A scaffold for bone-tissue engineering includes a mesh and a coating on the mesh. The mesh includes a plurality of offset layers of filaments of polyester. The coating covers the mesh and includes magnesium hydroxide/copper oxide nanoparticles suspended in gelatin. A method of constructing the scaffold comprises combining magnesium hydroxide/copper oxide nanoparticles with a gelatin solution and coating a polyester mesh with the combined magnesium hydroxide/copper oxide nanoparticle and gelatin solution.
2.
IMAGE CYTOMETRY-BASED NON-INVASIVE WHITE BLOOD CELL COUNT FROM FINGERTIP VIDEOS
Systems and methods for non-invasivc measurement of white blood cell (WBC) count acquire a plurality of images with a camera. A light source illuminates the target while a magnetic applies a magnetic field to the target. A processor receives the plurality of images. The processor is configured to extract at least one image attribute from each image of the plurality of images and apply a K-means clustering technique to the extracted image attributes to classify the plurality of images. The processor is configured to calculate a WBC rate from the classified images and use a cardiac output with the WBC rate to calculate the WBC count.
G01N 33/80 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir les groupes ou les types sanguins
G06F 18/23213 - Techniques non hiérarchiques en utilisant les statistiques ou l'optimisation des fonctions, p.ex. modélisation des fonctions de densité de probabilité avec un nombre fixe de partitions, p.ex. K-moyennes
G06T 7/73 - Détermination de la position ou de l'orientation des objets ou des caméras utilisant des procédés basés sur les caractéristiques
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p.ex. de la concentration des gaz dans le sang, de la valeur du pH du sang
3.
FLUID COOLED HEAT PIPE THERMAL MANAGEMENT SYSTEM FOR AN ELECTRIC MOTOR
An electrical machine includes a stator comprising a plurality of windings, each of the windings comprising a first plurality of legs connected to a second plurality of legs to form a coil configuration, each of the legs in the first plurality of legs and each of the legs in the second plurality of legs comprising a duct extending from a first end to a second end of a length portion of the leg; a rotor including a plurality of permanent magnets; and power electronics, the power electronics providing an AC power supply to the stator causing the rotor to rotate. A fluid cooled chamber extends between the power electronics and the stator, the fluid cooled chamber comprising a plurality of heat pipes coupled the stator and/or the power electronics.
H02K 3/24 - Enroulements caractérisés par la configuration, la forme ou le genre de construction du conducteur, p.ex. avec des conducteurs en barre avec des canaux ou des conduits pour un agent de refroidissement entre les conducteurs
H02K 9/10 - Dispositions de refroidissement ou de ventilation par un agent de refroidissement gazeux circulant en circuit fermé, dont une partie est à l'extérieur de l'enveloppe de la machine
H02K 9/19 - Dispositions de refroidissement ou de ventilation pour machines avec enveloppe fermée et circuit fermé de refroidissement utilisant un agent de refroidissement liquide, p.ex. de l'huile
H02K 9/20 - Dispositions de refroidissement ou de ventilation pour machines avec enveloppe fermée et circuit fermé de refroidissement utilisant un agent de refroidissement liquide, p.ex. de l'huile dans lesquels l'agent de refroidissement se vaporise dans l'enveloppe de la machine
H02K 3/22 - Enroulements caractérisés par la configuration, la forme ou le genre de construction du conducteur, p.ex. avec des conducteurs en barre formés de conducteurs creux
H02K 9/02 - Dispositions de refroidissement ou de ventilation par l'air ambiant s'écoulant à travers la machine
H02K 9/08 - Dispositions de refroidissement ou de ventilation par un agent de refroidissement gazeux circulant entièrement à l'intérieur de l'enveloppe de la machine
H02K 9/197 - Dispositions de refroidissement ou de ventilation pour machines avec enveloppe fermée et circuit fermé de refroidissement utilisant un agent de refroidissement liquide, p.ex. de l'huile dans lesquels l'espace du rotor ou du stator est étanche au fluide, p.ex. pour pourvoir le rotor et le stator d'agents de refroidissement différents
4.
SYSTEMS, METHODS, AND MEDIA FOR MULTIMODAL DATA COLLECTION AND ANALYSIS FOR CANCER SCREENING
In some embodiments, a system for cervical cancer diagnosis is provided, the system comprising: a display; a fluorescence imaging (FLI) subsystem; a diffuse reflectance spectroscopy (DRS) subsystem; a first camera optically coupled to the FLI subsystem; a second camera optically coupled to the DRS subsystem; a processor configured to: receive patient history data; receive FLI image data; receive DRS image data; determine, based on the patient history data, a first cancer diagnosis determination; determine, based on the FLI image data, a second cancer diagnosis determination; extract features from the DRS image data; provide the features to a trained machine learning model trained to predict a tissue optical property based on DRS data; determine, based on a predicted optical property received from the model, a third cancer diagnosis determination; determine a cancer diagnosis based on the first, second, and third cancer diagnosis determinations; and visually present the cancer diagnosis.
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (USA)
Inventeur(s)
Gilat-Schmidt, Tal
Grönberg, Fredrik
Sjölin, Martin
Fan, Jiahua
Thomsen, Brian, W.
Thibault, Jean-Baptiste
Hsieh, Jiang
Danielsson, Mats
Yang, Yirong
Pelc, Norbert
Wang, Adam, S.
Abrégé
Methods and systems are provided for downsampling detector data in a computed tomography imaging system. In an example, a method for a photon-counting computed tomography (PCCT) system includes, during a scan of an imaging subject, obtaining detector data from a photon-counting detector of the PCCT system, the detector data comprising, for each pixel or detector element of the photon-counting detector, photon counts partitioned into a plurality of energy bins based on an energy imparted by each photon on the photon-counting detector, applying a bin factor to the plurality of energy bins for each pixel to downsample the plurality of energy bins into a reduced number of energy bins, and reconstructing one or more images from the reduced number of energy bins.
G01N 23/046 - Recherche ou analyse des matériaux par l'utilisation de rayonnement [ondes ou particules], p.ex. rayons X ou neutrons, non couvertes par les groupes , ou en transmettant la radiation à travers le matériau et formant des images des matériaux en utilisant la tomographie, p.ex. la tomographie informatisée
G01T 1/166 - Scintigraphie impliquant un mouvement relatif entre le détecteur et le sujet
G06T 5/10 - Amélioration ou restauration d'image en utilisant le filtrage dans le domaine non spatial
7.
SYNTHESIS AND EVALUATION OF NOVEL (4-HYDROXYPHENYL) SUBSTITUTED CARBOCYCLES AS POTENT AND SELECTIVE ESTROGEN RECEPTOR BETA AGONISTS
Disclosed are 4-hydroxylphenyl substituted carbocycles and there use as selective agonists of the estrogen receptor beta isoform (ERβ). The disclosed compounds may be formulated as pharmaceutical compositions and administered to treat diseases associated with ER activity, such as proliferative diseases and disorders and/or psychiatric diseases or disorders.
Disclosed herein are deuterated compounds and transition metal catalyzed methods for making deuterated compounds. The disclosed methods are regioselective and enantioselective and may be utilized to prepare isomerically and/or enantiomerically pure or enriched deuterated compounds. The disclosed methods also may be modified in order to prepared fluorinated compounds.
C07C 67/38 - Préparation d'esters d'acides carboxyliques par réaction avec du monoxyde de carbone ou des formiates par addition à une liaison non saturée carbone-carbone
9.
CONTINUOUS HEAVY METAL WATER CONTAMINANT MEASUREMENT SYSTEM
A resonator includes a body, the body having a planar surface. An aperture through the body is configured to receive a tube configured for a fluid to be tested. A gap extends into the body from the planar surface to the aperture. At least one cut extends through the body from the planar surface towards the aperture. The at least one cut extends across the gap.
G01N 22/00 - Recherche ou analyse des matériaux par l'utilisation de micro-ondes ou d'ondes radio, c. à d. d'ondes électromagnétiques d'une longueur d'onde d'un millimètre ou plus
The present disclosure provides an apparatus comprising a primary treatment system configured to remove solids from an untreated fluid to generate a primary treated fluid. The apparatus further comprises an oxidation treatment system including an inlet configured to receive the primary treated fluid, an ozone inlet configured to receive ozone from an ozone generator, and an outlet configured to dispense secondary treated fluid. The apparatus may further comprise a controller in electrical communication with the ozone generator. The controller is programmed to regulate the flow of ozone through the oxidation treatment system such that an effective amount of ozone contacts the primary treated fluid to generate the secondary treated fluid. In some embodiments, the secondary treated fluid discharging from the oxidation treatment system has a chemical oxygen demand (COD) removal level of greater than 85%.
Described here are systems and methods that utilize visual imagery and an optical flow-based computer vision algorithm to measure river velocity in streams or other flowing bodies of water. The systems and methods described in the present disclosure overcome the barriers of conventional flow measurement techniques by providing a fast, non-intrusive, remote method to measure peak flows.
G01B 21/18 - Dispositions pour la mesure ou leurs détails, où la technique de mesure n'est pas couverte par les autres groupes de la présente sous-classe, est non spécifiée ou est non significative pour mesurer la profondeur
G01F 1/00 - Mesure du débit volumétrique ou du débit massique d'un fluide ou d'un matériau solide fluent, dans laquelle le fluide passe à travers un compteur par un écoulement continu
A multi -port converter includes a hybrid energy storage system (HESS) that provides a faster dynamic response to load changes than prior art systems, and enables either downsizing of the main energy storage system (ESS) to increase the life of the main ESS (e.g. energy battery), or retaining the same size ESS and increasing the range or life of the power source. The multi-port convertor can advantageously result in lower investment and maintenance costs, and can also advantageously provide a path for inputs to directly feed the load. All these benefits can be achieved while reducing the number of active switches and overall component count as compared to prior art systems.
H02M 7/00 - Transformation d'une puissance d'entrée en courant alternatif en une puissance de sortie en courant continu; Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant alternatif
H02M 3/00 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant continu
Disclosed herein are methods for treating wastewater grit to inactivate any pathogens that are present in the grit and for forming a solidified material comprising wastewater grit such as a chemically bonded phosphate ceramic (CBPC). The CBPC may be utilized in methods for repairing depressions in a road surface that include applying the uncured CBPC to the depression in the road surface and allowing the CBPC to cure.
C04B 28/34 - Compositions pour mortiers, béton ou pierre artificielle, contenant des liants inorganiques ou contenant le produit de réaction d'un liant inorganique et d'un liant organique, p.ex. contenant des ciments de polycarboxylates contenant des liants phosphate froids
E01C 23/09 - Dispositifs ou aménagements pour travailler la surface terminée; Dispositifs pour réparer la surface des revêtements endommagés pour rogner les bords du revêtement
C04B 103/60 - Agents de protection contre la dégradation chimique, physique ou biologique
C02F 1/52 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par floculation ou précipitation d'impuretés en suspension
A stator winding includes a plurality of conductors including ducts. The ducts can be connected to a heat pipe or a conduit providing a coolant flow to directly cool the winding. The heat pipe can be connected to a heat exchanger that includes a coolant flow. The stator winding can be produced using additive manufacturing, with hollow ducts extending through leg sections and solid end sections. The heat exchanger can also be additively manufactured. A circuit for driving an electrical machine can be in thermal communication with the heat exchanger, such that the thermal system manages both the stators and the drive circuit.
H02K 3/28 - Schémas d'enroulements ou de connexions entre enroulements
H02K 3/00 - MACHINES DYNAMO-ÉLECTRIQUES - Détails des enroulements
H02K 3/04 - Enroulements caractérisés par la configuration, la forme ou le genre de construction du conducteur, p.ex. avec des conducteurs en barre
H02K 3/22 - Enroulements caractérisés par la configuration, la forme ou le genre de construction du conducteur, p.ex. avec des conducteurs en barre formés de conducteurs creux
H02K 3/24 - Enroulements caractérisés par la configuration, la forme ou le genre de construction du conducteur, p.ex. avec des conducteurs en barre avec des canaux ou des conduits pour un agent de refroidissement entre les conducteurs
H02K 3/26 - Enroulements caractérisés par la configuration, la forme ou le genre de construction du conducteur, p.ex. avec des conducteurs en barre constitués par des conducteurs imprimés
15.
MATERIALS BASED ON NATURAL POLLEN GRAINS AND USES THEREOF
Disclosed herein are methods for preparing sporopollenin exine capsules (SECs) and methods for preparing composite materials that comprise SECs that utilize ionic liquid compositions. The composite materials typically include structural polymers and the SECs, and the SECs optionally may encapsulate useful materials, such as flame retardant materials, phase change materials, and therapeutic materials, such as probiotics and prebiotics. The composite materials may be prepared from ionic liquid compositions comprising the structural polymers and the SECs which optionally may encapsulate the useful materials, where the ionic liquid is removed from the ionic liquid compositions to obtain the composite materials comprising the SECs. The composite materials may be used in applications include (1) wound dressings to cool down damaged tissue; (2) as textiles to regulate the body temperature; (3) in building materials to regulate building temperature; (3) to provide fire retardation in textile and building materials; and (4) to deliver and protect probiotics and prebiotics from acidic conditions and digestive enzymes in the stomach, so that they fully retain their biological activity in the guts.
The present invention provides novel compounds with increased plasma stability that modulate PAR1 signaling, and methods of using them. The present invention provides methods of using the novel PAR1 modulators for the treatment of a number of disorders, including, inflammation, thrombosis, kidney disease, sepsis, stroke, as well as proliferation- related diseases. Furthermore, the PAR1 modulators of the present invention provide cytoprotection for certain cells and tissues, for example, in coronary blood vessels and tissues after a heart attack.
C07D 231/02 - Composés hétérocycliques contenant des cycles diazole-1, 2 ou diazole-1, 2 hydrogéné non condensés avec d'autres cycles
C07D 233/54 - Composés hétérocycliques contenant des cycles diazole-1, 3 ou diazole-1, 3 hydrogéné, non condensés avec d'autres cycles comportant deux liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques
C07D 263/02 - Composés hétérocycliques contenant des cycles oxazole-1, 3 ou oxazole-1, 3 hydrogéné non condensés avec d'autres cycles
17.
PROCESS FOR CONTROLLED ADSORPTION AND DESORPTION OF PHOSPHATE FROM LIQUIDS USING PHOSPHATE-SELECTIVE PROTEINS
The present invention provides systems and methods for concentrating and recovering phosphate from samples. The method comprises using immobilized PBP for binding phosphate and a desorption solution having a pH of 11 or greater to recover phospoate from a sample when the phosphate is found at very low detection levels.
C07K 17/14 - Peptides immobilisés sur, ou dans, un support inorganique
C12P 1/04 - Préparation de composés ou de compositions, non prévue dans les groupes , utilisant des micro-organismes ou des enzymes; Procédés généraux de préparation de composés ou de compositions utilisant des micro-organismes ou des enzymes utilisant des bactéries
C12Q 1/02 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des micro-organismes viables
G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides
The present invention provides novel fluorinated analogs of fentanyl and methods of use. Specifically, the analogs of fentanyl can be used for the treatment of pain, including inflammation associated pain or chronic pain.
The present invention provides a stretchable hydrogel able to stretch over 200 times its length, methods of preparing such a hydrogel and compositions comprising the hydrogel.
A61L 27/40 - Matériaux composites, c. à d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent
A61L 31/12 - Matériaux composites, c. à d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent
B32B 27/06 - Produits stratifiés composés essentiellement de résine synthétique comme seul composant ou composant principal d'une couche adjacente à une autre couche d'une substance spécifique
20.
METHOD AND APPARATUS FOR NON-INVASIVE HEMOGLOBIN LEVEL PREDICTION
An image-based hemoglobin estimation tool for measuring hemoglobin can be embedded in hand held devices such as smartphones, and similar known and to be developed technology. The hand-held device acquires video data of a finger illuminated from the dorsal surface by a first near infrared light responsive to hemoglobin and a second near infrared light near responsive to plasma. The acquired video is segmented into frames and processed to produce a Photoplethysmography (PPG) waveform. The features of the PPG waveform can then be identified, and the waveform and corresponding features evaluated by a predictive hemoglobin model. The predictive hemoglobin model can be provided at a remote computer, enabling non- invasive hemoglobin analysis from point of care locations. Near infrared lights of 850 nm and 1070 nm are particularly effective in the process.
A computer implemented method for selecting m appropriately sized meter tor use in a selected application implemented by a computer processor Implementing instructions stored in a non-transient memory is described. The instructions include receiving utility meter data transmitted from a plurality of utility meters, each utility meter being installed at a unique utility monitoring location, identifying incorrectly sized utility meters based on utility meter data for particular utility meters feat displays quantization effects, and selecting an appropriate meter based on the identification of the utility meters displaying quantization effects.
An anchoring device for securing objects within a rack mount system using fasteners. The anchoring device has a base portion with flush and anchor faces, the anchor faces defining apertures. Hooks are provided for securing the anchoring device to the rack mount system. Each hook has a horizontal arm with base and distal ends, and a vertical arm with upper and lower ends. Each base end is coupled to the anchor face and each distal end is coupled to the upper end of one vertical arm. Hooks are receivable within openings in the rack mount system to secure the anchoring device. The apertures in the base portion align with the openings in the rack mount system when the anchoring device is secured to the rack mount system such that the object is securable to the rack mount system by engaging the fasteners with the apertures in the anchoring device.
Methods and systems for rating fiduciaries that govern assets. Governance variables relating to at least one of environmental and social factors for governing the assets that impact performance of the assets and related financial securities are collected. Control variables that also impact the performance are assigned. A collection of actual test values are compiled for the governance variables, the control variables, and the performance for test assets within the assets. A weight factor indicating the impacts on the performance by each of the governance variables and the control variables is assigned. A rating model incorporating the governance variables and the control variables and each respective weight factor is constructed. Actual asset values for the governance variables and the control variables for a given asset within the assets are collected. A given fiduciary within the fiduciaries that governs the given asset is rated using the rating model with the actual asset values collected.
A device for processing a surface of a work piece. A motor is configured to produce a rotary force. A driving pulley is operatively coupled to the motor such that the rotary force produced by the motor causes rotation of the driving pulley. A belt is operatively coupled to the driving pulley such that rotation of the driving pulley causes rotation of the belt. A second pulley is also operatively coupled to the belt such that rotation of the belt causes rotation of the second pulley. Bristles are coupled to the belt and extend away from the belt. The rotary force produced by the motor causes the plurality of bristles to move relative to the motor. The surface of the work piece is processed when the bristles contacts the surface while the bristles are moving.
B24B 23/06 - Machines de meulage portatives, p.ex. à guidage manuel; Accessoires à cet effet avec des courroies abrasives, p.ex. avec des courroies sans fin; Accessoires à cet effet
B24B 21/12 - Machines ou dispositifs utilisant des bandes de meulage ou de polissage; Accessoires à cet effet pour meuler des surfaces planes munis d'une roue de contact ou d'un tambour qui pousse la courroie contre la pièce à meuler
B24D 13/10 - Meules dont le corps comporte des parties flexibles au travail, p.ex. meules souples de polissage; Accessoires pour le montage de ces meules travaillant par leur périphérie comprenant des assemblages de brosses
Split-crank pedaling devices and methods of operation support patient use and rehabilitation, particularly for stroke patients. A split-crank pedaling device includes first and second crank assemblies. First and second motors are operably connected to the first and second crank assemblies. A first shaft sensor produces an indication of a position of the shaft of the first crank assembly. A second shaft sensor produces an indication of a position of the shaft of the second crank assembly. A controller is communicatively connected to the first and second motors and the first and second shaft sensors and calculates a phase error between the positions of the first and second shafts and a predetermined phase relationship between the first and second shafts. The controller operates at least one of the first motor or the second motor to provide a supplemental torque to one of the first crank assembly and the second crank assembly.
A63B 23/04 - Appareils d'exercice spécialement adaptés à des parties déterminées du corps pour les membres, c. à d. supérieurs ou inférieurs, p.ex. en même temps pour les membres inférieurs
26.
MEDICAL AND DENTAL INTEGRATED MULTIPHASIC BIOMATERIALS FOR SINGLE OR MULTI-TISSUE RECONSTRUCTION/REGENERATION
Disclosed herein are composite materials which may be used as biomedical materials or constructs. The disclosed biomedical materials or constructs may be multiphasic and typically provide a surface for cell growth. The disclosed biomedical materials and constructs typically comprise conjugable and/or adhesive chemical moieties, such as hydroxylated aromatic moieties, which facilitate integration of the components of the biomedical materials and constructs. Suitable hydroxylated aromatic moieties may include dihydoxybenzene (DHB) moieties, such as 1,2-DHB moieities, and derivatives thereof.
SUBSTITUTED (4'-HYDROXYPHENYL)CYCLOALKANE AND (4'-HYDROXYPHENYL)CYCLOALKENE COMPOUNDS AND USES THEREOF AS SELECTIVE AGONISTS OF THE ESTROGEN RECEPTOR BETA ISOFORM FOR ENHANCED MEMORY CONSOLIDATION
Disclosed are substituted (4'-hydroxylphenyl)cycloalkane compounds and substituted (4'-hydroxylphenyl)cycloalkene compounds and there use as selective agonists of the estrogen receptor beta isoform (ERβ). The disclosed compounds may be formulated as pharmaceutical compositions and administered for treating diseases associated with ER activity, such as neurological, psychiatric, and/or cell proliferative diseases and disorders as well as for enhancing memory consolidation in subjects in need thereof.
C07C 39/17 - Composés comportant au moins un groupe hydroxyle ou O-métal lié à un atome de carbone d'un cycle aromatique à six chaînons polycycliques sans autre insaturation que celle des cycles aromatiques contenant d'autres cycles en plus des cycles aromatiques à six chaînons
C07D 311/00 - Composés hétérocycliques contenant des cycles à six chaînons comportant un atome d'oxygène comme unique hétéro-atome du cycle, condensés avec d'autres cycles
A61K 31/351 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p.ex. fungichromine ayant des cycles à six chaînons avec un oxygène comme seul hétéro-atome d'un cycle non condensés avec un autre cycle
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p.ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
28.
SYNTHETIC PROSTHESIS FOR USE IN OSTEO-ODONTO-KERATOPROSTHESIS (OOKP) SURGERY
Disclosed herein is a prosthesis that may be used to replace standard prosthetic material used in osteo-odonto-keratoprosthesis (OOKP) surgery. The disclosed prosthesis is not prepared from tissue removed from a patient's tooth and jaw bone, but rather is a synthetic prosthesis. The synthetic prosthesis typically includes a solid part for supporting an optical cylinder and a porous part that facilitates bio-integration of the implanted prosthesis into the patient's eye.
Disclosed are devices for controlling movement of an aerial bucket via a hydraulic system. The hydraulic system has a plurality of valves that control movement of the aerial bucket. A control head of the device has a joystick that is moveable and a plurality of encoders that detect movement of the joystick. A valve actuator manifold of the device is coupled between the control head and the hydraulic system and supports a plurality of valve actuators moveably coupled to the plurality of valves. A plurality of servo drive systems supported by the valve actuator manifold is coupled to the plurality of valve actuators and is controllable to move the plurality of valve actuators. A processor module of the device is in communication with the plurality of encoders and the plurality of servo drive systems. The processor module controls the plurality of servo drive systems based on input from the plurality of encoders such that moving the joystick controls movement of the aerial bucket.
B66F 11/04 - Dispositifs de levage spécialement adaptés à des buts particuliers, non prévus ailleurs pour plates-formes ou cabines mobiles, p.ex. sur des véhicules, permettant à des ouvriers d'occuper toute position convenable pour exécuter les travaux demandés
F15B 11/16 - Systèmes de servomoteurs dépourvus d'asservissement avec plusieurs servomoteurs
G06F 3/0338 - Dispositifs de pointage déplacés ou positionnés par l'utilisateur; Leurs accessoires avec détection du déplacement linéaire ou angulaire limité d’une partie agissante du dispositif à partir d’une position neutre, p.ex. manches à balai isotoniques ou isométriques
Disclosed are systems and methods of sensor fusion for exemplary use with robotic navigation control. Systems and methods include providing local estimates of a target location from a plurality of expert modules that process sensor data. The local estimates are weighted based upon a Mahalanobis distance from an expected estimated value and based upon a Euclidean distance between the local estimates. The local estimates are fused in a Bayesian fusion center based upon the weight given to each of the local estimates.
G05D 1/00 - Commande de la position, du cap, de l'altitude ou de l'attitude des véhicules terrestres, aquatiques, aériens ou spatiaux, p.ex. pilote automatique
31.
STORAGE MEDIA AND POWDER FORMULATIONS FOR AVULSED TEETH AND EXPLANTED TISSUES COMPRISING FIBROBLASTS
Disclosed herein are methods and compositions for preserving avulsed teeth and/or explanted tissue. The disclosed methods for preserving avulsed teeth and/or explanted tissue typically include placing the avulsed teeth and/or explanted tissue in a preservation solution comprising at least about 2.75 g/L sugar. Suitable explanted tissues for the disclosed methods may include explanted tissues comprising fibroblasts, such as dental tissue and/or oral tissue. The preservation solution of the disclosed preservation methods may include additional components which may include but are not limited to inorganic salts, amino acids, vitamins, and buffering agents. The preservation solution may be prepared from a powder formulation having a long shelf-life.
Disclosed herein are composite materials, ionic liquid compositions for preparing the composite materials, and methods for using the composite materials prepared from the ionic liquid compositions. The composite materials typically include structural polymers and nitric oxide releasing agents, and preferably photo-reactive nitric oxide releasing compounds or complexes. The composite materials may be prepared from ionic liquid compositions comprising the structural polymers and the nitric oxide releasing agent, where the ionic liquid is removed from the ionic liquid compositions to obtain the composite materials. The composite materials may be used in applications include dressing for wounds, where the nitric oxide releasing agents may be induced to release nitric oxide in order to inhibit microbial growth and promote healing.
A61L 15/18 - Bandages, pansements ou garnitures absorbant les fluides physiologiques tels que l'urine, le sang, p.ex. serviettes hygiéniques, tampons contenant des matériaux inorganiques
Disclosed herein are processes, systems, and catalysts for improving pyrolysis technology. The disclosed processes and systems utilize a catalyst to increase pyrolysis gas (py-gas) and decrease bio-oil yields in pyrolysis reactions. The disclosed catalysts may include biochar derived from pyrolysis of industrial residuals, such as pyrolysis of wastewater biosolids (WB) and paper mill sludge (PMS). The disclosed catalysts also may include ash derived from incineration of wastewater biosolids ("biosolids incineration ash" (BIA)).
C02F 11/10 - Traitement des boues d'égout; Dispositifs à cet effet par pyrolyse
C10L 5/46 - Combustibles solides à base essentielle de matières d'origine non minérale de boues d'égouts, d'ordures ménagères, de gadoues
C10K 3/02 - Modification de la composition chimique des gaz combustibles contenant l'oxyde de carbone en vue de produire un carburant amélioré, p.ex. un carburant de pouvoir calorifique différent qui peut ne pas contenir d'oxyde de carbone par traitement catalytique
Scaffolds for use in bone tissue engineering include a skeleton and a host component. Methods of preparation of scaffolds include identification of biodegradation properties for the skeleton and the host component. The skeleton is constructed to form a three- dimensional shape. The skeleton is constructed of a first material and has a first rate of biodegradation. The host component fills the three-dimensional shape formed by the skeleton. The host component is constructed of a second material and has a second rate of biodegradation. The first rate of biodegradation is slower than the second rate of biodegradation.
A61K 38/18 - Facteurs de croissance; Régulateurs de croissance
A61L 27/58 - Matériaux au moins partiellement résorbables par le corps
A61L 27/42 - Matériaux composites, c. à d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice inorganique
A61L 27/44 - Matériaux composites, c. à d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice macromoléculaire
An ankle prosthesis comprises a foot prosthesis. A lower ankle is pivotably secured to the foot prosthesis at an ankle joint. An upper ankle is connected to the lower ankle in a manner that permits vertical movement of the upper ankle relative to the lower ankle. A coupling spring is biased in an extended condition. The coupling spring is connected at a first end to the upper ankle. A second end of the coupling spring is movable in a first condition which is engaged to the lower ankle and in a second condition engaged to the foot prosthesis. Energy is stored in compression of the coupling spring when the coupling spring is in the first condition and energy is released from the coupling spring when the coupling spring is in the second condition.
Disclosed are systems, methods, and apparatuses to prevent actuation of a base device upon a non-target substrate. This invention is referred to as a smart trigger system in the present disclosure. The disclosed systems, methods, and apparatuses may include or utilize a detector generating a profile signal for a test substrate, a processing unit receiving the profile signal from the detector and determining whether the profile signal of the test substrate corresponds to a profile signal of a target substrate, and if so, generating an actuation signal. The disclosed systems, methods, and apparatuses may include or utilize an actuation unit which receives the actuation signal from the processing unit and permits the base device to actuate.
B25C 7/00 - Accessoires pour outils à clouer ou à agrafer, p.ex. supports
F16P 3/14 - Dispositifs de sécurité agissant en conjonction avec la commande ou le fonctionnement d'une machine; Commandes exigeant l'emploi simultané de plusieurs parties du corps humain avec dispositifs, p.ex. des éléments sensibles, qui agissent sur la commande ou le fonctionnement de la machine lorsqu'une partie du corps humain se trouve dans ou près de la zone de danger les dispositifs étant des cellules photo-électriques ou d'autres dispositifs sensibles sans contact mécanique
A variable stiffness actuator comprises a flexure plate which comprises a first cantilevered beam that extends inwards from an outer periphery of the flexure plate. A housing and the flexure plate rotatable about a common joint axis. A first contactor is pivotably secured at a revolute joint to the housing. The first contactor rotates about the revolute joint at a first rotation axis. The first rotation axis offset on the housing from the joint axis. The first contactor engages the first cantilevered beam at a variable angle about the rotation axis to adjust a stiffness of a mechanical connection between the flexure plate and the housing.
Disclosed are fluorescent markers that include a known number of copies of a fluorescently-labeled protein regularly interspersed along the length of the fluorescent marker. The fluorescent markers may be used to quantify fluorescently-labeled samples in fluorescent microscopy.
Disclosed herein are composite materials, ionic liquid compositions for preparing the composite materials, and methods for using the composite materials prepared from the ionic liquid compositions. The composite materials typically include structural polysaccharides, structural proteins, and optionally including metal or metal oxide particles. The composite materials may be prepared from ionic liquid compositions comprising the structural polysaccharides, structural proteins, and the optional metal or metal oxide particles, where the ionic liquid is removed from the ionic liquid compositions to obtain the composite materials.
C08J 3/09 - Production de solutions, dispersions, latex ou gel par d'autres procédés que ceux utilisant les techniques de polymérisation en solution, en émulsion ou en suspension dans des liquides organiques
Systems and methods of fault tolerant power conversion include an inverter with a plurality of inverter phase legs. Each phase leg includes a positive switch, a negative switch, and a bi-directional midpoint switch. Redundant phase leg includes a positive redundant switch connected between the positive switches and the bi-directional midpoint switches. The redundant phase leg includes a negative redundant switch connected between the negative switches and the bi-directional midpoint switches. Upon detection of a fault condition in at least one switch of the plurality of inverted phase legs, one of the positive redundant switch and the negative redundant switch is closed to bypass at least one switch with the fault condition to maintain operation of the power converter.
H02H 7/22 - Circuits de protection de sécurité spécialement adaptés pour des machines ou appareils électriques de types particuliers ou pour la protection sectionnelle de systèmes de câble ou ligne, et effectuant une commutation automatique dans le cas d'un chan pour dispositifs de commutation
41.
AN ON-LINE DIAGNOSTIC METHOD FOR SWITCH FAULTS IN POWER CONVERTERS
Systems and methods of diagnosing open-circuit fault in power converters receives a neutral point current value, a switching state of the power converter, and load current values. At least one fault condition is identified based upon the switching state of the power converter and the load current values. The neutral point current value current value is compared to the at least one fault condition. An open circuit fault is determined to be present at the switching state of the power converter based upon the comparison.
H02H 7/122 - Circuits de protection de sécurité spécialement adaptés pour des machines ou appareils électriques de types particuliers ou pour la protection sectionnelle de systèmes de câble ou ligne, et effectuant une commutation automatique dans le cas d'un chan pour redresseurs pour convertisseurs ou redresseurs statiques pour onduleurs, c. à d. convertisseurs de courant continu en courant alternatif
42.
SHEAR HORIZONTAL-SURFACE ACOUSTIC WAVE SYSTEM AND METHOD FOR MEASUREMENT AND SPECIAION OF HYDROCARBONS IN GROUNDWATER
An exemplary embodiment of a method of detecting hydrocarbons in Systems and methods for sensing analytes in an aqueous solution, include pretreating a water sample to provide a test sample. A flow cell includes at least one sensor with a polymer coating having at least partial selectivity for at least one analyte. The flow cell receives a test sample and a reference sample. At least one output signal from the at least one sensor is processed with a microcontroller using a model of the sensor response and a bank of Kalman filters to estimate a concentration of at least one analyte in the aqueous solution.
The present invention is directed to compounds that specifically target DUSP5 and act as antagonists of that enzyme. Such compounds are useful in the treatment of various conditions including, but not limited to vascular anomalies, cancer, and macular degeneration.
C07C 309/33 - Acides sulfoniques ayant des groupes sulfo liés à des atomes de carbone de cycles aromatiques à six chaînons d'un squelette carboné de cycles aromatiques à six chaînons faisant partie de systèmes cycliques condensés
C07C 309/88 - Halogénures d'acides sulfoniques ayant des groupes halogénosulfonyle liés à des atomes de carbone de cycles aromatiques à six chaînons d'un squelette carboné contenant des atomes d'azote, ne faisant pas partie de groupes nitro ou nitroso, liés au squelette carboné
Disclosed herein are spectrofluorometric adaptors for cell holders in spectrofluorometers and spectrofluorometric methods that enable fluorescence detection from surfaces of a microcell in conventional horizontal-beam spectrofluorometers equipped with standard cell holders and having multiple excitation channels.
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (USA)
Inventeur(s)
Becker, Daniel, Paul
Holz, Richard, C.
Heath, Tahirah, K.
Reidl, Cory
Starus, Anna
Fast, Walter
Abrégé
Indoline sulfonamide compounds that can inhibit DapE and/or bacterial metallo-β- lactamases (MBLs), such as NDM-1, are disclosed. Also disclosed are methods of treating an individual suffering from a bacterial infection using the indoline sulfonamide compounds disclosed herein.
C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 403/12 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
46.
SUBSTITUTED (4'-HYDROXYPHENYL)CYCLOALKANE COMPOUNDS AND USES THEREOF AS SELECTIVE AGONISTS OF THE ESTROGEN RECEPTOR BETA ISOFORM
Disclosed are substituted (4'-hydroxylphenyl)cycloalkane compounds and there use as selective agonists of the estrogen receptor beta isoform (ΕΚβ). The disclosed compounds may be formulated as pharmaceutical compositions and administered to treat diseases associated with ERβ activity, such as proliferative diseases and disorders and/or psychiatric diseases or disorders.
C07C 39/17 - Composés comportant au moins un groupe hydroxyle ou O-métal lié à un atome de carbone d'un cycle aromatique à six chaînons polycycliques sans autre insaturation que celle des cycles aromatiques contenant d'autres cycles en plus des cycles aromatiques à six chaînons
C07C 39/23 - Composés comportant au moins un groupe hydroxyle ou O-métal lié à un atome de carbone d'un cycle aromatique à six chaînons polycycliques contenant des cycles aromatiques à six chaînons et d'autres cycles avec une insaturation autre que celle des cycles aromatiques
C07C 62/32 - Composés non saturés contenant des groupes hydroxyle ou O-métal
C07C 69/757 - Esters d'acides carboxyliques dont un groupe carboxyle est lié à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons dont l'un des groupes OH, O-métal, —CHO, céto, éther, acyloxy, des groupes , des groupes ou des groupes se trouve dans la partie acide
C07C 251/44 - Oximes avec des atomes d'oxygène de groupes oxyimino liés à des atomes d'hydrogène ou à des atomes de carbone de radicaux hydrocarbonés non substitués avec l'atome de carbone d'au moins un des groupes oxyimino faisant partie d'un cycle autre qu'un cycle aromatique à six chaînons
Passive wireless sensors include an antenna. The antenna receives a combined signal The combined signal includes a low frequency modulating signal modulated on a high frequency carrier wave. A demodulator receives the combined signal and extracts the modulating signal. A sensor receives the extracted modulating signal and produces an output signal with a lime delay indicative of a property to be sensed. A modulator receives the output signal and the high frequency carrier wave and modulates the output signal onto the high frequency carrier wave to create a combined output signal broadcast by the antenna.
Disclosed herein are composite materials, ionic liquid compositions for preparing the composite materials, and methods for using the composite materials prepared from the ionic liquid compositions. The composite materials typically include structural polysaccharides and preferably include macrocyclic compounds. The composite materials may be prepared from ionic liquid compositions comprising the structural polysaccharides and preferably the macrocyclic compounds dissolved in the ionic liquid, where the ionic liquid is removed from the ionic liquid compositions to obtain the composite materials.
In one embodiment a selectable-rate spring comprises a flexure bar connected to a rotatable shaft, the flexure bar having at least one arched portion. The selectable-rate spring also includes at least one rotational contactor connectable to a link member, wherein the rotational contactor rotates about an axis while maintaining contact with the arched portion of the flexure bar. As the rotational contactor rotates, it changes the connection stiffness between the rotatable shaft and the link member.
F16F 1/22 - Ressorts à lames avec moyens pour modifier la caractéristique d'élasticité
F16D 3/56 - Accouplements extensibles, c. à d. avec moyens permettant le mouvement entre parties accouplées durant leur entraînement avec pièces d'accouplement reliées par un ou plusieurs organes intermédiaires comportant des lamelles métalliques élastiques, des bielles élastiques ou des éléments analogues, p.ex. disposés radialement ou parallèlement à l'axe, les organes étant soumis ensemble à un effet de cisaillement sous l'action de la charge totale
B25J 19/00 - Accessoires adaptés aux manipulateurs, p.ex. pour contrôler, pour observer; Dispositifs de sécurité combinés avec les manipulateurs ou spécialement conçus pour être utilisés en association avec ces manipulateurs
50.
PRESERVATION OF METHANOGENIC, HYDROGEN-UTILIZING MICROBIAL CULTURES
Disclosed are drying methods for preserving cultures of methanogens and dried cultures obtained by the disclosed drying methods. The dried cultures of methanogens may be reconstituted and utilized to bioaugment anaerobic digester systems.
Disclosed herein are methods for improving performance of an anaerobic digester system. The methods typically include adding a culture comprising hydrogenoirophie methanogens to the system, otherwise referred to as bioaugmentation.
Disclosed are dithio compounds that include a quenched fluorophore and a non-fluoropbore peptide linked via a dithio bond to the fluorophore The dithio compounds may be used in methods for detecting thiol-containing compounds or dithio-containing compounds The dithio compounds al&o may be used as cellular probes where the peptide portion of the compounds targets the compounds to a specific cellular location.
G01N 33/52 - Utilisation de composés ou de compositions pour des recherches colorimétriques, spectrophotométriques ou fluorométriques, p.ex. utilisation de bandes de papier indicateur
G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides
C07K 2/00 - Peptides à nombre indéterminé d'amino-acides; Leurs dérivés
53.
CHEMICAL FRAGMENT SCREENING AND ASSEMBLY UTILIZING COMMON CHEMISTRY FOR NMR PROBE INTRODUCTION AND FRAGMENT LINKAGE
Disclosed herein are methods related to drug development- The methods typically include steps whereby two chemical fragments are identified as binding to a target protein and subsequently the two chemical fragments are joined to create a new chemical entity that binds to the target protein.
Disclosed herein are methods related to drug development. The methods typically include steps whereby an existing drug is modified to obtain a derivative form or whereby an analog of an existing drug is identified in order to obtain a new therapeutic agent that preferably has a higher efficacy and fewer side effects than the existing drug.
G01N 33/53 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet
G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides
Disclosed herein are compositions and methods for treating a psychiatric disorder or symptoms thereof in a patient. The compositions comprise a compound that modulates KCNQ (Kv7) potassium channel activity and the methods include administering an effective amount of the compound that modulates KCNQ (Kv7) potassium channel activity.
A61K 31/4427 - Pyridines non condensées; Leurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques
A61K 31/4725 - Isoquinoléines non condensées, p.ex. papavérine contenant d'autres hétérocycles
A61K 31/4025 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p.ex. sulpiride, succinimide, tolmétine, buflomédil non condensés et contenant d'autres hétérocycles, p.ex. cromakalim
A61K 31/122 - Cétones ayant l'atome d'oxygène lié directement à un cycle, p.ex. quinones, vitamine K1, anthraline
A61P 25/18 - Antipsychotiques, c. à. d. neuroleptiques; Médicaments pour le traitement de la manie ou de la schizophrénie
A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
56.
CYSTEINE AND CYSTINE BIOISOSTERES TO TREAT SCHIZOPHRENIA AND REDUCE DRUG CRAVINGS
UNIVERSITY OF WISCONSIN-MILWAUKEE RESEARCH FOUNDATION (USA)
Inventeur(s)
Cook, James, M.
Baker, David, A.
Yin, Wenyuan
Johnson, Edward, Merle
Abrégé
The present invention provides cysteine and cystine bioisosteres for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing such bioisosteres and methods of using the bioisosteres for treatment of schizophrenia and drug addiction.
C07D 413/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
A61P 25/18 - Antipsychotiques, c. à. d. neuroleptiques; Médicaments pour le traitement de la manie ou de la schizophrénie
A61P 25/30 - Médicaments pour le traitement des troubles du système nerveux des états d'abus ou de dépendance
C07C 323/02 - Thiols, sulfures, hydropolysulfures ou polysulfures substitués par des halogènes, des atomes d'oxygène ou d'azote ou par des atomes de soufre ne faisant pas partie de groupes thio contenant des groupes thio et des atomes d'halogène ou des groupes nitro ou nitroso liés au même squelette carboné ayant des atomes de soufre de groupes thio liés à des atomes de carbone acycliques du squelette carboné
57.
CYSTEINE AND CYSTINE PRODRUGS TO TREAT SCHIZOPHRENIA AND REDUCE DRUG CRAVINGS
UNIVERSITY OF WISCONSIN-MILWAUKEE RESEARCH FOUNDATION (USA)
Inventeur(s)
Cook, James, M.
Baker, David, A.
Yin, Wenyuan
Johnson, Edward, Merle, Ii
Abrégé
The present invention provides cysteine and cystine prodrugs for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing prodrugs and methods of using the prodrugs and compositions for treatment of schizophrenia and drug addiction.
C07D 241/08 - Composés hétérocycliques contenant des cycles diazine-1,4 ou diazine-1,4 hydrogéné non condensés avec d'autres cycles comportant une ou deux liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec des atomes d'oxygène liés directement aux atomes de carbone du cycle
A61K 31/4985 - Pyrazines ou pipérazines condensées en ortho ou en péri avec des systèmes hétérocycliques
C07C 321/14 - Sulfures, hydropolysulfures ou polysulfures ayant des groupes thio liés à des atomes de carbone acycliques d'un squelette carboné acyclique saturé
C07C 321/16 - Sulfures, hydropolysulfures ou polysulfures ayant des groupes thio liés à des atomes de carbone acycliques d'un squelette carboné saturé contenant des cycles
C07C 327/26 - Esters d'acides monothiocarboxyliques ayant des atomes de carbone de groupes thiocarboxyle estérifiés liés à des atomes de carbone de cycles aromatiques à six chaînons
A61P 25/18 - Antipsychotiques, c. à. d. neuroleptiques; Médicaments pour le traitement de la manie ou de la schizophrénie