The present invention provides stable pre-fusion respiratory syncytial virus (RSV) FB proteins, nucleic acid molecules and vectors encoding such proteins, and compositions comprising said proteins, nucleic acid molecules and/or vectors, and uses thereof for the prevention and/or treatment of RSV infection.
A61K 31/436 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à six chaînons ayant l'oxygène comme hétéro-atome du cycle, p.ex. rapamycine
A61K 31/4985 - Pyrazines ou pipérazines condensées en ortho ou en péri avec des systèmes hétérocycliques
C07D 519/00 - Composés hétérocycliques contenant plusieurs systèmes de plusieurs hétérocycles déterminants condensés entre eux ou condensés avec un système carbocyclique commun non prévus dans les groupes ou
A phacoemulsification system, method and computer program product, the system comprising: a phacoemulsification probe having at its distal end a needle to be inserted into an eye, the probe comprising an ultrasonic transducer; an optical fiber transferring light from a source and having a distal end positioned in proximity to the tip of the needle for emitting light of predetermined frequency or pattern; a light sensor for detecting the light; and a processor, for repeatedly: receive from the sensor an indication of the detected light; determine whether the detected light complies with a condition indicating contact between the needle and a lens of the eye; subject to determining compliance with the condition and that the ultrasonic transducer being inactive, toggle the ultrasonic transducer ON; and subject to determining that the detected light does not comply with the condition and that the ultrasonic transducer being active, toggle the ultrasonic transducer OFF.
Provided herein are methods, constructs, and kits for positioning a first bone segment relative to a second bone segment within a subject's body, for example, in order to establish a reduced position of the first and second bone segments. The present disclosure provides, among other things, alternatives to traditional ligament reconstruction and tendon interposition (LRTI) and suture suspension arthroplasty procedures.
A61B 17/06 - Aiguilles; Supports ou empaquetages pour aiguilles ou matériaux de suture
A61B 17/04 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour refermer les plaies ou les maintenir fermées, p.ex. agrafes chirurgicales; Accessoires utilisés en liaison avec ces opérations pour la suture des plaies; Supports ou emballages pour aiguilles ou matériaux de suture
A61F 2/42 - Articulations pour les pieds, p.ex. pour les orteils
5.
CALIBRATION OF ELISA FOR CLINICAL ANTIBODY RESPONSE BY QUANTITATIVE MASS SPECTROMETRY
Van Den Kerkof, Thomas Lodewijk, Gertrudis, Mathilda
Abrégé
Methods of calibrating ELISA read-out for clinical antibody response are described. In particular, the invention relates to methods for calibrating ELISA read-out for the clinical antibody response to vaccines by quantitative mass spectrometry.
G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides
Materials and methods to control a nutrient feed in a cell culture process is provided. A sample is received from a bioreactor comprising a cell culture. A viable cell density and a residual nutrient measurement are determined from the received sample. A daily nutrient feeding target is calculated based on the viable cell density and the residual nutrient measurement. The nutrient is fed to the bioreactor according to the calculated daily nutrient feeding target.
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p.ex. lignées cellulaires; Tissus; Leur culture ou conservation; Milieux de culture à cet effet
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12M 1/06 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens d'introduction de gaz avec agitateur, p.ex. avec agitateur à turbine
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p.ex. par des compteurs de colonies
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p.ex. fermenteurs commandés automatiquement
7.
METHOD OF ROBOTIC HUB COMMUNICATION, DETECTION, AND CONTROL
Various surgical systems are disclosed. A surgical system can include a surgical robot and a surgical hub. The surgical robot can include a control unit in signal communication with a control console and a robotic tool. The surgical hub can include a display. The surgical hub can be in signal communication with the control unit. A facility can include a plurality of surgical hubs that communicate data from the surgical robots to a primary server. To alleviate bandwidth competition among the surgical hubs, the surgical hubs can include prioritization protocols for collecting, storing, and/or communicating data to the primary server.
H04L 67/10 - Protocoles dans lesquels une application est distribuée parmi les nœuds du réseau
A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p.ex. endoscopes; Dispositions pour l'éclairage dans ces instruments
A61B 1/05 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p.ex. endoscopes; Dispositions pour l'éclairage dans ces instruments combinés avec des dispositifs photographiques ou de télévision caractérisés par le fait que le capteur d'images, p.ex. l'appareil photographique, est placé dans la partie de l'extrémité distale
A61B 1/06 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p.ex. endoscopes; Dispositions pour l'éclairage dans ces instruments avec dispositifs d'éclairement
A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
A61B 17/072 - Agrafeuses chirurgicales pour appliquer une rangée d'agrafes en une seule opération
A61B 17/11 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour refermer les plaies ou les maintenir fermées, p.ex. agrafes chirurgicales; Accessoires utilisés en liaison avec ces opérations pour réaliser l'anastomose; Boutons pour anastomose
A61B 17/128 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p.ex. les vaisseaux sanguins ou le cordon ombilical pour appliquer ou enlever les clamps ou les pinces
A61B 34/00 - Chirurgie assistée par ordinateur; Manipulateurs ou robots spécialement adaptés à l’utilisation en chirurgie
A61B 34/20 - Systèmes de navigation chirurgicale; Dispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p.ex. pour la stéréotaxie sans cadre
A61B 34/32 - Robots chirurgicaux opérant de façon autonome
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures
A61M 1/00 - Dispositifs de succion ou de pompage à usage médical; Dispositifs pour retirer, traiter ou transporter les liquides du corps; Systèmes de drainage
G06K 7/10 - Méthodes ou dispositions pour la lecture de supports d'enregistrement par radiation corpusculaire
G06K 19/077 - Supports d'enregistrement avec des marques conductrices, des circuits imprimés ou des éléments de circuit à semi-conducteurs, p.ex. cartes d'identité ou cartes de crédit avec des puces à circuit intégré - Détails de structure, p.ex. montage de circuits dans le support
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p.ex. pour des dossiers électroniques de patients
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p.ex. basé sur des systèmes experts médicaux
G16H 70/20 - TIC spécialement adaptées au maniement ou au traitement de références médicales concernant des pratiques ou des directives
H01Q 1/22 - Supports; Moyens de montage par association structurale avec d'autres équipements ou objets
H04L 67/12 - Protocoles spécialement adaptés aux environnements propriétaires ou de mise en réseau pour un usage spécial, p.ex. les réseaux médicaux, les réseaux de capteurs, les réseaux dans les véhicules ou les réseaux de mesure à distance
H04N 5/272 - Moyens pour insérer une image de premier plan dans une image d'arrière plan, c. à d. incrustation, effet inverse
H04N 7/18 - Systèmes de télévision en circuit fermé [CCTV], c. à d. systèmes dans lesquels le signal vidéo n'est pas diffusé
Provided is a method for detecting a microbe in a sample comprising measuring an infrared spectrum of the sample. In some embodiments, the measuring is automated. In some embodiments, the monitoring is continuous and/or non-invasive. Also provided is a system for detecting a microbe in a sample comprising a means for measuring an infrared spectrum of the sample. In some embodiments, the measuring is automated. In some embodiments, the monitoring is continuous and/or non-invasive.
G01N 21/3577 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p.ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge pour l'analyse de liquides, p.ex. l'eau polluée
C12Q 1/04 - Détermination de la présence ou du type de micro-organisme; Emploi de milieux sélectifs pour tester des antibiotiques ou des bactéricides; Compositions à cet effet contenant un indicateur chimique
Provided is a method for detecting a microbe in a sample comprising measuring a Raman spectrum of the sample. In some embodiments, the measuring is automated. In some embodiments, the monitoring is continuous and/or non-invasive and/or non-destructive. Also provided is a system for detecting a microbe in a sample comprising a means for measuring a Raman spectrum of the sample. In some embodiments, the measuring is automated. In some embodiments, the monitoring is continuous and/or non-invasive and/or non-destructive. Also provided are methods and systems for assaying a test agent.
C12Q 1/04 - Détermination de la présence ou du type de micro-organisme; Emploi de milieux sélectifs pour tester des antibiotiques ou des bactéricides; Compositions à cet effet contenant un indicateur chimique
G01J 3/44 - Spectrométrie Raman; Spectrométrie par diffusion
Methods of orthopedic fixation and imagery analysis are provided. Images of first and second bone segments attached to a fixation apparatus are captured. Fixator elements identified in the images can be used to obtain imaging scene parameters. Bone elements identified in the images can be used with the imaging scene parameters to reconstruct a three dimensional representation of positions and/or orientations of the first and second bone segments with respect to the fixation apparatus.
A61B 34/10 - Planification, simulation ou modélisation assistées par ordinateur d’opérations chirurgicales
A61B 17/62 - Structures en anneau, c.à d. dispositifs entourant les os à mettre en position
A61B 17/66 - Mécanismes de compression ou de traction
G16H 20/40 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p.ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies mécaniques, la radiothérapie ou des thérapies invasives, p.ex. la chirurgie, la thérapie laser, la dialyse ou l’acuponcture
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p.ex. l’édition
G16Z 99/00 - Matière non prévue dans les autres groupes principaux de la présente sous-classe
11.
TECHNOLOGIES FOR DETERMINING THE ACCURACY OF THREE-DIMENSIONAL MODELS FOR USE IN AN ORTHOPAEDIC SURGICAL PROCEDURE
Technologies for determining the accuracy of three-dimensional models include a device having circuitry to obtain two-dimensional images of an anatomical object (e.g., a bone of a human joint), to obtain a candidate three-dimensional model of the anatomical object, and to produce two-dimensional silhouettes of the candidate three-dimensional model. The circuitry is also to apply an edge detection algorithm to the two-dimensional images to produce corresponding edge images and to compare the two-dimensional silhouettes to the edge images to produce a score indicative of an accuracy of the candidate three-dimensional model.
The present invention relates to comprehensive systems, devices and methods for delivering energy to tissue for a wide variety of applications, including medical procedures (e.g., tissue ablation, resection, cautery, vascular thrombosis, treatment of cardiac arrhythmias and dysrhythmias, electrosurgery, tissue harvest, etc.). In certain embodiments, systems, devices, and methods are provided for treating a tissue region (e.g., a tumor) through application of energy.
A61B 18/18 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par application de radiations électromagnétiques, p.ex. de micro-ondes
An apparatus includes a base housing, an actuator, and a blade. The base housing defines an upwardly presented support surface. The base housing also defines a distally oriented tip receiving recess. The distally oriented tip receiving recess is sized and configured to receive a bulbous distal tip of a dilation catheter. The actuator is movably coupled with the base housing. The blade us secured to the actuator. The actuator is operable to move the blade downwardly relative to the base housing. The blade is configured to sever a portion of a dilation catheter along a plane longitudinally interposed between the support surface and the tip receiving recess to thereby sever the bulbous distal tip of the dilation catheter in response to movement of the actuator relative to the base housing.
A61M 29/02 - Dilatateurs gonflables; Dilatateurs faits de matériaux dilatables
B26D 1/08 - Coupe d'une pièce caractérisée par la nature ou par le mouvement de l'élément coupant; Appareils ou machines à cet effet; Eléments coupants à cet effet comportant un élément qui ne suit pas le mouvement de la pièce ayant un élément coupant se déplaçant linéairement l'élément coupant étant animé d'un mouvement de va-et-vient du genre guillotine
14.
POWERED STAPLING DEVICE CONFIGURED TO ADJUST FORCE, ADVANCEMENT SPEED, AND OVERALL STROKE OF CUTTING MEMBER BASED ON SENSED PARAMETER OF FIRING OR CLAMPING
A powered stapling device includes a circular stapling head assembly, an anvil, a trocar coupled to the anvil, and a motor also coupled to the trocar. The motor is configured to advance and retract the trocar. The device further includes a control circuit coupled to the motor, in which the control circuit is configured to determine a position of the trocar in one of a plurality of zones, and set an anvil closure rate based on the determined position of the trocar.
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A system for applying a series of pulse field ablation (PFA) pulse trains to tissue of a heart includes energy-generating circuitry and a processor. The processor is configured to apply one of the pulse trains using the energy-generating circuitry and a catheter in the heart, to store a location of the catheter at which the one of the pulse trains is applied, to track a position of the catheter following the application of the one of the pulse trains, to detect, based on the tracking, that the catheter is within a predefined distance from the location following a predefined minimum duration from a most recent one of the pulse trains, and to apply another one of the pulse trains, in response to the detecting, using the energy-generating circuitry and the catheter. Other examples are also described.
Devices, systems, and methods are provided in which movement of a tool is controlled based on sensed parameters. In one embodiment, an electromechanical tool is provided having an instrument shaft and an end effector formed thereon. The electromechanical tool is configured to be mounted on an electromechanical arm, and the electromechanical tool is configured to move with or relative to the electromechanical arm and perform surgical functions. A controller is operatively coupled to the electromechanical arm and the electromechanical tool and is configured to retard advancement of the electromechanical tool toward a tissue surface based on a sensed amount of displacement of a tissue surface, a strain on the tissue of the patient, the temperature of the electromechanical tool, or the like.
A61B 18/08 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage à l'aide de sondes chauffées électriquement
The present invention relates to improved contact lens packages and methods of use and manufacture/assembly. A contact lens package may include a first cavity that houses a contact lens and packaging solution, and a second cavity that houses an absorbent member. In one aspect, the first cavity and the second cavity may be in fluid isolation from one another when the package is in an unopened state.
A system, includes (i) a processor, which is configured to receive, in a zone between first and second regions of an organ of a patient, one or more signals, at least a signal among the signals includes first and second components indicative of an electrophysiological (EP) property of the organ, and based on a relation between the first and second components, the processor is configured to estimate a location of at least a transition zone between the first and second regions, and (ii) a display, configured to display at least the estimated transition zone over a map of the organ.
A61B 5/367 - Modalités électriques se rapportant au cœur, p.ex. électrocardiographie [ECG] Études électrophysiologiques [EEP], p.ex. cartographie de l’activation électrique ou cartographie électroanatomique
A61N 1/00 - SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE ÉLECTROTHÉRAPIE; MAGNÉTOTHÉRAPIE; THÉRAPIE PAR RADIATIONS; THÉRAPIE PAR ULTRASONS Électrothérapie; Circuits à cet effet
Provided is a method for detecting a microbe in a sample comprising detecting confluence of the sample. Also provided is a method for assaying a test agent comprising adding the test agent to a sample comprising a microbe, and measuring confluence of the sample. In some embodiments, the detecting is automated. In some embodiments, the detecting is continuous. In some embodiments, the confluence is percent confluence.
G01N 33/58 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des substances marquées
Variations of integral navigation controls may be used in conjunction with a medical instrument to provide navigation functions for an image guided surgery (IGS) system that is in communication with the integral navigation controls. In some variations, a medical instrument with integrated navigation wheels allows movement of a cursor of the IGS system along the x and y axis by scrolling the wheel, or allows selection, zooming, or other controls by combined clicking and/or scrolling of wheels, and may be sterilized or discarded along with the device. In some other variations, a control overlay may be temporarily attached to the medical instrument to provide additional controls, such as buttons or a pointing stick, and then removed and sterilized or discarded after a procedure. In each variation, inputs may be communicated via wire or wirelessly to an IGS system to provide navigation of images during a surgical procedure.
A61B 17/24 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour la cavité buccale, le larynx, les conduits des bronches ou le nez; Grattoirs pour la langue
A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p.ex. endoscopes; Dispositions pour l'éclairage dans ces instruments
A61B 34/20 - Systèmes de navigation chirurgicale; Dispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p.ex. pour la stéréotaxie sans cadre
A robot connector, including: a connector configured to connect to a mounting surface of a robot; a guiding insert that is compressible, wherein the guiding insert has an opening configured to receive a guide tube; a guide tube holder with an opening wherein the guide tube is attached to the connector and the opening is configured to receive the compressible guiding insert; and a locking mechanism configured to lock the guiding insert and the guide tube to the connector.
A system, includes (i) a processor, which is configured to receive, in a zone between first and second regions of an organ of a patient, one or more signals, at least a signal among the signals includes first and second components indicative of an electrophysiological (EP) property of the organ, and based on a relation between the first and second components, the processor is configured to estimate a location of at least a transition zone between the first and second regions, and (ii) a display, configured to display at least the estimated transition zone over a map of the organ.
Described embodiments include apparatus that includes a catheter and a tip electrode, at a distal end of the catheter, shaped to define a plurality of microelectrode apertures. The apparatus further includes at least one printed circuit board (PCB) disposed within a lumen of the catheter, and a plurality of microelectrodes coupled to the PCB and at least partly situated within the microelectrode apertures, the PCB being configured to carry signals from the microelectrodes. Other embodiments are also described.
The present invention relates to pharmaceutical agents of formula (I) useful for therapy and/or prophylaxis in a subject, pharmaceutical composition comprising such compounds, and their use as MCL-1 inhibitors, useful for treating diseases such as cancer.
The present invention relates to pharmaceutical agents of formula (I) useful for therapy and/or prophylaxis in a subject, pharmaceutical composition comprising such compounds, and their use as MCL-1 inhibitors, useful for treating diseases such as cancer.
C07D 498/22 - Composés hétérocycliques contenant dans le système condensé au moins un hétérocycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle dans lesquels le système condensé contient au moins quatre hétérocycles
The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.
C07D 413/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
C07D 271/07 - Oxadiazoles-1, 2, 4; Oxadiazoles-1, 2, 4 hydrogénés avec des atomes d'oxygène, de soufre ou d'azote, liés directement aux atomes de carbone du cycle, les atomes d'azote ne faisant pas partie d'un radical nitro
C07D 413/04 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
C07D 413/10 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne carbonée contenant des cycles aromatiques
C07D 417/04 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
C07D 417/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant au moins trois hétérocycles
The disclosure encompasses systems, compositions, and methods for use in vivo, including for reinforcement of soft tissue in an individual. The systems, compositions, and methods may utilize three-dimensionally printed scaffolds comprising at least a polymer scaffold and an extracellular matrix component(s), including comprised on the scaffold. The polymer scaffold may comprise particular unit cell structures of a specific design and patterns of alternating configurations of the unit cell structures.
A61L 27/36 - Matériaux pour prothèses ou pour revêtement de prothèses contenant des constituants de constitution indéterminée ou leurs produits réactionnels
A61L 27/28 - Matériaux pour le revêtement de prothèses
A method includes obtaining an electroanatomical map, which maps a portion of a heart while the heart experiences an arrhythmia, obtaining a sequence of images of the heart acquired by an ultrasonic probe, the sequence including one or more arrhythmic images acquired while the heart experiences the arrhythmia and one or more rhythmic images acquired while the heart is in sinus rhythm, the ultrasonic probe including a sensor that outputs, during the acquisition of the sequence of images, a signal indicating a location and an orientation of the probe in a coordinate system of the electroanatomical map, based on the signal, identifying, in one of the arrhythmic images, an anatomical portion represented by a particular portion of the electroanatomical map, by tracking the anatomical portion through the sequence of images, identifying the anatomical portion in at least one of the rhythmic images, and displaying an output in response thereto.
A61B 5/367 - Modalités électriques se rapportant au cœur, p.ex. électrocardiographie [ECG] Études électrophysiologiques [EEP], p.ex. cartographie de l’activation électrique ou cartographie électroanatomique
A61B 8/08 - Détection de mouvements ou de changements organiques, p.ex. tumeurs, kystes, gonflements
A61B 8/12 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores dans des cavités ou des conduits du corps, p.ex. en utilisant des cathéters
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets
30.
POWERED SURGICAL CUTTING AND STAPLING APPARATUS WITH MANUALLY RETRACTABLE FIRING SYSTEM
In one general aspect, various embodiments of the present invention can include a motorized surgical cutting and fastening instrument having a drive shaft, a motor selectively engageable with the drive shaft, and a manual return mechanism configured to operably disengage the motor from the drive shaft and retract the drive shaft. In at least one embodiment, a surgeon, or other operator of the surgical instrument, can utilize the manual return mechanism to retract the drive shaft after it has been advanced, especially when the motor, or a power source supplying the motor, has failed or is otherwise unable to provide a force sufficient to retract the drive shaft.
A61B 17/10 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour refermer les plaies ou les maintenir fermées, p.ex. agrafes chirurgicales; Accessoires utilisés en liaison avec ces opérations pour poser ou retirer les clamps pour blessures; Chargeurs de clamps pour blessures
The present invention relates to improved contact lens packages and methods of use and manufacture/assembly. A contact lens package may include a first cavity that houses a contact lens and packaging solution, and a second cavity that houses an absorbent member. In one aspect, the first cavity and the second cavity may be in fluid isolation from one another when the package is in an unopened state.
A stabilized coronary sinus catheter system having a proximal section and a distal section with a memory shape portion, and a tip, distal of the memory shape portion. A handle having a body, a tip deflection actuator, a memory shape portion deployment actuator, and an axis. The tip is in line with the axis and the tip deflection actuator is at a first position. The tip is deflected out of alignment with the axis when the tip deflection actuator is at a second position. A third position is a delivery configuration where the memory shape portion and the tip are in line with the axis. The memory shape portion deployment actuator is at a first location. A deployed configuration allows the memory shape portion to form a predetermined shape conforming to the shape of the coronary sinus when the memory shape portion deployment actuator is at a second location.
A delivery sheath to catheter coupler includes a cylindrical shaft and a coupling member. The cylindrical shaft extends along an axis and is configured for longitudinal alignment with an insertion port of a catheter delivery sheath. The cylindrical shaft includes a proximal end, a distal end, and a lumen extending from the proximal end to the distal end along the axis. The lumen is sized to receive an end effector of a catheter. The coupling member is attached to the cylindrical shaft and is configured for selective securement to the catheter delivery sheath. The coupling member is configured to align the axis of the lumen with a longitudinal axis of the insertion port when the coupling member is selectively secured to the catheter delivery sheath.
The present invention relates to a method of treating agitation in a human patient with dementia, comprising administering to the human patient with dementia in need thereof a pharmaceutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof to treat agitation, wherein R1-R4 are defined herein:
The present invention relates to a method of treating agitation in a human patient with dementia, comprising administering to the human patient with dementia in need thereof a pharmaceutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof to treat agitation, wherein R1-R4 are defined herein:
The present invention relates to a method of treating agitation in a human patient with dementia, comprising administering to the human patient with dementia in need thereof a pharmaceutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof to treat agitation, wherein R1-R4 are defined herein:
wherein the human patient has at least an about 20% reduction in their symptom of agitation, relative to the patient prior to administration of the compound of formula (I).
A61K 31/506 - Pyrimidines; Pyrimidines hydrogénées, p.ex. triméthoprime non condensées et contenant d'autres hétérocycles
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p.ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
35.
Monocyclic And Bicyclic Ring System Substituted Carbanucleoside Analogues For Use As PRMT5 Inhibitors
The present invention relates to novel novel monocyclic and bicyclic ring system substituted carbanucleoside analogues of Formula (I)
The present invention relates to novel novel monocyclic and bicyclic ring system substituted carbanucleoside analogues of Formula (I)
The present invention relates to novel novel monocyclic and bicyclic ring system substituted carbanucleoside analogues of Formula (I)
wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
C07D 519/00 - Composés hétérocycliques contenant plusieurs systèmes de plusieurs hétérocycles déterminants condensés entre eux ou condensés avec un système carbocyclique commun non prévus dans les groupes ou
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
Embodiments of the present invention provide isolated proteins comprising antigen binding domains that bind kallikrein related peptidase 2 (hK2), including monospecific and bispecific antibodies. Additional embodiments of the invention provide polynucleotides encoding the hk2-specific proteins, vectors, host cells, and methods of making and using them.
C07K 16/28 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
C07K 16/34 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des antigènes de groupes sanguins
37.
METHOD FOR DETECTION OF ANTIBODY-DEPENDENT CELLULAR PHAGOCYTOSIS
222 atmosphere for a period of time sufficient to increase ADCP activity of the phagocytic cell; and detecting ADCP activity of the phagocytic cell in the sample. In some embodiments, the phagocytic cells are cultured in the presence of target cells.
G01N 33/50 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
(1) Human pharmaceutical preparations for the prevention and treatment of auto-immune diseases, cardiovascular diseases, pulmonary hypertension, pulmonary arterial hypertension, gastro-intestinal diseases, oncologic diseases, ophthalmic diseases, respiratory diseases, cerebrovascular diseases and digital ulcers; human pharmaceutical preparations for the prevention and treatment of metabolic diseases and disorders, namely diabetes, gout, arthritis and anemia; human pharmaceutical preparations for the prevention and treatment of neurological diseases, namely Alzheimer's, Huntington's disease, multiple sclerosis, and cerebral palsy; human pharmaceutical preparations for the prevention and treatment of psychiatric diseases, namely, mood disorders, anxiety disorders, cognitive disorders, and schizophrenia; human pharmaceutical preparations for use in dermatology, namely dermatitis, skin pigmentation diseases, psoriasis; Human pharmaceutical preparations for the prevention and treatment of hemolytic disease of the newborn; human pharmaceuticals preparations, namely anxiolytic medications, anti-virals, anti-inflammatories, anti-infectives, anti-allergic medications; human pharmaceutical preparations for the relief of pain
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
(1) Human pharmaceutical preparations for the prevention and treatment of auto-immune diseases, cardiovascular diseases, pulmonary hypertension, pulmonary arterial hypertension, gastro-intestinal diseases, oncologic diseases, ophthalmic diseases, respiratory diseases, cerebrovascular diseases and digital ulcers; human pharmaceutical preparations for the prevention and treatment of metabolic diseases and disorders, namely diabetes, gout, arthritis and anemia; human pharmaceutical preparations for the prevention and treatment of neurological diseases, namely Alzheimer's, Huntington's disease, multiple sclerosis, and cerebral palsy; human pharmaceutical preparations for the prevention and treatment of psychiatric diseases, namely, mood disorders, anxiety disorders, cognitive disorders, and schizophrenia; human pharmaceutical preparations for use in dermatology, namely dermatitis, skin pigmentation diseases, psoriasis; Human pharmaceutical preparations for the prevention and treatment of hemolytic disease of the newborn; human pharmaceuticals preparations, namely anxiolytic medications, anti-virals, anti-inflammatories, anti-infectives, anti-allergic medications; human pharmaceutical preparations for the relief of pain
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
(1) Human pharmaceutical preparations for the prevention and treatment of auto-immune diseases, cardiovascular diseases, pulmonary hypertension, pulmonary arterial hypertension, gastro-intestinal diseases, oncologic diseases, ophthalmic diseases, respiratory diseases, cerebrovascular diseases and digital ulcers; human pharmaceutical preparations for the prevention and treatment of metabolic diseases and disorders, namely diabetes, gout, arthritis and anemia; human pharmaceutical preparations for the prevention and treatment of neurological diseases, namely Alzheimer's, Huntington's disease, multiple sclerosis, and cerebral palsy; human pharmaceutical preparations for the prevention and treatment of psychiatric diseases, namely, mood disorders, anxiety disorders, cognitive disorders, and schizophrenia; human pharmaceutical preparations for use in dermatology, namely dermatitis, skin pigmentation diseases, psoriasis; Human pharmaceutical preparations for the prevention and treatment of hemolytic disease of the newborn; human pharmaceuticals preparations, namely anxiolytic medications, anti-virals, anti-inflammatories, anti-infectives, anti-allergic medications; human pharmaceutical preparations for the relief of pain
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
(1) Human pharmaceutical preparations for the prevention and treatment of auto-immune diseases, cardiovascular diseases, pulmonary hypertension, pulmonary arterial hypertension, gastro-intestinal diseases, oncologic diseases, ophthalmic diseases, respiratory diseases, cerebrovascular diseases and digital ulcers; human pharmaceutical preparations for the prevention and treatment of metabolic diseases and disorders, namely diabetes, gout, arthritis and anemia; human pharmaceutical preparations for the prevention and treatment of neurological diseases, namely Alzheimer's, Huntington's disease, multiple sclerosis, and cerebral palsy; human pharmaceutical preparations for the prevention and treatment of psychiatric diseases, namely, mood disorders, anxiety disorders, cognitive disorders, and schizophrenia; human pharmaceutical preparations for use in dermatology, namely dermatitis, skin pigmentation diseases, psoriasis; Human pharmaceutical preparations for the prevention and treatment of hemolytic disease of the newborn; human pharmaceuticals preparations, namely anxiolytic medications, anti-virals, anti-inflammatories, anti-infectives, anti-allergic medications; human pharmaceutical preparations for the relief of pain
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
(1) Human pharmaceutical preparations for the prevention and treatment of auto-immune diseases, cardiovascular diseases, pulmonary hypertension, pulmonary arterial hypertension, gastro-intestinal diseases, oncologic diseases, ophthalmic diseases, respiratory diseases, cerebrovascular diseases and digital ulcers; human pharmaceutical preparations for the prevention and treatment of metabolic diseases and disorders, namely diabetes, gout, arthritis and anemia; human pharmaceutical preparations for the prevention and treatment of neurological diseases, namely Alzheimer's, Huntington's disease, multiple sclerosis, and cerebral palsy; human pharmaceutical preparations for the prevention and treatment of psychiatric diseases, namely, mood disorders, anxiety disorders, cognitive disorders, and schizophrenia; human pharmaceutical preparations for use in dermatology, namely dermatitis, skin pigmentation diseases, psoriasis; Human pharmaceutical preparations for the prevention and treatment of hemolytic disease of the newborn; human pharmaceuticals preparations, namely anxiolytic medications, anti-virals, anti-inflammatories, anti-infectives, anti-allergic medications; human pharmaceutical preparations for the relief of pain
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
(1) Human pharmaceutical preparations for the prevention and treatment of auto-immune diseases, cardiovascular diseases, pulmonary hypertension, pulmonary arterial hypertension, gastro-intestinal diseases, oncologic diseases, ophthalmic diseases, respiratory diseases, cerebrovascular diseases and digital ulcers; human pharmaceutical preparations for the prevention and treatment of metabolic diseases and disorders, namely diabetes, gout, arthritis and anemia; human pharmaceutical preparations for the prevention and treatment of neurological diseases, namely Alzheimer's, Huntington's disease, multiple sclerosis, and cerebral palsy; human pharmaceutical preparations for the prevention and treatment of psychiatric diseases, namely, mood disorders, anxiety disorders, cognitive disorders, and schizophrenia; human pharmaceutical preparations for use in dermatology, namely dermatitis, skin pigmentation diseases, psoriasis; Human pharmaceutical preparations for the prevention and treatment of hemolytic disease of the newborn; human pharmaceuticals preparations, namely anxiolytic medications, anti-virals, anti-inflammatories, anti-infectives, anti-allergic medications; human pharmaceutical preparations for the relief of pain
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
(1) Human pharmaceutical preparations for the prevention and treatment of auto-immune diseases, cardiovascular diseases, pulmonary hypertension, pulmonary arterial hypertension, gastro-intestinal diseases, oncologic diseases, ophthalmic diseases, respiratory diseases, cerebrovascular diseases and digital ulcers; human pharmaceutical preparations for the prevention and treatment of metabolic diseases and disorders, namely diabetes, gout, arthritis and anemia; human pharmaceutical preparations for the prevention and treatment of neurological diseases, namely Alzheimer's, Huntington's disease, multiple sclerosis, and cerebral palsy; human pharmaceutical preparations for the prevention and treatment of psychiatric diseases, namely, mood disorders, anxiety disorders, cognitive disorders, and schizophrenia; human pharmaceutical preparations for use in dermatology, namely dermatitis, skin pigmentation diseases, psoriasis; Human pharmaceutical preparations for the prevention and treatment of hemolytic disease of the newborn; human pharmaceuticals preparations, namely anxiolytic medications, anti-virals, anti-inflammatories, anti-infectives, anti-allergic medications; human pharmaceutical preparations for the relief of pain
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
(1) Human pharmaceutical preparations for the prevention and treatment of auto-immune diseases, cardiovascular diseases, pulmonary hypertension, pulmonary arterial hypertension, gastro-intestinal diseases, oncologic diseases, ophthalmic diseases, respiratory diseases, cerebrovascular diseases and digital ulcers; human pharmaceutical preparations for the prevention and treatment of metabolic diseases and disorders, namely diabetes, gout, arthritis and anemia; human pharmaceutical preparations for the prevention and treatment of neurological diseases, namely Alzheimer's, Huntington's disease, multiple sclerosis, and cerebral palsy; human pharmaceutical preparations for the prevention and treatment of psychiatric diseases, namely, mood disorders, anxiety disorders, cognitive disorders, and schizophrenia; human pharmaceutical preparations for use in dermatology, namely dermatitis, skin pigmentation diseases, psoriasis; Human pharmaceutical preparations for the prevention and treatment of hemolytic disease of the newborn; human pharmaceuticals preparations, namely anxiolytic medications, anti-virals, anti-inflammatories, anti-infectives, anti-allergic medications; human pharmaceutical preparations for the relief of pain
The present invention is directed to compounds of Formulas (I, IIa and IIb):
The present invention is directed to compounds of Formulas (I, IIa and IIb):
The present invention is directed to compounds of Formulas (I, IIa and IIb):
The invention also relates to pharmaceutical compositions comprising compounds of Formulas (I, IIa and IIb). Methods of making and using the compounds of Formulas (I, IIa and IIb) are also within the scope of the invention.
A bunion correcting system can include a first body portion and a second body portion. One of the first and second body portions can be pivotable relative to the other of the first and second body portions. The first body portion can include a first surface, a second surface spaced from the first surface along a transverse direction, and a first aperture extending from the first surface to the second surface. The first aperture can be adapted to receive a first bone anchor to couple the first body portion to a metatarsal bone. The second body portion can include a third surface, a fourth surface spaced from the third surface along the transverse direction, and a second aperture extending from the third surface to the fourth surface. The second aperture can be adapted to receive a second bone anchor to couple the second body portion to a cuneiform bone.
The objectives for the designs presented herein can be for a variably flexible catheter for vascular applications. The catheter can include a catheter shaft extending along a longitudinal axis. The catheter can include an exterior surface that includes an exterior surface area. The catheter can include a plurality of ridges each including an apex, an amplitude, a wavelength, and a trough with respect to the longitudinal axis. The apexes of the plurality of ridges can define a contact exterior surface area less than the exterior surface area. When the exterior surface of the catheter is applied to vascular tissue, contact between the vascular tissue made primarily by the contact exterior surface area.
An embolic implantation system configured to deliver an embolic implant intravascularly to a treatment site includes an elongated delivery tube to which the embolic implant is detachably attached by a flexible loop extending through a retaining ring or opening on the embolic implant and an elongated detachment member or pull wire extending through the delivery tube and flexible loop. The pull wire has a bump near its distal end that inhibits the pull wire from moving further distally when the bump presses distally against the flexible loop and/or retaining ring. The flexible loop and retaining ring thereby serve as a distal obstruction obstructing distal movement of the bump and thereby distal movement of the pull wire into the implant.
A61B 17/12 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p.ex. les vaisseaux sanguins ou le cordon ombilical
Provided herein are hydrogel-hydrocolloid sealant compositions for use as soft-tissue sealants. The compositions can include a cross-linkable electrophilic component; a cross-linkable nucleophilic component; a swellable filler material including gelatin; and, a buffer having a pH in the range of about 9.0 to about 10.0. The compositions can have a first fluid state and a second crosslinked state, and in the crosslinked state, the electrophilic and nucleophilic components can crosslink to form a crosslinked hydrogel network where the swellable filler material including gelatin is disposed within the crosslinked network. Also provided are systems and methods of manufacturing the sealant compositions as well as methods of repairing soft tissue defects including applying the sealant compositions disclosed herein.
Methods of designing a hybrid clinical trial including an external control arm (ECA) study located in at least one site, to support a randomized clinical trial (RCT) study for a treatment of a condition are disclosed. A Mahalanobis distance value is calculated based on a point comprising a set of values corresponding to a first plurality of feature variables corresponding to at least one ECA candidate; and a distribution of points comprising a set of values corresponding to the first plurality of feature variables of each of a plurality of RCT participants that have received the treatment. ECA candidates may be excluded as ECA participants if they are deemed outliers based on the Mahalanobis distance value. Recruitment is dynamically adjusted into at least one ECA participant site database by comparing sets of feature variables in at least one ECA participant site database to corresponding sets of feature variables in the RCT participant database.
G16H 10/20 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des essais ou des questionnaires cliniques électroniques
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p.ex. pour des dossiers électroniques de patients
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p.ex. basé sur des systèmes experts médicaux
61.
PHACOEMULSIFICATION PROBE STROKE LENGTH MAXIMIZATION SYSTEM
A phacoemulsification system including a phacoemulsification probe having a probe body, a horn disposed at least partially in the probe body, a needle coupled with the horn and configured to be inserted into an eye, and a piezoelectric actuator disposed in the probe body and configured to vibrate the horn and the needle in a first direction with a stroke length with respect to the probe body; a signal generator configured to generate a drive signal to drive a vibration of the piezoelectric actuator; a stroke measurement apparatus configured to provide indications of the stroke length of the needle over time; and a controller configured to dynamically adjust a frequency of the drive signal so as to maximize the stroke length and maintain mechanical resonance of the needle responsively to the provided indications of the stroke length.
A61F 9/007 - Procédés ou dispositifs pour la chirurgie de l'œil
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures
Provided herein are hydrogel-hydrocolloid sealant compositions for use as soft-tissue sealants. The compositions can include a cross-linkable electrophilic component; a cross-linkable nucleophilic component; a swellable filler material including gelatin; and, a buffer having a pH in the range of about 9.0 to about 10.0. The compositions can have a first fluid state and a second crosslinked state, and in the crosslinked state, the electrophilic and nucleophilic components can crosslink to form a crosslinked hydrogel network where the swellable filler material including gelatin is disposed within the crosslinked network. Also provided are systems and methods of manufacturing the sealant compositions as well as methods of repairing soft tissue defects including applying the sealant compositions disclosed herein.
A system includes an interface and a processor. The interface is configured to receive multiple electrophysiological (EP) signals from a tissue area along an ablation curve inside a cardiac chamber of a heart of a patient. The processor is configured to (i) generate local conduction vectors (LCVs) for the area based on the multiple EP signals, (ii) estimate a level of change between sets of LCVs along the ablation curve within the tissue area, and (iii) based on the level of change, identify a presence of a conduction gap in the ablation curve.
A61B 5/367 - Modalités électriques se rapportant au cœur, p.ex. électrocardiographie [ECG] Études électrophysiologiques [EEP], p.ex. cartographie de l’activation électrique ou cartographie électroanatomique
64.
SURGICAL STAPLER WITH DISCRETELY POSITIONABLE DISTAL TIP
An apparatus includes a first jaw (16) and a second jaw (618, 718, 900) that cooperate to clamp and staple tissue (90). The second jaw includes a jaw body (620, 720, 902) and a distal tip (619, 719, 906) pivotable relative to the jaw body between a first discrete and a second discrete position. First and second openings (663, 784, 785, 932, 934) are both defined by one of the distal tip or a structure (621, 920) located proximal to the distal tip. A projection (637, 781, 918) is defined by the other of the distal tip or the structure. The projection is positionable within the first opening (663, 785, 932) to releasably retain the distal tip in the first discrete position, and within the second opening (663, 784, 934) to releasably retain the distal tip in the second discrete position.
In one exemplary mode, a phacoemulsification system includes a phacoemulsification probe, an irrigation tube to provide irrigation fluid into an eye, an irrigation pump to pump irrigation fluid into the eye, an aspiration tube convey aspiration fluid from the eye, an aspiration pump to pump the aspiration fluid from the eye, a sensor to provide a signal indicative of current intraocular pressure in the eye, and a pump controller to receive the signal provided by the sensor, compute a value of intraocular pressure at a future time responsively to the provided signal and an indicator of change in the intraocular pressure over time, and control the irrigation pump to adjust a flow rate of the irrigation fluid to maintain the intraocular pressure at a given intraocular pressure responsively to the computed value of the intraocular pressure at the future time.
A61L 27/42 - Matériaux composites, c. à d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice inorganique
A system includes an interface and a processor. The interface is configured to receive multiple electrophysiological (EP) signals from a tissue area along an ablation curve inside a cardiac chamber of a heart of a patient. The processor is configured to (i) generate local conduction vectors (LCVs) for the area based on the multiple EP signals, (ii) estimate a level of change between sets of LCVs along the ablation curve within the tissue area, and (iii) based on the level of change, identify a presence of a conduction gap in the ablation curve.#
A method includes obtaining an electroanatomical map, which maps a portion of a heart while the heart experiences an arrhythmia, obtaining a sequence of images of the heart acquired by an ultrasonic probe, the sequence including one or more arrhythmic images acquired while the heart experiences the arrhythmia and one or more rhythmic images acquired while the heart is in sinus rhythm, the ultrasonic probe including a sensor that outputs, during the acquisition of the sequence of images, a signal indicating a location and an orientation of the probe in a coordinate system of the electroanatomical map, based on the signal, identifying, in one of the arrhythmic images, an anatomical portion represented by a particular portion of the electroanatomical map, by tracking the anatomical portion through the sequence of images, identifying the anatomical portion in at least one of the rhythmic images, and displaying an output in response thereto.
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
A61B 5/339 - Affichages spécialement adaptés à cet effet
A61B 5/367 - Modalités électriques se rapportant au cœur, p.ex. électrocardiographie [ECG] Études électrophysiologiques [EEP], p.ex. cartographie de l’activation électrique ou cartographie électroanatomique
A61B 8/08 - Détection de mouvements ou de changements organiques, p.ex. tumeurs, kystes, gonflements
A61B 8/12 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores dans des cavités ou des conduits du corps, p.ex. en utilisant des cathéters
G06T 7/73 - Détermination de la position ou de l'orientation des objets ou des caméras utilisant des procédés basés sur les caractéristiques
A surgical data management system may enable a patient to provide conditional consent(s). The patient granted consent may be associated with one or more condition(s), stipulation(s), and/or limitations of the scope, duration, and/or usage of their health data. The surgical data management system may be configured to check that patient data is only being used in accordance with the consent data (e.g., for the agreed upon purpose(s) and for the agreed upon time). In response to a data request for health data associated with a patient, the system may obtain a conditional consent associated with the patient. The system may determine whether to block access to at least a portion of the health data associated with the patient based on the data request and whether the condition(s) associated with the conditional consent have been met.
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p.ex. pour des dossiers électroniques de patients
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p.ex. basé sur des systèmes experts médicaux
A data propagation reporting system may obtain an annotation associated with health data associated with a patient and may determine, based on the annotation, utilization information associated with the patient's health data. The data propagation reporting system may generate a patient data utilization report that may include at least a portion of the utilization information associated with the patient. The utilization information may indicate at least one of: the system(s) in which the health data associated with the patient has been used, when the health data associated with the patient has been accessed, or the purpose(s) for which the health data associated with the patient has been used. The utilization information may indicate the control program(s) (e.g., system algorithms) to which the patient's data has been contributed. The utilization information may indicate the data collection(s) in which the patient's data has been included.
G16H 15/00 - TIC spécialement adaptées aux rapports médicaux, p.ex. leur création ou leur transmission
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p.ex. pour des dossiers électroniques de patients
71.
SURGICAL STAPLER WITH DISCRETELY POSITIONABLE DISTAL TIP
An apparatus includes a first jaw (16) and a second jaw (618, 718, 900) that cooperate to clamp and staple tissue (90). The second jaw includes a jaw body (620, 720, 902) and a distal tip (619, 719, 906) pivotable relative to the jaw body between a first discrete and a second discrete position. First and second openings (663, 784, 785, 932, 934) are both defined by one of the distal tip or a structure (621, 920) located proximal to the distal tip. A projection (637, 781, 918) is defined by the other of the distal tip or the structure. The projection is positionable within the first opening (663, 785, 932) to releasably retain the distal tip in the first discrete position, and within the second opening (663, 784, 934) to releasably retain the distal tip in the second discrete position.
A phacoemulsification method includes specifying a target intraocular pressure (IOP) level to be maintained in an eye of a patient during a phacoemulsification procedure. A phacoemulsification probe is inserted into the eye. The eye is irrigated with irrigation fluid and material is aspired from the eye while aiming to maintain the target IOP level, including controlling IOP fluctuations by (i) when an actual IOP in the eye is in a defined high range, limiting the IOP fluctuations to a given value, and (ii) when the actual IOP is in a defined low range that is lower than the high range, allowing the IOP fluctuations to exceed the given value.
The present invention relates to stabilized pre-fusion human parainfluenza virus 3 (HPIV3) F protein, and fragments thereof. The invention also relates to nucleic acid molecules encoding such proteins and fragments, and to the use of the proteins, fragments and nucleic acid molecules.
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND (Irlande)
Inventeur(s)
Stamatas, Georgios N.
Sato, Takahiro
Oddos, Thierry
Hourihane, Jonathan
Irvine, Alan D.
Insel, Richard A.
Abrégé
A method to predict a propensity of an infant to develop atopic dermatitis. The method includes observing the expression of S100A8/A9 on a skin area of an infant; comparing the expression to determined standard, wherein the determined standard is ascertained by measuring a level of the biomarker in a subject or pool of subjects who have demonstrated an absence of atopic dermatitis; and determining the propensity of an infant to develop atopic dermatitis, wherein an increase in the expression as compared to the determined standard indicates propensity of the infant to develop atopic dermatitis.
C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
75.
REDUCING INTRAOCULAR PRESSURE (IOP) FLUCTUATIONS DURING PHACOEMULSIFICATION
A phacoemulsification method includes specifying a target intraocular pressure (IOP) level to be maintained in an eye of a patient during a phacoemulsification procedure. A phacoemulsification probe is inserted into the eye. The eye is irrigated with irrigation fluid and material is aspired from the eye while aiming to maintain the target IOP level, including controlling IOP fluctuations by (i) when an actual IOP in the eye is in a defined high range, limiting the IOP fluctuations to a given value, and (ii) when the actual IOP is in a defined low range that is lower than the high range, allowing the IOP fluctuations to exceed the given value.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Human pharmaceutical preparations for the prevention and treatment of viral diseases, auto-immune and inflammatory diseases, alloimmune diseases, cardiovascular and pulmonary diseases, central nervous system diseases, peripheral neurological system diseases, pain, dermatologic diseases, gastro-intestinal diseases, infectious-related diseases, metabolic diseases, oncologic diseases, ophthalmic diseases, respiratory diseases, hematological diseases, urological diseases, maternal fetal disorders, digital ulcers
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Human pharmaceutical preparations for the prevention and treatment of viral diseases, auto-immune and inflammatory diseases, alloimmune diseases, cardiovascular and pulmonary diseases, central nervous system diseases, peripheral neurological system diseases, pain, dermatologic diseases, gastro-intestinal diseases, infectious-related diseases, metabolic diseases, oncologic diseases, ophthalmic diseases, respiratory diseases, hematological diseases, urological diseases, maternal fetal disorders, digital ulcers
78.
Display screen or portion thereof with computer icon
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Human pharmaceutical preparations for the prevention and treatment of viral diseases, auto-immune and inflammatory diseases, alloimmune diseases, cardiovascular and pulmonary diseases, central nervous system diseases, peripheral neurological system diseases, pain, dermatologic diseases, gastro-intestinal diseases, infectious-related diseases, metabolic diseases, oncologic diseases, ophthalmic diseases, respiratory diseases, hematological diseases, urological diseases, maternal fetal disorders, digital ulcers
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Human pharmaceutical preparations for the prevention and treatment of viral diseases, auto-immune and inflammatory diseases, alloimmune diseases, cardiovascular and pulmonary diseases, central nervous system diseases, peripheral neurological system diseases, pain, dermatologic diseases, gastro-intestinal diseases, infectious-related diseases, metabolic diseases, oncologic diseases, ophthalmic diseases, respiratory diseases, hematological diseases, urological diseases, maternal fetal disorders, digital ulcers
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Human pharmaceutical preparations for the prevention and treatment of viral diseases, auto-immune and inflammatory diseases, alloimmune diseases, cardiovascular and pulmonary diseases, central nervous system diseases, peripheral neurological system diseases, pain, dermatologic diseases, gastro-intestinal diseases, infectious-related diseases, metabolic diseases, oncologic diseases, ophthalmic diseases, respiratory diseases, hematological diseases, urological diseases, maternal fetal disorders, digital ulcers
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Human pharmaceutical preparations for the prevention and treatment of viral diseases, auto-immune and inflammatory diseases, alloimmune diseases, cardiovascular and pulmonary diseases, central nervous system diseases, peripheral neurological system diseases, pain, dermatologic diseases, gastro-intestinal diseases, infectious-related diseases, metabolic diseases, oncologic diseases, ophthalmic diseases, respiratory diseases, hematological diseases, urological diseases, maternal fetal disorders, digital ulcers
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Human pharmaceutical preparations for the prevention and treatment of viral diseases, auto-immune and inflammatory diseases, alloimmune diseases, cardiovascular and pulmonary diseases, central nervous system diseases, peripheral neurological system diseases, pain, dermatologic diseases, gastro-intestinal diseases, infectious-related diseases, metabolic diseases, oncologic diseases, ophthalmic diseases, respiratory diseases, hematological diseases, urological diseases, maternal fetal disorders, digital ulcers
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Human pharmaceutical preparations for the prevention and treatment of viral diseases, auto-immune and inflammatory diseases, alloimmune diseases, cardiovascular and pulmonary diseases, central nervous system diseases, peripheral neurological system diseases, pain, dermatologic diseases, gastro-intestinal diseases, infectious-related diseases, metabolic diseases, oncologic diseases, ophthalmic diseases, respiratory diseases, hematological diseases, urological diseases, maternal fetal disorders, digital ulcers
The present invention is related to compounds of formula (I) and compounds of formula (II) and pharmaceutical composition thereof, useful as agonists of the CB1 and/or CB2 receptor(s).
Disubstituted octahydropyrrolo[3,4-c]pyrrole compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.
A61K 31/5377 - 1,4-Oxazines, p.ex. morpholine non condensées et contenant d'autres hétérocycles, p.ex. timolol
A61K 31/506 - Pyrimidines; Pyrimidines hydrogénées, p.ex. triméthoprime non condensées et contenant d'autres hétérocycles
A61K 31/428 - Thiazoles condensés avec des carbocycles
A61K 31/498 - Pyrazines ou pipérazines condensées en ortho ou en péri avec des systèmes carbocycliques, p.ex. quinoxaline, phénazine
A61K 31/4709 - Quinoléines non condensées contenant d'autres hétérocycles
A61K 31/4439 - Pyridines non condensées; Leurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p.ex. oméprazole
A61K 31/53 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec trois azote comme seuls hétéro-atomes d'un cycle, p.ex. chlorazanil, mélamine
TPLO plate includes a body and first and second distal holes. The body extends longitudinally from a proximal end to a distal end and defined via a first surface which, in an operative configuration, faces away from a bone and a second surface which, in the operative configuration, faces toward the bone. The body includes a proximal portion configured to be positioned over a cut and repositioned proximal segment of a tibia during a procedure and a distal portion extending along a longitudinal axis and configured to be positioned over a distal segment of the tibia during the procedure. The first hole extends through a proximal end of the distal portion of the body from the first surface to the second surface. The first hole includes an elongated portion and an offset portion open to and in communication with one another. The elongated portion extends along the longitudinal axis and an offset portion extending distally from the elongated portion along an offset axis, which extends at an angle relative to the longitudinal axis. The second hole extends through the distal portion of the body distally of the first hole from the first surface to the second surface. The second hole extends along the longitudinal axis in alignment with the elongated portion of the first hole and including a sloped compression surface along a distal portion thereof. The first hole is configured such that when a first distal compression to the osteotomy cut is applied via insertion of a bone fixation element into a distal portion of the second hole. The element translates along the offset axis from a central axis to a point of intersection to provide a cranial compression to the osteotomy cut.
Devices and methods for improved access to a surgical site are the basis of the present disclosure. The improved access can be provided by way of a displacement wrap that can be used to engage tissue that impedes access to the surgical site. The displacement wrap, which can be a textile, can be wrapped around the tissue and subsequently manipulated to move the wrap, and thus the tissue, out of the way to improve access. The displacement wrap includes locking features formed in it that allow for selective tensioning of the tissue being engaged and moved. The locking features can engage another portion of the wrap and/or can be engaged by another component associated with the wrap, such as a locking suture. Methods of using the wrap in various surgical procedures that would benefit from moving tissue to improve surgical site access are also provided.
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures
90.
INSTRUMENT WITH INTEGRAL IMAGING AND IRRIGATION FEATURES
A surgical instrument and related method includes an instrument body, a guide shaft distally projecting from the instrument body, and a first surgical tool. The guide shaft has a guide sidewall, a guide lumen, and a clearance opening radially extending through the guide sidewall in communication with the guide lumen. The first surgical tool has an elongate body and a distal head configured to deflect relative to the elongate body from a first position to a second position. The distal head in the first position is positioned within the guide lumen along the central axis. The distal head in the second position is deflected from the central axis and extends at least partially through the clearance opening thereby vacating at least a portion of the guide lumen for introducing a second surgical tool through the guide lumen.
A61B 17/24 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour la cavité buccale, le larynx, les conduits des bronches ou le nez; Grattoirs pour la langue
A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p.ex. endoscopes; Dispositions pour l'éclairage dans ces instruments
A61B 1/015 - Commande de l'alimentation en fluide ou de l'évacuation de fluide
A61B 1/05 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p.ex. endoscopes; Dispositions pour l'éclairage dans ces instruments combinés avec des dispositifs photographiques ou de télévision caractérisés par le fait que le capteur d'images, p.ex. l'appareil photographique, est placé dans la partie de l'extrémité distale
A61B 1/06 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p.ex. endoscopes; Dispositions pour l'éclairage dans ces instruments avec dispositifs d'éclairement
A system includes an interface and a processor. The interface is configured to receive a lesion parameter indicative of a specification of a lesion intended to be formed in tissue of an organ using at least one of first and second ablation modes intended to be applied sequentially to multiple sections of the tissue. The processor is configured to (i) select, for the first and second ablation modes, first and second sets of parameters, respectively, that when applied to the tissue, form the lesion having the lesion parameter, (ii) detect, for a section selected among the multiple sections, whether the first or second ablation mode has been selected, and (iii) control a catheter having at least an ablation electrode, to apply to the section ablation signals that are based on the selected ablation mode and are corresponding to the first or second ablation modes.
Disclosed is a surgical instrument for treating tissue in a surgical procedure. The surgical instrument comprises an end effector, comprising an anvil, and a staple cartridge. The surgical instrument further comprises a drive train operably coupled to the end effector, a motor configured to motivate the drive train based on a default control algorithm to affect a tissue treatment motion of the end effector, and a sensor configured to monitor an independent parameter of the surgical procedure. The independent parameter is independent of the motion of the end effector. The surgical instrument further comprises a control circuit coupled to the motor and the sensor. The control circuit is configured to receive an input from the sensor indicative of the independent parameter, and adjust the default control algorithm based on the independent parameter.
A surgical stapling system includes a motor, a gear reducer assembly, a drive train, and a motor controller. A method of controlling the motor includes applying a first signal to the motor, receiving drive train operational data, comparing the drive train data to baseline data, and applying a signal having a different shape than the first signal to the motor. A method of characterizing the motor includes transmitting a perturbation signal, receiving motor function parameters, determining stapler system characteristics, and adjusting a controller function. A method of controlling a stepper motor includes applying a signal to the stepper motor, receiving stepper motor operational data, comparing the data to baseline data, and adjusting the signal. Another method of controlling the motor includes receiving motor rotational data, receiving gear rotation data, calculating a mechanical transfer function, determining non-idealities of the stapling system, and modifying a control signal based on the non-idealities.
Disclosed is a surgical system for use with a surgical device. The surgical system comprises a remote processing device comprising a device control circuit and a surgical hub configured to communicably couple to the remote processing device and the surgical device. The surgical hub comprises a hub control circuit, wherein the hub control circuit and the device control circuit perform distributed processing. The surgical hub control circuit is configured to transmit a synchronization feature to the remote processing device, transmit a first subset of data associated with the surgical device to the remote processing device, perform a second analysis on a second subset of the data, determine a second result based on the second analysis, receive a first result from the remote processing device and synchronization data of the first result, assess a synchronicity of the first result and the second result based on the synchronization data.
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
96.
SURGICAL SYSTEM WITH MOTOR RELATIVE CAPACITY INTERROGATIONS
A surgical instrument system comprising a drive train and a control circuit is disclosed. The drive train comprises a motor and a shaft actuatable by the motor to actuate a function of an end effector. The control circuit is coupled to the motor, wherein the control circuit is configured to determine a relative excess capacity of the drive train, compare the relative excess capacity to a predetermined shifting threshold, and increase the speed of the motor based on the relative excess capacity exceeding the predetermined shifting threshold.
A surgical instrument system comprising a motor system and a control circuit is disclosed. The motor system comprises a motor and a drive train movable by the motor to actuate a firing member through a staple firing stroke. The control circuit is coupled to the motor, wherein, during the staple firing stroke, the control circuit is configured to perform a first sensory action to determine if a speed of the motor can be increased to a first target speed, monitor a result of the first sensory action, adjust a parameter of a subsequent sensory action based on the monitored result of the first sensory action, and perform the subsequent sensory action with the adjusted parameter.
A surgical instrument is disclosed including an end effector, a firing member movable from an unfired position toward a fired position during a firing stroke, a firing system comprising a motor, and a control system. The end effector comprises a first jaw, a second jaw moveable relative to the first jaw, and a staple cartridge. The firing system is configured to drive the firing member through the firing stroke. The control system is configured to drive the firing member from the unfired position toward the fired position with the firing system, detect a force to fire the firing member toward the fired position, predict a future force to fire the firing member, based on the detected force to fire, and dynamically adjust a firing algorithm of the firing system, based on the prediction.
Patient health data and consent data may be managed. Conditional consent by a patient may be provided for utilizing their private health data in one or more of the following: the adaptation of procedures, instrument operation, system configuration, display of results and/or plans for device usage. The patient granted consent may be associated with one or more condition(s), stipulation(s), and/or limitations of the scope, duration, and/or usage of their health data. A health data management system may check that patient data is only being used in accordance with the consent data (e.g., for the agreed upon purpose(s) and for the agreed upon time).
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p.ex. pour des dossiers électroniques de patients
G16H 40/40 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion d’équipement ou de dispositifs médicaux, p.ex. pour planifier la maintenance ou les mises à jour
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
G16H 80/00 - TIC spécialement adaptées pour faciliter la communication entre les professionnels de la santé ou les patients, p.ex. pour le diagnostic collaboratif, la thérapie collaborative ou la surveillance collaborative de l’état de santé
A surgical data management system may adjust patient data access and display capabilities based on the location, the data origin, and/or the patient geographic characteristics associated with a patient data display interface. The patient data display interface may be located within or outside of the privacy protection boundary. The system may identify a region of the patient or a controlling jurisdiction of the patient's data usage. The system may determine a region-based consent requirement associated with the dataset based on the relevant controlling region and may determine whether to display the dataset via the patient data display interface based on the determined region-based consent requirement and patient consent data. The system may generate the patient data display interface based on the determining. The system may determine a regional law's bearing on patient consent and may adapt consent management accordingly.
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p.ex. pour des dossiers électroniques de patients
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
