• C01F 17/32 - Composés contenant des métaux de terres rares et au moins un élément autre qu’un métal des terres rares, l'oxygène ou l'hydrogène, p.ex. La4S3Br6 le seul anion étant oxyde ou hydroxyde, p.ex. NaCeO2 ou MgxCayEuO

Abrégé

Provided herein are various metallopolymers and methods of making the same.

Classes IPC  ?

• C08G 79/00 - Composés macromoléculaires obtenus par des réactions créant dans la chaîne principale de la macromolécule une liaison contenant des atomes autres que le silicium, le soufre, l'azote, l'oxygène et le carbone, avec ou sans ces derniers éléments

Abrégé

Aspects of the disclosure relate to methods and compositions (e.g., kits) for detecting certain repeat-associated non-ATG (RAN) proteins in a subject (e.g., a subject having or suspected of having a disease associated with a CAG and/or CTG repeat expansion). In some embodiments, methods described by the disclosure comprise detecting one or more RAN proteins in a biological sample obtained from a subject by an immunoassay using one or more antibodies that target homopolymeric repeat regions of RAN proteins. In some embodiments, the disclosure relates to kits comprising one or more antibodies that target homopolymeric repeat regions of RAN proteins, and an immunoassay plate and/or reagents. In some embodiments, the disclosure provides methods of producing anti-RAN protein antibodies.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

Provided herein are methods for improving various traits in plants, such as in Vanilla sp. plants, by genetically-modifying the genome of plants, introducing heterologous sequences into the plants, or breeding plants with selected alleles. Such traits that can be improved by the methods and compositions of the present invention include an increase in levels of vanillin or one or more precursors thereof, reducing dehiscence, reducing the size of a rostellum or eliminating its presence, and increasing fungal resistance. Also disclosed herein are genetically-modified plants, extract from such plants or plant parts thereof, and methods of producing such plants or progeny thereof.

Classes IPC  ?

• C12N 15/82 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules végétales
• C07K 14/415 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant de végétaux
• C12N 9/50 - Protéinases
• C12N 9/88 - Lyases (4.)

Abrégé

Various examples are related to prediction of neutronics parameters using deep learning. In one embodiment, a method includes generating a training data set based upon one or more principled approaches that provide a gradient of values; generating a neural network using structured or unstructured sampling of a hyperparameter space augmented by probabilistic machine learning; training the generated neural network based on the training data set to produce one or more neutronics parameters; and generating at least one neutronics parameter utilizing the trained neural network.

Classes IPC  ?

• G06N 3/0985 - Optimisation d’hyperparamètres; Meta-apprentissage; Apprendre à apprendre
• G06N 3/047 - Réseaux probabilistes ou stochastiques

Abrégé

Autoregulatory systems that have been implemented to control the expression and activity of Cast 3d, including the activity of Cast 3d in vivo, thereby reducing collateral damage in cells at off-target sites (e.g., non-target messenger RNA transcripts. The autoregulatory system is in the form of a nucleic acid molecule comprising a zinc finger binding site, a promoter, and a nucleotide sequence encoding a Cast 3d fusion protein, and a transcriptional repressor domain, and wherein the Cast 3d fusion protein binds to the zinc finger binding site and represses transcription of the nucleotide sequence encoding the Cast 3d fusion protein.

Classes IPC  ?

• C12N 15/90 - Introduction stable d'ADN étranger dans le chromosome
• C12N 15/86 - Vecteurs viraux
• C12N 15/11 - Fragments d'ADN ou d'ARN; Leurs formes modifiées
• C12N 9/22 - Ribonucléases

Abrégé

Provided for herein are polynucleotides, including codon-optimized polynucleotides, encoding genes for use in, for example, virally-mediated gene therapy for Friedreich's ataxia. Some embodiments related to viral vector constructs for use in such gene therapy. Also provided are dosing regimens and therapeutic combinations or systems for use in modulating immune responses to such viral vectors.

Classes IPC  ?

• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiques; Thérapie génique
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p.ex. composés antiphlogistiques et pour le cœur 
• A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
• C07K 14/47 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• C12N 15/86 - Vecteurs viraux

Abrégé

An exemplary focused tomography system and method involve obtaining a computed tomography scan image from a computed tomography scanner, wherein the computed tomography scan is an image of a subject that received a first radiation dosage level when a path of a radiation beam of the computed tomography scanner intersects a region of interest of the subject and that received a second radiation dosage level when the path of the radiation beam did not intersect the region of interest of the subject; computing an additive correction factor based on a radiation dosage factor that is applied to the areas outside the region of interest during computed tomography scanning; and applying the additive correction factor to the computed tomography scan image that improves a quality of the computed tomography scan image that corresponds to areas of the subject that received the second radiation dosage level.

Classes IPC  ?

• A61B 6/00 - Appareils pour diagnostic par radiations, p.ex. combinés avec un équipement de thérapie par radiations
• A61B 6/03 - Tomographes assistés par ordinateur
• A61B 6/06 - Diaphragmes

Abrégé

According to at least one aspect, a series of images of a scene are obtained, such as by a head mounted display. The scene includes a medical device and a tracking device, and the series of images including at least the tracking device. Relative pose information indicative of a relative spatial relationship between the tracking device and the medical device is accessed, the 3D representation of the patient is registered with the medical device using the series of images of the scene and the relative pose information, and a mixed reality visualization of the 3D representation of the patient and the medical device generating, based on results of the registering. The mixed reality visualization can further include a visual indication indicative of an alignment of the patient with the 3D representation.

Classes IPC  ?

• G06T 19/20 - Transformation de modèles ou d'images tridimensionnels [3D] pour infographie Édition d'images tridimensionnelles [3D], p.ex. modification de formes ou de couleurs, alignement d'objets ou positionnements de parties
• G06T 7/30 - Détermination des paramètres de transformation pour l'alignement des images, c. à d. recalage des images
• G06T 7/70 - Détermination de la position ou de l'orientation des objets ou des caméras
• A61N 5/10 - Radiothérapie; Traitement aux rayons gamma; Traitement par irradiation de particules
• G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local

Abrégé

Systems and methods for remote human motor training. The method comprises generating visual guidance data based on first motion data received from a first client computing device, transmitting the visual guidance data to a second client computing device, receiving second motion data from the second client computing device, generating haptic guidance data based on a comparison of the second motion data with the first motion data, and transmitting the haptic guidance data to the second client computing device.

Classes IPC  ?

• G09B 5/02 - Matériel à but éducatif à commande électrique avec présentation visuelle du sujet à étudier, p.ex. en utilisant une bande filmée
• G06F 3/01 - Dispositions d'entrée ou dispositions d'entrée et de sortie combinées pour l'interaction entre l'utilisateur et le calculateur
• G06T 13/40 - Animation tridimensionnelle [3D] de personnages, p.ex. d’êtres humains, d’animaux ou d’êtres virtuels
• G06T 13/80 - Animation bidimensionnelle [2D], p.ex. utilisant des motifs graphiques programmables

Abrégé

Disclosed herein is a method for forming an anti-microbial layer on an apparatus. Also disclosed is a method for improving the anti-bacterial properties of a titanium device coated with titanium-nitride (TiN). Also disclosed is a medical apparatus comprising an anti-microbial layer prepared by the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Classes IPC  ?

• A61C 13/083 - Dents en porcelaine ou en céramique
• A61C 8/00 - Moyens destinés à être fixés à l'os de la mâchoire pour consolider les dents naturelles ou pour y assujettir des prothèses dentaires; Implants dentaires; Outils pour l'implantation

Abrégé

A system, apparatus, and method are provided herein for haptic-based force balance for anti-sway control of a payload. A haptic feedback system for crane operation is provided including: a controller; a first haptic device including a first haptic device tip; a second haptic device including a second haptic device tip; and a structural member connecting the first haptic device and the second haptic device, where the controller is configured to correlate the first haptic device tip to a first reference point on a payload and to correlate the second haptic device tip to a second reference point on the payload, and where anti-sway control of the payload is effected by movement of the structural member by an operator.

Classes IPC  ?

• B66C 13/40 - Utilisation de dispositifs pour transmettre des impulsions de commande; Utilisation de dispositifs de commande à distance
• G06F 3/01 - Dispositions d'entrée ou dispositions d'entrée et de sortie combinées pour l'interaction entre l'utilisateur et le calculateur
• B66C 13/06 - Dispositifs auxiliaires pour commander les mouvements des charges suspendues ou pour empêcher le câble de prendre du mou pour limiter ou empêcher le balancement longitudinal ou transversal des charges
• B66C 13/46 - Indicateurs de position pour charges suspendues ou pour éléments de grues

Abrégé

The present disclosure describes various systems and apparatuses for a compact frequency reconfigurable array antenna and methods related thereto. An exemplary array antenna system comprises a substrate; an array of patch antennas positioned on the substrate; a plurality of PIN diodes placed on a top surface of the substrate, wherein individual PIN diodes are located in individual gaps between respective ones of the patch antennas; and a plurality of meander-line (ML) complementary split-ring resonator (CSRR) decouplers placed on a bottom surface of the substrate, wherein individual ML-CSRR decouplers are placed under individual patch antennas in a diagonal direction.

Classes IPC  ?

• H01Q 21/06 - Réseaux d'unités d'antennes, de même polarisation, excitées individuellement et espacées entre elles
• H01Q 9/04 - Antennes résonnantes
• H01Q 5/385 - Combinaison d’éléments alimentés et d’éléments passifs avec plusieurs éléments passifs

Abrégé

Provided herein is a method, apparatus, and system a motor-assisted stationary rehabilitation cycle employing a closed-loop control scheme. Methods may include: determining a desired set point rotational speed of a pair of pedals connected to a crankshaft; determining an upper bound and a lower bound about the desired set point rotational speed; determining a crankshaft rotational speed; increasing torque using a motor connected, at least indirectly, to the crankshaft in a first rotational direction, resisting rotation of the crankshaft in response to the rotational speed of the crankshaft approaching the upper bound; and increasing torque using the motor in a second rotational direction, opposite the first rotational direction in response to the rotational speed of the crankshaft approaching the lower bound.

Classes IPC  ?

• A63B 21/005 - Appareils de gymnastique pour développer ou fortifier les muscles ou les articulations du corps en surmontant des résistances, avec ou sans dispositifs de mesure utilisant des dispositifs résistants électromagnétiques ou électriques
• A63B 22/06 - Appareils d'exercice spécialement adaptés à l'entraînement du système cardio-vasculaire, pour exercer l'agilité ou la coordination des mouvements avec un mouvement de pédalier
• A63B 24/00 - Commandes électriques ou électroniques pour les appareils d'exercice des groupes
• A63B 71/06 - Dispositifs indicateurs ou de marque pour jeux ou joueurs

Abrégé

Various examples are provided related to predicting perfusion images from non-contrast scans. In one example, a method for predicting perfusion images includes generating perfusion maps of an organ of a subject from non-contrast computed tomography (NCCT) slices of the organ; processing the perfusion maps based upon weights determined by a Physicians-in-the-Loop (PILO) module; and generating synthetic computed tomography perfusion (CTP) maps from the processed perfusion maps, the synthetic CTP maps generated by deep learning-based multimodal image translation. In another example, a system includes at least one computing device that can generate prefusion maps of an organ from NCCT slices; process the perfusion maps based upon weights determined by a PILO module; and generate synthetic CTP maps from the processed perfusion maps using deep learning-based multimodal image translation. The CTP maps can be rendered for display to a user.

Classes IPC  ?

• A61B 6/00 - Appareils pour diagnostic par radiations, p.ex. combinés avec un équipement de thérapie par radiations
• A61B 6/03 - Tomographes assistés par ordinateur
• G06T 11/00 - Génération d'images bidimensionnelles [2D]

Abrégé

The present disclosure includes biocompatible, nanocomposite hydrogel compositions and vaccines, where the compositions and vaccines include a biocompatible hydrogel material, a plurality of immune stimulating cytokines, such as CXCL9, and a plurality of nano liposomes loaded with mRNA molecules corresponding to a target antigen, such as for a condition to be treated. This disclosure also includes methods of making the biocompatible, nanocomposite hydrogel compositions and vaccines as well as methods of using the vaccines of the present disclosure to treat and/or prevent a disease in a subject.

Classes IPC  ?

• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61P 35/00 - Agents anticancéreux

Abrégé

Disclosed is a method and composition for using plant extracellular vesicles (EVs) as vectors for delivering therapeutic molecules to the CNS. We demonstrated that plant EVs are more efficient vectors than delivery with other methods. These vectors can used to treat diseases in the CNS, such as cancer, injuries like TBI, degeneration such as Alzheimer's and aging and cognitive disorders such as PTSD, depression and anxiety. New data using hemp derived EVs to treat cancers in the brain and to impact precursor cells in the brain and isolation of EVs are included. In addition, disclosed is an improvement on the efficacy of intra-nasal delivery and oral delivery when using EVs.

Classes IPC  ?

• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 31/00 - Préparations médicinales contenant des ingrédients actifs organiques 
• A61P 35/00 - Agents anticancéreux
• A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p.ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
• A61K 36/185 - Magnoliopsida (dicotylédones)
• A61K 9/51 - Nanocapsules
• A61M 15/08 - Dispositifs d'inhalation placés dans le nez

Abrégé

In one aspect, the disclosure relates to methods for preparation of terpene and terpene-like molecules. In a further aspect, the disclosure relates to the products of the disclosed methods, i.e., terpene and terpene-like molecules prepared using the disclosed methods. Intermediates for the synthesis of a wide variety of terpenoids are γ-allyl Knoevenagel adducts or quasi γ-allyl Knoevenagel adducts are disclosed. In various aspects, methods of preparing terpenoids through these intermediates are disclosed. The methods can comprise α-alkylation of an allylic electrophile followed by ring-closure metathesis to a polycyclic terpenoid structure. In a further aspect, the disclosure pertains to terpenoid frameworks, and compounds prepared via disclosed oxidation and substitution reactions on the disclosed terpenoid frameworks. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Classes IPC  ?

• C07C 253/30 - Préparation de nitriles d'acides carboxyliques par des réactions n'impliquant pas la formation de groupes cyano
• C07B 37/02 - Addition
• C07C 255/31 - Nitriles d'acides carboxyliques ayant des groupes cyano liés à des atomes de carbone acycliques ayant des groupes cyano liés à des atomes de carbone acycliques d'un squelette carboné contenant des cycles autres que des cycles aromatiques à six chaînons
• C07C 255/47 - Nitriles d'acides carboxyliques ayant des groupes cyano liés à des atomes de carbone de cycles autres que des cycles aromatiques à six chaînons à des atomes de carbone de cycles faisant partie de systèmes cycliques condensés
• C07D 221/22 - Systèmes cycliques pontés
• C07D 307/94 - Composés hétérocycliques contenant des cycles à cinq chaînons comportant un atome d'oxygène comme unique hétéro-atome du cycle condensés en spiro avec des carbocycles ou avec des systèmes carbocycliques, p.ex. griséofulvines
• C07D 311/94 - Composés hétérocycliques contenant des cycles à six chaînons comportant un atome d'oxygène comme unique hétéro-atome du cycle, condensés avec d'autres cycles condensés en ortho ou en péri avec des carbocycles ou avec des systèmes carbocycliques condensés avec des cycles autres que des cycles à six chaînons ou avec des systèmes cycliques contenant de tels cycles
• C07D 317/72 - Composés hétérocycliques contenant des cycles à cinq chaînons comportant deux atomes d'oxygène comme uniques hétéro-atomes du cycle comportant les hétéro-atomes en positions 1, 3 condensés en spiro avec des carbocycles
• C07C 403/18 - Dérivés du cyclohexane ou d'un cyclohexène, comportant une chaîne latérale avec une partie non saturée d'au moins quatre atomes de carbone en ligne, ladite partie étant directement attachée aux cycles cyclohexane ou cyclohexène, p.ex. vitamine A, bêt ayant des chaînes latérales substituées par des atomes d'azote

Abrégé

The present disclosure relates to compositions and methods for the treatment of TECPR2-associated diseases or disorders. Several embodiments provided for herein relate to virally-mediated transfer of a gene to target cells to induce expression of an encoded polypeptide, protein or other product in order to ameliorate one or more symptoms of a TECPR2-associated disease or disorder in a subject. In several embodiments, the disclosed methods and compositions relate to recombinant adeno-associated virus particles encoding human TECPR2 in order to treat TECPR2-associated diseases or disorders, including spastic paraplegic type 49 (SPG49) and/or hereditary sensory and autonomic neuropathy 9 (HSAN9).

Classes IPC  ?

• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiques; Thérapie génique
• C12N 15/86 - Vecteurs viraux
• C07K 14/47 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères

Abrégé

The subject invention provides therapeutic compositions, and uses thereof for the treatment or amelioration of injury to small intestine mucosa. In preferred embodiments, the composition comprises one or more nutrients and/or electrolytes that acquire or retain considerable absorptive capacity.

Classes IPC  ?

• A61K 31/405 - Acides indole-alkanecarboxyliques; Leurs dérivés, p.ex. tryptophane, indométhacine
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 31/7004 - Monosaccharides ayant uniquement des atomes de carbone, d'hydrogène et d'oxygène 
• A61K 31/7016 - Disaccharides, p.ex. lactose, lactulose
• A61K 47/18 - Amines; Amides; Urées; Composés d’ammonium quaternaire; Acides aminés; Oligopeptides ayant jusqu’à cinq acides aminés
• A61P 1/12 - Antidiarrhéiques
• A61K 47/20 - Composés organiques, p.ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant du soufre, p.ex. sulfoxyde de diméthyle [DMSO], docusate, laurylsulfate de sodium ou acides aminosulfoniques
• A61K 31/197 - Acides carboxyliques, p.ex. acide valproïque ayant un groupe amino les groupes amino et carboxyle étant liés à la même chaîne carbone acyclique, p.ex. acide gamma-aminobutyrique (GABA), bêta-alanine, acide epsilon-aminocaproïque, acide pantothénique
• A61K 31/198 - Alpha-amino-acides, p.ex. alanine, acide édétique (EDTA)

Abrégé

The present disclosure provides systems and methods for predicting the occurrence of an outbreak of an infectious disease. One such method includes acquiring environmental risk factor data associated with a particular disease, wherein the environmental risk factor data corresponds to a particular geographic region; acquiring social risk factor data associated with the particular disease; applying a prediction algorithm to the environmental and social risk factor data to generate a disease risk model for generating at least a trigger prediction and a transmission prediction for a disease-causing pathogen at the particular geographic region; generating the trigger prediction by applying the disease risk model to a forecast of data for a first lead time for the particular geographic region; and/or generating the transmission prediction by applying the disease risk model to the transmission prediction for a second lead time for the particular geographic region. Other methods and systems are also provided.

Classes IPC  ?

• G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
• G16H 50/80 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la détection, le suivi ou la modélisation d’épidémies ou des pandémies, p.ex. de la grippe
• G16H 50/50 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la simulation ou la modélisation des troubles médicaux

Abrégé

Described herein are eye implants that can include a pressure-responsive material that can be capable of changing color in response to pressure exerted on it. Also described here are methods of implanting and using the eye implants described herein to monitor intraocular pressure in a subject. The pressure-responsive material can be used to diagnose and monitor human or animal subjects.

Classes IPC  ?

• A61B 3/16 - Appareils pour l'examen optique des yeux; Appareils pour l'examen clinique des yeux du type à mesure objective, c. à d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient pour mesurer la pression intraoculaire, p.ex. tonomètres
• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
• A61F 2/16 - Lentilles intraoculaires
• A61F 9/007 - Procédés ou dispositifs pour la chirurgie de l'œil

Abrégé

Disclosed herein are compositions comprising magnetoelectric composite materials and collagen, along with uses and kits thereof. Described herein is the use of DNA aptamer assemblies of varying DNA length, structure, and sequence to both bind to collagen and other proteins, to then act as a biocompatible, degradable, reversible, or permanent 3D crosslinkers between proteins, and to service as a biologically functional material when using the appropriate aptamer sequence. Therefore, disclosed herein are compositions comprising collagen fibers crosslinked with DNA aptamers. Also disclosed are devices and implants made from or coated with collagen fibers crosslinked with DNA aptamers. Also disclosed are methods of making collagen fibers. Also disclosed are kits for producing collagen fibers. Also disclosed herein are compositions DNA aptamers in a collagen fiber matrix that stabilizes the DNA aptamer.

Classes IPC  ?

• C12N 13/00 - Traitement de micro-organismes ou d'enzymes par énergie électrique ou ondulatoire, p.ex. par magnétisme, par des ondes sonores
• C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p.ex. lignées cellulaires; Tissus; Leur culture ou conservation; Milieux de culture à cet effet
• C12N 15/115 - Aptamères, c. à d. acides nucléiques liant spécifiquement une molécule cible avec une haute affinité sans s'y hybrider

Abrégé

Embodiments of the present disclosure provide for methods of making substrates having an (AR) antireflective layer, substrates having an antireflective layer, devices including a substrate having an antireflective layer, and the like. The AR layer can have a total specular reflection of less than 10% at a wavelength of about 400-800 nm, and a height of about 500-1000 nm.

Classes IPC  ?

• H01L 31/0216 - Revêtements
• H01L 31/18 - Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de ces dispositifs ou de leurs parties constitutives
• G02B 1/118 - Revêtements antiréfléchissants ayant des structures de surface de longueur d’onde sous-optique conçues pour améliorer la transmission, p.ex. structures du type œil de mite

Abrégé

In one aspect, the disclosure relates to open cell hydrogel networks, methods of making the same and baits formed from the same, methods of loading the same with attractant molecules and compositions, and methods of catching fish and/or other aquatic organisms using the same. The open cell hydrogel networks disclosed herein can be configured to have different properties based on the specific polymers used for synthesis as well as any initiators, catalysts, and/or crosslinkers, thus allowing the fabrication of suitable baits for a variety of target species. In some aspects, the open cell hydrogel networks can be used as a filter or drug delivery device.

Classes IPC  ?

• A01N 25/04 - Dispersions ou gels
• A01N 25/16 - Mousses
• A01N 25/10 - Composés macromoléculaires
• A01P 19/00 - Attractifs des animaux nuisibles

Abrégé

Various examples are provided related to machine learning for Parkinson's Disease diagnosis, systems, and methods. In one example, a method for identification of onset or presence of Parkinson's disease (PD) includes receiving a retinal image that has been acquired by an image acquisition system; processing the acquired retinal image using one or more trained machine learning models to classify one or more retinal features contained in the acquired retinal image; and predicting, by the processing circuitry, whether the retinal image is indicative of an onset or presence of PD in the human subject based on the classification. A machine learning system can perform trained machine learning. Machine learning models can trained on stored retinal images obtained from a group of subjects who have previously been diagnosed as having PD and a group of subjects who have not previously been diagnosed as having PD.

Classes IPC  ?

• G06T 7/00 - Analyse d'image
• G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p.ex. l’édition
• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p.ex. basé sur des systèmes experts médicaux

Abrégé

Disclosed herein are anti-CCL21 antibodies useful in treating autoimmune diseases, treating or preventing allograft transplant rejection, and treating metastatic cancer or preventing cancer metastasis in a subject.

Classes IPC  ?

• C07K 16/24 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des cytokines, des lymphokines ou des interférons
• A61P 1/00 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif

Abrégé

The invention provides methods of treatment of a progressive bone disease, such as osteoporosis, Paget's Disease, multiple myeloma, or hyperparathyroidism, comprising administration of an effective amount of a non-agonist PPARG modulator to a patient afflicted with the disease.

Classes IPC  ?

• A61K 31/404 - Indoles, p.ex. pindolol
• A61K 31/4045 - Indole-alkylamines; Leurs amides, p.ex. sérotonine, mélatonine
• C07D 209/08 - Indoles; Indoles hydrogénés avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés directement aux atomes de carbone de l'hétérocycle 
• A61K 31/41 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec plusieurs hétéro-atomes cycliques, l'un au moins étant l'azote, p.ex. tétrazole
• A61K 31/4245 - Oxadiazoles
• A61K 31/4439 - Pyridines non condensées; Leurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p.ex. oméprazole
• A61K 31/454 - Pipéridines non condensées, p.ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p.ex. pimozide, dompéridone
• A61K 31/4709 - Quinoléines non condensées contenant d'autres hétérocycles
• A61K 31/5377 - 1,4-Oxazines, p.ex. morpholine non condensées et contenant d'autres hétérocycles, p.ex. timolol
• C07D 209/18 - Radicaux substitués par des atomes de carbone comportant trois liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, p.ex. radicaux ester ou nitrile

Abrégé

A system, apparatus, and method are provided herein for remote control of a robotic device, and more particularly, to a haptic system for robot teleoperation. A system for robot teleoperation is provided including: an underwater robot vehicle; a subsea sensing module associated with the underwater robot vehicle; a workplace module; and a user interface, where the subsea sensing module senses an environment of the underwater robot vehicle and provides sensor data to the workplace module, where the workplace module reproduces the environment and instructs the user interface to provide sensory augmentation associated with the environment to an operator. The system of an example embodiment further includes a robot control module, where the user interface receives input from the operator and the robot control module controls the underwater robot vehicle according to the input.

Classes IPC  ?

• G05D 1/00 - Commande de la position, du cap, de l'altitude ou de l'attitude des véhicules terrestres, aquatiques, aériens ou spatiaux, p.ex. pilote automatique
• B63G 8/00 - Navires submersibles, p.ex. sous-marins
• B63C 11/52 - Outillage spécialement adapté au travail sous l'eau, non prévu ailleurs

Abrégé

A laminated ScxAl1-xN BAW resonator with complementary-switchable operation in thickness extensional modes (TEl and TEN). The resonator comprises ferroelectric ScxAl1-xN layers alternatively stacked with metal electrodes, enabling independent polarization switching of each piezoelectric layer. Opting for unanimous or alternative poling of the ScxAl1-xN layers, the resonator can be switched to operate in two complementary states with either TEl or TEN active resonance modes of similarly large kt2.

Classes IPC  ?

• H03H 9/02 - Réseaux comprenant des éléments électromécaniques ou électro-acoustiques; Résonateurs électromécaniques - Détails

Abrégé

The instant invention describes macrocyclic compounds having antiproliferation activity, and methods of treating disorders such as cancer, tumors and cell proliferation related disorders.

Classes IPC  ?

• C07D 498/04 - Systèmes condensés en ortho

Abrégé

Disclosed herein is a multifunctional probe that may be inserted into tissue (e.g. brain tissue) that includes an optical waveguide, a microfluidic channel and a plurality of carbon nanofiber electrodes. In another embodiment, the probe includes a shank onto which carbon nanofiber electrodes are disposed. Also disclosed are methods of making disclosed probes.

Classes IPC  ?

• A61M 37/00 - Autres appareils pour introduire des agents dans le corps; Percutanisation, c. à d. introduction de médicaments dans le corps par diffusion à travers la peau
• A61N 1/05 - Electrodes à implanter ou à introduire dans le corps, p.ex. électrode cardiaque
• A61N 5/06 - Thérapie par radiations utilisant un rayonnement lumineux
• A61N 1/08 - Aménagements ou circuits de surveillance, de protection, de commande ou d'indication

Abrégé

Provided herein is a method of improving sensitivity of a tumor to a host immune response, the method comprising administering to a subject in need thereof a Type I interferon and an immune checkpoint inhibitor, thereby increasing sensitivity of the tumor to a host immune response.

Classes IPC  ?

• A61K 38/21 - Interférons
• A61K 39/395 - Anticorps; Immunoglobulines; Immunsérum, p.ex. sérum antilymphocitaire
• A61P 35/00 - Agents anticancéreux

Abrégé

The present disclosure presents improved combustion turbine engine systems and related methods. One such system includes a turbine system comprising a high pressure compressor, a high pressure turbine, a combustor, and a recuperator. The system further includes a turbocharger system comprising a low pressure compressor and a low pressure turbine; an air cooler device that is configured to cool intake air output to the low pressure compressor; and a refrigeration system comprising a hot gas heat exchanger and a cold gas heat exchanger, wherein the refrigeration system receives combustion products from the turbine system and compressed air from the turbocharger system. The refrigeration system cools the combustion products and the compressed air to generate a cooled combustion product mixture that is provided to the turbine system, and the refrigeration system further generates steam that is provided to the turbine system. Other systems and methods are also presented.

Classes IPC  ?

• F02C 7/143 - Refroidissement des ensembles fonctionnels des fluides dans l'ensemble fonctionnel du fluide de travail avant ou entre les étages du compresseur
• F02C 6/12 - Turbocompresseurs de suralimentation, c. à d. ensembles fonctionnels destinés à augmenter la sortie de puissance mécanique des moteurs à piston à combustion interne en augmentant la pression de suralimentation
• F02C 3/30 - Addition d'eau, de vapeur ou d'autres fluides aux composants combustibles ou au fluide de travail avant l'échappement de la turbine

Abrégé

Low-dose IL-2 has been proposed as a therapy to rectify regulatory T cell (Treg) fitness in type 1 diabetes (T1D). Identification of a combinatorial approach permits lower IL-2 dosing and avoids off-target effects. Insulin-like growth factor-1 (IGF1) is a hormone that promotes immunoregulation. Disclosed are methods that synergizes IGF1 with IL-2 to expand Tregs. In vivo IL-2+IGF1 treatment expands murine Tregs to a greater extent than either agent alone. IGF1+IL-2 treatment permits gene transfer in primary human Treg without the requirement for conventional activation stimuli, observing that IGF1+IL-2 maintains Treg naivety.

Classes IPC  ?

• A61K 38/20 - Interleukines
• C12N 5/0783 - Cellules T; Cellules NK; Progéniteurs de cellules T ou NK
• A61K 38/30 - Facteurs de croissance analogues à l'insuline (Somatomédines), p.ex. IGF-1, IGF-2
• C07K 16/24 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des cytokines, des lymphokines ou des interférons
• A61K 35/17 - Lymphocytes; Lymphocytes B; Lymphocytes T; Cellules tueuses naturelles; Lymphocytes activés par un interféron ou une cytokine

Abrégé

Various embodiments provide a robust backdoor attack on machine learning (ML)-based detection systems that can be applied to demonstrate and identify vulnerabilities thereof. In various embodiments, an artificial intelligence (AI)-based Trojan attack is generated and implanted inside a ML model trained for classification and/or detection tasks, and the AI-based Trojan attack can be triggered by specific inputs to manipulate the expected outputs of the ML model. Analysis of the behavior of an ML model having the AI-based Trojan implanted (and/or triggered) then enables identification of vulnerabilities of the ML model and further enables the design of ML models with improved security. Various embodiments of the present disclosure provide a fast and cost-effective solution in achieving 100% attack success rate that significantly outperforms adversarial attacks on ML models, thereby improving applicability and depth in testing ML-based detection systems.

Classes IPC  ?

• H04L 9/40 - Protocoles réseaux de sécurité
• H04L 41/16 - Dispositions pour la maintenance, l’administration ou la gestion des réseaux de commutation de données, p.ex. des réseaux de commutation de paquets en utilisant l'apprentissage automatique ou l'intelligence artificielle

Abrégé

System, devices, and methods relating to breastfeeding assistance systems, nipple shields, supplemental nursing systems, and use thereof are described herein. Various embodiments provide a nipple shield to be placed on a breast and cover a nipple of a nursing woman. In various embodiments, the nipple shield comprises micro-structures configured to adhere to a breast. In various embodiments, the micro-structures comprise angled fibers. In various embodiments, the nipple shield comprises a Supplementary Nursing System (SNS) conduction system configured to fluidly connect an SNS to the nipple shield. In various embodiments, the SNS conduction system comprises a port and microtubes.

Classes IPC  ?

• A61J 13/00 - Articles de protection des bouts de seins
• A61J 11/00 - Tétines

Abrégé

The invention relates to kinase inhibitor compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for treating or preventing herpesvirus infection and/or herpesvirus-associated diseases and disorders.

Classes IPC  ?

• A61K 31/4965 - Pyrazines non condensées
• A61P 31/22 - Antiviraux pour le traitement des virus ADN des virus de l'herpès
• A61K 31/439 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle le cycle formant une partie d'un système cyclique ponté, p.ex. quinuclidine
• A61K 31/497 - Pyrazines non condensées contenant d'autres hétérocycles
• A61K 31/5377 - 1,4-Oxazines, p.ex. morpholine non condensées et contenant d'autres hétérocycles, p.ex. timolol
• A61K 31/5517 - 1,4-Benzodiazépines, p.ex. diazépam condensées avec des cycles à cinq chaînons ayant l'azote comme hétéro-atome d'un cycle, p.ex. imidazobenzodiazépines, triazolam
• A61K 31/505 - Pyrimidines; Pyrimidines hydrogénées, p.ex. triméthoprime
• A61K 31/4745 - Quinoléines; Isoquinoléines condensées en ortho ou en péri avec des systèmes hétérocycliques condensées avec des systèmes cycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. phénanthrolines
• A61K 31/5355 - Oxazines non condensées contenant d'autres hétérocycles
• A61K 31/4709 - Quinoléines non condensées contenant d'autres hétérocycles
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p.ex. composés antiphlogistiques et pour le cœur 
• A61K 31/36 - Composés contenant des groupes méthylènedioxyphényle, p.ex. sésamine

Abrégé

Compositions for treatment of cystinosis, products for administering eye drops, and products for storing contact lenses are provided. Compositions include solutions that can contain an effective amount of cysteamine to treat cystinosis, and an oil with a lower density than the solution. Also provided is a product including a bottle for containing a solution, the bottle being substantially free of O2. Also provided is a contact lens holder for storing one or more contact lenses in a solution, the holder including barrier layers reducing the amount of O2 entering the contact lens holder.

Classes IPC  ?

• A61K 31/145 - Amines, p.ex. amantadine ayant des atomes de soufre, p.ex. thiurames (N-C(S)-S-C(S)-N ou N-C(S)-S-S-C(S)-N); Sulfinylamines (-N=SO); Sulfonylamines (-N=SO2)
• A61K 47/42 - Protéines; Polypeptides; Leurs produits de dégradation; Leurs dérivés p.ex. albumine, gélatine ou zéine
• A45C 11/00 - Récipients pour articles non prévus dans les groupes
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61F 9/00 - Procédés ou dispositifs pour le traitement des yeux; Dispositifs pour mettre en place des verres de contact; Dispositifs pour corriger le strabisme; Appareils pour guider les aveugles; Dispositifs protecteurs pour les yeux, portés sur le corps ou dans la main
• A61K 47/22 - Composés hétérocycliques, p.ex. acide ascorbique, tocophérol ou pyrrolidones

Abrégé

The invention provides compositions comprising a ribonucleotide or ribonucleotides or a deoxyribonucleotide or deoxyribonucleotides encoding at least two cell fate determinants (CFD) selected from the group consisting of PBX2, ACTN2, POU2F1, HAND1, TRIM24, GATA4, PBX1, ZBTB39, HAND2, IKZF4, NROB2, NACA2, SMYD1, JUP, NEUROD1, CKMT2, TSHZ2, MITF, MYOCD, and PPARGC1B. The compositions are useful in the treatment of cardiac disorders and in reprogramming a mesenchymal stem cell (MSC) to an autologous induced cardiomyocyte (iCM).

Classes IPC  ?

• C12N 5/077 - Cellules mésenchymateuses, p.ex. cellules osseuses, cellules de cartilage, cellules stromales médulaires, cellules adipeuses ou cellules musculaires
• C12N 15/86 - Vecteurs viraux

Abrégé

Provided herein are methods of improving rAAV production in mammalian cells via the manipulation of a concentration of potassium chloride present in the media in which the mammalian cells are cultured and/or in which the rAAV particles are produced. The concentration of potassium chloride present in such media may be manipulated by, for example, supplementing a base medium with additional potassium chloride either before, at the same time as, or after the cells are contacted (e.g., infected) with one or more viral vectors (e.g., recombinant Herpes Simplex Virus (rHSV) vectors). Some embodiments of the present invention further contemplate supplementing the base medium with additional potassium chloride and sodium chloride in combination.

Classes IPC  ?

• C12N 15/86 - Vecteurs viraux

Abrégé

Provided herein are compositions and methods for packaging a recombinant adeno-associated virus (rAAV) particle comprising using inverted terminal repeats (ITRs) and rep genes of different serotypes and/or using chimeric rep genes.

Classes IPC  ?

• C12N 15/861 - Vecteurs adénoviraux

Abrégé

Various examples are provided related to self-assembled carbon nanotube (CNT) films. In one example, a method includes providing a CNT dispersion solution including an aqueous solution comprising a quantity of amphiphilic pendant polymer dispersant; and a plurality of carbon nanotubes in the aqueous solution, the pendant polymer dispersant enabling CNT self-assembly. The method further includes forming a self-assembled CNT film on a surface of a substrate using the CNT dispersion solution.

Classes IPC  ?

• C08K 3/04 - Carbone
• C08J 3/03 - Production de solutions, dispersions, latex ou gel par d'autres procédés que ceux utilisant les techniques de polymérisation en solution, en émulsion ou en suspension dans un milieux aqueux
• C08J 5/18 - Fabrication de bandes ou de feuilles

Abrégé

A system, apparatus, and method are provided herein for remote control of a robotic device, and more particularly, to a haptic system for robot teleoperation in confined spaces. A haptic feedback system for robot teleoperation is provided including: a robot; a robot control; and an upper-body haptic feedback garment including a first vibrating module array disposed across a front side of an upper body of an operator and a second vibrating module array disposed across a back side of the upper body of the operator, where the upper-body haptic feedback garment provides haptic feedback to the operator reflecting a position and orientation of the robot.

Classes IPC  ?

• B25J 13/00 - Commandes pour manipulateurs
• B25J 9/16 - Commandes à programme
• G06F 3/01 - Dispositions d'entrée ou dispositions d'entrée et de sortie combinées pour l'interaction entre l'utilisateur et le calculateur

Abrégé

Various embodiments of the present disclosure provide functional verification flow of obfuscated designs for circuits. In one example, an embodiment provides for applying an input sequence to an obfuscated design for an integrated circuit that is formatted in a hardware description language, applying the input sequence to an original design for the integrated circuit that is formatted in the hardware description language, and comparing respective outputs provided by the obfuscated design and the original design to determine functional correctness of the obfuscated design.

Classes IPC  ?

• G06F 30/33 - Vérification de la conception, p.ex. simulation fonctionnelle ou vérification du modèle
• G06F 30/327 - Synthèse logique; Synthèse de comportement, p.ex. logique de correspondance, langage de description de matériel [HDL] à liste d’interconnections [Netlist], langage de haut niveau à langage de transfert entre registres [RTL] ou liste d’interconnections [Netlist]
• G06F 30/392 - Conception de plans ou d’agencements, p.ex. partitionnement ou positionnement

Abrégé

Various embodiments of the present disclosure provide a multi-layered framework for security of integrated circuits. In one example, an embodiment provides for removing one or more routing tables in a Register Transfer Level (RTL) source code that models a design for an SoC via a hardware description language, comprising replacing the one or more routing tables in the RTL source code with respective programmable memory, transforming a state space of one or more embedded state machines in the RTL source code, transforming one or more portions of combinational logic in the RTL source code, and/or removing one or more portions of security-critical logic in the RTL source code, comprising replacing the one or more portions of security-critical logic in the RTL source code with respective lookup tables.

Classes IPC  ?

• G06F 21/14 - Protection des logiciels exécutables contre l’analyse de logiciel ou l'ingénierie inverse, p.ex. par masquage
• G06F 21/57 - Certification ou préservation de plates-formes informatiques fiables, p.ex. démarrages ou arrêts sécurisés, suivis de version, contrôles de logiciel système, mises à jour sécurisées ou évaluation de vulnérabilité

Abrégé

Various embodiments provide computer vision techniques for ensuring system- and component-level integrity via component characterization. Various embodiments may comprise computer vision systems that are configured to extract pin information from surface-mount device (“SMD”) contours. Accordingly, the disclosed embodiments may include a computer vision system configured to detect the extremities of each pin in a SMD contour image based on a combination of at least one of machine learning and one or more PCB image collection datasets.

Classes IPC  ?

• G06T 7/00 - Analyse d'image
• G06T 7/564 - Récupération de la profondeur ou de la forme à partir de plusieurs images à partir des contours
• G06T 7/11 - Découpage basé sur les zones

Abrégé

Various examples are provided related to electrical planarization of carbon nanotube thin films or networks. In one example, a method includes depositing one or more thin protective organic and/or inorganic layer across a nanotube film; disrupting electrical conductance of portions of the nanotube film by exposure of out-of-plane nanotubes to a planarization process that disrupts the electrical conductance through the one or more thin protective organic and/or inorganic layer; and removing the one or more thin protective organic and/or inorganic layer from the nanotube film.

Classes IPC  ?

• H10K 71/18 - Dépôt d'une matière active organique en utilisant des techniques d'impression non liquides, p. ex. l’impression par transfert thermique à partir d'une feuille donneuse
• B82Y 40/00 - Fabrication ou traitement des nanostructures
• H10K 71/60 - Formation de régions ou de couches conductrices, p. ex. d’électrodes

Abrégé

Embodiments of the disclosure include means of identifying and quantifying particular metabolite-based biomarkers for diagnosis and prognosis of prostate cancer in African American men, including at least Methionine, Homocysteine, Glutamic acid, Ornithine, and/or Inosine, and, in some cases, also N-Acetyl Aspartate, Glutamine, Sarcosine, Succinate, and/or Malate.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides
• G01N 33/574 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour le cancer
• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p.ex. basé sur des systèmes experts médicaux

Abrégé

Described are small molecule embodiments, ALS compounds, that bind with the (G4C2)exp RNA repeat transcription of the chromosome 9 open reading frame 72 involved in amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). These ALS compounds comprise a pyridocarbazole moiety having at least one substituent. Preferred ALS compounds comprise bridged dimers of the pyridocarbazole moiety in which the bridge between the two pyridocarbazole moieties is a polyoxyethylenyl group or an aminobispolyoxyethylenyl group.

Classes IPC  ?

• A61K 31/475 - Quinoléines; Isoquinoléines ayant un cycle indole, p.ex. yohimbine, réserpine, strychnine, vinblastine
• A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
• A61K 47/60 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique macromoléculaire, p.ex. une molécule oligomérique, polymérique ou dendrimérique obtenu par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p.ex. polyurées ou polyuréthanes le composé organique macromoléculaire étant un oligomère, un polymère ou un dendrimère de polyoxyalkylène, p.ex. PEG, PPG, PEO ou polyglycérol
• A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p.ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence

Abrégé

Disclosed are AAV viral-based vector compositions useful in delivering a variety of nucleic segments, including those encoding therapeutic polypetides to selected mammalian host cells for use in therapeutic autoimmune modalities, including, for example, the in vivo induction of immunological tolerance via a liver-directed AAV-based gene therapeutic regimen for treating and/or ameliorating autoimmune disorders such as multiple sclerosis.

Classes IPC  ?

• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiques; Thérapie génique
• C12N 15/86 - Vecteurs viraux
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps

Abrégé

Provided herein are microfluidic devices that can be configured to generate an electrophoretic flow that is in opposition to a fluid flow through a microcapillary of a microfluidic device provided herein for nucleic acid isolation. Also provided herein are systems comprising such. Also provided herein are methods that include adding an amount of a sample comprising nucleic acids to the inlet area of a microfluidic device as provided herein, generating a first fluid flow through a microcapillary of a microfluidic device provided herein; and applying a uniform electric field to the microfluidic device, where the uniform electric field generates an electrophoretic flow that is in opposition to the fluid flow. Methods as described herein can further comprise quantifying or otherwise characterizing isolated nucleic acids separated by devices, systems, and methods as described herein.

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes

Abrégé

Aspects of the disclosure relate to compositions and methods for delivering inhibitory nucleic acids to prokaryotic cells using extracellular vesicles (e.g., exosomes, microvesicles, etc.) derived from mammalian cells. The disclosure provides methods for regulating the expression of one or more genes in a prokaryotic cell. The disclosure further provides methods of treating diseases associated with prokaryotic gene dysregulation.

Classes IPC  ?

• A61K 9/127 - Liposomes
• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p.ex. oligonucléotides anti-sens
• C12N 15/88 - Introduction de matériel génétique étranger utilisant des procédés non prévus ailleurs, p.ex. co-transformation utilisant la micro-encapsulation, p.ex. utilisant des vésicules liposomiques
• C12N 5/09 - Cellules tumorales
• A61K 31/7105 - Acides ribonucléiques naturels, c. à d. contenant uniquement des riboses liés à l'adénine, la guanine, la cytosine ou l'uracile et ayant des liaisons 3'-5' phosphodiester 
• A61P 31/04 - Agents antibactériens

Abrégé

A system including a tissue bath; a portion of intestine positioned within the tissue bath, the portion of intestine having a first end and a second end; a pump coupled to the first end of the portion of the intestine and configured to pump a fluid through the portion of intestine; a light source positioned to illuminate the portion of intestine, a camera positioned to capture a stream of images showing movement of the portion of intestine; and a computing system coupled to the camera, the computing system including: a processor, and a memory storing instructions causing the processor to: receive the stream of images, identify a location along the portion of intestine in each image of the stream of images in real time, and measure an edge width at the location along the portion of intestine in each image of the stream of images in real time.

Classes IPC  ?

• G01N 33/50 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique
• A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p.ex. tremblement de la tête ou des mains ou mobilité d'un membre
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes

Abrégé

Disclosed herein is the use of DNA aptamer assemblies of varying DNA length, structure, and sequence to both bind to collagen and other ECM proteins, to then act as a biocompatible, degradable, reversible, or permanent 3D crosslinkers between proteins, and to service as a biologically functional material when using the appropriate aptamer sequence. Therefore, disclosed herein are compositions comprising collagen fibers and additional ECM components crosslinked with DNA aptamers. Also disclosed are devices and implants made from or coated with collagen fibers and additional ECM components crosslinked with DNA aptamers. Also disclosed are methods of making collagen fibers. Also disclosed are kits for producing collagen fibers.

Classes IPC  ?

• C07K 14/78 - Peptides du tissu connectif, p.ex. collagène, élastine, laminine, fibronectine, vitronectine, globuline insoluble à froid (CIG)
• C12N 15/115 - Aptamères, c. à d. acides nucléiques liant spécifiquement une molécule cible avec une haute affinité sans s'y hybrider

Abrégé

Autofluorescence is the inherent emission of light from cells or tissues that occurs when biological samples are exposed to different wavelengths of excitation light. Tissue autofluorescence is usually ascribed to biological components such as flavins, porphyrins, chlorophyll (in plants), collagen, elastin, red blood cells (RBCs), and lipofuscin. Tissue autofluorescence often presents a significant problem in microscopy, pathology, and surgical applications. Autofluorescence interferes and complicates signal detection in a variety of fluorescence microscopy methods. Tissue autofluorescence reduces the signal detection sensitivity, and in some cases may cause failure in the detection of fluorescent dye signals. Accordingly, there is a need for further improved methods to decrease the autofluorescence intensity from microscopy samples both in research and clinical venues. Described herein is a photobleaching device utilizing a light source tuned to the full spectrum of light to quench autofluorescence of a biological sample.

Classes IPC  ?

• G01N 21/64 - Fluorescence; Phosphorescence

Abrégé

Various embodiments of the present disclosure provide for redacting Network-on-Chip (NoC) functionality in a System-on-Chip (SoC). In one example, an embodiment provides for receiving a Register Transfer Level (RTL) source code that models a design for an SoC via a hardware description language, converting one or more routing tables related to the RTL source code with one or more configurable logic tables, replacing one or more connections related to the RTL source code with one or more programmable multiplexers, generating a transformed RTL source code for the SoC based on the one or more configurable logic tables and the one or more programmable multiplexers, and/or providing an attack-resistant obfuscated SoC based on the transformed RTL source code.

Classes IPC  ?

• G06F 30/327 - Synthèse logique; Synthèse de comportement, p.ex. logique de correspondance, langage de description de matériel [HDL] à liste d’interconnections [Netlist], langage de haut niveau à langage de transfert entre registres [RTL] ou liste d’interconnections [Netlist]
• G06F 30/3323 - Vérification de la conception, p.ex. simulation fonctionnelle ou vérification du modèle utilisant des méthodes formelles, p.ex. vérification de l’équivalence ou vérification des propriétés
• H03K 19/17728 - Blocs logiques reconfigurables, p.ex. tables de consultation

Abrégé

Provided herein are charge complementary peptides coupled to a cargo polypeptide (e.g., a uricase protein) (e.g., uricase) that are capable of self-assembling under stimulating conditions. The charge complementary peptides can be capable of forming supramolecular structures. Also provided herein are methods of using the charge complementary peptides provided herein (e.g., to treat gout).

Classes IPC  ?

• C12N 9/06 - Oxydoréductases (1.), p.ex. luciférase agissant sur des composés contenant de l'azote comme donneurs (1.4, 1.5, 1.7)
• A61P 19/06 - Agents antigoutte, p.ex. agents antihyperuricémiants ou uricosuriques

Abrégé

The present disclosure relates to compact waveguides. One example includes a primary bar, and an impedance-matched series of secondary bars with a number of turns, where turns provide at least one of: a turn that is perpendicular to an immediately preceding turn, and an increase in length of a subset of secondary bars for the turn.

Classes IPC  ?

• G01N 3/06 - Adaptations particulières des moyens d'indication ou d'enregistrement
• G01N 3/30 - Recherche des propriétés mécaniques des matériaux solides par application d'une contrainte mécanique en appliquant une force unique et brève

Abrégé

Various embodiments of the present disclosure provide a distributed ledger platform for electronic voting and/or polling. In one example, an embodiment provides for receiving a request to commit a transaction to a distributed ledger in the distributed ledger system. The transaction may include one or more encrypted votes, a cryptography authentication proof, and/or an input validation proof. Another embodiment provides for executing a smart contract to (i) authenticate a user identifier associated with the transaction based on the cryptography authentication proof and (ii) validate the one or more encrypted votes based on the input validation proof. In an instance in which the smart contract authenticates the user identifier and validates the one or more encrypted votes, a data block associated with the transaction is added to the distributed ledger.

Classes IPC  ?

• H04L 9/32 - Dispositions pour les communications secrètes ou protégées; Protocoles réseaux de sécurité comprenant des moyens pour vérifier l'identité ou l'autorisation d'un utilisateur du système
• G07C 13/00 - Appareils à voter
• G06F 16/27 - Réplication, distribution ou synchronisation de données entre bases de données ou dans un système de bases de données distribuées; Architectures de systèmes de bases de données distribuées à cet effet
• H04L 9/00 - Dispositions pour les communications secrètes ou protégées; Protocoles réseaux de sécurité

Abrégé

Embodiments of the present disclosure integrate magnetoelectric nanowire arrays within antenna assemblies to form ultra-compact antennas. An exemplary method comprises using a dielectrophoretic force to orient a magnetoelectric nanowire across an electrode gap separating a pair of electrodes; and transmitting or receiving electromagnetic waves through a magnetoelectric effect of the magnetoelectric nanowire. Other methods, apparatuses, and systems are also presented.

Classes IPC  ?

• H01Q 15/00 - Dispositifs pour la réflexion, la réfraction, la diffraction ou la polarisation des ondes rayonnées par une antenne, p.ex. dispositifs quasi optiques
• H01Q 1/36 - Forme structurale pour éléments rayonnants, p.ex. cône, spirale, parapluie
• H01Q 21/06 - Réseaux d'unités d'antennes, de même polarisation, excitées individuellement et espacées entre elles

Abrégé

Aspects of the disclosure relate to compositions and methods for treating certain (e.g., CD33-positive) cancers. In some aspects, the disclosure provides antibodies that specifically bind to CD33 protein variants that lack an IgV domain. In some aspects, the disclosure provides adaptable cell engagers (ACEs) and recombinant proteins (e.g., BiTEs) comprising an anti-CD33 antibody of the disclosure and an anti-CD3 antibody. In some embodiments, the disclosure provides methods of treating cancer by administering the antibodies, ACEs, or recombinant proteins (e.g., BiTEs) to a subject in need thereof.

Classes IPC  ?

• C07K 16/28 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p.ex. un fragment Fc
• A61P 35/02 - Agents anticancéreux spécifiques pour le traitement de la leucémie

Abrégé

The present disclosure provides systems and methods for removing artifacts from data signals. One such method comprises obtaining a data signal across a plurality of data channels, wherein the data signal has artifacts across one or more channels; obtaining a reference signal representing noise activity across a plurality of noise channels; analyzing the data signal with the reference signal to identify noise components that exist within both the data signal and the reference signal; scaling the noise components to project upon the data signal across the plurality of channels; and/or cleaning the data signal by subtracting the scaled noise components from the data signal across individual ones of the data channels. Other methods and systems are also provided.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
• A61B 5/369 - Modalités, c. à d. méthodes diagnostiques spécifiques Électroencéphalographie [EEG]
• A61B 5/389 - Modalités, c. à d. méthodes diagnostiques spécifiques Électromyographie [EMG]
• A61B 5/398 - Modalités, c. à d. méthodes diagnostiques spécifiques Électrorétinographie [ERG]
• A61B 5/291 - Détection, mesure ou enregistrement de signaux bioélectriques ou biomagnétiques du corps ou de parties de celui-ci Électrodes bioélectriques à cet effet spécialement adaptées à des utilisations particulières pour l’électroencéphalographie [EEG]
• A61B 5/31 - Circuits d’entrée à cet effet spécialement adaptés à des utilisations particulières pour l’électroencéphalographie [EEG]

Abrégé

The present disclosure provides for compositions including coated magnetic particles (e.g., coated magnetic nanoparticles), methods of using the coated magnetic particles such as imaging a subject (e.g., a mammal), tissue, organ, or the like, a cryopreservation composition including the coated magnetic particles, methods of use of the cryopreservation composition in biomaterials (e.g., tissue, organ, and the like), methods of making the composition and cryopreservation composition, and the like.

Classes IPC  ?

• A61K 49/18 - Préparations de contraste pour la résonance magnétique nucléaire (RMN); Préparations de contraste pour l'imagerie par résonance magnétique (IRM) caractérisées par un aspect physique particulier, p.ex. émulsions, microcapsules, liposomes
• A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiques; Mesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p.ex. formation d'images par résonance magnétique

Abrégé

The present disclosure provides for compositions including at least one type of water-soluble polymer having a molecular weight of about 10 kDa to 10,000 kDa, methods of making the water-soluble polymer, structures having the water-soluble polymer disposed thereof, and methods of use thereof. The present disclosure provides for branched and hyperbranched water-soluble polymers and methods of making branched and hyperbranched water-soluble polymers.

Classes IPC  ?

• C08F 120/56 - Acrylamide; Méthacrylamide
• C08L 33/26 - Homopolymères ou copolymères de l'acrylamide ou de la méthacrylamide

Abrégé

Provided herein are materials, methods of making materials, and methods of use, wherein the materials have switchable adhesive properties. Materials of the present disclosure can reversibly change coloration in conjunction with the changing adhesive state. The films, made from a porous polymer material, can be reversibly changed from a smooth state to a rough state, allowing for reversible and tunable gripping and/or adhesive properties.

Classes IPC  ?

• C09J 7/32 - Adhésifs sous forme de films ou de pellicules caractérisés par la composition de l’adhésif activés au contact de l’eau, p.ex. pour papier gommé
• C08J 9/26 - Mise en œuvre de substances macromoléculaires pour produire des matériaux ou objets poreux ou alvéolaires; Leur post-traitement par élimination d'une phase solide d'un objet ou d'une composition macromoléculaire, p.ex. par lessivage
• C09J 7/10 - Adhésifs sous forme de films ou de pellicules sans support
• C09J 5/08 - Emploi d'adhésifs sous forme de mousse

Abrégé

Mass spectrometry (MS) based systems and methods of implementing multi-stage MS/MS analysis for identification of experimental glycolipid samples. A processor communicatively coupled to a memory and a reference spectral database (1) implements a first stage analysis of glycan fragment data including determining, based on a matching reference glycan of a candidate reference glycolipid, a glycan structure of a glycan portion of the experimental glycolipid. The processor further (2) implements a second stage analysis of lipid/glycolipid fragment data including determining a lipid structure of a lipid portion of the experimental glycolipid by performing a spectral comparison of one or more MS/MS spectral values of a shifted experimental lipid fragment data with one or more MS/MS spectral values of matching reference lipid/glycolipid fragment data of the candidate reference glycolipid. A combination of the determined glycan structure and lipid structure gives the structure of each specific glycolipid in the experimental glycolipid sample.

Classes IPC  ?

• G01N 33/92 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des lipides, p.ex. le cholestérol
• H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules

Abrégé

The present disclosure relates to compositions comprising nitroreductase enzymes; plants, plant calluses, plant seeds, and vegetables incorporating genes expressing nitroreductase enzymes; methods for stably and operably incorporating genes expressing nitroreductase enzymes into plants and plant tissues; wherein the nitroreductase enzymes are capable of reducing nitro groups on phytotoxic and/or otherwise harmful compounds such as, for example, thaxtomins, wherein the thaxtomins are secreted by plant pathogenic bacteria and/or exogenously applied as an agricultural composition such as an herbicide, and wherein reducing the nitro groups renders the thaxtomins non-damaging or reduces the level of damage from the thaxtomins to the plants expressing the nitroreductase enzymes.

Classes IPC  ?

• C12N 15/82 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules végétales
• C12N 9/04 - Oxydoréductases (1.), p.ex. luciférase agissant sur des groupes CHOH comme donneurs, p.ex. oxydase de glucose, déshydrogénase lactique (1.1)