A device for mixing and dispensing bone material is provided. The device comprises a tubular member having an interior surface configured to receive bone material and a fluid to mix the bone material disposed within the tubular member. The tubular member is flexible and has a proximal opening configured to slidably receive a plunger, and a distal opening configured to dispense a mixed bone material from the interior surface of the tubular member. The plunger is less flexible than the tubular member. Methods of mixing and dispensing bone material are also provided.
A method of treating a spine includes implanting a spinal implant within a patient. The spinal implant includes a first member having a first wall defining an axial passageway and a first opening, the first opening being in communication with the axial passageway. A second member includes a second wall defining an axial channel having the first member disposed therein, the second wall defining a second opening in communication with the axial channel. Bone graft is injected through the first opening and into the axial passageway and through the second opening and into the axial channel after the spinal implant is implanted within the patient.
A device for hydrating particulate bone material is provided. The device comprises a tubular member having an interior surface and an exterior surface. The interior surface is configured to receive the particulate bone material and a hydration fluid. The exterior surface has a plurality of pores configured to allow the hydration fluid to flow into the interior surface of the tubular member and hydrate the particulate bone material. The plurality of pores are smaller in size than the particulate bone material. Methods of dispensing particulate the bone material are also provided.
A surgical implant and a method for the making the surgical implant is provided. The surgical implant includes various granules incorporated into an upper surface and a lower surface of a body portion thereof. The granules can be pressed into the upper surface and the lower surface via physical force using at least one mold portion. The physical force applied by the at least one mold portion can deform and/or extrude the upper surface and the lower surface to impregrate these surfaces with the granules. The granules can provide the implant with bioresorbable and/or mechanically-reinforced properties.
A surgical implant includes a body portion, a first tier, and a second tier. The first tier is attached to an upper surface of the body portion, and the second tier is attached to a lower surface of the body portion. Each of the upper surface and the lower surface of the body portion includes channels formed therein. The first tier includes a first layer including a plurality of first slats and a second layer including a plurality of second slats, where the plurality of first slats and the plurality of second slats intersect one another to form openings therebetween. The second tier includes a third layer including a plurality of third slats and a fourth layer including a plurality of fourth slats, where the plurality of third slats and the plurality of fourth slats intersect one another to form openings therebetween. When the first tier and the second tier are attached to the body portion, a passageway is formed through the openings formed in the first tier to the channels in the upper surface of the body portion, and a passageway is formed through the openings formed in the second tier to the channels in the lower surface of the body portion.
A driver includes a sleeve having an inner surface defining a passageway. The sleeve extends along a longitudinal axis between a proximal end and an opposite distal end. The proximal end includes a groove in the inner surface. A biasing element is positioned partially in the groove. A shaft is disposed in the passageway. The shaft includes an outer surface, a first engagement portion, and a second engagement portion.
A bone material dispensing device is provided. The bone material dispensing device comprises a housing having a proximal end, a distal end, and a longitudinal axis. The proximal end having a first opening and the distal end having a second opening. The first opening and the second opening configured to slidably receive at least a portion of a plunger. A locking member is provided that is pivotably connected to an upper surface of the housing and extends adjacent to the upper surface of the housing. The locking member comprises a locking surface extending adjacent to the distal end of the housing configured to engage a portion of a tubular member, a funnel, or a combination thereof. The locking member is movable in a locking position to lock the portion of the tubular member, the funnel, or the combination thereof with the housing. A bone material dispensing system and a method of implanting bone material with the bone material dispensing system are also provided.
A device for delivering a bone material to a surgical site is provided. The device comprises a body having an upper portion and a lower portion. The lower portion of the body is substantially transverse to the upper portion and has an opening for receiving a bone material. An internal chamber is disposed within the upper portion and the lower portion, and a plunger is slidably disposed in at least the internal chamber of the body. The plunger has a distal end configured for delivering the bone material out of the lower portion of the body, wherein movement of the plunger in a first position toward the lower portion of the body delivers the bone material from the lower portion of the body to the surgical site. Methods of delivering the bone material are also provided.
A spinal implant for insertion into a disc space between an upper vertebral body and a lower vertebral body is provided. The spinal implant includes an upper first end plate portion and a lower second end plate portion each extending from at least adjacent a proximal end to a distal end of the spinal implant. The spinal implant is configured to facilitate insertion into the disc space and inhibit withdrawal from the disc space. To the end, the leading end of the spinal implant can be configured to facilitate ease of insertion into the disc space, and an upper surface and a lower surface of the upper first end plant portion and the lower second end plate portion, respectively, can be provided with depressions or dimples forming ridges and points therebetween to inhibit withdrawal from the disc space.
A bone material dispensing apparatus for preparing, mixing, and dispensing bone material into a foldable container is provided. In some embodiments, the dispensing apparatus comprises a tray and a foldable container. The tray includes a mixing surface, a dispensing surface and a means to measure the amount of material to be dispensed. A kit including a tray, a foldable container, and a spatula are also provided. A method of using the dispensing apparatus to deliver the bone material to a bone defect is also provided.
Effective treatments of pain for extended periods of time are pro-vided. Through the administration of an effective amount of clonidine at or near a target site, one can relieve pain caused by diverse sources, including but not limit-ed, to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appro-priate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.
An osteoinductive composition comprises tissue which has been treated to improve remodeling characteristics of the tissue. The tissue is treated to degrade collagen within the tissue and to increase the biologic activity of the tissue. The treatment to improve remodeling characteristics includes heating the tissue. The composition includes a thermal coating forming an oxygen barrier to protect the tissue from oxygen when heated. The tissue exhibits increased biologic activity when compared to untreated tissue. The tissue may be cortical bone and the biologic activity may be osteoinductivity. The treated cortical bone may have a faster remodeling time compared to cortical bone in which the collagen is not degraded
In one embodiment, the method comprises providing tissue, preparing the tissue, and treating the tissue to improve remodeling characteristics of the tissue. The tissue may be, for example, cortical bone. Treating the tissue to improve remodeling characteristics may comprise heating the tissue, treating the tissue with a chemical, or other. Heating the tissue may be done in the absence of oxygen and may comprise heating the tissue in a vacuum, heating the tissue in an inert atmosphere, heating the tissue in a reducing atmosphere, coating the tissue with a protective coating and heating the tissue, or other. Further embodiments comprise treating the tissue in supercritical fluids, for example, to dry or virally inactivate the tissue.
Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoin-ductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosisinducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone, and optionally providing a tissue-derived extract and adding the tissue-derived extract to the partially demineralized bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized bone, wherein the collagen structure of the bone has been disrupted, and, optionally, a tissue- derived extract.
In one embodiment, the method comprises providing tissue, preparing the tissue, and treating the tissue to improve remodeling characteristics of the tissue. The tissue may be, for example, cortical bone. Treating the tissue to improve remodeling characteristics may comprise heating the tissue, treating the tissue with a chemical, or other. Heating the tissue may be done in the absence of oxygen and may comprise heating the tissue in a vacuum, heating the tissue in an inert atmosphere, heating the tissue in a reducing atmosphere, coating the tissue with a protective coating and heating the tissue, or other. Further embodiments comprise treating the tissue in supercritical fluids, for example, to dry or virally inactivate the tissue.
A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
A61L 27/44 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
A61L 27/54 - Biologically active materials, e.g. therapeutic substances
Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.
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