Abstract

mnn and a method for the detection or prognosis of a disease in the exhaled breath of a subject. X, when present is a moiety operable to target the compound to a site of interest in vivo; m is 0 or at least 1, Y is a cleavable group; L is a self-immolative linker, T is a terminating moiety, and n is 1 when m is 0 or n is at least 1 when m is at least 1, L is a self-immolative linker. The terminating moiety, T, may comprise an isotopically labelled reporter molecule or a precursor thereof. The reporter molecule is operable to be released upon cleavage of the cleavable group, Y; and the reporter molecule, upon release, is a volatile compound.

IPC Classes  ?

• A61K 49/00 - Preparations for testing in vivo
• C07B 59/00 - Introduction of isotopes of elements into organic compounds
• G01N 33/497 - Physical analysis of biological material of gaseous biological material, e.g. breath
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances

Abstract

The invention relates to a method for detecting, staging, monitoring or prognosing a liver disease in a subject. The method comprises measuring the concentration of 2-pentanone, 4-methyl-1- pentene and/or 1-hexene, indole, dimethyl selenide, limonene, eucalyptol and (1- propylnonyl)benzene in a biological sample obtained from the subject.

IPC Classes  ?

• A61B 5/08 - Measuring devices for evaluating the respiratory organs
• G01N 33/497 - Physical analysis of biological material of gaseous biological material, e.g. breath

Goods & Services

Computer hardware and peripheral devices; computer software and computer programs; computer application software; computer software for use in connection with and as part of medical apparatus and instruments; clinical software, including database systems for patient medical information; medical diagnostic software; computer systems; data processing equipment; electronic devices for storing, recording, transmitting and reproducing information, data or images; diagnostic apparatus, not for medical purposes; testing apparatus, not for medical purposes; chemical detection systems and apparatus; detectors; spectrometers; sensors; computer software and computer programs for medical purposes; parts and fittings for all of the aforesaid. Medical apparatus and instruments; diagnostic apparatus for medical purposes; chemical detection systems and apparatus for medical purposes; medical imaging apparatus; medical and clinical devices; medical kits; respiratory equipment; testing apparatus for medical purposes; detectors for medical purposes; spectrometers for medical purposes; sensors for medical purposes; parts and fittings for all of the aforesaid. Scientific and technological services and research and design relating thereto; design and development of computer hardware and software; design and development of computer hardware and software for medical and clinical use; medical research services; clinical research; chemical analysis; chemical research; analytical laboratory services; biological analysis; laboratory analysis; laboratory (Scientific) services; laboratory testing services; medical laboratory services; computer programming; design and development of medical technology and medical apparatus; research and development services relating to medical apparatus and instruments; advice, information and consultancy relating to any of the aforesaid services. Medical services; consulting services relating to health care; healthcare services; health advice and information services; medical care services; medical clinic services; health clinic services; medical health assessment services; health screening services; diagnostic health screening services; preparation of reports relating to health matters; medical testing; diagnostic testing; testing for medical purposes; advice, information and consultancy services relating to any of the aforesaid services.

Abstract

This invention relates to methods of detecting, staging, monitoring or prognosing non-alcoholic steatohepatitis (NASH) in a subject. The method comprises measuring the concentration of an exogenous substrate for an enzyme and/or measuring the concentration of a metabolite of said substrate in a biological sample obtained from said subject. The substrate is a generally recognised as safe (GRAS) compound.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Goods & Services

Computer hardware and peripheral devices; computer software and computer programs; computer application software; computer software for use in connection with and as part of medical apparatus and instruments; clinical software, including database systems for patient medical information; medical diagnostic software; computer systems; data processing equipment; electronic devices for storing, recording, transmitting and reproducing information, data or images; diagnostic apparatus, not for medical purposes; testing apparatus, not for medical purposes; chemical detection systems and apparatus; detectors; spectrometers; sensors; computer software and computer programs for medical purposes; parts and fittings for all of the aforesaid; none of the aforesaid relating to orthopaedics or to edema and vascular management. Medical apparatus and instruments; diagnostic apparatus for medical purposes; chemical detection systems and apparatus for medical purposes; medical imaging apparatus; medical and clinical devices; medical kits (term considered too vague by the International Bureau - Rule 13 (2) (b) of the Regulation); respiratory equipment; testing apparatus for medical purposes; detectors for medical purposes; spectrometers for medical purposes; sensors for medical purposes; parts and fittings for all of the aforesaid; only in relation to the field of disease detection breath sampling, and none of the aforesaid relating to orthopaedics or to edema and vascular management. Scientific and technological services and research and design relating thereto; design and development of computer hardware and software; design and development of computer hardware and software for medical and clinical use; medical research services; clinical research; chemical analysis; chemical research; analytical laboratory services; biological analysis; laboratory analysis; laboratory (scientific) services; laboratory testing services; medical laboratory services; computer programming; design and development of medical technology and medical apparatus; research and development services relating to medical apparatus and instruments; advice, information and consultancy relating to any of the aforesaid services; none of the aforesaid relating to orthopaedics or to edema and vascular management. Medical services; consulting services relating to health care; healthcare services; health advice and information services; medical care services; medical clinic services; health clinic services; medical health assessment services; health screening services; diagnostic health screening services; preparation of reports relating to health matters; medical testing; diagnostic testing; testing for medical purposes; advice, information and consultancy services relating to any of the aforesaid services; none of the aforesaid relating to orthopaedics or to edema and vascular management.

Goods & Services

(1) Computer hardware and peripheral devices; computer software and computer programs; computer application software; computer software for use in connection with and as part of medical apparatus and instruments; clinical software, including database systems for patient medical information; medical diagnostic software; computer systems; data processing equipment; electronic devices for storing, recording, transmitting and reproducing information, data or images; diagnostic apparatus, not for medical purposes; testing apparatus, not for medical purposes; chemical detection systems and apparatus; detectors; spectrometers; sensors; computer software and computer programs for medical purposes; parts and fittings for all of the aforesaid; none of the aforesaid relating to orthopaedics or to edema and vascular management. (2) Medical apparatus and instruments; diagnostic apparatus for medical purposes; chemical detection systems and apparatus for medical purposes; medical imaging apparatus; medical and clinical devices; medical kits (term considered too vague by the International Bureau - Rule 13 (2) (b) of the Regulation); respiratory equipment; testing apparatus for medical purposes; detectors for medical purposes; spectrometers for medical purposes; sensors for medical purposes; parts and fittings for all of the aforesaid; only in relation to the field of disease detection breath sampling, and none of the aforesaid relating to orthopaedics or to edema and vascular management. (1) Scientific and technological services and research and design relating thereto; design and development of computer hardware and software; design and development of computer hardware and software for medical and clinical use; medical research services; clinical research; chemical analysis; chemical research; analytical laboratory services; biological analysis; laboratory analysis; laboratory (scientific) services; laboratory testing services; medical laboratory services; computer programming; design and development of medical technology and medical apparatus; research and development services relating to medical apparatus and instruments; advice, information and consultancy relating to any of the aforesaid services; none of the aforesaid relating to orthopaedics or to edema and vascular management. (2) Medical services; consulting services relating to health care; healthcare services; health advice and information services; medical care services; medical clinic services; health clinic services; medical health assessment services; health screening services; diagnostic health screening services; preparation of reports relating to health matters; medical testing; diagnostic testing; testing for medical purposes; advice, information and consultancy services relating to any of the aforesaid services; none of the aforesaid relating to orthopaedics or to edema and vascular management.

Goods & Services

Computer hardware and peripheral devices; downloadable and recorded computer software and computer programs to control collection of medical samples and to perform analysis of medical samples in connection with and as part of medical apparatus and instruments; downloadable and recorded computer application software for hand-held computing devices and to perform analysis of medical samples in connection with and as part of medical apparatus and instruments; downloadable and recorded computer software to perform analysis of medical samples in connection with and as part of medical apparatus and instruments; downloadable and recorded clinical computer software for storing and analyzing data in database systems featuring patient medical information; downloadable and recorded medical diagnostic software for use to control collection of medical samples and to perform analysis of medical samples in connection with and as part of medical apparatus and instruments; recorded and downloadable computer operating systems; data processing equipment; electronic devices for storing, recording, transmitting, and reproducing information, data, or images, namely, computer hardware, laptops; diagnostic apparatus for detection of disease bio-markers, not for medical purposes; testing apparatus, not for medical purposes, for use to test calibration of spectrometers and gas detectors; Chemical detection systems and apparatus, namely, portable detection and identification instruments using gas detectors for detecting and identifying chemical substances, not for medical purposes; gas particle detectors; spectrometers; pressure sensors; downloadable and recorded computer software and computer programs for medical purposes for use to diagnose and monitor diseases in connection with and as part of medical apparatus and instruments; structural and replacement parts and fittings for all the aforesaid goods Medical apparatus and instruments for treating cancer, celiac disease, tuberculosis, asthma, inflammatory bowel disease, and fatty liver disease; medical diagnostic apparatus for detecting cancer cells; chemical detection systems and apparatus for medical purposes, namely, analyzers and sampling equipment in the nature of sample collection devices used to collect and analyze liquid, solid and gas samples; medical imaging apparatus; medical and clinical devices in the nature of breath samplers, gas collection tubes used for the collection, recording, concentration and analysis of volatile organic compounds in human breath; medical testing kits for home use in the nature of a medical device for detection of cancer, celiac disease, tuberculosis, asthma, inflammatory bowel disease, and fatty liver disease; medical apparatus for the treatment of respiratory conditions; medical diagnostic apparatus for testing, namely, breath detectors for use to detect disease biomarkers; respiratory sensors for medical purposes; spectrometers for medical purposes; structural and replacement parts and fittings for all the aforesaid goods Scientific and technological services namely research and design relating to medical equipment; design and development of computer hardware and software; design and development of computer hardware and software for medical and clinical use; medical research services; clinical research in the field of cancer treatment; chemical analysis; chemical research; analytical laboratory services in the field of chemistry; biological analysis; research laboratory analysis in the field of chemistry; laboratory and scientific services, namely, research laboratory services in the field of biochemistry; laboratory testing services, namely, research laboratory services in the field of biochemistry; medical research laboratory services; computer programming; design and development of medical technology and medical apparatus; research and development services relating to medical apparatus and instruments; advice, information and consultancy relating to any of the aforesaid services; none of the aforesaid relating to orthopaedics or to edema and vascular management Medical services; consulting services relating to health care; healthcare services; health advice and information services; medical care services; medical clinic services; health clinic services; medical health assessment services; health screening services; diagnostic health screening services; preparation of reports relating to health matters; medical testing; diagnostic testing; testing for medical purposes; advice, information and consultancy services relating to any of the aforesaid services; none of the aforesaid relating to orthopaedics or to edema and vascular management

Abstract

A method for the detection or prognosis of cancer comprising; administering an exogenous substrate in combination with a sugar to a subject, measuring the concentration of a metabolite of said substrate in a biological sample that has been obtained from said subject. The invention extends to a kit comprising an exogenous substrate, a sugar and a device for obtaining a biological sample from a subject, and a composition comprising an exogenous compound and a sugar.

IPC Classes  ?

• C12Q 1/54 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
• G01N 33/574 - Immunoassay; Biospecific binding assay; Materials therefor for cancer
• A61K 31/70 - Carbohydrates; Sugars; Derivatives thereof
• C12Q 1/34 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase

Goods & Services

Computer software and computer programs; computer application software; computer software for use in connection with and as part of medical apparatus and instruments; clinical software, including database systems for patient medical information; medical diagnostic software; diagnostic apparatus, not for medical purposes; testing apparatus, not for medical purposes; chemical detection systems and apparatus; detectors; spectrometers; sensors; computer software and computer programs for medical purposes; parts and fittings for all of the aforesaid: all of the aforesaid relating to medical diagnosis and medical analysis: none of the foregoing for use in connection with gynaecological apparatus or instruments; none of the foregoing for use in haemodialysis, haemofiltration, haemodiafiltration and plasma therapy. Chemical detection systems and apparatus for medical purposes; medical kits (term considered too vague by the International Bureau - Rule 13 (2) (b) of the Regulations); medical apparatus for the treatment of respiratory conditions; testing apparatus for medical purposes; spectrometers for medical purposes; sensors [measurement apparatus], for medical purposes; parts and fittings for all of the aforesaid; excluding surgical instruments for performing surgery: none of the foregoing for use in connection with gynaecological apparatus or instruments; none of the foregoing for use in haemodialysis, haemofiltration, haemodiafiltration and plasma therapy. Scientific and technological services and research and design relating thereto; design and development of computer software; design and development of computer software for medical and clinical use; medical research services; clinical research; chemical analysis; chemical research; analytical laboratory services; biological analysis; laboratory analysis; laboratory (scientific) services; laboratory testing services; medical laboratory services; computer programming; design and development of medical technology and medical apparatus; research and development services relating to medical apparatus and instruments; advice, information and consultancy relating to any of the aforesaid services; all the aforesaid relating to medical diagnosis and medical analysis; none of the foregoing for use in connection with gynaecological apparatus or instruments; none of the foregoing for use in haemodialysis, haemofiltration, haemodiafiltrafion and plasma therapy. Medical services; consulting services relating to health care; healthcare services; health advice and information services; medical care services; medical clinic services; health clinic services; healthcare services; medical health assessment services; health screening services; diagnostic health screening services; preparation of reports relating to health matters; medical testing; medical diagnostic services [testing and analysis]; testing for medical purposes; advice, information and consultancy services relating to any of the aforesaid services; none of the foregoing for use in connection with gynaecological apparatus or instruments; none of the foregoing for use in haemodialysis, haemofiltration, haemodiafiltration and plasma therapy.

Abstract

A process for the synthesis of a glycoside, comprising the step of; performing hydrolysis of a methyl ester glycoside in the presence of a base in water, to form a glycoside, wherein the propensity to reform the methyl ester glycoside is reduced. The invention also extends to methods for the detection or prognosis of cancer using a glycoside obtained by said process.

IPC Classes  ?

• C07H 15/04 - Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of a saccharide radical
• C07H 1/00 - Processes for the preparation of sugar derivatives
• C07H 15/00 - Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals

Abstract

A process for the synthesis of a glycoside, comprising the step of; performing hydrolysis of a methyl ester glycoside in the presence of a base in water, to form a glycoside, wherein the propensity to reform the methyl ester glycoside is reduced. The invention also extends to methods for the detection or prognosis of cancer using a glycoside obtained by said process.

IPC Classes  ?

• C07H 15/04 - Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of a saccharide radical
• A61K 31/7012 - Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid
• A61P 35/00 - Antineoplastic agents

Goods & Services

(1) Computer software and computer programs; computer application software; computer software for use in connection with and as part of medical apparatus and instruments; clinical software, including database systems for patient medical information; medical diagnostic software; diagnostic apparatus, not for medical purposes; testing apparatus, not for medical purposes; chemical detection systems and apparatus; detectors; spectrometers; sensors; computer software and computer programs for medical purposes; parts and fittings for all of the aforesaid: all of the aforesaid relating to medical diagnosis and medical analysis: none of the foregoing for use in connection with gynaecological apparatus or instruments; none of the foregoing for use in haemodialysis, haemofiltration, haemodiafiltration and plasma therapy. (2) Chemical detection systems and apparatus for medical purposes; medical kits (term considered too vague by the International Bureau - Rule 13 (2) (b) of the Regulations); medical apparatus for the treatment of respiratory conditions; testing apparatus for medical purposes; spectrometers for medical purposes; sensors [measurement apparatus], for medical purposes; parts and fittings for all of the aforesaid; excluding surgical instruments for performing surgery: none of the foregoing for use in connection with gynaecological apparatus or instruments; none of the foregoing for use in haemodialysis, haemofiltration, haemodiafiltration and plasma therapy. (1) Scientific and technological services and research and design relating thereto; design and development of computer software; design and development of computer software for medical and clinical use; medical research services; clinical research; chemical analysis; chemical research; analytical laboratory services; biological analysis; laboratory analysis; laboratory (scientific) services; laboratory testing services; medical laboratory services; computer programming; design and development of medical technology and medical apparatus; research and development services relating to medical apparatus and instruments; advice, information and consultancy relating to any of the aforesaid services; all the aforesaid relating to medical diagnosis and medical analysis; none of the foregoing for use in connection with gynaecological apparatus or instruments; none of the foregoing for use in haemodialysis, haemofiltration, haemodiafiltrafion and plasma therapy. (2) Medical services; consulting services relating to health care; healthcare services; health advice and information services; medical care services; medical clinic services; health clinic services; healthcare services; medical health assessment services; health screening services; diagnostic health screening services; preparation of reports relating to health matters; medical testing; medical diagnostic services [testing and analysis]; testing for medical purposes; advice, information and consultancy services relating to any of the aforesaid services; none of the foregoing for use in connection with gynaecological apparatus or instruments; none of the foregoing for use in haemodialysis, haemofiltration, haemodiafiltration and plasma therapy.

Goods & Services

Computer hardware and peripheral devices; downloadable and recorded computer software and computer programs to control collection of medical samples and to perform analysis of medical samples in connection with and a part of medical apparatus and instruments; downloadable and recorded computer application software for hand-held computing devices and to perform analysis of medical samples in connection with and as part of medical apparatus and instruments; downloadable and recorded computer software to perform analysis of medical samples in connection with and as part of medical apparatus and instruments; downloadable and recorded clinical computer software for storing and analyzing data in database systems featuring patient medical information; downloadable and recorded medical diagnostic software for use to control collection of medical samples and to perform analysis of medical samples in connection with and as part of medical apparatus and instruments; computer operating systems; data processing equipment; electronic devices for storing, recording, transmitting, and reproducing information, data, or images, namely, computer hardware, laptops; diagnostic apparatus for detection of disease bio-markers, not for medical purposes; testing apparatus, not for medical purposes, for use to test calibration of spectrometers and gas detectors; chemical detection systems and apparatus, namely, analyzers and sampling equipment for use to diagnose and monitor diseases in connection with and as part of medical apparatus and instruments; particle detectors; spectrometers; pressure sensors; downloadable and recorded computer software and computer programs for medical purposes for use to diagnose and monitor diseases in connection with and as part of medical apparatus and instruments; structural and replacement parts and fittings for all the aforesaid Medical apparatus and instruments for treating cancer, celiac disease, tuberculosis, asthma, inflammatory bowel disease, and fatty liver disease; medical diagnostic apparatus for detecting cancer cells; chemical detection systems and apparatus for medical purposes, namely, analyzers and sampling equipment used to collect and analyse liquid, solid and gas samples; medical imaging apparatus; medical and clinical devices used for the collection, recording, concentration and analysis of volatile organic compounds in human breath; medical testing kits for home use in the nature of a medical device for detection of cancer, celiac disease, tuberculosis, asthma, inflammatory bowel disease, and fatty liver disease; medical apparatus for the treatment of respiratory conditions; medical diagnostic apparatus for testing, namely, breath detectors for use to detect disease biomarkers; respiratory sensors for medical purposes; spectrometers for medical purposes; structural and replacement parts and fittings for all the aforesaid Scientific and technological services, namely, scientific research in the field of medical technology; design and development of computer hardware and software; design and development of computer hardware and software for medical and clinical use; medical research services; clinical research in the field of disease biomarkers; chemical analysis; chemical research; analytical laboratory services in the field of disease biomarkers; biological analysis; laboratory analysis in the field of disease biomarkers; scientific laboratory services; laboratory testing services, namely, testing for disease biomarkers within gas, liquid and solid samples; medical laboratory services; computer programming; product design and development in the field of medical technology; product research and development services relating to medical apparatus and instruments; providing advice, information and consultancy relating to the aforesaid services Medical services; consulting services relating to health care; health care; providing advice and information in the field of health; medical care; medical clinic services; health clinic services; medical health assessment services; health screening services in the field of cancer, celiac disease, tuberculosis, asthma, inflammatory bowel disease, fatty liver disease; diagnostic health screening services in the field of cancer, celiac disease, tuberculosis, asthma, inflammatory bowel disease, fatty liver disease; providing medical information to medical professionals in the form of reports in the field of cancer, celiac disease, tuberculosis, asthma, inflammatory bowel disease, fatty liver disease; medical testing for diagnostic or treatment purposes; medical diagnostic testing services; testing for disease biomarkers for medical purposes; providing advice, information, and consultancy services relating to the aforesaid

Abstract

The present techniques relate to sampling devices, and in particular to breath sampling devices. We describe a computer-implemented method of designing a breath sampling device comprising a housing through which a substantial portion of an exhaled breath passes and sorbent material which extends across a cross-section of the housing. The method comprises identifying a plurality of parameters of the device which are variable with different designs of the breath sampling device and selecting values of the plurality of parameters which maximise a global fitness value. The plurality of parameters comprises at least two of mass of the sorbent material, size of the sorbent material, thickness of the sorbent material, breakthrough volume and flowrate within the device.

IPC Classes  ?

• A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements

Abstract

The invention relates to methods for predicting the response of a subject suffering from asthma or a respiratory disorder to a therapy comprising a Th2 pathway modulator and a device for use in such methods.

IPC Classes  ?

• G01N 33/497 - Physical analysis of biological material of gaseous biological material, e.g. breath
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
• A61B 5/08 - Measuring devices for evaluating the respiratory organs
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons

Abstract

The invention provides a breath test for assessing a metabolic phenotypeand/or assessing a disease state.

IPC Classes  ?

• C12Q 1/26 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

Abstract

The present disclosure relates to sensor systems and methods for analysing fluid samples. The sensor system comprises a housing (220) having an inlet for a fluid sample to enter the housing, an outlet for the fluid sample to exit the housing, and a fluid sample path within the housing for the fluid sample to flow between the inlet and the outlet. The sensor system also comprises an ionizer (210) which is external to the housing and which is for ionizing the fluid sample at a first location on the fluid sample path to generate sample ions, an ion mobility filter (212) which is at least partially located within the housing and which is for filtering the generated sample ions at a second location on the fluid sample path, and a detector (214) which is external to the housing and which is for detecting the sample ions which pass through the ion mobility filter at a third location on the fluid sample path.

IPC Classes  ?

• G01N 27/624 - Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]

Abstract

The present techniques relate to methods of manufacturing MEMS gas sensors, for example, an ion mobility filter which may be used as a field asymmetric ion mobility spectrometry filter. The method comprises a step of providing a support with an aperture (S300, S302) and forming electrical connections (S304) in the support. The method also comprises steps of attaching an electrode layer to the support (S306) so that the electrode layer covers the aperture and forming a plurality of ion mobility electrodes (S308) by mechanically dicing through the electrode layer. Each adjacent pair of electrodes defines an ion channel between them and each electrode is separate from the adjacent electrode(s).

IPC Classes  ?

• G01N 27/624 - Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]

Goods & Services

Computer hardware and peripheral devices; computer software and computer programs; computer application software; computer software for use in connection with and as part of medical apparatus and instruments; clinical software, including database systems for patient medical information; medical diagnostic software; computer systems; data processing equipment; electronic devices for storing, recording, transmitting and reproducing information, data or images; diagnostic apparatus, not for medical purposes; testing apparatus for diagnostic purposes, [other than medical]; chemical detection systems and apparatus; detectors; spectrometers; sensors; computer software and computer programs for medical purposes; parts and fittings for all of the aforesaid. Medical apparatus and instruments; diagnostic apparatus for medical purposes; chemical detection systems and apparatus for medical purposes; medical imaging apparatus; medical and clinical devices; medical kits (in the opinion of the International Bureau these terms are too vague - Rule 13.2.b) of the Common Regulations); medical apparatus for the treatment of respiratory conditions; testing apparatus for medical purposes; medical apparatus for detecting diseases; spectrometers for medical purposes; sensors [measurement apparatus], for medical purposes; parts and fittings for all of the aforesaid. Scientific and technological services and research and design relating thereto; design and development of computer hardware and software; design and development of computer hardware and software for medical and clinical use; medical research services; clinical research; chemical analysis; chemical research; analytical laboratory services; biological analysis; laboratory analysis; laboratory (scientific) services; laboratory testing services; medical laboratory services; computer programming; design and development of medical technology and medical apparatus; research and development services relating to medical apparatus and instruments; advice, information and consultancy relating to any of the aforesaid services. Medical services; consulting services relating to health care; healthcare services; health advice and information services; medical care services; medical clinic services; health clinic services; medical health assessment services; health screening services; diagnostic health screening services; preparation of reports relating to health matters; medical testing; medical diagnostic services [testing and analysis]; testing for medical purposes; advice, information and consultancy services relating to any of the aforesaid services.

Goods & Services

Computer hardware and peripheral devices; computer software and computer programs; computer application software; computer software for use in connection with and as part of medical apparatus and instruments; clinical software, including database systems for patient medical information; medical diagnostic software; computer systems; data processing equipment; electronic devices for storing, recording, transmitting and reproducing information, data or images; diagnostic apparatus, not for medical purposes; testing apparatus for diagnostic purposes [other than medical]; chemical detection systems and apparatus; detectors; spectrometers; sensors; computer software and computer programs for medical purposes; parts and fittings for all of the aforesaid. Medical apparatus and instruments; diagnostic apparatus for medical purposes; chemical detection systems and apparatus for medical purposes; medical imaging apparatus; medical and clinical devices; medical kits (in the opinion of the International Bureau these terms are too vague - Rule 13.2.b) of the Common Regulations); medical apparatus for the treatment of respiratory conditions; testing apparatus for medical purposes; medical apparatus for detecting diseases; spectrometers for medical purposes; sensors [measurement apparatus], for medical purposes; parts and fittings for all of the aforesaid. Scientific and technological services and research and design relating thereto; design and development of computer hardware and software; design and development of computer hardware and software for medical and clinical use; medical research services; clinical research; chemical analysis; chemical research; analytical laboratory services; biological analysis; laboratory analysis; laboratory (scientific) services; laboratory testing services; medical laboratory services; computer programming; design and development of medical technology and medical apparatus; research and development services relating to medical apparatus and instruments; advice, information and consultancy relating to any of the aforesaid services. Medical services; consulting services relating to health care; healthcare services; health advice and information services; medical care services; medical clinic services; health clinic services; medical health assessment services; health screening services; diagnostic health screening services; preparation of reports relating to health matters; medical testing; medical diagnostic services [testing and analysis]; testing for medical purposes; advice, information and consultancy services relating to any of the aforesaid services.

Abstract

The waveform generator (10) comprises a switch (13). The waveform generator (10) comprises a transformer (15) having a primary side circuit and a secondary side circuit. The primary side circuit has a first terminal arranged to be conductively coupled to a DC voltage source, and a second terminal conductively coupled to the switch (13). The waveform generator (10) further comprises a controller (11) arranged to supply a drive signal to the switch for switching the switch between on and off states. The controller (11) is arranged to adjust the frequency of the drive signal so as to control at least one of the peak voltage and the duty cycle of a waveform generated by the waveform generator (10). The frequency of the drive signal may be adjusted as the voltage level of the DC voltage source remains constant. The frequency of the drive signal may be adjusted in response to a change in the voltage level of the DC voltage source.

IPC Classes  ?

• H03K 3/017 - Adjustment of width or dutycycle of pulses
• H03B 19/14 - Generation of oscillations by non-regenerative frequency multiplication or division of a signal from a separate source by means of discharge device or semiconductor device with more than two electrodes by means of a semiconductor device
• G01N 27/624 - Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]

Goods & Services

Computer hardware and peripheral devices; Downloadable and recorded computer software and computer programs for collection and analyzing of medical samples in connection with and as part of medical apparatus and instruments; Downloadable and recorded computer application software for hand-held computing devices for analyzing medical samples in connection with and as part of medical apparatus and instruments; Downloadable and recorded computer software for analyzing medical samples in connection with and as part of medical apparatus and instruments; Downloadable and recorded clinical computer software for storing and analyzing data in database systems featuring patient medical information; Downloadable and recorded medical diagnostic software for collection and analyzing of medical samples in connection with and as part of medical apparatus and instruments; Downloadable and recorded computer operating system software; Data processing equipment; Electronic devices for storing, recording, transmitting, and reproducing information, data, or images, namely, computer hardware and laptops; Diagnostic apparatus for detection of disease bio-markers for laboratory or research use, not for medical purposes; Testing apparatus, not for medical purposes, for use to test calibration of spectrometers and gas detectors; Chemical detection systems and apparatus, namely, portable detection and identification instruments using gas detectors for detecting and identifying chemical substances, not for medical purposes; Particle detectors; Spectrometers; Pressure sensors; Downloadable and recorded computer software and computer programs for medical purposes for use to diagnose and monitor diseases in connection with and as part of medical apparatus and instruments; Structural and replacement parts and fittings for all the aforesaid Medical apparatus and instruments for treating cancer, celiac disease, tuberculosis, asthma, inflammatory bowel disease, and fatty liver disease; Medical diagnostic apparatus for detecting cancer cells; Chemical detection systems and apparatus for medical purposes, namely, portable detection and identification medical apparatus using gas detectors for detecting and identifying cancer, celiac disease, tuberculosis, asthma, inflammatory bowel disease, and fatty liver disease; Medical imaging apparatus; Medical devices used for the collection, recording and analysis of volatile organic compounds in human breath; Medical testing kits for home use comprised of a medical device for detection of cancer, celiac disease, tuberculosis, asthma, inflammatory bowel disease, and fatty liver disease; Medical apparatus for the treatment of respiratory conditions; Medical diagnostic apparatus in the nature of breath detectors for testing for disease biomarkers for medical purposes; Spectrometers for medical purposes; Respiratory sensors, for medical purposes Scientific and technological services, namely, scientific research in the field of medical technology; Design and development of computer hardware and software; Design and development of computer hardware and software for medical and clinical use; Medical research services; Clinical research in the field of disease biomarkers; Chemical analysis; Chemical research; Analytical scientific and medical laboratory services in the field of disease biomarkers; Biological analysis; Laboratory analysis in the field of disease biomarkers; Scientific laboratory services; Laboratory testing services, namely, testing for disease biomarkers within gas, liquid, and solid samples for scientific research purposes; Medical laboratory services; Computer programming; Product design and development in the field of medical technology; Product research and development services relating to medical apparatus and instruments; Providing advice, information, and consultancy relating to the aforesaid services Medical services; Consulting services relating to health care; Health care; Providing advice and information in the field of health; Medical care; Medical clinic services; Health clinic services; Medical health assessment services; Health screening services in the fields of cancer, celiac disease, tuberculosis, asthma, inflammatory bowel disease, and fatty liver disease; Diagnostic health screening services in the fields of cancer, celiac disease, tuberculosis, asthma, inflammatory bowel disease, and fatty liver disease; Providing medical information to medical professionals in the form of reports in the fields of cancer, celiac disease, tuberculosis, asthma, inflammatory bowel disease, and fatty liver disease; Medical testing for diagnostic or treatment purposes; Medical testing and analysis services for diagnostic purposes; Medical testing for disease biomarkers for diagnostic or treatment purposes; Providing advice, information, and consultancy services relating to the aforesaid

Goods & Services

Computer hardware and peripheral devices; downloadable and recorded computer software and computer programs to control collection of medical samples and to perform analysis of medical samples in connection with and a part of medical apparatus and instruments; downloadable and recorded computer application software for hand-held computing devices and to perform analysis of medical samples in connection with and as part of medical apparatus and instruments; downloadable and recorded computer software to perform analysis of medical samples in connection with and as part of medical apparatus and instruments; downloadable and recorded clinical computer software for storing and analyzing data in database systems featuring patient medical information; downloadable and recorded medical diagnostic software for use to control collection of medical samples and to perform analysis of medical samples in connection with and as part of medical apparatus and instruments; computer operating systems; data processing equipment; electronic devices for storing, recording, transmitting, and reproducing information, data, or images, namely, computer hardware, laptops; diagnostic apparatus for detection of disease bio-markers, not for medical purposes; testing apparatus, not for medical purposes, for use to test calibration of spectrometers and gas detectors; chemical detection systems and apparatus, namely, analyzers and sampling equipment for use to diagnose and monitor diseases in connection with and as part of medical apparatus and instruments; particle detectors; spectrometers; pressure sensors; downloadable and recorded computer software and computer programs for medical purposes for use to diagnose and monitor diseases in connection with and as part of medical apparatus and instruments; spectrometers for medical purposes; structural and replacement parts and fittings for all the aforesaid Medical apparatus and instruments for treating cancer, celiac disease, tuberculosis, asthma, inflammatory bowel disease, and fatty liver disease; medical diagnostic apparatus for detecting cancer cells; chemical detection systems and apparatus for medical purposes, namely, analyzers and sampling equipment used to collect and analyse liquid, solid and gas samples; medical imaging apparatus; medical and clinical devices used for the collection, recording, concentration and analysis of volatile organic compounds in human breath; medical testing kits for home use in the nature of a medical device for detection of cancer, celiac disease, tuberculosis, asthma, inflammatory bowel disease, and fatty liver disease; respiratory equipment; medical diagnostic apparatus for testing, namely breath detectors for use to detect disease biomarkers; respiratory sensors for medical purposes; structural and replacement parts and fittings for all the aforesaid Scientific and technological services, namely, scientific research in the field of medical technology; design and development of computer hardware and software; design and development of computer hardware and software for medical and clinical use; medical research services; clinical research in the field of disease biomarkers; chemical analysis; chemical research; analytical laboratory services in the field of disease biomarkers; biological analysis; laboratory analysis in the field of in the field of disease biomarkers; scientific laboratory services; laboratory testing services, namely, testing for disease biomarkers within gas, liquid and solid samples; medical laboratory services; computer programming; product design and development in the field of medical technology; product research and development services relating to medical apparatus and instruments; providing advice, information and consultancy relating to the aforesaid services Medical services; consulting services relating to health care; health care; providing advice and information in the field of health; medical care; medical clinic services; health clinic services; medical health assessment services; health screening services in the field of cancer, celiac disease, tuberculosis, asthma, inflammatory bowel disease, fatty liver disease; diagnostic health screening services in the field of cancer, celiac disease, tuberculosis, asthma, inflammatory bowel disease, fatty liver disease; providing medical information to medical professionals in the form of reports in the field of cancer, celiac disease, tuberculosis, asthma, inflammatory bowel disease, fatty liver disease; medical testing for diagnostic or treatment purposes; medical diagnostic testing services; testing for disease biomarkers for medical purposes; providing advice, information, and consultancy services relating to the aforesaid

Abstract

A method for the early detection and monitoring of the progression of cancer by detecting breath biomarkers is provided. The method comprises assessing the activity of an aldo-keto reductase by measuring the concentration of an exogenous substrate for said enzyme and/or measuring the concentration of a metabolite of said substrate in exhaled breath of a subject. Preferably, the cancer is lung cancer.

IPC Classes  ?

• G01N 33/497 - Physical analysis of biological material of gaseous biological material, e.g. breath
• A61B 5/08 - Measuring devices for evaluating the respiratory organs

Goods & Services

Scientific and technological services, namely, scientific research in the field of medical technology; Design and development of computer hardware and software; Design and development of computer hardware and software for medical and clinical use; Medical research services; Clinical research in the field of disease biomarkers; Chemical analysis; Chemical research; Analytical scientific laboratory services in the field of disease biomarkers; Biological analysis; Laboratory analysis in the field of in the field of disease biomarkers; Scientific laboratory services; Laboratory testing services, namely, testing for disease biomarkers within gas, liquid and solid samples for scientific research purposes; Medical laboratory services; Computer programming; Product design and development in the field of medical technology; Product research and development services relating to medical apparatus and instruments; Providing advice, information and consultancy relating to the aforesaid services

Abstract

Disclosed is a method for collecting different selected exhaled breath samples, or fractions thereof, on a single sample capture device, the method comprising the steps of: (a) collecting a first exhaled breath sample by contacting the sample with a capture device comprising an adsorbent material; (b) collecting a second exhaled breath sample by contacting the second sample with said capture device, wherein the first and second exhaled breath samples are caused to be captured on the capture device in a spatially separated manner.

IPC Classes  ?

• B01D 53/02 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography
• A61B 5/097 - Devices for facilitating collection of breath or for directing breath into or through measuring devices
• A61B 5/08 - Measuring devices for evaluating the respiratory organs
• B01J 20/20 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising carbon obtained by carbonising processes
• B01J 20/26 - Synthetic macromolecular compounds
• B01J 20/28 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties

Abstract

The invention relates to methods for predicting the response of a subject suffering from asthma or a respiratory disorder to a therapy comprising a Th2 pathway modulator and a device for use in such methods.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
• A61B 5/08 - Measuring devices for evaluating the respiratory organs
• G01N 33/497 - Physical analysis of biological material of gaseous biological material, e.g. breath

Abstract

A sensor system comprising a housing having an inlet aperture through which fluid enters the housing and a conditioning material in the housing, the conditioning material being adapted to control levels of a substance within the housing. The sensor system comprises a sensor for analysing the fluid in the housing. The sensor system comprises circulation means which is configured to alternate circulation of fluid within the housing between a sensing fluid path in which the fluid is analysed by the sensor and a second fluid path in which the fluid flow is conditioned. A method for analysing fluid in a housing using a sensor is also provided.

IPC Classes  ?

• B01D 53/04 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
• G01N 1/34 - Purifying; Cleaning
• G01N 1/22 - Devices for withdrawing samples in the gaseous state
• B01D 53/26 - Drying gases or vapours
• G01N 1/40 - Concentrating samples
• G01N 27/622 - Ion mobility spectrometry
• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
• G05D 7/01 - Control of flow without auxiliary power

Abstract

We describe a method and apparatus for detecting humidity using a Field Asymmetric Ion Mobility Spectrometry (FAIMS) system. The system may comprise an ionizer for generating ions within a gas sample, wherein each ion has an associated ion mobility; an ion filter for separating the ions by applying a compensation field and a dispersion field to the generated ions; a detector for detecting an output from the ion filter; and a processor. The processor may be configured to extract a spectrum of peak intensity of the detected output as a function of the compensation field and the dispersion field; calculate a turning point for the extracted spectrum; determine operating parameters of the field asymmetric ion mobility system; obtain, from a database, a plurality of known turning points each of which have an associated humidity and each of which were obtained using a field asymmetric ion mobility system having operating parameters aligned with the determined operating parameters; and determine the humidity by comparing the calculated turning point with known turning points.

IPC Classes  ?

• G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
• G01N 27/624 - Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]

Abstract

Mobile device (110) is disclosed. The present techniques relate to a mobile device or portable electronic device, particularly a device including a breath sampling device. The mobile electronic device (110) comprises a collection device (112) for collecting and storing a gas sample. The collection device (112) is accessible to enable analysis of the gas stored in the collection device (112). The collection device (112) comprises a mouthpiece (118) into which a user exhales. The collection device (112) further comprises a plurality of sorbent tubes (114) to collect and store the breath sample(s). Each tube (114) has a one-way valve (116) to prevent captured breath escaping.

IPC Classes  ?

• A61B 5/08 - Measuring devices for evaluating the respiratory organs
• A61B 5/097 - Devices for facilitating collection of breath or for directing breath into or through measuring devices
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons

Abstract

The present disclosure relates to sensor systems and methods for analysing fluid samples. The sensor system comprises a housing (220) having an inlet for a fluid sample to enter the housing, an outlet for the fluid sample to exit the housing, and a fluid sample path within the housing for the fluid sample to flow between the inlet and the outlet. The sensor system also comprises an ionizer (210) which is external to the housing and which is for ionizing the fluid sample at a first location on the fluid sample path to generate sample ions, an ion mobility filter (212) which is at least partially located within the housing and which is for filtering the generated sample ions at a second location on the fluid sample path, and a detector (214) which is external to the housing and which is for detecting the sample ions which pass through the ion mobility filter at a third location on the fluid sample path.

IPC Classes  ?

• G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode

Abstract

A method of manufacture for a ion mobility filter is disclosed. The method of manufacturing an ion filter for a spectrometry system includes providing a sheet of conductive material and defining a plurality of ion filters on the sheet. The definition of the plurality of ion filters is achieved by forming an electrode layer for each ion filter on the sheet, where each electrode layer comprises at least one ion channel and an isolation channel surrounding the at least one ion channel. A support layer on each electrode layer is also formed. Each support layer comprises an aperture at least partially aligned with the at least one ion channel. The ion filter is then separated. The risk of contaminants entering the at least one ion channel when separating the ion filters is reduced by surrounding the at least one ion channel with the isolation channel.

IPC Classes  ?

• G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
• H01J 49/00 - Particle spectrometers or separator tubes
• H01J 49/06 - Electron- or ion-optical arrangements
• G01N 27/624 - Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]

Abstract

The present techniques relate to methods of manufacturing MEMS gas sensors, for example, an ion mobility filter which may be used as a field asymmetric ion mobility spectrometry filter. The method comprises a step of providing a support with an aperture (S300, S302) and forming electrical connections (S304) in the support. The method also comprises steps of attaching an electrode layer to the support (S306) so that the electrode layer covers the aperture and forming a plurality of ion mobility electrodes (S308) by mechanically dicing through the electrode layer. Each adjacent pair of electrodes defines an ion channel between them and each electrode is separate from the adjacent electrode(s).

IPC Classes  ?

• G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode

Abstract

An ion filter for filtering ions in a gas sample. The ion filter has a first ion channel for filtering ions from a target chemical in the gas sample. The ion filter has a second ion channel for filtering ions from the target chemical in the gas sample. The second ion channel is separated from the first ion channel. A temperature control region is in thermal contact with the first and second ion channels for controlling a difference in temperature between the first and second ion channels. A method of filtering ions from a target chemical in a gas sample is also provided.

IPC Classes  ?

• G01N 27/624 - Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]
• H01J 49/00 - Particle spectrometers or separator tubes

Abstract

An ion mobility filter is disclosed. The present invention relates to but not exclusively a field asymmetric ion spectrometry filter. For example, we describe an ion filter for filtering ions in a gas sample. The ion filter is comprised of a plurality of electrodes, a first ion channel, and a second ion channel. The first ion channel filters ions from a target chemical in the gas sample, defines a gap between a first pair of electrodes in the plurality of electrodes, and has a first ion channel gap width. The second ion channel filters ions from the target chemical in the gas sample, defines a gap between a second pair of electrodes in the plurality of electrodes, and has a second ion channel gap width. The first ion channel gap width is greater than the second ion channel gap width.

IPC Classes  ?

• G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
• G01N 27/624 - Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]

Abstract

A waveform generator configured to generate two waveforms of opposite polarity so as to provide a voltage gain across a load. The waveform generator has a primary side circuit comprising a first inductor. The waveform generator has a secondary side circuit comprising a second inductor, a first output region conductively coupled to the load, and a second output region conductively coupled to the load. The second inductor is inductively coupled to the first inductor. The first inductor is conductively coupled to the first output region so as to supply a first of the two waveforms to the load. The second inductor is conductively coupled to the second output region so as to supply a second of the two waveforms to the load. A system incorporating the waveform generator and a method of driving the waveform generator are also provided.

IPC Classes  ?

• H03K 3/57 - Generators characterised by the type of circuit or by the means used for producing pulses by the use of an energy-accumulating element discharged through the load by a switching device controlled by an external signal and not incorporating positive feedback the switching device being a semiconductor device
• G01N 27/624 - Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]
• G05F 3/08 - Regulating voltage or current wherein the variable is dc
• H03K 17/687 - Electronic switching or gating, i.e. not by contact-making and -breaking characterised by the use of specified components by the use, as active elements, of semiconductor devices the devices being field-effect transistors

Abstract

The waveform generator (10) comprises a switch (13). The waveform generator (10) comprises a transformer (15) having a primary side circuit and a secondary side circuit. The primary side circuit has a first terminal arranged to be conductively coupled to a DC voltage source, and a second terminal conductively coupled to the switch (13). The waveform generator (10) further comprises a controller (11) arranged to supply a drive signal to the switch for switching the switch between on and off states. The controller (11) is arranged to adjust the frequency of the drive signal so as to control at least one of the peak voltage and the duty cycle of a waveform generated by the waveform generator (10). The frequency of the drive signal may be adjusted as the voltage level of the DC voltage source remains constant. The frequency of the drive signal may be adjusted in response to a change in the voltage level of the DC voltage source.

IPC Classes  ?

• H02M 7/48 - Conversion of dc power input into ac power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode

Abstract

A method for the early detection and monitoring of the progression of cancer by detecting breath biomarkers is provided. The method comprises assessing the activity of an aldo-keto reductase by measuring the concentration of an exogenous substrate for said enzyme and/or measuring the concentration of a metabolite of said substrate in exhaled breath of a subject. Preferably, the cancer is lung cancer.

IPC Classes  ?

• C12Q 1/26 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
• G01N 33/574 - Immunoassay; Biospecific binding assay; Materials therefor for cancer
• A61B 5/08 - Measuring devices for evaluating the respiratory organs
• A61K 51/04 - Organic compounds
• G01N 33/497 - Physical analysis of biological material of gaseous biological material, e.g. breath

Abstract

A method for the early detection and monitoring of the progression of cancer by detecting breath biomarkers is provided. The method comprises assessing the activity of an aldo-keto reductase by measuring the concentration of an exogenous substrate for said enzyme and/or measuring the concentration of a metabolite of said substrate in exhaled breath of a subject. Preferably, the cancer is lung cancer.

IPC Classes  ?

• C12Q 1/26 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
• A61B 5/08 - Measuring devices for evaluating the respiratory organs
• A61K 51/04 - Organic compounds
• G01N 33/497 - Physical analysis of biological material of gaseous biological material, e.g. breath
• G01N 33/574 - Immunoassay; Biospecific binding assay; Materials therefor for cancer

Abstract

Disclosed is apparatus for collecting a breath sample from a human subject, the apparatus comprising at least a mask portion which, in use, is positioned over the subject's mouth and nostrils so as to collect breath exhaled from the subject, the apparatus further comprising movement detection means for detecting movement of the mask portion, and an alarm signal generator, which alarm signal generator generates an alarm signal if the subject's head is outside a predetermined range of acceptable orientations during collection of a breath sample, but only after the subject's head has been outside the predetermined range of acceptable orientations for a defined or measurable period of time.

IPC Classes  ?

• A61B 5/08 - Measuring devices for evaluating the respiratory organs
• A61B 5/097 - Devices for facilitating collection of breath or for directing breath into or through measuring devices
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
• G01N 33/497 - Physical analysis of biological material of gaseous biological material, e.g. breath
• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb

Abstract

Disclosed is a method of identifying if a subject is sufficiently prepared to permit successful colonoscopic examination, the method comprising the steps of: (a) obtaining a stool sample from a subject having undergone preparation for a colonoscopic examination; (b) analysing the sample to detect the presence and/or amount of faecal matter, if any, in the stool sample; and (c) from the analysis in step (b), identifying whether the subject has been sufficiently prepared.

IPC Classes  ?

• G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
• A61B 1/31 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the rectum, e.g. proctoscopes, sigmoidoscopes
• G01N 33/483 - Physical analysis of biological material
• G01N 33/487 - Physical analysis of biological material of liquid biological material
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

Abstract

The invention provides a breath test for assessing a metabolic phenotypeand/or assessing a disease state.

IPC Classes  ?

• C12Q 1/26 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
• G01N 33/497 - Physical analysis of biological material of gaseous biological material, e.g. breath

Abstract

Mobile device (110) is disclosed. The present techniques relate to a mobile device or portable electronic device, particularly a device including a breath sampling device. The mobile electronic device (110) comprises a collection device (112) for collecting and storing a gas sample. The collection device (112) is accessible to enable analysis of the gas stored in the collection device (112). The collection device (112) comprises a mouthpiece (118) into which a user exhales. The collection device (112) further comprises a plurality of sorbent tubes (114) to collect and store the breath sample(s). Each tube (114) has a one-way valve (116) to prevent captured breath escaping.

IPC Classes  ?

• G01N 33/497 - Physical analysis of biological material of gaseous biological material, e.g. breath
• A61B 5/08 - Measuring devices for evaluating the respiratory organs
• G01N 1/22 - Devices for withdrawing samples in the gaseous state
• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups

Abstract

Disclosed is apparatus for use in obtaining a breath sample from a mammalian, preferably human, subject, the apparatus comprising: a headset which is attachable to the subject; a separate suction pump; and an umbilical connecting the suction pump to the headset so as to allow the suction pump to create a lower than ambient pressure within the headset; wherein the headset comprises: a mask piece which fits over the nostrils and mouth of the subject; at least one breath sample capture device, and at least one valve to regulate the passage of gas into the sample capture device.

IPC Classes  ?

• A61B 5/097 - Devices for facilitating collection of breath or for directing breath into or through measuring devices
• A61B 5/083 - Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
• A61B 5/087 - Measuring breath flow
• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons

Abstract

We describe a method and apparatus for detecting humidity using a Field Asymmetric Ion Mobility Spectrometry (FAIMS) system. The system may comprise an ionizer for generating ions within a gas sample, wherein each ion has an associated ion mobility; an ion filter for separating the ions by applying a compensation field and a dispersion field to the generated ions; a detector for detecting an output from the ion filter; and a processor. The processor may be configured to extract a spectrum of peak intensity of the detected output as a function of the compensation field and the dispersion field; calculate a turning point for the extracted spectrum; determine operating parameters of the field asymmetric ion mobility system; obtain, from a database, a plurality of known turning points each of which have an associated humidity and each of which were obtained using a field asymmetric ion mobility system having operating parameters aligned with the determined operating parameters; and determine the humidity by comparing the calculated turning point with known turning points.

IPC Classes  ?

• G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode

Abstract

A method of manufacture for a ion mobility filter is disclosed. The present techniques relate to a method of manufacturing a MEMS gas sensor, for example, an ion mobility filter which may be used as a field asymmetric ion mobility spectrometry filter. The method of manufacturing an ion filter for a spectrometry system is comprised of providing a sheet of conductive material and defining a plurality of ion filters on the sheet. The definition of the plurality of ion filters is achieved by forming an electrode layer (22) for each ion filter on the sheet, wherein each electrode layer (22) comprisesat least one ion channel (28) and an isolation channel (30) surrounding the at least one ion channel (28). A support layer (24) on each electrode layer is also formed. Each support layer (24) comprises an aperture (25) at least partially aligned with the at least one ion channel (28). The ion filter is then separated. The risk of contaminants entering the at least one ion channel (28) when separating the ion filters is reduced by surrounding the at least one ion channel (28) with the isolation channel (30).

IPC Classes  ?

• G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
• H01J 49/00 - Particle spectrometers or separator tubes
• H01J 49/06 - Electron- or ion-optical arrangements
• H01L 21/78 - Manufacture or treatment of devices consisting of a plurality of solid state components or integrated circuits formed in, or on, a common substrate with subsequent division of the substrate into plural individual devices

Goods & Services

Computer hardware and peripheral devices; computer software and computer programs; computer application software; computer software for use in connection with and as part of medical apparatus and instruments; clinical software, including database systems for patient medical information; medical diagnostic software; computer systems; data processing equipment; electronic devices for storing, recording, transmitting and reproducing information, data or images; diagnostic apparatus, not for medical purposes; testing apparatus, not for medical purposes; chemical detection systems and apparatus; detectors; spectrometers; sensors; computer software and computer programs for medical purposes; parts and fittings for all of the aforesaid; none of the aforesaid relating to dermatology or skincare; none relating to vehicles or the automotive industry. Medical apparatus and instruments; diagnostic apparatus for medical purposes; chemical detection systems and apparatus for medical purposes; medical imaging apparatus; medical and clinical devices; medical testing kits (terms considered too vague by the International Bureau - rule 13.2.b) of the Common Regulations); respiratory equipment for medical purposes; testing apparatus for medical purposes; detectors for medical purposes; spectrometers for medical purposes; sensors for medical purposes; parts and fittings for all of the aforesaid; none of the aforesaid relating to dermatology or skincare; none of the aforesaid goods being related to hip prosthesis or orthopaedic articles. Scientific and technological services and research and design relating thereto; design and development of computer hardware and software; design and development of computer hardware and software for medical and clinical use; medical research services; clinical research; chemical analysis; chemical research; analytical laboratory services; biological analysis; laboratory analysis; laboratory (scientific) services; laboratory testing services; medical research laboratory services; computer programming; design and development of medical technology and medical apparatus; research and development services relating to medical apparatus and instruments; advice, information and consultancy relating to any of the aforesaid services; none of the aforesaid relating to dermatology or skincare; none relating to vehicles or the automotive industry. Medical services; consulting services relating to health care; healthcare services; health advice and information services; medical care services; medical clinic services; health clinic services; medical health assessment services; health screening services; diagnostic health screening services; preparation of reports relating to health matters; medical testing; medical testing for diagnostic purposes; testing for medical purposes; advice, information and consultancy services relating to any of the aforesaid services; none of the aforesaid relating to dermatology or skincare.

Abstract

An Ion mobility filter (20) is disclosed. The present invention relates to but not exclusively a field asymmetric ion spectrometry filter. For example, we describe an ion filter for filtering ions in a gas sample. The ion filter is comprised of a plurality of electrodes (30a, 30b, 30c, 32a, 32b, 32c), a first ion channel (34a), and a second ion channel (34b). The first ion channel (34a) is used for filtering ions from a target chemical in the gas sample, wherein the first ion channel (34a) defines a gap between a first pair of electrodes (30a and 32a) in the plurality of electrodes (30a, 30b, 30c, 32a, 32b, 32c) and has a first ion channel gap width (d1). The second ion channel (34b) is used for filtering ions from the target chemical in the gas sample, wherein the second ion channel (34b) defines a gap between a second pair of electrodes (30b and 32b) in the plurality of electrodes (30a, 30b, 30c, 32a, 32b, 32c) and has a second ion channel gap width (d2), wherein the first ion channel gap width (d1) is greater than the second ion channel gap width (d2). Various arrangements of the ion channels in ion mobility filters are also disclosed.

IPC Classes  ?

• G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
• H01J 49/00 - Particle spectrometers or separator tubes
• H01J 49/06 - Electron- or ion-optical arrangements

Abstract

A spectrometry system is provided. The spectrometry system has an ionizer (210) for generating ions within a sample with an associated ion mobility. The spectrometry system has an excitation source (240) for generating an excitation signal to modulate the ion mobility associated with ions from a target chemical within the gas sample. The spectrometry system has an ion filter (220) for separating the ions having modulated ion mobility from the gas sample. The spectrometry system has a detector (230) for detecting an output from the ion filter (220).

IPC Classes  ?

• G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode

Abstract

An ion filter (120) for filtering ions in a gas sample. The ion filter (120) has a first ion channel (132) for filtering ions from a target chemical in the gas sample. The ion filter (120) has a second ion channel (134) for filtering ions from the target chemical in the gas sample. The second ion channel (134) is separated from the first ion channel (132). A temperature control region (136) is in thermal contact with the first and second ion channels for controlling a difference in temperature between the first and second ion channels (132), (134).A method of filtering ions from a target chemical in a gas sample is also provided.

IPC Classes  ?

• G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
• H01J 49/06 - Electron- or ion-optical arrangements

Abstract

A sensor system comprising a housing (10) having an inlet aperture (18) through which fluid enters the housing (10) and a conditioning material (32) in the housing (10), the conditioning material (32) being adapted to control levels of a substance within the housing (10). The sensor system comprises a sensor (12) for analysing the fluid in the housing (10). The sensor system comprises circulation means (14) which is configured to alternate circulation of fluid within the housing (10) between a sensing fluid path in which the fluid is analysed by the sensor (12) and a second fluid path in which the fluid flow is conditioned. A method for analysing fluid in a housing (10) using a sensor (12) is also provided.

IPC Classes  ?

• H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
• G01N 1/22 - Devices for withdrawing samples in the gaseous state
• G01N 1/34 - Purifying; Cleaning
• G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
• B01D 53/26 - Drying gases or vapours

Abstract

A waveform generator (200) configured to generate two waveforms (211, 213) of opposite polarity so as to provide a voltage gain across a load (207). The waveform generator (200) has a primary side circuit comprising a first inductor (201). The waveform generator (200) has a secondary side circuit comprising a second inductor (203), a first output region (231) conductively coupled to the load (207), and a second output region (233) conductively coupled to the load (207). The second inductor (203) is inductively coupled to the first inductor (201). The first inductor (201) is conductively coupled to the first output region (231) so as to supply a first (211) of the two waveforms (211, 213) to the load (207). The second inductor (203) is conductively coupled to the second output region (233) so as to supply a second (213) of the two waveforms (211, 213) to the load (207). A system (500) incorporating the waveform generator (200) and a method of driving the waveform generator (200) are also provided.

IPC Classes  ?

• H03K 3/57 - Generators characterised by the type of circuit or by the means used for producing pulses by the use of an energy-accumulating element discharged through the load by a switching device controlled by an external signal and not incorporating positive feedback the switching device being a semiconductor device

Goods & Services

Downloadable and recorded computer software and computer programs to control collection of medical samples by modifying the timing of data collection and to perform analysis of medical samples in connection with and as part of medical apparatus; Downloadable and recorded computer application software for hand-held computing devices, namely, software to control collection of medical samples and to perform analysis of medical samples for use in connection with and as part of medical apparatus and instruments; Downloadable and recorded medical diagnostic software for use to control collection of medical samples and to perform analysis of medical samples in connection with and as part of medical apparatus and instruments; Chemical detection systems and apparatus, namely, analyzers and sampling equipment for use to collect and analyze liquid, solid and gas samples; gas detectors for detecting the presence of gas; Particle counters; Pressure sensors; Downloadable and recorded computer software and computer programs for medical purposes for use to diagnose and monitor diseases in connection with and as part of medical apparatus and instruments; replacement parts and fittings for all of the aforesaid; none of the aforesaid relating to dermatology or skincare; none of the aforesaid relating to vehicles or the automotive industry Medical apparatus and instruments for treating cancer, celiac disease, tuberculosis, asthma, inflammatory bowel disease, fatty liver disease; Diagnostic apparatus for medical purposes for detecting cancer cells; Chemical detection systems and apparatus for medical purposes, namely, analyzers and sampling equipment for use to collect and analyze liquid, solid and gas samples; Medical imaging apparatus; Medical and clinical devices used for the collection, recording, concentration and analysis of volatile organic compounds in human breath; Medical testing kits in the nature of a medical device for detection of cancer, celiac disease, tuberculosis, asthma, inflammatory bowel disease, fatty liver disease for home use; Respiratory equipment for medical purposes; Testing apparatus for medical purposes, namely, breath detectors for use to detect disease biomarkers; Detectors for medical purposes, namely, breath detectors for use to detect disease biomarkers; Sensors for medical purposes, namely, respiratory sensors; Replacement parts and fittings for all of the aforesaid; none of the aforesaid relating to dermatology or skincare; none of the aforesaid goods being related to hip prosthesis or orthopaedic articles Medical research services; Clinical research services in the field of disease biomarkers; Chemical analysis; Chemical research; Analytical laboratory services in the field of disease biomarkers; Biological analysis; Laboratory analysis in the field of disease biomarkers; Scientific laboratory services; Laboratory testing services of disease biomarkers within gas, liquid and solid samples; Medical research laboratory services; Design and development of medical technology and medical apparatus research and development services relating to medical apparatus and instruments; Advice, information and consultancy relating to any of the aforesaid scientific laboratory services; none of the aforesaid relating to dermatology or skincare; none of the aforesaid relating to vehicles or the automotive industry Medical services; Consulting services relating to health care; Healthcare services; health advice and information services; Medical care services; Medical clinic services; health clinic services; Medical health assessment services; Health screening services in the field of cancer, celiac disease, tuberculosis, asthma, inflammatory bowel disease, fatty liver disease; Diagnostic health screening services in the field of cancer, celiac disease, tuberculosis, asthma, inflammatory bowel disease, fatty liver disease; providing health information in the form of preparing reports relating to health matters; Medical testing for diagnostic or treatment purposes; Medical testing for diagnostic purposes; Genetic testing for medical purposes; advice, information and consultancy services relating to any of the aforesaid medical services; none of the aforesaid relating to dermatology or skincare

Abstract

Disclosed is a method for collecting different selected exhaled breath samples, or fractions thereof, on a single sample capture device, the method comprising the steps of: (a)collecting a first exhaled breath sample by contacting the sample with a capture device comprising an adsorbent material; (b)collecting a second exhaled breath sample by contacting the second sample with said capture device, wherein the first and second exhaled breath samples are caused to be captured on the capture device in a spatially separated manner.

IPC Classes  ?

• A61B 5/097 - Devices for facilitating collection of breath or for directing breath into or through measuring devices
• A61B 5/08 - Measuring devices for evaluating the respiratory organs

Abstract

Disclosed is apparatus for collecting a breath sample from a human subject, the apparatus comprising at least a mask portion which, in use, is positioned over the subject's mouth and nostrils so as to collect breath exhaled from the subject, the apparatus further comprising movement detection means for detecting movement of the mask portion, and an alarm signal generator, which alarm signal generator generates an alarm signal if the subject's head is outside a predetermined range of acceptable orientations during collection of a breath sample, but only after the subject's head has been outside the predetermined range of acceptable orientations for a defined or measurable period of time.

IPC Classes  ?

• A61B 5/097 - Devices for facilitating collection of breath or for directing breath into or through measuring devices
• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• G01N 33/497 - Physical analysis of biological material of gaseous biological material, e.g. breath
• A61B 5/08 - Measuring devices for evaluating the respiratory organs
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons

Goods & Services

Computer hardware and peripheral devices; computer software and computer programs; computer application software; computer software for use in connection with and as part of medical apparatus and instruments; clinical software, including database systems for patient medical information; medical diagnostic software; computer systems; data processing equipment; electronic devices for storing, recording, transmitting and reproducing information, data or images; diagnostic apparatus, not for medical purposes; testing apparatus, not for medical purposes; chemical detection systems and apparatus; detectors; spectrometers; sensors; computer software and computer programs for medical purposes; parts and fittings for all of the aforesaid. Medical apparatus and instruments; diagnostic apparatus for medical purposes; chemical detection systems and apparatus for medical purposes; medical imaging apparatus; medical and clinical devices; medical test kits; medical respiratory equipment; testing apparatus for medical purposes; detectors for medical purposes; spectrometers for medical purposes; sensors for medical purposes; parts and fittings for all of the aforesaid. Scientific and technological services and research and design relating thereto; design and development of computer hardware and software; design and development of computer hardware and software for medical and clinical use; medical research services; clinical research; chemical analysis; chemical research; analytical laboratory services; biological analysis; laboratory analysis; laboratory (scientific) services; laboratory testing services; medical laboratory services; computer programming; design and development of medical technology and medical apparatus; research and development services relating to medical apparatus and instruments; advice, information and consultancy relating to any of the aforesaid services. Medical services; consultancy services relating to health care; healthcare services; health advice and information services; medical care services; medical clinic services; health clinic services; medical health assessment services; health screening services; diagnostic health screening services; preparation of reports relating to health matters; medical testing; medical diagnostic services [testing and analysis]; testing for medical purposes; advice, information and consultancy services relating to any of the aforesaid services.

Abstract

Disclosed is a method of identifying if a subject is sufficiently prepared to permit successful colonoscopic examination, the method comprising the steps of: (a) obtaining a stool sample from a subject having undergone preparation for a colonoscopic examination; (b) analysing the sample to detect the presence and/or amount of faecal matter, if any, in the stool sample; and (c) from the analysis in step (b), identifying whether the subject has been sufficiently prepared.

IPC Classes  ?

• A61B 1/31 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the rectum, e.g. proctoscopes, sigmoidoscopes

Goods & Services

Computer software for use in connection with and as part of medical apparatus and instruments; clinical software, including database systems for patient medical information; medical diagnostic software; diagnostic apparatus, not for medical purposes; testing apparatus, not for medical purposes; chemical detection systems and apparatus; detectors; spectrometers; sensors; computer software and computer programs for medical purposes; parts and fittings for all of the aforesaid; none of the aforesaid relating to dermatology or skincare; none relating to vehicles or the automotive industry. Medical apparatus and instruments; diagnostic apparatus for medical purposes; chemical detection systems and apparatus for medical purposes; medical imaging apparatus; medical and clinical devices; medical testing kits; respiratory equipment; testing apparatus for medical purposes; detectors for medical purposes; spectrometers for medical purposes; sensors for medical purposes; parts and fittings for all of the aforesaid; none of the aforesaid relating to dermatology or skincare; none of the aforesaid goods being related to hip prosthesis or orthopaedic articles. Scientific and technological services and research and design relating thereto; design and development of computer hardware and software for medical and clinical use; medical research services; clinical research; chemical analysis; chemical research; analytical laboratory services; biological analysis; laboratory analysis; laboratory (scientific) services; laboratory testing services; medical research laboratory services; design and development of medical technology and medical apparatus; research and development services relating to medical apparatus and instruments; advice, information and consultancy relating to any of the aforesaid services; none of the aforesaid relating to dermatology or skincare; none relating to vehicles or the automotive industry. Medical services; consulting services relating to health care; healthcare services; health advice and information services; medical care services; medical clinic services; health clinic services; medical health assessment services; health screening services; diagnostic health screening services; preparation of reports relating to health matters; medical testing; diagnostic testing; testing for medical purposes; advice, information and consultancy services relating to any of the aforesaid services; none of the aforesaid relating to dermatology or skincare.

Goods & Services

Computer hardware and peripheral devices; computer software and computer programs for use to collect and analyse medical samples; computer application software for hand-held computing devices, namely, software to control collection of medical samples and to perform analysis of medical samples; computer software for use to collect and analyse medical samples for use in connection with and as part of medical apparatus and instruments; clinical software, including database systems for patient medical information for use to store and analyse data; medical diagnostic software; computer operating systems; calculating machines and data processing equipment; electronic devices for storing, recording, transmitting and reproducing information, data or images; diagnostic apparatus, not for medical purposes, for use to analyse chemical samples; testing apparatus, not for medical purposes, for use to test calibration of equipment; chemical detection systems and apparatus, namely, analysers and sampling equipment for use to collect and analyse liquid, solid and gas samples; gas detectors, particle detectors; spectrometers; temperature sensors, gas sensors, movement sensors, pressure sensors; computer software and computer programs for medical purposes for use to diagnose and monitor diseases Medical apparatus and instruments for treating cancer, celiac disease, tuberculosis, asthma, inflammatory bowel disease, fatty liver disease; diagnostic apparatus for the detection of disease biomarkers; medical apparatus for dosage, measuring and monitoring, namely, drug delivery devices and systems; medical apparatus, namely, breath gas analysers for medical diagnostics; medical apparatus, namely, patient medical monitors for monitoring lung function; medical apparatus, namely, spirometers; medical instruments for measuring and displaying lung capacity; chemical detection systems and apparatus for medical purposes consisting of analysers and sampling equipment for use to collect and analyse liquid, solid and gas samples; medical imaging apparatus; medical devices used for the collection, recording, concentration and analysis of volatile organic compounds in human breath; medical testing kits for detection of cancer, celiac disease, tuberculosis, asthma, inflammatory bowel disease, fatty liver disease for home use; testing apparatus for medical purposes, namely, breath detectors for use to detect disease biomarkers; detectors for medical purposes; sensors for medical purposes, namely, respiratory sensors; medical products, namely, biofeedback sensors; patient monitoring sensors and alarms; parts and fittings for all of the aforesaid Scientific and technological services, namely, research and design in the field of computer data storage and interpretation of data; design and development of computer hardware and software; design and development of computer hardware and software for medical and clinical use; medical research services; clinical research in the field of disease biomarkers; chemical analysis undertaken using a spectrometer to analyse disease biomarkers within gas, liquid and solid samples; chemical research; laboratory analysis in the field of chemistry; biological analysis using a spectrometer to analyse disease biomarkers within gas, liquid and solid samples; scientific laboratory services; laboratory testing services of disease biomarkers within gas, liquid and solid samples; medical research laboratory services; computer programming; design and development of medical technology and medical apparatus; research and development services relating to medical apparatus and instruments; advice, information and consultancy relating to any of the aforesaid services Medical services; consulting services relating to health care providers in the field of treating life-changing or life-threatening diseases; healthcare services; health advice and information services; medical care services; medical clinic services; medical health assessment services; health screening services in the field of cancer, celiac disease, tuberculosis, asthma, inflammatory bowel disease, fatty liver disease; diagnostic health screening services in the field of cancer, celiac disease, tuberculosis, asthma, inflammatory bowel disease, fatty liver disease; medical testing for diagnostic or treatment purposes; medical diagnostic testing, monitoring and reporting services; advice, information and consultancy services relating to any of the aforesaid services

Goods & Services

Computer hardware and peripheral devices; computer software and computer programs; computer application software; computer software for use in connection with and as part of medical apparatus and instruments; clinical software, including database systems for patient medical information; medical diagnostic software; computer systems; data processing equipment; electronic devices for storing, recording, transmitting and reproducing information, data or images; diagnostic apparatus, not for medical purposes; testing apparatus, not for medical purposes; chemical detection systems and apparatus; detectors; spectrometers; sensors; computer software and computer programs for medical purposes; parts and fittings for all of the aforesaid. Medical apparatus and instruments; diagnostic apparatus for medical purposes; chemical detection systems and apparatus for medical purposes; medical imaging apparatus; medical and clinical devices; medical test kits (term considered too vague by the International Bureau - rule 13 (2) (b) of the Common Regulations); medical respiratory equipment; testing apparatus for medical purposes; detectors for medical purposes; spectrometers for medical purposes; sensors for medical purposes; parts and fittings for all of the aforesaid. Scientific and technological services and research and design relating thereto; design and development of computer hardware and software; design and development of computer hardware and software for medical and clinical use; medical research services; clinical research; chemical analysis; chemical research; analytical laboratory services; biological analysis; laboratory analysis; laboratory (scientific) services; laboratory testing services; medical laboratory services; computer programming; design and development of medical technology and medical apparatus; research and development services relating to medical apparatus and instruments; advice, information and consultancy relating to any of the aforesaid services. Medical services; consulting services relating to health care; healthcare services; health advice and information services; medical care services; medical clinic services; health clinic services; healthcare services; medical health assessment services; health screening services; diagnostic health screening services; preparation of reports relating to health matters; medical testing; diagnostic testing; testing for medical purposes; advice, information and consultancy services relating to any of the aforesaid services.

Goods & Services

Computer hardware and peripheral devices; computer software and computer programs; computer application software; computer software for use in connection with and as part of medical apparatus and instruments; clinical software, including database systems for patient medical information; medical diagnostic software; computer systems; data processing equipment; electronic devices for storing, recording, transmitting and reproducing information, data or images; diagnostic apparatus, not for medical purposes; testing apparatus, not for medical purposes; chemical detection systems and apparatus; detectors; spectrometers; sensors; computer software and computer programs for medical purposes; parts and fittings for all of the aforesaid. Medical apparatus and instruments; diagnostic apparatus for medical purposes; chemical detection systems and apparatus for medical purposes; medical imaging apparatus; medical and clinical devices; medical kits; respiratory equipment; testing apparatus for medical purposes; detectors for medical purposes; spectrometers for medical purposes; sensors for medical purposes; parts and fittings for all of the aforesaid. Scientific and technological services and research and design relating thereto; design and development of computer hardware and software; design and development of computer hardware and software for medical and clinical use; medical research services; clinical research; chemical analysis; chemical research; analytical laboratory services; biological analysis; laboratory analysis; laboratory (Scientific) services; laboratory testing services; medical laboratory services; computer programming; design and development of medical technology and medical apparatus; research and development services relating to medical apparatus and instruments; advice, information and consultancy relating to any of the aforesaid services. Medical services; consulting services relating to health care; healthcare services; health advice and information services; medical care services; medical clinic services; health clinic services; medical health assessment services; health screening services; diagnostic health screening services; preparation of reports relating to health matters; medical testing; diagnostic testing; testing for medical purposes; advice, information and consultancy services relating to any of the aforesaid services.

Goods & Services

Computer hardware and peripheral devices; computer software and computer programs for use to control collection of medical samples by modifying the timing of data collection and to perform analysis of medical samples in connection with and as part of medical apparatus; computer application software for hand-held computing devices, namely, software to control collection of medical samples and to perform analysis of medical samples; computer software for use to control collection of medical samples and to perform analysis of medical samples for use in connection with and as part of medical apparatus and instruments; clinical software, featuring database systems for patient medical information for use to store and analyse data; medical diagnostic software for use to control collection of medical samples and to perform analysis of medical samples in connection with and as part of medical apparatus and instruments; computer operating systems; calculating machines and data processing equipment; digital electronic devices for storing, recording, transmitting and reproducing information, data or images; diagnostic apparatus, not for medical purposes, for use to analyse chemical samples; testing apparatus, not for medical purposes, for use to test calibration of spectrometers and gas detectors; chemical detection systems and apparatus, namely, analysers and sampling equipment for use to collect and analyse liquid, solid and gas samples; gas detectors for detecting the presence of gas; particle counters; scientific apparatus, namely, spectrometers; temperature sensors, gas sensors, movement sensors, pressure sensors; computer software and computer programs for medical purposes for use to diagnose and monitor diseases Medical apparatus and instruments for treating cancer, celiac disease, tuberculosis, asthma, inflammatory bowel disease, fatty liver disease; medical diagnostic apparatus for the detection of disease biomarkers; medical apparatus for dosage, measuring and monitoring, namely, drug delivery devices and systems; medical apparatus, namely, breath gas analysers for medical diagnostics; medical apparatus, namely, patient medical monitors for monitoring lung function; medical apparatus, namely, spirometers; medical instruments for measuring and displaying lung capacity; chemical detection systems and apparatus for medical purposes consisting of analysers and sampling equipment for use to collect and analyse liquid, solid and gas samples; medical imaging apparatus; medical devices used for the collection, recording, concentration and analysis of volatile organic compounds in human breath; medical test kit in the nature of a medical device for detection of cancer, celiac disease, tuberculosis, asthma, inflammatory bowel disease, fatty liver disease for home use; testing apparatus for medical purposes, namely, breath detectors for use to detect disease biomarkers; detectors for medical purposes; sensors for medical purposes, namely, respiratory sensors; medical products, namely, biofeedback sensors; patient monitoring sensors and alarms; parts and fittings for all of the aforesaid Scientific and technological services, namely, research and design in the field of computer data storage and interpretation of data; design and development of computer hardware and software; design and development of computer hardware and software for medical and clinical use; medical research services; clinical research in the field of disease biomarkers; chemical analysis undertaken using a spectrometer to analyse disease biomarkers within gas, liquid and solid samples; chemical research; laboratory analysis in the field of chemistry; biological analysis using a spectrometer to analyse disease biomarkers within gas, liquid and solid samples; scientific laboratory services; laboratory testing services of disease biomarkers within gas, liquid and solid samples; medical research laboratory services; computer programming; design and development of medical technology and medical apparatus; research and development services relating to medical apparatus and instruments; advice, information and consultancy relating to any of the aforesaid services Medical services; consulting services relating to health care providers in the field of treating life-changing or life-threatening diseases; healthcare services; health advice and information services; medical care services; medical clinic services; medical health assessment services; health screening services in the field of cancer, celiac disease, tuberculosis, asthma, inflammatory bowel disease, fatty liver disease; diagnostic health screening services in the field of cancer, celiac disease, tuberculosis, asthma, inflammatory bowel disease, fatty liver disease; medical testing for diagnostic or treatment purposes; medical diagnostic testing, monitoring and reporting services; advice, information and consultancy services relating to any of the aforesaid services

Abstract

There is provided a device (10) for collecting a breath portion from a patient for analysis, comprising a housing structure including an inlet port (30) associated with a mask structure for receiving a portion of the patient's breath, at least one sensor (22) operatively coupled to the inlet port (30) for detecting one or more parameters regarding the patient's breath, at least one collection container (20) for collecting a portion of the patient's breath received in the inlet port (30), at least one pump (28) for pumping a selective portion of the patient's breath from the inlet port (30) to the at least one collection container (20) and a control system (32) for controlling operation of the at least one sensor and at least one pump (30). The control system (32) selectively operates the pump based on sensed parameters such as CO2 and/or pressure to collect breath samples.

IPC Classes  ?

• A61B 5/097 - Devices for facilitating collection of breath or for directing breath into or through measuring devices
• A61B 5/08 - Measuring devices for evaluating the respiratory organs

Abstract

Disclosed is a method for selectively capturing one or more portions of a patient's breath, comprising: detect one or more parameters regarding the patient's breath duringa breathing routine; determine one or more data points from the detected one or moreparameters wherein the one or more data points identifies one or more portions of thepatient's breath to capture; and capture one or more portions of the patient's breathduring the breathing routine.

IPC Classes  ?

• A61B 5/08 - Measuring devices for evaluating the respiratory organs
• A61B 5/097 - Devices for facilitating collection of breath or for directing breath into or through measuring devices

Abstract

2 and/or pressure to collect breath samples.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
• A61B 5/097 - Devices for facilitating collection of breath or for directing breath into or through measuring devices
• A61B 5/08 - Measuring devices for evaluating the respiratory organs
• B01D 46/00 - Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
• B01D 53/02 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography
• B01D 53/30 - Controlling by gas-analysis apparatus
• G01N 33/497 - Physical analysis of biological material of gaseous biological material, e.g. breath

Abstract

capture one or more portions of the patient's breath during the breathing routine.

IPC Classes  ?

• A61B 5/097 - Devices for facilitating collection of breath or for directing breath into or through measuring devices
• A61M 16/08 - Bellows; Connecting tubes
• A61B 5/08 - Measuring devices for evaluating the respiratory organs
• A61M 16/06 - Respiratory or anaesthetic masks
• A61B 5/083 - Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
• A61B 5/091 - Measuring volume of inspired or expired gases, e.g. to determine lung capacity
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
• A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
• A61B 5/085 - Measuring impedance of respiratory organs or lung elasticity
• A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes

Goods & Services

Computer hardware and peripheral devices; computer software and computer programs; computer application software; computer software for use in connection with and as part of medical apparatus and instruments; clinical software, including database systems for patient medical information; medical diagnostic software; computer systems; data processing equipment; electronic devices for storing, recording, transmitting and reproducing information, data or images; diagnostic apparatus, not for medical purposes; testing apparatus, not for medical purposes; chemical detection systems and apparatus; detectors; spectrometers; sensors; computer software and computer programs for medical purposes; parts and fittings for all of the aforesaid. Medical apparatus and instruments; diagnostic apparatus for medical purposes; chemical detection systems and apparatus for medical purposes; medical imaging apparatus; medical and clinical devices; medical testing kits; respiratory equipment; testing apparatus for medical purposes; detectors for medical purposes; spectrometers for medical purposes; sensors for medical purposes; parts and fittings for all of the aforesaid. Scientific and technological services and research and design relating thereto; design and development of computer hardware and software; design and development of computer hardware and software for medical and clinical use; medical research services; clinical research; chemical analysis; chemical research; analytical laboratory services; biological analysis; laboratory analysis; laboratory (scientific) services; laboratory testing services; medical research laboratory services; computer programming; design and development of medical technology and medical apparatus; research and development services relating to medical apparatus and instruments; advice, information and consultancy relating to any of the aforesaid services. Medical services; consulting services relating to health care; healthcare services; health advice and information services; medical care services; medical clinic services; health clinic services; healthcare services; medical health assessment services; health screening services; diagnostic health screening services; preparation of reports relating to health matters; medical testing; diagnostic testing; testing for medical purposes; advice, information and consultancy services relating to any of the aforesaid services.

Goods & Services

Computer hardware and peripheral devices; computer software and computer programs for use to collect and analyse medical samples; computer application software for hand-held computing devices, namely software to control collection of medical samples and to perform analysis of medical samples; computer software for use to collect and analyse medical samples for use in connection with and as part of medical apparatus and instruments; clinical software, including database systems for patient medical information for use to store and analyse data; medical diagnostic software; computer operating systems; calculating machines and data processing equipment; electronic devices for storing, recording, transmitting and reproducing information, data or images; diagnostic apparatus, not for medical purposes, for use to analyse chemical samples; testing apparatus, not for medical purposes, for use to test calibration of equipment; chemical detection systems and apparatus, namely, analysers and sampling equipment for use to collect and analyse liquid, solid and gas samples; gas detectors, particle detectors; spectrometers; temperature sensors, gas sensors, movement sensors, pressure sensors; computer software and computer programs for medical purposes for use to diagnose and monitor diseases Medical apparatus and instruments for treating cancer, celiac disease, tuberculosis, asthma, inflammatory bowel disease, fatty liver disease; diagnostic apparatus for the detection of disease biomarkers; medical apparatus for dosage, measuring and monitoring, namely, drug delivery devices and systems; medical apparatus, namely, breath gas analysers for medical diagnostics; medical apparatus, namely, patient medical monitors for monitoring lung function; medical apparatus, namely, spirometers; medical instruments for measuring and displaying lung capacity; chemical detection systems and apparatus for medical purposes consisting of analysers and sampling equipment for use to collect and analyse liquid, solid and gas samples; medical imaging apparatus; medical devices used for the collection, recording, concentration and analysis of volatile organic compounds in human breath; medical testing kits for detection of cancer, celiac disease, tuberculosis, asthma, inflammatory bowel disease, fatty liver disease for home use; testing apparatus for medical purposes, namely, breath detectors for use to detect disease biomarkers; detectors for medical purposes; sensors for medical purposes, namely, respiratory sensors; medical products, namely, biofeedback sensors; patient monitoring sensors and alarms; parts and fittings for all of the aforesaid Scientific and technological services, namely, research and design in the field of computer data storage and interpretation of data; design and development of computer hardware and software; design and development of computer hardware and software for medical and clinical use; medical research services; clinical research in the field of disease biomarkers; chemical analysis undertaken using a spectrometer to analyse disease biomarkers within gas, liquid and solid samples; chemical research; laboratory analysis in the field of chemistry; biological analysis using a spectrometer to analyse disease biomarkers within gas, liquid and solid samples; scientific laboratory services; laboratory testing services of disease biomarkers within gas, liquid and solid samples; medical research laboratory services; computer programming; design and development of medical technology and medical apparatus; research and development services relating to medical apparatus and instruments; advice, information and consultancy relating to any of the aforesaid services Medical services; consulting services relating to health care providers in the field of treating life-changing or life-threatening diseases; healthcare services; health advice and information services; medical care services; medical clinic services; medical health assessment services; health screening services in the field of cancer, celiac disease, tuberculosis, asthma, inflammatory bowel disease, fatty liver disease; diagnostic health screening services in the field of cancer, celiac disease, tuberculosis, asthma, inflammatory bowel disease, fatty liver disease; medical testing for diagnostic or treatment purposes; medical diagnostic testing, monitoring and reporting services; advice, information and consultancy services relating to any of the aforesaid services

Abstract

A corona discharge ionizer device which emits ions generated by corona discharge to a gas flow to be ionized includes a discharge electrode having a pin configured tip portion. A second grid electrode positioned at a spaced distance from the discharge electrode is provided. The grid electrode is preferably formed from a sheet configured material which has at least one hole formed therein adapted and configured to permit the gas flow to pass therethrough. A power supply is coupled to the discharge electrode and grid electrode configured cause ion emission from the discharge electrode. The power supply is preferably an alternating current power supply configured to produce an alternating electric field region in close proximity to the tip portion of the discharge electrode sufficient to cause avalanche breakdown in the gas flowing in close proximity to the tip portion of the discharge electrode.

IPC Classes  ?

• H01J 49/16 - Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
• G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode

Abstract

An ion filter and a method of manufacturing an ion filter. The method including providing a monolithic structure; selectively removing regions of the structure, to form a pair of electrodes defining at least one ion channel therebetween. The electrodes are preferably mechanically connected at one or more locations by a portion of the structure; wherein the connecting portion of the structure provides a higher electrical impedance than the filter would provide without such a mechanical connection, to thereby electrically separate the electrodes.

IPC Classes  ?

• H01J 49/00 - Particle spectrometers or separator tubes
• G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
• H01J 49/42 - Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons

Abstract

An ion mobility gas detector apparatus including a detector core, an inlet gas path, an exhaust gas path, a source of diluent gas, and at least one or more sensors for measuring temperature, pressure and humidity of gas streams. Further included is a mixing mechanism adapted to mix at least first and second gas streams in response to one or more sensor measurements. A controller is provided for applying drive signals to the detector core.

IPC Classes  ?

• G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
• H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
• H01J 49/40 - Time-of-flight spectrometers
• G01N 27/68 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode using electric discharge to ionise a gas

Abstract

Ion filter for FAIMS fabricated using the LIGA technique. The ion filter is manufactured using a metal layer to form the ion channels and an insulating support layer to hold the structure rigidly together after separation of the metal layer into two electrodes.

IPC Classes  ?

• G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
• H01J 49/06 - Electron- or ion-optical arrangements
• H01J 49/00 - Particle spectrometers or separator tubes

Abstract

An apparatus, system and method for detecting, identifying, classifying and/or quantifying chemical species in a gas flow using a micro-fabricated ion filter coupled to a system adapted to apply drive signals to the ion filter. Coupled to the ion filter is a system adapted to measure the output of the ion filter, which in turn is coupled to a system adapted to extract numerical parameters from the measured output of the ion filter to facilitate chemical detection, identification, classification and/or quantification of the gas flow.

IPC Classes  ?

• G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode

Abstract

An ion filter and a method of manufacturing an ion filter. The method including providing a monolithic structure; selectively removing regions of the structure, to form a pair of electrodes defining at least one ion channel therebetween. The electrodes are preferably mechanically connected at one or more locations by a portion of the structure; wherein the connecting portion of the structure provides a higher electrical impedance than the filter would provide without such a mechanical connection, to thereby electrically separate the electrodes.

IPC Classes  ?

• H01J 49/00 - Particle spectrometers or separator tubes
• G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
• H01J 49/42 - Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons

Abstract

A method of quantifying the amount of at least two analytes Al and A2 comprised in a sample, comprising: • (a) adding at least one salt (S) to at least a portion (PI) of the sample comprising the at least two analytes Al and A2, • (b) ionizing at least a portion of the sample according to (a) thereby forming an analyte flow comprising the analytes Al and A2 in ionized form, • (c) separating the ionized analytes Al and A2 from each other by using at least one ion mobility separator (124), wherein the analyte flow according to (b) at least partially passes through the ion mobility separator (124), • (d) quantifying the amount of the separated ionized analytes obtained according to (c).

IPC Classes  ?

• C07B 63/00 - Purification; Separation specially adapted for the purpose of recovering organic compounds; Stabilisation; Use of additives
• C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
• G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode

Abstract

Ion filter for FAIMS fabricated using the LIGA technique. The ion filter is manufactured using a metal layer to form the ion channels and an insulating support layer to hold the structure rigidly together after separation of the metal layer into two electrodes.

IPC Classes  ?

• H01J 49/00 - Particle spectrometers or separator tubes
• H01J 49/06 - Electron- or ion-optical arrangements
• G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode

Abstract

An ion mobility gas detector apparatus including a detector core, an inlet gas path, an exhaust gas path, a source of diluent gas, and at least one or more sensors for measuring temperature, pressure and humidity of gas streams. Further included is a mixing mechanism adapted to mix at least first and second gas streams in response to one or more sensor measurements. A controller is provided for applying drive signals to the detector core.

IPC Classes  ?

• G01N 27/68 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode using electric discharge to ionise a gas
• G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
• H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
• H01J 49/40 - Time-of-flight spectrometers

Abstract

A corona discharge ionizer device which emits ions generated by corona discharge to a gas flow to be ionized includes a discharge electrode having a pin configured tip portion. A second grid electrode positioned at a spaced distance from the discharge electrode is provided. The grid electrode is preferably formed from a sheet configured material which has at least one hole formed therein adapted and configured to permit the gas flow to pass therethrough. A power supply is coupled to the discharge electrode and grid electrode configured cause ion emission from the discharge electrode. The power supply is preferably an alternating current power supply configured to produce an alternating electric field region in close proximity to the tip portion of the discharge electrode sufficient to cause avalanche breakdown in the gas flowing in close proximity to the tip portion of the discharge electrode.

IPC Classes  ?

• H01J 49/16 - Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission

Abstract

An apparatus, system and method for detecting, identifying, classifying and/or quantifying chemical species in a gas flow using a micro-fabricated ion filter coupled to a system adapted to apply drive signals to the ion filter. Coupled to the ion filter is a system adapted to measure the output of the ion filter, which in turn is coupled to a system adapted to extract numerical parameters from the measured output of the ion filter to facilitate chemical detection, identification, classification and/or quantification of the gas flow.

IPC Classes  ?

• B01D 59/44 - Separation by mass spectrography
• B01D 59/46 - Separation by mass spectrography using only electrostatic fields
• H01J 49/00 - Particle spectrometers or separator tubes
• G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode

Abstract

An ion mobility spectrometer is described which makes use of a pulsed flow pump to draw gas through an ion filter in pulsed operation. A gas counterflow may also be provided, in some embodiments this may also be a pulsed counterflow.

IPC Classes  ?

• H01J 49/34 - Dynamic spectrometers

Abstract

A method and sensor for monitoring chemical species in a gas flow are described. An ionized sample of gas is passed through a flow channel, with a DC electric field applied transverse to the longitudinal axis of the channel. Any electric current produced by the ion flow is measured, with variations in the current being indicative of a change in composition of the gas flow. In certain embodiments, the DC field may be varied over time, to sweep the field voltage. The detected current against field voltage graph may be taken as a profile of a particular gas composition. Variations in the profile again are indicative of a change in gas composition.

IPC Classes  ?

• H01J 49/00 - Particle spectrometers or separator tubes

Abstract

An ion mobility spectrometer is described having an ion filter in the form of at least one ion channel having a plurality of electrodes. A time-varying electric potential applied to the conductive layers allows the filler to selectively admit ion species. The electric potential has a drive and a transverse component, and in preferred embodiments each of the electrodes is involved in generating a component of both the drive and transverse fields. The device may be used without a drift gas flow. Microfabrication techniques are described for producing microscale spectrometers, as are various uses of the spectrometer.

IPC Classes  ?

• H01J 49/28 - Static spectrometers

Abstract

A smart FAIMS sensor system and method includes a 2/2-electrode filter that pumps the ions through the system and separates the ionic species, a detector for collecting the separated ions and generating a detector signal in response to the collected ions, and a controller configured to change the operating parameters of the system in response to changes in the sensor's environment detected by the sensor. The ability to dynamically change the operating parameters of the sensor enables the sensor to maintain high sensitivity to environmental threats while decreasing the incidences of false positive events.

IPC Classes  ?

• H01J 49/00 - Particle spectrometers or separator tubes
• B01D 59/44 - Separation by mass spectrography

Goods & Services

Chemical detection systems and apparatus, namely, spectrometers programmed to detect, analyze and measure the presence of chemical compounds and chemical agents.

Goods & Services

Chemical detection systems and apparatus, namely, spectrometers programmed to detect, analyze and measure the presence of chemical compounds and chemical agents.

Goods & Services

Gas analyzer and portable chemical detection and sensor systems, namely, spectrometers programmed for both alerts and sample analysis of chemicals.

Abstract

An ion filter (10) for use in ion mobility spectrometry is described, together with a method for manufacturing the filter. The filter (10) is manufactured by removing portions from a monolithic structure to form a pair of electrodes which remain mechanically connected. The connecting portion (22) provides sufficient electrical impedance between the electrodes to effectively electrically separate the electrodes. The connecting portion may be doped or chemically modified to obtain a desired impedance, or this may be obtained through appropriate selection of physical dimensions.

IPC Classes  ?

• H01J 49/00 - Particle spectrometers or separator tubes
• H01J 49/06 - Electron- or ion-optical arrangements
• G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
• H01J 49/42 - Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons

Abstract

An ion mobility spectrometer is described having an ion filter in the form of at least one ion channel having a plurality of electrodes. A time-varying electric potential applied to the conductive layers allows the filler to selectively admit ion species. The electric potential has a drive and a transverse component, and in preferred embodiments each of the electrodes is involved in generating a component of both the drive and transverse fields. The device may be used without a drift gas flow, Microfabrication techniques are described for producing microscale spectrometers, as are various uses of the spectrometer.

IPC Classes  ?

• H01J 49/28 - Static spectrometers

Abstract

An ion mobility spectrometer is described having an ion filter in the form of multiple parallel ion channels defined by conductive layers separated by non-conductive layers. A time-varying electric potential applied to the conductive layers allows the filter to selectively admit ion species. The device may be used without a drift gas flow. Microfabrication techniques are described for producing microscale spectrometers, as are various uses of the spectrometer.

IPC Classes  ?

• B01D 59/44 - Separation by mass spectrography
• H01J 49/40 - Time-of-flight spectrometers

Abstract

A smart FAIMS sensor system and method includes a 2/2-electrode filter that pumps the ions through the system and separates the ionic species, a detector for collecting the separated ions and generating a detector signal in response to the collected ions, and a controller configured to change the operating parameters of the system in response to changes in the sensor's environment detected by the sensor. The ability to dynamically change the operating parameters of the sensor enables the sensor to maintain high sensitivity to environmental threats while decreasing the incidences of false positive events.

IPC Classes  ?

• H01J 49/00 - Particle spectrometers or separator tubes
• B01D 59/44 - Separation by mass spectrography

Abstract

The present invention relates to an ion drive for selectively isolating an analyte of interest and methods of use thereof. The ion drive includes a substrate with channels therethrough, a conductive material coating on the bottom and top of the substrate, a top electrical lead connected to the conductive material coating covering the top of the substrate, and a bottom electrical lead connected to the conductive material coating covering the bottom of the substrate. The invention further relates to an odor emitter which is made up of an ion drive mounted towards the top of a vessel.

IPC Classes  ?

• H01J 49/00 - Particle spectrometers or separator tubes

Abstract

The present invention relates to a three dimensional preconcentrator and inlet heater. The preconcentrator consists of a substrate with passageways, a conductive material coated to the top and the bottom of the substrate and an adsorbent coating covering the entire substrate. This substrate is suspended in a holding frame by a connecting bridge. The preconcentrator may also include a resistor and a proportional-integral-differential controller. The device may be used inline with a detector and can be retrofitted to existing devices. An array of preconcentrators may also be formed. The invention also relates to methods of use of the preconcentrator and methods of manufacture. A method of use includes contacting an analyte and a preconcentrator, allowing the analyte to adsorb to the preconcentrator and then desorbing the analyte. A method of manufacture involves applying the adsorbent coating by misted chemical deposition.

IPC Classes  ?

• B01D 53/02 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography

Abstract

A compact ionization source includes first and second electrodes, each having a plurality of fingers that are interdigitated with each other. The spacing between the first and second electrode, preferably less than 1 mm, creates a large electric field when a potential is applied across the first and second electrodes. The large electric field creates an ionization volume between the fingers of the first and second electrode and ionizes a portion of the molecules occupying the ionization volume. The interdigitated fingers of the first and second electrodes allow for a narrow gap separating the electrodes while presenting a large flow area for ionizing molecules for downstream analysis.

IPC Classes  ?

• H01J 27/00 - Ion beam tubes

Abstract

An ion gate is disposed between a first volume occupied by a first carrier gas and ions of the first carrier gas and a second volume occupied by a second carrier gas. The ion gate includes at least one channel connecting the first volume to the second volume, a first electrode disposed on an inlet surface of the ion gate facing the first volume, and a second electrode disposed on an outlet surface of the ion gate facing the second volume. Ions are transported from the first volume to the second volume through the channel under an electric field produced by the first and second electrode.

IPC Classes  ?

• H01J 49/40 - Time-of-flight spectrometers