Disclosed are 4-hydroxylphenyl substituted carbocycles and there use as selective agonists of the estrogen receptor beta isoform (ER?). The disclosed compounds may be formulated as pharmaceutical compositions and administered to treat diseases associated with ER activity, such as proliferative diseases and disorders and/or psychiatric diseases or disorders.
C07C 35/31 - Composés comportant au moins un groupe hydroxyle ou O-métal lié à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons polycycliques, avec au moins un groupe hydroxyle lié à un système cyclique condensé le groupe hydroxyle étant sur un système cyclique condensé à deux cycles le système cyclique condensé contenant huit atomes de carbone
C07C 35/21 - Composés comportant au moins un groupe hydroxyle ou O-métal lié à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons polycycliques, avec au moins un groupe hydroxyle lié à un cycle non condensé
C07C 35/23 - Composés comportant au moins un groupe hydroxyle ou O-métal lié à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons polycycliques, avec au moins un groupe hydroxyle lié à un système cyclique condensé le groupe hydroxyle étant sur un système cyclique condensé à deux cycles
2.
SELECTIVE TRANSITION METAL CATALYZED DEUTERIUM INCORPORATION INTO ALKYNE AND ALKENE FUNCTIONALITIES
Disclosed herein are deuterated compounds and transition metal catalyzed methods for making deuterated compounds. The disclosed methods are regioselective and enantioselective and may be utilized to prepare isomerically and/or enantiomerically pure or enriched deuterated compounds. The disclosed methods also may be modified in order to prepared fluorinated compounds.
C07C 67/38 - Préparation d'esters d'acides carboxyliques par réaction avec du monoxyde de carbone ou des formiates par addition à une liaison non saturée carbone-carbone
3.
CONTINUOUS HEAVY METAL WATER CONTAMINANT MEASUREMENT SYSTEM
A resonator includes a body, the body having a planar surface. An aperture through the body is configured to receive a tube configured for a fluid to be tested. A gap extends into the body from the planar surface to the aperture. At least one cut extends through the body from the planar surface towards the aperture. The at least one cut extends across the gap.
G01N 22/00 - Recherche ou analyse des matériaux par l'utilisation de micro-ondes ou d'ondes radio, c. à d. d'ondes électromagnétiques d'une longueur d'onde d'un millimètre ou plus
The present disclosure provides an apparatus comprising a primary treatment system configured to remove solids from an untreated fluid to generate a primary treated fluid. The apparatus further comprises an oxidation treatment system including an inlet configured to receive the primary treated fluid, an ozone inlet configured to receive ozone from an ozone generator, and an outlet configured to dispense secondary treated fluid. The apparatus may further comprise a controller in electrical communication with the ozone generator. The controller is programmed to regulate the flow of ozone through the oxidation treatment system such that an effective amount of ozone contacts the primary treated fluid to generate the secondary treated fluid. In some embodiments, the secondary treated fluid discharging from the oxidation treatment system has a chemical oxygen demand (COD) removal level of greater than 85%.
Described here are systems and methods that utilize visual imagery and an optical flow-based computer vision algorithm to measure river velocity in streams or other flowing bodies of water. The systems and methods described in the present disclosure overcome the barriers of conventional flow measurement techniques by providing a fast, non-intrusive, remote method to measure peak flows.
G01B 21/18 - Dispositions pour la mesure ou leurs détails, où la technique de mesure n'est pas couverte par les autres groupes de la présente sous-classe, est non spécifiée ou est non significative pour mesurer la profondeur
G01F 1/00 - Mesure du débit volumétrique ou du débit massique d'un fluide ou d'un matériau solide fluent, dans laquelle le fluide passe à travers un compteur par un écoulement continu
Disclosed herein are methods for treating wastewater grit to inactivate any pathogens that are present in the grit and for forming a solidified material comprising wastewater grit such as a chemically bonded phosphate ceramic (CBPC). The CBPC may be utilized in methods for repairing depressions in a road surface that include applying the uncured CBPC to the depression in the road surface and allowing the CBPC to cure.
C04B 28/34 - Compositions pour mortiers, béton ou pierre artificielle, contenant des liants inorganiques ou contenant le produit de réaction d'un liant inorganique et d'un liant organique, p.ex. contenant des ciments de polycarboxylates contenant des liants phosphate froids
E01C 23/09 - Dispositifs ou aménagements pour travailler la surface terminée; Dispositifs pour réparer la surface des revêtements endommagés pour rogner les bords du revêtement
A computer implemented method for selecting m appropriately sized meter tor use in a selected application implemented by a computer processor Implementing instructions stored in a non-transient memory is described. The instructions include receiving utility meter data transmitted from a plurality of utility meters, each utility meter being installed at a unique utility monitoring location, identifying incorrectly sized utility meters based on utility meter data for particular utility meters feat displays quantization effects, and selecting an appropriate meter based on the identification of the utility meters displaying quantization effects.
Disclosed herein are composite materials which may be used as biomedical materials or constructs. The disclosed biomedical materials or constructs may be multiphasic and typically provide a surface for cell growth. The disclosed biomedical materials and constructs typically comprise conjugable and/or adhesive chemical moieties, such as hydroxylated aromatic moieties, which facilitate integration of the components of the biomedical materials and constructs. Suitable hydroxylated aromatic moieties may include dihydoxybenzene (DHB) moieties, such as 1,2-DHB moieities, and derivatives thereof.
SUBSTITUTED (4'-HYDROXYPHENYL)CYCLOALKANE AND (4'-HYDROXYPHENYL)CYCLOALKENE COMPOUNDS AND USES THEREOF AS SELECTIVE AGONISTS OF THE ESTROGEN RECEPTOR BETA ISOFORM FOR ENHANCED MEMORY CONSOLIDATION
Disclosed are substituted (4'-hydroxylphenyl)cycloalkane compounds and substituted (4'-hydroxylphenyl)cycloalkene compounds and there use as selective agonists of the estrogen receptor beta isoform (ERß). The disclosed compounds may be formulated as pharmaceutical compositions and administered for treating diseases associated with ER activity, such as neurological, psychiatric, and/or cell proliferative diseases and disorders as well as for enhancing memory consolidation in subjects in need thereof.
C07C 39/17 - Composés comportant au moins un groupe hydroxyle ou O-métal lié à un atome de carbone d'un cycle aromatique à six chaînons polycycliques sans autre insaturation que celle des cycles aromatiques contenant d'autres cycles en plus des cycles aromatiques à six chaînons
A61K 31/352 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p.ex. fungichromine ayant des cycles à six chaînons avec un oxygène comme seul hétéro-atome d'un cycle condensés avec des carbocycles, p.ex. cannabinols, méthanthéline
C07C 39/23 - Composés comportant au moins un groupe hydroxyle ou O-métal lié à un atome de carbone d'un cycle aromatique à six chaînons polycycliques contenant des cycles aromatiques à six chaînons et d'autres cycles avec une insaturation autre que celle des cycles aromatiques
C07D 311/00 - Composés hétérocycliques contenant des cycles à six chaînons comportant un atome d'oxygène comme unique hétéro-atome du cycle, condensés avec d'autres cycles
10.
SYNTHETIC PROSTHESIS FOR USE IN OSTEO-ODONTO-KERATOPROSTHESIS (OOKP) SURGERY
Disclosed herein is a prosthesis that may be used to replace standard prosthetic material used in osteo-odonto-keratoprosthesis (OOKP) surgery. The disclosed prosthesis is not prepared from tissue removed from a patient's tooth and jaw bone, but rather is a synthetic prosthesis. The synthetic prosthesis typically includes a solid part for supporting an optical cylinder and a porous part that facilitates bio-integration of the implanted prosthesis into the patient's eye.
Disclosed herein are methods and compositions for preserving avulsed teeth and/or explanted tissue. The disclosed methods for preserving avulsed teeth and/or explanted tissue typically include placing the avulsed teeth and/or explanted tissue in a preservation solution comprising at least about 2.75 g/L sugar. Suitable explanted tissues for the disclosed methods may include explanted tissues comprising fibroblasts, such as dental tissue and/or oral tissue. The preservation solution of the disclosed preservation methods may include additional components which may include but are not limited to inorganic salts, amino acids, vitamins, and buffering agents. The preservation solution may be prepared from a powder formulation having a long shelf-life.
Disclosed herein are composite materials, ionic liquid compositions for preparing the composite materials, and methods for using the composite materials prepared from the ionic liquid compositions. The composite materials typically include structural polymers and nitric oxide releasing agents, and preferably photo-reactive nitric oxide releasing compounds or complexes. The composite materials may be prepared from ionic liquid compositions comprising the structural polymers and the nitric oxide releasing agent, where the ionic liquid is removed from the ionic liquid compositions to obtain the composite materials. The composite materials may be used in applications include dressing for wounds, where the nitric oxide releasing agents may be induced to release nitric oxide in order to inhibit microbial growth and promote healing.
A61L 15/18 - Bandages, pansements ou garnitures absorbant les fluides physiologiques tels que l'urine, le sang, p.ex. serviettes hygiéniques, tampons contenant des matériaux inorganiques
A61K 47/36 - Polysaccharides; Leurs dérivés, p.ex. gommes, amidon, alginate, dextrine, acide hyaluronique, chitosane, inuline, agar-agar ou pectine
Disclosed herein are processes, systems, and catalysts for improving pyrolysis technology. The disclosed processes and systems utilize a catalyst to increase pyrolysis gas (py-gas) and decrease bio-oil yields in pyrolysis reactions. The disclosed catalysts may include biochar derived from pyrolysis of industrial residuals, such as pyrolysis of wastewater biosolids (WB) and paper mill sludge (PMS). The disclosed catalysts also may include ash derived from incineration of wastewater biosolids ("biosolids incineration ash" (BIA)).
B01J 19/24 - Réacteurs fixes sans élément interne mobile
A62D 3/40 - Procédés pour rendre les substances chimiques nuisibles inoffensives ou moins nuisibles en effectuant un changement chimique dans les substances par chauffage pour effectuer une modification chimique, p.ex. par pyrolyse
C01B 32/05 - Préparation ou purification du carbone non couvertes par les groupes , , ,
B01J 23/70 - Catalyseurs contenant des métaux, oxydes ou hydroxydes métalliques non prévus dans le groupe du cuivre ou des métaux du groupe du fer
C01B 3/04 - Production d'hydrogène ou de mélanges gazeux contenant de l'hydrogène par décomposition de composés inorganiques, p.ex. de l'ammoniac
C02F 11/10 - Traitement des boues d'égout; Dispositifs à cet effet par pyrolyse
C10G 1/02 - Production de mélanges liquides d'hydrocarbures à partir de schiste bitumineux, de sable pétrolifère ou de matières carbonées solides non fusibles ou similaires, p.ex. bois, charbon par distillation
Scaffolds for use in bone tissue engineering include a skeleton and a host component. Methods of preparation of scaffolds include identification of biodegradation properties for the skeleton and the host component. The skeleton is constructed to form a three- dimensional shape. The skeleton is constructed of a first material and has a first rate of biodegradation. The host component fills the three-dimensional shape formed by the skeleton. The host component is constructed of a second material and has a second rate of biodegradation. The first rate of biodegradation is slower than the second rate of biodegradation.
A61K 38/18 - Facteurs de croissance; Régulateurs de croissance
A61L 27/42 - Matériaux composites, c. à d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice inorganique
A61L 27/44 - Matériaux composites, c. à d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice macromoléculaire
A61L 27/58 - Matériaux au moins partiellement résorbables par le corps
An ankle prosthesis comprises a foot prosthesis. A lower ankle is pivotably secured to the foot prosthesis at an ankle joint. An upper ankle is connected to the lower ankle in a manner that permits vertical movement of the upper ankle relative to the lower ankle. A coupling spring is biased in an extended condition. The coupling spring is connected at a first end to the upper ankle. A second end of the coupling spring is movable in a first condition which is engaged to the lower ankle and in a second condition engaged to the foot prosthesis. Energy is stored in compression of the coupling spring when the coupling spring is in the first condition and energy is released from the coupling spring when the coupling spring is in the second condition.
A variable stiffness actuator comprises a flexure plate which comprises a first cantilevered beam that extends inwards from an outer periphery of the flexure plate. A housing and the flexure plate rotatable about a common joint axis. A first contactor is pivotably secured at a revolute joint to the housing. The first contactor rotates about the revolute joint at a first rotation axis. The first rotation axis offset on the housing from the joint axis. The first contactor engages the first cantilevered beam at a variable angle about the rotation axis to adjust a stiffness of a mechanical connection between the flexure plate and the housing.
Disclosed are systems, methods, and apparatuses to prevent actuation of a base device upon a non-target substrate. This invention is referred to as a smart trigger system in the present disclosure. The disclosed systems, methods, and apparatuses may include or utilize a detector generating a profile signal for a test substrate, a processing unit receiving the profile signal from the detector and determining whether the profile signal of the test substrate corresponds to a profile signal of a target substrate, and if so, generating an actuation signal. The disclosed systems, methods, and apparatuses may include or utilize an actuation unit which receives the actuation signal from the processing unit and permits the base device to actuate.
B25C 7/00 - Accessoires pour outils à clouer ou à agrafer, p.ex. supports
F16P 3/14 - Dispositifs de sécurité agissant en conjonction avec la commande ou le fonctionnement d'une machine; Commandes exigeant l'emploi simultané de plusieurs parties du corps humain avec dispositifs, p.ex. des éléments sensibles, qui agissent sur la commande ou le fonctionnement de la machine lorsqu'une partie du corps humain se trouve dans ou près de la zone de danger les dispositifs étant des cellules photo-électriques ou d'autres dispositifs sensibles sans contact mécanique
18.
COMPOSITE MATERIALS CONTAINING STRUCTURAL POLYSACCHARIDES AND STRUCTURAL PROTEINS AND FORMED FROM IONIC LIQUID COMPOSITIONS
Disclosed herein are composite materials, ionic liquid compositions for preparing the composite materials, and methods for using the composite materials prepared from the ionic liquid compositions. The composite materials typically include structural polysaccharides, structural proteins, and optionally including metal or metal oxide particles. The composite materials may be prepared from ionic liquid compositions comprising the structural polysaccharides, structural proteins, and the optional metal or metal oxide particles, where the ionic liquid is removed from the ionic liquid compositions to obtain the composite materials.
C08J 3/09 - Production de solutions, dispersions, latex ou gel par d'autres procédés que ceux utilisant les techniques de polymérisation en solution, en émulsion ou en suspension dans des liquides organiques
Systems and methods of fault tolerant power conversion include an inverter with a plurality of inverter phase legs. Each phase leg includes a positive switch, a negative switch, and a bi-directional midpoint switch. Redundant phase leg includes a positive redundant switch connected between the positive switches and the bi-directional midpoint switches. The redundant phase leg includes a negative redundant switch connected between the negative switches and the bi-directional midpoint switches. Upon detection of a fault condition in at least one switch of the plurality of inverted phase legs, one of the positive redundant switch and the negative redundant switch is closed to bypass at least one switch with the fault condition to maintain operation of the power converter.
H02H 7/22 - Circuits de protection de sécurité spécialement adaptés pour des machines ou appareils électriques de types particuliers ou pour la protection sectionnelle de systèmes de câble ou ligne, et effectuant une commutation automatique dans le cas d'un chan pour dispositifs de commutation
20.
AN ON-LINE DIAGNOSTIC METHOD FOR ELECTRONIC SWITCH FAULTS IN NEUTRAL-POINT-CLAMPED POWER CONVERTERS
Systems and methods of diagnosing open-circuit fault in power converters receives a neutral point current value, a switching state of the power converter, and load current values. At least one fault condition is identified based upon the switching state of the power converter and the load current values. The neutral point current value current value is compared to the at least one fault condition. An open circuit fault is determined to be present at the switching state of the power converter based upon the comparison.
H02H 7/122 - Circuits de protection de sécurité spécialement adaptés pour des machines ou appareils électriques de types particuliers ou pour la protection sectionnelle de systèmes de câble ou ligne, et effectuant une commutation automatique dans le cas d'un chan pour redresseurs pour convertisseurs ou redresseurs statiques pour onduleurs, c. à d. convertisseurs de courant continu en courant alternatif
21.
SHEAR HORIZONTAL-SURFACE ACOUSTIC WAVE SYSTEM AND METHOD FOR MEASUREMENT AND SPECIATION OF HYDROCARBONS IN GROUNDWATER
An exemplary embodiment of a method of detecting hydrocarbons in systems and methods for sensing analytes in an aqueous solution, include pretreating a water sample to provide a test sample. A flow cell includes at least one sensor with a polymer coating having at least partial selectivity for at least one analyte. The flow cell receives a test sample and a reference sample. At least one output signal from the at least one sensor is processed with a microcontroller using a model of the sensor response and a bank of Kalman filters to estimate a concentration of at least one analyte in the aqueous solution.
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (USA)
LOYOLA UNIVERSITY OF CHICAGO (USA)
Inventeur(s)
Becker, Daniel Paul
Holz, Richard C.
Heath, Tahirah K.
Reidl, Cory
Starus, Anna
Fast, Walter
Abrégé
Indoline sulfonamide compounds that can inhibit DapE and/or bacterial metallo-ß- lactamases (MBLs), such as NDM-1, are disclosed. Also disclosed are methods of treating an individual suffering from a bacterial infection using the indoline sulfonamide compounds disclosed herein.
C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 403/12 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
23.
SUBSTITUTED (4'-HYDROXYPHENYL)CYCLOALKANE COMPOUNDS AND USES THEREOF AS SELECTIVE AGONISTS OF THE ESTROGEN RECEPTOR BETA ISOFORM
Disclosed are substituted (4'-hydroxylphenyl)cycloalkane compounds and there use as selective agonists of the estrogen receptor beta isoform (??ß). The disclosed compounds may be formulated as pharmaceutical compositions and administered to treat diseases associated with ERß activity, such as proliferative diseases and disorders and/or psychiatric diseases or disorders.
C07C 39/17 - Composés comportant au moins un groupe hydroxyle ou O-métal lié à un atome de carbone d'un cycle aromatique à six chaînons polycycliques sans autre insaturation que celle des cycles aromatiques contenant d'autres cycles en plus des cycles aromatiques à six chaînons
C07C 39/23 - Composés comportant au moins un groupe hydroxyle ou O-métal lié à un atome de carbone d'un cycle aromatique à six chaînons polycycliques contenant des cycles aromatiques à six chaînons et d'autres cycles avec une insaturation autre que celle des cycles aromatiques
C07C 62/32 - Composés non saturés contenant des groupes hydroxyle ou O-métal
C07C 69/757 - Esters d'acides carboxyliques dont un groupe carboxyle est lié à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons dont l'un des groupes OH, O-métal, —CHO, céto, éther, acyloxy, des groupes , des groupes ou des groupes se trouve dans la partie acide
C07C 251/44 - Oximes avec des atomes d'oxygène de groupes oxyimino liés à des atomes d'hydrogène ou à des atomes de carbone de radicaux hydrocarbonés non substitués avec l'atome de carbone d'au moins un des groupes oxyimino faisant partie d'un cycle autre qu'un cycle aromatique à six chaînons
Passive wireless sensors include an antenna. The antenna receives a combined signal The combined signal includes a low frequency modulating signal modulated on a high frequency carrier wave. A demodulator receives the combined signal and extracts the modulating signal. A sensor receives the extracted modulating signal and produces an output signal with a lime delay indicative of a property to be sensed. A modulator receives the output signal and the high frequency carrier wave and modulates the output signal onto the high frequency carrier wave to create a combined output signal broadcast by the antenna.
In one embodiment a selectable-rate spring comprises a flexure bar connected to a rotatable shaft, the flexure bar having at least one arched portion. The selectable-rate spring also includes at least one rotational contactor connectable to a link member, wherein the rotational contactor rotates about an axis while maintaining contact with the arched portion of the flexure bar. As the rotational contactor rotates, it changes the connection stiffness between the rotatable shaft and the link member.
F16F 1/22 - Ressorts à lames avec moyens pour modifier la caractéristique d'élasticité
B25J 19/00 - Accessoires adaptés aux manipulateurs, p.ex. pour contrôler, pour observer; Dispositifs de sécurité combinés avec les manipulateurs ou spécialement conçus pour être utilisés en association avec ces manipulateurs
F16D 3/56 - Accouplements extensibles, c. à d. avec moyens permettant le mouvement entre parties accouplées durant leur entraînement avec pièces d'accouplement reliées par un ou plusieurs organes intermédiaires comportant des lamelles métalliques élastiques, des bielles élastiques ou des éléments analogues, p.ex. disposés radialement ou parallèlement à l'axe, les organes étant soumis ensemble à un effet de cisaillement sous l'action de la charge totale
26.
MODULATION OF KCNQ POTASSIUM CHANNEL ACTIVITY FOR TREATMENT OF PSYCHIATRIC DISORDERS AND THE SYMPTOMS THEREOF
Disclosed herein are compositions and methods for treating a psychiatric disorder or symptoms thereof in a patient. The compositions comprise a compound that modulates KCNQ (Kv7) potassium channel activity and the methods include administering an effective amount of the compound that modulates KCNQ (Kv7) potassium channel activity.
A61K 31/4427 - Pyridines non condensées; Leurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques
A61K 31/122 - Cétones ayant l'atome d'oxygène lié directement à un cycle, p.ex. quinones, vitamine K1, anthraline
A61K 31/4025 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p.ex. sulpiride, succinimide, tolmétine, buflomédil non condensés et contenant d'autres hétérocycles, p.ex. cromakalim
A61K 31/4725 - Isoquinoléines non condensées, p.ex. papavérine contenant d'autres hétérocycles
A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
A61P 25/18 - Antipsychotiques, c. à. d. neuroleptiques; Médicaments pour le traitement de la manie ou de la schizophrénie