An illustrative optical measurement system includes a light source configured to emit light directed at a target, an array of photodetectors configured to detect photons of the light after the light is scattered by the target, and a processing unit configured to measure a noise level of a photodetector included in the array of photodetectors, the noise level comprising a dark count rate that measures a dark count divided by a time period, determine that the noise level meets a predetermined threshold comprising a dark count rate threshold, and prevent, based on the determining that the noise level meets the predetermined threshold, an output of the photodetector from being used in generating a histogram based on a temporal distribution of photons detected by the array of photodetectors, the preventing comprising switching the output to a monitoring circuit that monitors a characteristic of the optical measurement system separate from the photodetector.
An illustrative multimodal measurement system includes a wearable assembly configured to be worn by a user; and a module configured to be removably inserted into the wearable assembly and comprising: a housing, a printed circuit board (PCB) and a light guide assembly configured to emit light directed at a target within the user. The light guide assembly comprises: a lower light guide portion housed within the housing and having a proximal end attached to the PCB, a conductive spring member housed within the housing and comprising a coil positioned around an external surface of the lower light guide portion, and a conductive upper light guide portion connected to the lower light guide portion and configured to protrude from an upper surface of the housing and be in contact with a surface of a body of the user.
An illustrative optical measurement system includes a light source configured to emit light directed at a target. The optical measurement system further includes a photodetector configured to detect a photon of the light after the light is scattered by the target. The optical measurement system further includes a control circuit configured to receive a first input voltage that is a temperature-dependent voltage. The control circuit is further configured to receive a second input voltage that is a temperature-invariant voltage. The control circuit is further configured to output, based on a combination of the first input voltage and the second input voltage, a bias voltage for the photodetector, wherein the combination of the first and second input voltages is configured to cause the bias voltage to vary based on temperature.
An illustrative system may include a memory storing instructions and a processor communicatively coupled to the memory and configured to execute the instructions to: cause a signal to be applied to a component within an optical measurement system; generate, based on a response of the component to the signal, characterization data representative of a timing uncertainty associated with the component; and perform, based on the characterization data, an action associated with the component.
An optical measurement system comprising an optical source configured for delivering sample light in an anatomical structure, such that the sample light is scattered by the anatomical structure, resulting in physiological-encoded signal light that exits the anatomical structure, an optical detector configured for detecting the physiological-encoded signal light, and a processor configured for acquiring a TOF profile derived from the physiological-encoded signal light, the initial TOF profile having an initial contrast-to-noise ratio (CNR) between a plurality of states of a physiological activity in the anatomical structure. The processor is further configured for applying one or more weighting functions to the initial TOF profile to generate a weighted TOF profile having a subsequent CNR greater than the initial CNR between the plurality of states of the physiological activity. The processor is further configured for processing the weighted TOF profile, and identifying one of the plurality of states of the physiological activity.
An illustrative system may include a TDC configured to monitor for an occurrence of a photodetector output pulse during a measurement time window that is within and shorter in duration than a light pulse time period, the photodetector output pulse generated by a photodetector when the photodetector detects a photon from a light pulse having a light pulse time period; a PLL circuit for the TDC and having a PLL feedback period defined by a reference clock, the PLL circuit configured to: output a plurality of fine phase signals and output one or more signals representative of a plurality of feedback divider states during the PLL feedback period; and a precision timing circuit configured to adjust, based on one or more of the fine phase signals and/or the feedback divider states, a temporal position of the measurement time window within the light pulse time period.
An optical measurement system includes a wearable assembly comprising a first slot surrounded by a first wall, a second slot surrounded by a second wall, a first module configured to be inserted into the first slot, the first module comprising a first light source configured to emit first light directed at a brain of the user and a first set of detectors configured to detect first arrival times for photons of the first light after the first light is scattered by the brain, and a second module configured to be inserted into the second slot, the second module comprising a second light source configured to emit second light directed at the brain and a second set of detectors configured to detect second arrival times for photons of the second light after the second light is scattered by the brain.
G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
A63F 13/212 - Input arrangements for video game devices characterised by their sensors, purposes or types using sensors worn by the player, e.g. for measuring heart beat or leg activity
A63F 13/67 - Generating or modifying game content before or while executing the game program, e.g. authoring tools specially adapted for game development or game-integrated level editor adaptively or by learning from player actions, e.g. skill level adjustment or by storing successful combat sequences for re-use
8.
Wearable devices and wearable assemblies with adjustable positioning for use in an optical measurement system
An optical measurement system includes a wearable device configured to be worn on a body of a user and a position alignment system. The wearable device includes a support assembly and a wearable assembly supported by the support assembly. The wearable assembly includes a plurality of light sources configured to emit a plurality of light pulses toward a target within the body of the user and a plurality of detectors each configured to receive a set of photons included in a light pulse included in the plurality of light pulses after the set of photons is scattered by the target. The position alignment system is configured to facilitate positioning of the wearable assembly at a same position on the body of the user during different use sessions of the wearable device.
A system comprises memory configured for storing an emotional response engine configured for predicting an emotional state set in response to an input of a real-life scenario that may occur in the context of a range of use of an AI control system. The system further comprises user interfaces (UIs) configured for presenting the real-life scenario to human subjects. The system further comprises at least one non-invasive brain interface assembly configured for detecting brain activity of the human subjects in response to presenting the real-life scenario to each of the human subjects. The system further comprises a processor configured for determining a plurality of emotional state sets respectively for the human subjects based on the detected brain activity of the respective human subject, and updating the emotional response engine based on the predicted emotional state set and the determined emotional state sets.
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
10.
Devices, Systems, and Methods for Calibrating an Optical Measurement Device
An illustrative calibration member made from a material that scatters light may be used to perform a calibration operation with respect to an optical measurement device having a plurality of light sources and a plurality of detectors distributed among a plurality of modules. The calibration member may form an exterior surface configured to support the optical measurement device and scatter photons of light emitted by the optical measurement device. The calibration operation may be performed based on arrival times of the scattered photons detected by the optical measurement device.
z are amplitudes and ω is a frequency; directing the light source(s) to direct the light beams through the vapor cell(s); receiving signals from the detector(s); and determining three orthogonal components of the external magnetic field using the received signals. Multi-frequency modulation patterns can alternatively be used.
G01R 33/26 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance for measuring direction or magnitude of magnetic fields or magnetic flux using optical pumping
12.
Maintaining Consistent Photodetector Sensitivity in an Optical Measurement System
An illustrative optical measurement system includes a light source configured to emit a light pulse directed at a target. The optical measurement system further includes a control circuit configured to drive the light source with a current pulse comprising a non-linear rise, and a decline from a maximum output to zero having a duration within a threshold percentage of a total pulse duration of the current pulse.
G01J 1/08 - Arrangements of light sources specially adapted for photometry
H01L 31/107 - Devices sensitive to infrared, visible or ultraviolet radiation characterised by only one potential barrier or surface barrier the potential barrier working in avalanche mode, e.g. avalanche photodiode
G06F 1/16 - Constructional details or arrangements
13.
GRAPHICAL EMOTION SYMBOL DETERMINATION BASED ON BRAIN MEASUREMENT DATA FOR USE DURING AN ELECTRONIC MESSAGING SESSION
An illustrative system includes a brain interface system configured to be worn by a user and to output brain measurement data representative of brain activity of the user while the user is engaged in an electronic messaging session provided by an electronic messaging platform and a computing device configured to obtain the brain measurement data, determine, based on the brain measurement data, a graphical emotion symbol representative of a mental state of the user while the user is engaged in the electronic messaging session, and provide the graphical emotion symbol for use during the electronic messaging session.
A61B 5/16 - Devices for psychotechnics; Testing reaction times
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/291 - Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
An illustrative system includes a brain interface system configured to be worn by a user and to output brain measurement data representative of brain activity of the user while the user is engaged in an electronic messaging session provided by an electronic messaging platform and a computing device configured to obtain the brain measurement data, determine, based on the brain measurement data, a graphical emotion symbol representative of a mental state of the user while the user is engaged in the electronic messaging session, and provide the graphical emotion symbol for use during the electronic messaging session.
A headgear for magnetoencephalography includes a body defining a plurality of ports, where the body includes a first portion and a second portion; an adjustment mechanism coupled to the first portion and the second portion of the body and configured to adjust a separation between the first and second portion to facilitate fitting the headgear to a head of a user; and a plurality of optically pumped magnetometer (OPM) modules, where each of the OPM modules includes at least one vapor cell and is configured to be removably inserted into a one of the ports of the body, where each of the OPM modules is configured for coupling to a light source for receiving light.
A61B 5/245 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetoencephalographic [MEG] signals
G01R 33/26 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance for measuring direction or magnitude of magnetic fields or magnetic flux using optical pumping
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
16.
OPM MODULE ASSEMBLY WITH ALIGNMENT AND MOUNTING COMPONENTS AS USED IN A VARIETY OF HEADGEAR ARRANGEMENTS
A headgear for magnetoencephalography includes a body defining a plurality of ports, where the body includes a first portion and a second portion; an adjustment mechanism coupled to the first portion and the second portion of the body and configured to adjust a separation between the first and second portion to facilitate fitting the headgear to a head of a user; and a plurality of optically pumped magnetometer (OPM) modules, where each of the OPM modules includes at least one vapor cell and is configured to be removably inserted into a one of the ports of the body, where each of the OPM modules is configured for coupling to a light source for receiving light.
A61B 5/245 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetoencephalographic [MEG] signals
G01R 33/032 - Measuring direction or magnitude of magnetic fields or magnetic flux using magneto-optic devices, e.g. Faraday
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
17.
OPTIMIZING AN INDIVIDUAL'S WELLNESS THERAPY USING A NON-INVASIVE BRAIN MEASUREMENT SYSTEM
An illustrative system includes a brain interface system configured to be worn by a user and to output brain measurement data representative of brain activity of the user while the user concurrently receives a wellness therapy and a computing device configured to obtain the brain measurement data, and modify, based on the brain measurement data, an attribute of the wellness therapy.
A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
G16H 20/00 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
A61B 5/16 - Devices for psychotechnics; Testing reaction times
18.
Optimizing an Individual's Wellness Therapy Using a Non-Invasive Brain Measurement System
An illustrative system includes a brain interface system configured to be worn by a user and to output brain measurement data representative of brain activity of the user while the user concurrently receives a wellness therapy and a computing device configured to obtain the brain measurement data, and modify, based on the brain measurement data, an attribute of the wellness therapy.
G01R 33/02 - Measuring direction or magnitude of magnetic fields or magnetic flux
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
19.
DEVICES, SYSTEMS, AND METHODS FOR SUPPRESSING OPTICAL NOISE IN OPTICALLY PUMPED MAGNETOMETERS
A magnetic field measurement system includes a light source that emits a light beam; an optical fiber to transmit the light beam; a variable optical attenuator to increase stability of an intensity of the light beam; a beam splitter to divide the light beam into an OPM light beam and a monitor light beam; a monitor detector to detect the monitor light beam and generate a monitor signal; a vapor cell with alkali metal atoms disposed therein and configured for transmission of the OPM light beam through the vapor cell; an OPM detector to detect the OPM light beam after transmission through the vapor cell and generate an OPM signal; and a group delay filter to combine the monitor signal and the OPM signal to generate a reduced noise OPM signal, where the group delay filter accounts for a phase difference between the monitor signal and the OPM signal.
G01R 33/26 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance for measuring direction or magnitude of magnetic fields or magnetic flux using optical pumping
A61B 5/245 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetoencephalographic [MEG] signals
20.
PRESENTATION OF GRAPHICAL CONTENT ASSOCIATED WITH MEASURED BRAIN ACTIVITY
An illustrative system (100) includes a brain interface system (102) configured to be worn by a user and to output brain activity data representative of brain activity of the user and a computing device (104) configured to obtain the brain activity data, determine, based on the brain activity data, a characteristic of the user such as a mental state of the user, and present, by way of a graphical user interface (114), graphical content representative of the characteristic on a display (106). This may allow to transform complex and difficult to understand brain activity data into a relatively easy to understand graphical content that can then be used by the user and/or other personnel to take various actions.
An illustrative optical measurement system may include a primary controller; a plurality of secondary controllers communicatively coupled to the primary controller; and a plurality of modules, each module included in the plurality of modules comprising: a light source configured to emit light directed at a target, and a plurality of detectors configured to detect photon arrival times for the light after the light is scattered by the target; wherein: the plurality of modules is divided into a plurality of module subsets, and each module subset included in the plurality of module subsets is communicatively coupled to a respective secondary controller included in the plurality of secondary controllers
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
22.
Data Aggregation and Power Distribution in Time Domain-Based Optical Measurement Systems
An illustrative optical measurement system may include a primary controller; a plurality of secondary controllers communicatively coupled to the primary controller; and a plurality of modules, each module included in the plurality of modules comprising: a light source configured to emit light directed at a target, and a plurality of detectors configured to detect photon arrival times for the light after the light is scattered by the target; wherein: the plurality of modules is divided into a plurality of module subsets, and each module subset included in the plurality of module subsets is communicatively coupled to a respective secondary controller included in the plurality of secondary controllers.
An illustrative system includes a brain interface system configured to be worn by a user and to output brain activity data representative of brain activity of the user and a computing device configured to obtain the brain activity data, determine, based on the brain activity data, a characteristic of the user, and present, by way of a graphical user interface, graphical content representative of the characteristic.
An illustrative system includes a hearing device configured to be worn by a user, the hearing device comprising an output transducer configured to present audio content to the user and an optical measurement system configured to output optical measurement data representative of one or more optical measurements performed with respect to the user.
An illustrative optical measurement system includes a light source configured to emit light directed at a target. The system further includes a detector configured to detect arrival times for photons of the light after the light is scattered by the target. The system further includes a temperature sensor configured to output a temperature signal representative of a temperature of the light source. The system further includes an optical sensor configured to output a power signal representative of an optical power level of the light emitted by the light source. The system further includes a driver circuit configured to output, based on the temperature signal and the power signal, an input current for the light source.
An illustrative system includes a brain interface system configured to be worn by a user and to output brain activity data representative of brain activity of the user while the user concurrently plays an electronic game and a computing device configured to obtain the brain activity data and modify, based on the brain activity data, an attribute of the electronic game.
A63F 13/212 - Input arrangements for video game devices characterised by their sensors, purposes or types using sensors worn by the player, e.g. for measuring heart beat or leg activity
A63F 13/213 - Input arrangements for video game devices characterised by their sensors, purposes or types comprising photodetecting means, e.g. cameras, photodiodes or infrared cells
A63F 13/25 - Output arrangements for video game devices
A63F 13/30 - Interconnection arrangements between game servers and game devices; Interconnection arrangements between game devices; Interconnection arrangements between game servers
A63F 13/67 - Generating or modifying game content before or while executing the game program, e.g. authoring tools specially adapted for game development or game-integrated level editor adaptively or by learning from player actions, e.g. skill level adjustment or by storing successful combat sequences for re-use
A63F 13/69 - Generating or modifying game content before or while executing the game program, e.g. authoring tools specially adapted for game development or game-integrated level editor by enabling or updating specific game elements, e.g. unlocking hidden features, items, levels or versions
A61B 5/16 - Devices for psychotechnics; Testing reaction times
A61B 5/053 - Measuring electrical impedance or conductance of a portion of the body
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G01R 33/26 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance for measuring direction or magnitude of magnetic fields or magnetic flux using optical pumping
G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
H01L 31/107 - Devices sensitive to infrared, visible or ultraviolet radiation characterised by only one potential barrier or surface barrier the potential barrier working in avalanche mode, e.g. avalanche photodiode
27.
Systems and Methods for Calibration of an Optical Measurement System
An illustrative optical measurement system includes a light source configured to emit light directed at a target. The system further includes a detector configured to detect arrival times for photons of the light after the light is scattered by the target. The system further includes a temperature sensor configured to output a temperature signal representative of a temperature of the light source. The system further includes an optical sensor configured to output a power signal representative of an optical power level of the light emitted by the light source. The system further includes a driver circuit configured to output, based on the temperature signal and the power signal, an input current for the light source.
A non-invasive self-autonomous system (10) and method of optimizing a lifestyle regimen of a person (12) containing a combination of lifestyle variables is provided. At least one value of the combination of lifestyle variables is repeatedly modified by a lifestyle optimiser (22), thereby creating different variations of the combination of lifestyle variables respectively having different sets of values. The different variations of the combination of lifestyle variables are sequentially administered to the person (12) by a peripheral device (20). Physiological activity of the person (12) is detected, possibly by a non-invasive brain-computer interface BCI (16), in response to the administration of the combination of lifestyle variables to the person. Sets of qualitative indicators of an aspect of a lifestyle of the person are derived from the detected physiological activity of the person. The lifestyle regimen of the person is optimized based on the different variations of the combination of lifestyle variables and the derived sets of qualitative indicators.
An illustrative system includes a brain interface system configured to be worn by a user and to output brain activity data associated with the user; a sleep tracking device configured to be worn by the user and to output sleep tracking data associated with the user; and a computing device configured to generate, based on the brain activity data and the sleep tracking data, sleep routine data representative of a target sleep routine for the user.
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/291 - Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
A61B 5/245 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetoencephalographic [MEG] signals
A61B 5/16 - Devices for psychotechnics; Testing reaction times
An illustrative system includes a brain interface system configured to be worn by a user and to output brain activity data representative of brain activity of the user while the user concurrently plays an electronic game and a computing device configured to obtain the brain activity data and modify, based on the brain activity data, an attribute of the electronic game.
A63F 13/212 - Input arrangements for video game devices characterised by their sensors, purposes or types using sensors worn by the player, e.g. for measuring heart beat or leg activity
A61B 5/16 - Devices for psychotechnics; Testing reaction times
A63F 13/24 - Constructional details thereof, e.g. game controllers with detachable joystick handles
A63F 13/67 - Generating or modifying game content before or while executing the game program, e.g. authoring tools specially adapted for game development or game-integrated level editor adaptively or by learning from player actions, e.g. skill level adjustment or by storing successful combat sequences for re-use
A63F 13/69 - Generating or modifying game content before or while executing the game program, e.g. authoring tools specially adapted for game development or game-integrated level editor by enabling or updating specific game elements, e.g. unlocking hidden features, items, levels or versions
31.
Devices, Systems, and Methods for Calibrating an Optical Measurement Device
An illustrative optical measurement device includes a light source configured to emit light pulses directed at a target of a user. The optical measurement device further includes a detector configured to detect arrival times for photons of the light pulses after the photons are scattered by the target. The optical measurement device further includes a processing unit configured to determine, while the optical measurement device is being worn by the user, an instrument response function (IRF) associated with the optical measurement device. The processing unit is further configured to generate, based on the arrival times of the photons at the detector, histogram data associated with the target. The processing unit is further configured to determine, based on the IRF and the histogram data, a property of the target.
A61B 5/1495 - Calibrating or testing in vivo probes
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
32.
Photodetector systems with low-power time-to-digital converter architectures to determine an arrival time of photon at a photodetector based on event detection time window
An illustrative system may include a component configured to be worn on a body of a user, the component comprising a time-to-digital converter (TDC) configured to: receive, during a predetermined event detection time window that commences in response to an application of a light pulse to a target within the body, a signal triggered by an event in which a photodetector detects a photon of the light pulse after the light pulse reflects from the target; and measure, based on the receiving the signal, a time interval between when the event occurred and an end of the predetermined event detection time window. The system may further include a processor configured to determine, based on the time interval and the predetermined event detection time window, an arrival time of the photon at the photodetector.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
H01L 31/107 - Devices sensitive to infrared, visible or ultraviolet radiation characterised by only one potential barrier or surface barrier the potential barrier working in avalanche mode, e.g. avalanche photodiode
H01L 31/02 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof - Details
33.
Devices, systems, and methods with a piezoelectric-driven light intensity modulator
A light intensity modulator includes an input optical fiber; an output optical fiber; an optical arrangement having a lens, where the optical arrangement is configured to receive light from the input optical fiber, pass the light through the lens, and direct the light to the output optical fiber; and a piezoelectric device coupled to the lens, where the piezoelectric device is configured for moving the lens to alter overlap of the output optical fiber and the light directed to the output optical fiber to modulate intensity of light in the output optical fiber.
An illustrative optical measurement device includes a light source configured to emit light pulses directed at a target. The optical measurement device further includes a detector configured to detect arrival times for photons of the light pulses after the photons are scattered by the target. The optical measurement device further includes a processing unit configured to generate, based on the arrival times of the photons at the detector, histogram data associated with the target. The processing unit is further configured to determine, based on the histogram data, an absolute optical property associated with the target. The processing unit is further configured to determine, based on the absolute optical property, a blood oxygenation level of the user, and perform an operation based on the blood oxygenation level.
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
An illustrative optical measurement device includes a light source configured to emit light pulses directed at a target. The optical measurement device further includes a detector configured to detect arrival times for photons of the light pulses after the photons are scattered by the target. The optical measurement device further includes a processing unit configured to generate, based on the arrival times of the photons at the detector, histogram data associated with the target. The processing unit is further configured to determine, based on the histogram data, an absolute optical property associated with the target. The processing unit is further configured to determine, based on the absolute optical property, a blood oxygenation level of the user, and perform an operation based on the blood oxygenation level.
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
36.
Non-invasive systems and methods for detecting mental impairment
A mental impairment detection system and non-invasive method of detecting mental impairment of a user are provided. A test (e.g., an inhibitory reflex test or a sustained attention test) is administered to the user, brain activity in a frontal lobe of the user is non-invasively detected while the test is administered to the user, and a level of mental impairment of the user is determined based on the brain activity detected in the frontal lobe of the user.
G08B 23/00 - Alarms responsive to unspecified undesired or abnormal conditions
A61B 5/16 - Devices for psychotechnics; Testing reaction times
A61B 5/18 - Devices for psychotechnics; Testing reaction times for vehicle drivers
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/377 - Electroencephalography [EEG] using evoked responses
A61B 3/113 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining or recording eye movement
A61B 5/291 - Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
37.
Phase lock loop circuit based signal generation in an optical measurement system
An exemplary system includes a PLL circuit and a precision timing circuit connected to the PLL circuit. The PLL circuit has a PLL feedback period defined by a reference clock and includes a voltage controlled oscillator configured to lock to the reference clock and having a plurality of stages configured to output a plurality of fine phase signals each having a different phase, and a feedback divider configured to be clocked by a single fine phase signal included in the plurality of fine phase signals and have a plurality of feedback divider states during the PLL feedback period. The precision timing circuit is configured to generate a timing pulse and set, based on a first combination of one of the fine phase signals and one of the feedback divider states, a temporal position of the timing pulse within the PLL feedback period.
H03L 7/08 - Automatic control of frequency or phase; Synchronisation using a reference signal applied to a frequency- or phase-locked loop - Details of the phase-locked loop
H03L 7/197 - Indirect frequency synthesis, i.e. generating a desired one of a number of predetermined frequencies using a frequency- or phase-locked loop using a frequency divider or counter in the loop a time difference being used for locking the loop, the counter counting between numbers which are variable in time or the frequency divider dividing by a factor variable in time, e.g. for obtaining fractional frequency division
H03L 7/18 - Indirect frequency synthesis, i.e. generating a desired one of a number of predetermined frequencies using a frequency- or phase-locked loop using a frequency divider or counter in the loop
H03L 7/099 - Automatic control of frequency or phase; Synchronisation using a reference signal applied to a frequency- or phase-locked loop - Details of the phase-locked loop concerning mainly the controlled oscillator of the loop
H03L 7/089 - Automatic control of frequency or phase; Synchronisation using a reference signal applied to a frequency- or phase-locked loop - Details of the phase-locked loop concerning mainly the frequency- or phase-detection arrangement including the filtering or amplification of its output signal the phase or frequency detector generating up-down pulses
38.
WEARABLE EXTENDED REALITY-BASED NEUROSCIENCE ANALYSIS SYSTEMS
An illustrative system may include an extended reality system and a brain interface system configured to be concurrently worn by a user. The extended reality system may be configured to provide the user with an extended reality experience (e.g., an immersive virtual reality experience or a non-immersive augmented reality experience). The brain interface system may be configured to acquire one or more brain activity measurements while the extended reality experience is being provided to the user.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
39.
Synchronization between brain interface system and extended reality system
An illustrative system includes an extended reality system and a brain interface system configured to be concurrently worn by a user. The extended reality system is configured to provide the user with an extended reality experience and output a timing signal while the extended reality experience is being provided to the user, the timing signal representing a plurality of timing events that occur during the extended reality experience. The brain interface system is configured to receive the timing signal from the extended reality system while the extended reality experience is being provided to the user, acquire brain activity measurements while the extended reality experience is being provided to the user, and output measurement timestamp data representative of a temporal association of the brain activity measurements with the timing events.
An illustrative system may include an extended reality system and a brain interface system configured to be concurrently worn by a user. The extended reality system may be configured to provide the user with an extended reality experience (e.g., an immersive virtual reality experience or a non-immersive augmented reality experience). The brain interface system may be configured to acquire one or more brain activity measurements while the extended reality experience is being provided to the user.
H04L 7/00 - Arrangements for synchronising receiver with transmitter
A61B 5/246 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetoencephalographic [MEG] signals using evoked responses
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/291 - Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
An illustrative optical measurement system includes a light source configured to emit a light pulse directed at a target. The optical measurement system further includes a plurality of photodetectors configured to operate in accordance with an input bias voltage. The optical measurement system further includes a control circuit configured to identify a photodetector subset included in the plurality of photodetectors and that detects, while the input bias voltage has a first value, photons of the light pulse after the light pulse is scattered by the target. The control circuit is further configured to determine, based on the identifying of the photodetector subset, an overvoltage associated with the photodetector subset. The control circuit is further configured to update, based on the overvoltage, the input bias voltage for the plurality of photodetectors to have a second value.
An illustrative optical measurement system includes a light source configured to emit a light pulse directed at a target. The optical measurement system further includes a plurality of photodetectors configured to operate in accordance with an input bias voltage. The optical measurement system further includes a control circuit configured to identify a photodetector subset included in the plurality of photodetectors and that detects, while the input bias voltage has a first value, photons of the light pulse after the light pulse is scattered by the target. The control circuit is further configured to determine, based on the identifying of the photodetector subset, an overvoltage associated with the photodetector subset. The control circuit is further configured to update, based on the overvoltage, the input bias voltage for the plurality of photodetectors to have a second value.
An illustrative optical measurement system may include a wearable assembly comprising a plurality of modules each configured to fit within a different slot of the wearable assembly. The plurality of modules may include a module that comprises first and second light sources each configured to emit light directed at a target and a set of detectors configured to detect arrival times for photons of the light emitted by the first and second light sources. A ratio of a total number of the detectors to a total number of the light sources is at least two to one.
A non-invasive product customization system and a method of customizing a product formulation is provided. Brain activity of a user is detected in response to an input of a product formulation into a brain of the user via a sensory nervous system of the user. A mental state of the user is detected based on the detected brain activity. The product formulation is modified based on the determined mental state of the user. The modified product formulation may be presented to the user in a manner that modulates the mental state of the user.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G16H 20/90 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to alternative medicines, e.g. homeopathy or oriental medicines
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
A61B 5/16 - Devices for psychotechnics; Testing reaction times
45.
Interface configurations for a wearable sensor unit that includes one or more magnetometers
An exemplary magnetic field measurement system includes a wearable sensor unit that includes a magnetometer and a twisted pair cable interface assembly electrically connected to the magnetometer.
G01R 33/00 - Arrangements or instruments for measuring magnetic variables
G01R 33/032 - Measuring direction or magnitude of magnetic fields or magnetic flux using magneto-optic devices, e.g. Faraday
G01R 33/26 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance for measuring direction or magnitude of magnetic fields or magnetic flux using optical pumping
H01F 27/36 - Electric or magnetic shields or screens
H05K 1/18 - Printed circuits structurally associated with non-printed electric components
A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/245 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetoencephalographic [MEG] signals
46.
Systems and methods for measuring current output by a photodetector of a wearable sensor unit that includes one or more magnetometers
An exemplary controller may include a single clock source configured to generate a single clock signal used to drive one or more components within a plurality of magnetometers and a plurality of differential signal measurement circuits configured to measure current output by a photodetector of each of the plurality of magnetometers.
G01R 33/00 - Arrangements or instruments for measuring magnetic variables
G01R 33/032 - Measuring direction or magnitude of magnetic fields or magnetic flux using magneto-optic devices, e.g. Faraday
G01R 33/26 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance for measuring direction or magnitude of magnetic fields or magnetic flux using optical pumping
A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/245 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetoencephalographic [MEG] signals
47.
Methods for training and using a neurome that emulates the brain of a user
A system for training a neurome that emulates a brain of a user comprises a non-invasive brain interface assembly configured for detecting neural activity of the user in response to analog instances of a plurality of stimuli peripherally input into the brain of the user from at least one source of content, memory configured for storing a neurome configured for outputting a plurality of determined brain states of an avatar in response to inputs of the digital instances of the plurality of stimuli, and a neurome training processor configured for determining a plurality of brain states of the user based on the detected neural activity of the user, and modifying the neurome based on the plurality of determined brain states of the user and the plurality of determined brain states of the avatar.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
G06N 3/004 - Artificial life, i.e. computing arrangements simulating life
G06N 3/006 - Artificial life, i.e. computing arrangements simulating life based on simulated virtual individual or collective life forms, e.g. social simulations or particle swarm optimisation [PSO]
An illustrative method includes accessing, by a computing device, a model simulating light scattered by a simulated target, the model comprising a plurality of parameters. The method further includes generating, by the computing device, a set of possible histogram data using the model with a plurality of values for the parameters. The method further includes determining, by the computing device, a set of components that represent the set of possible histogram data, the set of components having a reduced dimensionality from the set of possible histogram data.
G06F 18/2132 - Feature extraction, e.g. by transforming the feature space; Summarisation; Mappings, e.g. subspace methods based on discrimination criteria, e.g. discriminant analysis
G06F 18/2135 - Feature extraction, e.g. by transforming the feature space; Summarisation; Mappings, e.g. subspace methods based on approximation criteria, e.g. principal component analysis
G06V 10/147 - Optical characteristics of the device performing the acquisition or on the illumination arrangements - Details of sensors, e.g. sensor lenses
G06V 10/50 - Extraction of image or video features by summing image-intensity values; Projection analysis
G06V 10/75 - Image or video pattern matching; Proximity measures in feature spaces using context analysis; Selection of dictionaries
A shielding arrangement for a magnetoencephalography (MEG) system includes a passively shielded enclosure having a plurality of walls defining the passively shielded enclosure, each of the plurality of walls including passive magnetic shielding material to reduce an ambient background magnetic field within the passively shielded enclosure; a vestibular wall extending from a first vertical wall to define, and at least partially separate, a vestibular area of the passively shielded enclosure adjacent the doorway and a user area of the passively shielded enclosure; and active shield coils distributed within the passively shielded enclosure and configured to further reduce the ambient background magnetic field within the user area of the passively shielded enclosure.
A61B 5/245 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetoencephalographic [MEG] signals
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G01R 33/26 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance for measuring direction or magnitude of magnetic fields or magnetic flux using optical pumping
50.
Systems and methods for recording biomagnetic fields of the human heart
A magnetocardiography (MCG) system includes a passively shielded enclosure having walls defining the passively shielded enclosure, each of the walls including passive magnetic shielding material to reduce an ambient background magnetic field within the passively shielded enclosure; an MCG measurement device including optically pumped magnetometers (OPMs); and active shield coils within the passively shielded enclosure and stationary relative to the passively shielded enclosure and the MCG measurement device, wherein the active shield coils are configured to further reduce the ambient background magnetic field within a user area of the passively shielded enclosure.
A61B 5/243 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetocardiographic [MCG] signals
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G01R 33/02 - Measuring direction or magnitude of magnetic fields or magnetic flux
G01R 33/421 - Screening of main or gradient magnetic field
A shielding arrangement for a magnetoencephalography (MEG) system includes a passively shielded enclosure having a plurality of walls defining the passively shielded enclosure, each of the plurality of walls including passive magnetic shielding material to reduce an ambient background magnetic field within the passively shielded enclosure; a vestibular wall extending from a first vertical wall to define, and at least partially separate, a vestibular area of the passively shielded enclosure adjacent the doorway and a user area of the passively shielded enclosure; and active shield coils distributed within the passively shielded enclosure and configured to further reduce the ambient background magnetic field within the user area of the passively shielded enclosure.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/245 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetoencephalographic [MEG] signals
A magnetocardiography (MCG) system includes a passively shielded enclosure having walls defining the passively shielded enclosure, each of the walls including passive magnetic shielding material to reduce an ambient background magnetic field within the passively shielded enclosure; an MCG measurement device including optically pumped magnetometers (OPMs); and active shield coils within the passively shielded enclosure and stationary relative to the passively shielded enclosure and the MCG measurement device, wherein the active shield coils are configured to further reduce the ambient background magnetic field within a user area of the passively shielded enclosure.
A61B 5/243 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetocardiographic [MCG] signals
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A magnetic field recording system includes a headgear to be placed on a user; optically pumped magnetometers (OPMs) disposed in or on the headgear to detect magnetic fields; at least two sensing modalities selected from the following: i) a magnetic sensing modality, ii) an optical sensing modality, or iii) an inertial sensing modality; and a tracking unit configured to receive, from each of the at least two sensing modalities, a corresponding magnetic data stream, optical data stream, or inertial data stream and to track a position or orientation of the headgear or user; and a system controller configured to control operation of the OPMs and to receive, from the tracking unit, the position or orientation of the headgear or user.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/246 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetoencephalographic [MEG] signals using evoked responses
G01R 33/26 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance for measuring direction or magnitude of magnetic fields or magnetic flux using optical pumping
54.
Magnetic field measurement or recording systems with validation using optical tracking data
A magnetic field recording system includes a headgear for a user; optically pumped magnetometers (OPMs) disposed in or on the headgear to detect magnetic fields and, in response to the detection, produce magnetic field data; at least one sensing modality including an optical sensing modality having at least one light source and at least one camera or light detector to receive light reflected or directed from the user and to produce an optical data stream; a tracking unit to receive the optical data stream and track a position or orientation of the headgear or user; a system controller to control operation of the OPMs and receive, from the tracking unit, the position or orientation of the headgear or user; and a processor to receive the optical data stream and the magnetic field data from the OPMs and analyze the magnetic field data using the optical data stream for validation.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
35 - Advertising and business services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Sensor system comprised of a wearable modular sensing unit,
namely, biofeedback sensors, optical sensors, and magnetic
sensors and supporting modular electronics for data
processing, signal processing, and connectivity, namely,
computer hardware for the purpose of measuring,
interpreting, tracking, and monitoring brain activity and
mental states; sensor system, namely, modular electronic
devices, namely, biofeedback sensors, optical sensors,
magnetic sensors, and computer hardware for the purpose of
measuring, interpreting, tracking, and monitoring brain
activity and mental states; recorded and downloadable
computer software and recorded and downloadable mobile
applications for processing, interpreting, monitoring, and
managing data produced by a wearable sensor system that
measures, tracks or monitors brain activity and mental
states. Medical devices, namely, sensor systems comprised of a
wearable modular sensing unit, namely, biofeedback sensors,
optical sensors, magnetic sensors, and computer hardware for
use in screening and diagnosing neurological conditions;
medical devices, namely, sensor systems comprised of a
wearable modular sensing unit, namely, biofeedback sensors,
optical sensors, magnetic sensors, and computer hardware for
recording and processing brain activity and mental states
from human and animal subjects. Data processing services, namely, processing data produced
by a sensor system that measures, tracks or monitors brain
activity and mental states. Providing temporary use of online non-downloadable software
for processing, interpreting, monitoring, and managing data
produced by a sensor system that measures, tracks or
monitors brain activity and mental states; leasing of sensor
systems comprised of a wearable modular sensing unit,
namely, biofeedback sensors, optical sensors, and magnetic
sensors and supporting modular electronics for data
processing, signal processing, and connectivity, namely,
computer hardware for the purpose of measuring,
interpreting, tracking, and monitoring brain activity and
mental states; leasing of sensor system, namely, modular
electronic devices, namely, biofeedback sensors, optical
sensors, magnetic sensors, and computer hardware for the
purpose of measuring, interpreting, tracking, and monitoring
brain activity and mental states; medical evaluation of
neurological conditions or neurological diseases for drug
development purposes. Medical evaluation of neurological conditions or
neurological diseases; medical testing for diagnostic or
treatment purposes; medical testing for diagnostic or
treatment purposes in the field of neurology; medical
diagnostic testing, monitoring and reporting services;
medical and healthcare services, namely, providing medical
and healthcare information, and medical and healthcare
advice; leasing of medical devices, namely, sensor systems
comprised of a wearable modular sensing unit, namely,
biofeedback sensors, optical sensors, magnetic sensors, and
computer hardware and software for use in screening and
diagnosing neurological conditions; leasing of medical
devices, namely, sensor systems comprised of a wearable
modular sensing unit, namely, biofeedback sensors, optical
sensors, magnetic sensors, and computer hardware and
software for recording and processing brain activity and
mental states from human and animal subjects.
56.
Interferometric parallel detection using digital rectification and integration
The source light having a range of optical wavelengths is split into sample light and reference light. The sample light is delivered into a sample, such that the sample light is scattered by the sample, resulting in signal light that exits the sample. The signal light and the reference light are combined into an interference light pattern having optical modes having oscillation frequency components respectively corresponding to optical pathlengths extending through the sample. Different sets of the optical modes of the interference light pattern are respectively detected, and high-bandwidth analog signals representative of the optical modes of the interference light pattern are output. The high-bandwidth analog signals are parallel processed, and mid-bandwidth digital signals are output. The mid-bandwidth digital signals are processed over an i number of iterations, and a plurality of low-bandwidth digital signals are output on the ith iteration. The sample is analyzed based on the low-bandwidth digital signals.
Source light having a range of optical wavelengths is generated. The source light is split into sample light and reference light. The sample light is delivered into a sample, such that it is scattered by the sample, resulting in signal light that exits the sample. The signal light and reference light are combined into an interference light pattern having optical modes. Different subsets of the optical modes of the interference light pattern are respectively detected, and high-bandwidth analog signals respectively corresponding to the different subsets of optical modes of the interference light pattern are output. At least one characteristic is extracted from each of the plurality of high-bandwidth analog signals, and low-bandwidth digital signals respectively comprising the extracted characteristics are output. The sample is analyzed based on the low-bandwidth digital signals.
G01N 21/359 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G01B 9/02091 - Tomographic interferometers, e.g. based on optical coherence
58.
Systems and Methods for Noise Removal in an Optical Measurement System
An illustrative optical measurement system includes a light source configured to emit light directed at a target within a user. The system further includes a detector configured to detect photon arrival times for photons of the light after the light is scattered by the target. The system further includes a processor configured to determine, based on the photon arrival times, histogram data associated with the target, the histogram data including noise. The processor is further configured to determine, based on the photon arrival times, a random matrix corresponding to the photon arrival times. The processor is further configured to determine, based on the random matrix, a noise distribution representing a distribution of the noise within the histogram data. The processor is further configured to generate clean histogram data using the noise distribution to filter at least a portion of the noise from the histogram data.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
59.
Wearable module assemblies for an optical measurement system
A wearable module assembly for an optical measurement system includes a first wearable module, a second wearable module, and a connector. The first and second wearable modules each include a light source configured to emit a light pulse toward a target within a body of a user, a housing that houses the light source and the plurality of detectors and includes a substantially hexagonal surface that faces a surface of the body of the user when the wearable module assembly is worn by the user, and a plurality of detectors each positioned at a fixed distance from the first light source and each configured to detect a set of photons included in the light pulse after the set of photons are scattered by the target. The connector directly connects the first wearable module and the second wearable module at mutually-facing side surfaces of the respective housings.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
G01N 33/483 - Physical analysis of biological material
60.
Compensation for Delays in an Optical Measurement System
An exemplary system includes a first photodetector configured to detect a first photon via a first path from a light source and a second photodetector configured to detect a second photon via a second path. The system includes a control system configured to record a first time based on the first photodetector detecting the first photon, the first time including a delay between the first photodetector detecting the first photon and the control system receiving a photodetector output pulse from the first photodetector. The control system is configured to record a second time based on the second photodetector detecting the second photon, the second time including a delay between the second photodetector and the control system. The control system is configured to determine, based on the first and second time, an amount of time for the second photon to travel from the light source to the second photodetector.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
61.
Control circuit for a light source in an optical measurement system by applying voltage with a first polarity to start an emission of a light pulse and applying voltage with a second polarity to stop the emission of the light pulse
An exemplary system includes a light source and a control circuit configured to apply voltage having a first polarity to the light source for a first time period to provide a threshold charge for the light source to start an emission of a light pulse that is directed at a target within a body. The control circuit is further configured to apply voltage having a second polarity opposite the first polarity to the light source for a second time period subsequent to the first time period to discharge the light source to stop the emission of the light pulse.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
H01S 5/062 - Arrangements for controlling the laser output parameters, e.g. by operating on the active medium by varying the potential of the electrodes
62.
Maintaining consistent photodetector sensitivity in an optical measurement system
An exemplary optical measurement system includes a light source configured to emit light directed at a target. The optical measurement system further includes a photodetector configured to detect a photon of the light after the light is scattered by the target. The optical measurement system further includes a control circuit configured to receive a first input voltage that is a temperature-dependent voltage. The control circuit is further configured to receive a second input voltage that is a temperature-invariant voltage. The control circuit is further configured to output, based on a combination of the first input voltage and the second input voltage, a bias voltage for the photodetector, wherein the combination of the first and second input voltages is configured to cause the bias voltage to vary based on temperature.
An exemplary system includes a photodetector configured to generate a photodetector output pulse when the photodetector detects a photon from a light pulse having a light pulse time period, a TDC configured to monitor for the occurrence of the photodetector output pulse during a measurement time window that is within and shorter in duration than the light pulse time period, a PLL circuit for the TDC, and a precision timing circuit connected to the PLL circuit and configured to adjust, based on at least one signal generated within the PLL circuit, a temporal position of the measurement time window within the light pulse time period.
An illustrative optical measurement system includes a signal generator configured to generate a signal and a processing unit configured to direct the signal generator to apply the signal to a TDC included in the optical measurement system and generate, based on timestamp symbols recorded by the TDC in response to the signal, characterization data representative of a nonlinearity of the TDC.
An illustrative optical measurement system may include a wearable assembly configured to be worn by a user and comprising a plurality of light sources each configured to emit light directed at a target and a plurality of detectors configured to detect arrival times for photons of the light after the light is scattered by the target, wherein a ratio of a total number of the detectors to a total number of the light sources is at least two to one.
An illustrative optical measurement system includes a light source configured to emit, during a measurement session time period, a sequence of light pulses towards a target; a plurality of photodetectors configured to remain in an armed state during an entire duration of the measurement session time period, and detect, while in the armed state, photons of the light pulses after the light pulses are scattered by the target; and a plurality of time-to-digital converters (TDCs) comprising a different TDC for each photodetector of the plurality of photodetectors, the TDCs configured to record timestamp symbols representative of when the photons are detected by the photodetectors.
An illustrative optical measurement system includes a light source configured to emit light directed at a target. The optical measurement system further includes a photodetector configured to detect a photon of the light after the light is scattered by the target. The optical measurement system further includes a control circuit configured to arm the photodetector by applying a bias voltage to a first terminal of the photodetector and applying, for a predetermined amount of time using a current source, a current to a second terminal of the photodetector to produce a predetermined voltage difference across the photodetector.
An exemplary optical measurement system includes a light source configured to emit light directed at a target. The optical measurement system further includes a photodetector configured to detect a photon of the light after the light is scattered by the target. The optical measurement system further includes a control circuit configured to receive a first input voltage that is a temperature-dependent voltage. The control circuit is further configured to receive a second input voltage that is a temperature-invariant voltage. The control circuit is further configured to output, based on a combination of the first input voltage and the second input voltage, a bias voltage for the photodetector, wherein the combination of the first and second input voltages is configured to cause the bias voltage to vary based on temperature.
An exemplary system includes a photodetector configured to generate a photodetector output pulse when the photodetector detects a photon from a light pulse having a light pulse time period, a TDC configured to monitor for the occurrence of the photodetector output pulse during a measurement time window that is within and shorter in duration than the light pulse time period, a PLL circuit for the TDC, and a precision timing circuit connected to the PLL circuit and configured to adjust, based on at least one signal generated within the PLL circuit, a temporal position of the measurement time window within the light pulse time period.
An exemplary system includes a photodetector configured to generate a plurality of photodetector output pulses over time as a plurality of light pulses are applied to and scattered by a target, a TPSF generation circuit configured to generate, based on the photodetector output pulses, a TPSF representative of a light pulse response of the target, and a control circuit configured to direct the TPSF generation circuit to selectively operate in different resolution modes.
An exemplary optical measurement system described herein includes a control circuit configured to output a global bias voltage and a module communicatively coupled to the control circuit. The module includes a light source configured to emit light directed at a target. The module further includes a plurality of detectors configured to detect arrival times for photons of the light after the light is scattered by the target. The module further includes a module control circuit configured to receive the global bias voltage and output a plurality of detector bias voltages based on the global bias voltage. The plurality of detector bias voltages include a respective detector bias voltage for each detector of the plurality of detectors.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G01S 7/4861 - Circuits for detection, sampling, integration or read-out
G01S 17/02 - Systems using the reflection of electromagnetic waves other than radio waves
H01L 31/107 - Devices sensitive to infrared, visible or ultraviolet radiation characterised by only one potential barrier or surface barrier the potential barrier working in avalanche mode, e.g. avalanche photodiode
72.
PHOTODETECTOR CALIBRATION OF AN OPTICAL MEASUREMENT SYSTEM
An illustrative optical measurement system includes a light source configured to emit light directed at a target, an array of photodetectors configured to detect photons of the light after the light is scattered by the target, and a processing unit. The processing unit is configured to measure a noise level of a photodetector included in the array of photodetectors and determine that the noise level meets a predetermined threshold. The processing unit is further configured to prevent, based on the determining that the noise level meets the predetermined threshold, an output of the photodetector from being used in generating a histogram based on a temporal distribution of photons detected by the array of photodetectors.
An exemplary system includes a PLL circuit and a precision timing circuit connected to the PLL circuit. The PLL circuit has a PLL feedback period defined by a reference clock and includes a voltage controlled oscillator configured to lock to the reference clock and having a plurality of stages configured to output a plurality of fine phase signals each having a different phase, and a feedback divider configured to be clocked by a single fine phase signal included in the plurality of fine phase signals and have a plurality of feedback divider states during the PLL feedback period. The precision timing circuit is configured to generate a timing pulse and set, based on a first combination of one of the fine phase signals and one of the feedback divider states, a temporal position of the timing pulse within the PLL feedback period.
H03L 7/08 - Automatic control of frequency or phase; Synchronisation using a reference signal applied to a frequency- or phase-locked loop - Details of the phase-locked loop
H03L 7/099 - Automatic control of frequency or phase; Synchronisation using a reference signal applied to a frequency- or phase-locked loop - Details of the phase-locked loop concerning mainly the controlled oscillator of the loop
H03L 7/089 - Automatic control of frequency or phase; Synchronisation using a reference signal applied to a frequency- or phase-locked loop - Details of the phase-locked loop concerning mainly the frequency- or phase-detection arrangement including the filtering or amplification of its output signal the phase or frequency detector generating up-down pulses
H03L 7/197 - Indirect frequency synthesis, i.e. generating a desired one of a number of predetermined frequencies using a frequency- or phase-locked loop using a frequency divider or counter in the loop a time difference being used for locking the loop, the counter counting between numbers which are variable in time or the frequency divider dividing by a factor variable in time, e.g. for obtaining fractional frequency division
74.
Device enumeration in an optical measurement system
An exemplary system includes a processor, a wearable device comprising a plurality of slots, and a first module including a plurality of detectors and a module control circuit. The processor is configured to successively transmit, to each slot of the plurality of slots, a command to enable a respective module located in each slot. The processor is further configured to determine, based on an acknowledgment received from the module control circuit, that the first module is enabled and located in a first slot, and to successively transmit, based on the determining that the first module is enabled and located in the first slot, a plurality of detector address identifiers. The module control circuit is configured to successively place the plurality of detectors into an enumeration mode in which each detector of the plurality of detectors is assigned a different detector address identifier of the plurality of detector address identifiers.
An exemplary optical measurement system includes a signal generator configured to generate a signal and a processing unit configured to direct the signal generator to apply the signal to a component within the optical measurement system, generate, based on a response of the component to the signal, characterization data representative of a timing uncertainty associated with the component, and perform, based on the characterization data, an action associated with the component.
An exemplary system includes a photodetector configured to generate a plurality of photodetector output pulses over time as a plurality of light pulses are applied to and scattered by a target, a TPSF generation circuit configured to generate, based on the photodetector output pulses, a TPSF representative of a light pulse response of the target, and a control circuit configured to direct the TPSF generation circuit to selectively operate in different resolution modes.
An exemplary optical measurement system described herein includes a control circuit configured to output a global bias voltage and a module communicatively coupled to the control circuit. The module includes a light source configured to emit light directed at a target. The module further includes a plurality of detectors configured to detect arrival times for photons of the light after the light is scattered by the target. The module further includes a module control circuit configured to receive the global bias voltage and output a plurality of detector bias voltages based on the global bias voltage. The plurality of detector bias voltages include a respective detector bias voltage for each detector of the plurality of detectors.
G02F 1/01 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
An illustrative system includes a wearable assembly configured to be worn by a user and comprising a first detector configured to detect a first set of photon arrival times and output a first signal representative of the first set of photon arrival times, and a second detector configured to detect a second set of photon arrival times and output a second signal representative of the second set of photon arrival times. The system further includes a processing unit configured to identify a first intensity change in the first signal, identify a second intensity change in the second signal, determine that the first and second intensity changes are time correlated, and determine, based on the determining that the first and second intensity changes are time correlated, that the first and second intensity changes are representative of a motion artifact caused by movement of the user.
An illustrative optical measurement system includes a light source configured to emit light directed at a target, an array of photodetectors configured to detect photons of the light after the light is scattered by the target, and a processing unit. The processing unit is configured to measure a noise level of a photodetector included in the array of photodetectors and determine that the noise level meets a predetermined threshold. The processing unit is further configured to prevent, based on the determining that the noise level meets the predetermined threshold, an output of the photodetector from being used in generating a histogram based on a temporal distribution of photons detected by the array of photodetectors.
An illustrative optical measurement system includes a light source configured to emit light directed at a target within a user, the target covered by a superficial layer, and an array of photodetectors configured to detect photons of the light after the light is scattered. The system further includes a processor configured to record, during a first and a second time period, a first and a second set of timestamp symbols, respectively, based on a first and a second subset of the array of photodetectors detecting a first subset of the photons that are scattered by the superficial layer and a second subset of the photons that are scattered by the target and the superficial layer, respectively. The processor is further configured to filter, based on the first set of histogram data, the second set of histogram data, and determine, based on the filtering, histogram data corresponding to the target.
An authentication system comprises a brain-computer interface (BCI) configured for detecting neural activity in a brain of a subject in response to the subject performing a repeatable mental task, and outputting neural data representative of the detected neural activity. The authentication system further comprises a computer configured for acquiring the neural data output by the BCI while the subject is performing the repeatable mental task, and generating an authorization request containing the neural data. The authentication system further comprises an authentication processor configured for acquiring the authorization request containing the neural data from the computer, authenticating the subject based on the acquired authorization request, and sending an authorization token to the computer.
An illustrative optical measurement system may include a wearable assembly configured to be worn by a user and comprising a plurality of light sources each configured to emit light directed at a target and a plurality of detectors configured to detect arrival times for photons of the light after the light is scattered by the target, wherein a ratio of a total number of the detectors to a total number of the light sources is at least two to one.
An illustrative optical measurement system includes a light source configured to emit, during a measurement session time period, a sequence of light pulses towards a target; a plurality of photodetectors configured to remain in an armed state during an entire duration of the measurement session time period, and detect, while in the armed state, photons of the light pulses after the light pulses are scattered by the target; and a plurality of time-to-digital converters (TDCs) comprising a different TDC for each photodetector of the plurality of photodetectors, the TDCs configured to record timestamp symbols representative of when the photons are detected by the photodetectors.
A system for training a neurome that emulates a brain of a user comprises a non-invasive brain interface assembly configured for detecting neural activity of the user in response to analog instances of a plurality of stimuli peripherally input into the brain of the user from at least one source of content, memory configured for storing a neurome configured for outputting a plurality of determined brain states of an avatar in response to inputs of the digital instances of the plurality of stimuli, and a neurome training processor configured for determining a plurality of brain states of the user based on the detected neural activity of the user, and modifying the neurome based on the plurality of determined brain states of the user and the plurality of determined brain states of the avatar.
A system for training a neurome that emulates a brain of a user comprises a non-invasive brain interface assembly configured for detecting neural activity of the user in response to analog instances of a plurality of stimuli peripherally input into the brain of the user from at least one source of content, memory configured for storing a neurome configured for outputting a plurality of determined brain states of an avatar in response to inputs of the digital instances of the plurality of stimuli, and a neurome training processor configured for determining a plurality of brain states of the user based on the detected neural activity of the user, and modifying the neurome based on the plurality of determined brain states of the user and the plurality of determined brain states of the avatar.
An exemplary wearable brain interface system includes a head-mountable component and a control system. The head-mountable component includes an array of photodetectors that includes a photodetector comprising a single-photon avalanche diode (SPAD) and a fast-gating circuit configured to arm and disarm the SPAD. The control system is for controlling a current drawn by the array of photodetectors.
H01L 31/107 - Devices sensitive to infrared, visible or ultraviolet radiation characterised by only one potential barrier or surface barrier the potential barrier working in avalanche mode, e.g. avalanche photodiode
An illustrative research support computing system maintains subject data representative of attributes for research subjects included in a potential subject pool for potential research studies. The system receives, from a client device, an input dataset representative of: 1) a set of parameters defining a research study to be conducted with respect to a research subject group, and 2) a set of criteria for research subjects that are to be included in the research subject group. The system designates a research subject included in the potential subject pool for inclusion in the research subject group based on the set of criteria, and receives research data detected for the research subject in accordance with the set of parameters. The system also provides an output dataset generated based on the research data detected for the research subject in accordance with the set of parameters. Corresponding methods and systems are also disclosed.
G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
G16H 80/00 - ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring
88.
Wearable devices and wearable assemblies with adjustable positioning for use in an optical measurement system
An optical measurement system includes a wearable device including a support assembly configured to be worn on a body of a user and a wearable assembly supported by the support assembly. The wearable assembly includes a plurality of light sources configured to emit a plurality of light pulses toward a target within the body of the user and a plurality of detectors each configured to receive a set of photons included in a light pulse included in the plurality of light pulses after the set of photons is scattered by the target. A position of the wearable assembly on the support assembly is adjustable.
An optical measurement system includes a wearable module having at least one time-resolved single photon photodetector configured to detect photons from at least one light pulse after the at least one light pulse is scattered by a target within a body of a user; at least one light guide configured to receive the photons and guide the photons to the at least one photodetector; and a housing that houses both the at least one photodetector and at least a portion of the at least one light guide. The optical measurement system further includes a signal processing circuit configured to determine a temporal distribution of the photons detected by the at least one photodetector and generate a histogram based on the temporal distribution of the photons.
A wearable module for use in an optical measurement system may include a first light source configured to emit a first light pulse in a first wavelength, a second light source configured to emit a second light pulse in a second wavelength that is different from the first wavelength, a light guide configured to guide the first light pulse and the second light pulse toward a target within a body of a user; an optical member configured to receive the first light pulse from the first light source and the second light pulse from the second light source and direct the first light pulse and the second light pulse to the light guide, and a housing that houses the first light source, the second light source, and the optical member.
A wearable module for use in an optical measurement system includes a light guide configured to receive a light pulse from a light source and guide signal photons included in the light pulse toward a target within a body of a user, and a light diverter configured to divert reference photons included in the light pulse toward at least one detector configured to detect the reference photons.
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
92.
MULTIMODAL WEARABLE MEASUREMENT SYSTEMS AND METHODS
An illustrative multimodal measurement system includes a wearable assembly configured to be worn by a user and comprising a plurality of light sources each configured to emit light directed at a target within the user, a plurality of detectors configured to detect arrival times for photons of the light after the light is scattered by the target, and a plurality of electrodes configured to be external to the user and detect electrical activity of the target.
An optical measurement system includes a wearable module assembly configured to be worn on a body of a user. The wearable module assembly includes a plurality of wearable modules and a connecting assembly. Each wearable module includes a light source configured to emit a light pulse toward a target within the body of the user and a plurality of detectors configured to receive photons included in the light pulse after the photons are scattered by the target. The connecting assembly physically and flexibly connects the plurality of wearable modules such that the wearable module assembly is conformable to a three-dimensional (3D) surface of the body of the user when the wearable module assembly is worn on the body of the user.
An optical measurement system includes a wearable module having at least one time-resolved single photon photodetector configured to detect photons from at least one light pulse after the at least one light pulse is scattered by a target within a body of a user; at least one light guide configured to receive the photons and guide the photons to the at least one photodetector; and a housing that houses both the at least one photodetector and at least a portion of the at least one light guide. The optical measurement system further includes a signal processing circuit configured to determine a temporal distribution of the photons detected by the at least one photodetector and generate a histogram based on the temporal distribution of the photons.
An illustrative system includes a sensor component and a controller conductively coupled by way of a first wire and a second wire in a twisted pair configuration. The controller includes a driver configured to drive the sensor component by way of the first and second wires with a drive current in accordance with a gain parameter and a control loop circuit. The control loop circuit is configured to receive a control signal representative of a target current value for the drive current, adjust the gain parameter based on a difference between the target current value and an actual current value of current that is actually being driven through the sensor component, and abstain from adjusting the gain parameter based on current capacitively coupled onto the first and second wires by an external electric field.
An optical measurement system includes a first wearable module comprising a first source configured to emit a first light pulse sequence comprising a plurality of light pulses and a first plurality of detectors configured to detect photons from the first light pulse sequence. The system further includes a second wearable module comprising a second source configured to emit a second light pulse sequence comprising a plurality of light pulses and that is time interleaved with the first light pulse sequence, and a second plurality of detectors configured to detect photons from the second light pulse sequence. The system further includes a control circuit configured to control light pulses emitted by the sources in accordance with time and/or frequency division multiplexing heuristics.
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
97.
Multimodal wearable measurement systems and methods
An illustrative multimodal measurement system includes a wearable assembly configured to be worn by a user and comprising a plurality of light sources each configured to emit light directed at a target within the user, a plurality of detectors configured to detect arrival times for photons of the light after the light is scattered by the target, and a plurality of electrodes configured to be external to the user and detect electrical activity of the target.
An illustrative biopotential measurement system includes a plurality of electrodes each configured to record a different signal included in a plurality of signals representative of electrical activity of a target within a user; a plurality of non-inverting operational amplifier circuits each connected to a different electrode included in the plurality of electrodes and each configured to output a different amplified signal included in a plurality of amplified signals representative of amplified versions of the plurality of signals; and a common-mode feedback circuit configured to measure a common-mode signal between the plurality of amplified signals and provide the common-mode signal to the non-inverting operational amplifier circuits. The non-inverting operational amplifier circuits are configured to use the common-mode signal to generate voltage-divided feedback signals used to generate the plurality of amplified signals.
An optical measurement system includes a first light source configured to emit a first light pulse toward a target, a second light source configured to emit a second light pulse toward the target, a first detector, a second detector, and a processing unit. The processing unit is configured to determine a plurality of temporal distributions of photons included in the first light pulse and the second light pulse and detected by the first detector and the second detector after the photons are scattered by the target. The processing unit is further configured to determine, based on the plurality of temporal distributions, a distance between the first light source and the second detector.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G01B 11/14 - Measuring arrangements characterised by the use of optical techniques for measuring distance or clearance between spaced objects or spaced apertures
100.
DETECTOR ASSEMBLIES FOR A WEARABLE MODULE OF AN OPTICAL MEASUREMENT SYSTEM AND INCLUDING SPRING-LOADED LIGHT-RECEIVING MEMBERS
A wearable module for use in an optical measurement system includes a housing including a top surface, a light guide including a distal end portion adapted to protrude from the top surface of the housing, and a spring member configured to bias the distal end portion of the light guide away from the top surface of the housing. The light guide is configured to receive, at the distal end portion, photons from a light pulse scattered by a target within a body of a user and guide the received photons toward a photodetector.
