An illustrative system includes a brain interface system configured to be worn by a user and to output brain measurement data representative of brain activity of the user while the user is engaged in an electronic messaging session provided by an electronic messaging platform and a computing device configured to obtain the brain measurement data, determine, based on the brain measurement data, a graphical emotion symbol representative of a mental state of the user while the user is engaged in the electronic messaging session, and provide the graphical emotion symbol for use during the electronic messaging session.
A61B 5/16 - Devices for psychotechnics; Testing reaction times
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/291 - Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
A headgear for magnetoencephalography includes a body defining a plurality of ports, where the body includes a first portion and a second portion; an adjustment mechanism coupled to the first portion and the second portion of the body and configured to adjust a separation between the first and second portion to facilitate fitting the headgear to a head of a user; and a plurality of optically pumped magnetometer (OPM) modules, where each of the OPM modules includes at least one vapor cell and is configured to be removably inserted into a one of the ports of the body, where each of the OPM modules is configured for coupling to a light source for receiving light.
A61B 5/245 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetoencephalographic [MEG] signals
G01R 33/26 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance for measuring direction or magnitude of magnetic fields or magnetic flux using optical pumping
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
3.
OPTIMIZING AN INDIVIDUAL'S WELLNESS THERAPY USING A NON-INVASIVE BRAIN MEASUREMENT SYSTEM
An illustrative system includes a brain interface system configured to be worn by a user and to output brain measurement data representative of brain activity of the user while the user concurrently receives a wellness therapy and a computing device configured to obtain the brain measurement data, and modify, based on the brain measurement data, an attribute of the wellness therapy.
A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
G16H 20/00 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
A61B 5/16 - Devices for psychotechnics; Testing reaction times
4.
PRESENTATION OF GRAPHICAL CONTENT ASSOCIATED WITH MEASURED BRAIN ACTIVITY
An illustrative system (100) includes a brain interface system (102) configured to be worn by a user and to output brain activity data representative of brain activity of the user and a computing device (104) configured to obtain the brain activity data, determine, based on the brain activity data, a characteristic of the user such as a mental state of the user, and present, by way of a graphical user interface (114), graphical content representative of the characteristic on a display (106). This may allow to transform complex and difficult to understand brain activity data into a relatively easy to understand graphical content that can then be used by the user and/or other personnel to take various actions.
An illustrative optical measurement system may include a primary controller; a plurality of secondary controllers communicatively coupled to the primary controller; and a plurality of modules, each module included in the plurality of modules comprising: a light source configured to emit light directed at a target, and a plurality of detectors configured to detect photon arrival times for the light after the light is scattered by the target; wherein: the plurality of modules is divided into a plurality of module subsets, and each module subset included in the plurality of module subsets is communicatively coupled to a respective secondary controller included in the plurality of secondary controllers
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
6.
SYSTEMS AND METHODS FOR CALIBRATION OF AN OPTICAL MEASUREMENT SYSTEM
An illustrative optical measurement system includes a light source configured to emit light directed at a target. The system further includes a detector configured to detect arrival times for photons of the light after the light is scattered by the target. The system further includes a temperature sensor configured to output a temperature signal representative of a temperature of the light source. The system further includes an optical sensor configured to output a power signal representative of an optical power level of the light emitted by the light source. The system further includes a driver circuit configured to output, based on the temperature signal and the power signal, an input current for the light source.
A non-invasive self-autonomous system (10) and method of optimizing a lifestyle regimen of a person (12) containing a combination of lifestyle variables is provided. At least one value of the combination of lifestyle variables is repeatedly modified by a lifestyle optimiser (22), thereby creating different variations of the combination of lifestyle variables respectively having different sets of values. The different variations of the combination of lifestyle variables are sequentially administered to the person (12) by a peripheral device (20). Physiological activity of the person (12) is detected, possibly by a non-invasive brain-computer interface BCI (16), in response to the administration of the combination of lifestyle variables to the person. Sets of qualitative indicators of an aspect of a lifestyle of the person are derived from the detected physiological activity of the person. The lifestyle regimen of the person is optimized based on the different variations of the combination of lifestyle variables and the derived sets of qualitative indicators.
An illustrative system includes a brain interface system configured to be worn by a user and to output brain activity data associated with the user; a sleep tracking device configured to be worn by the user and to output sleep tracking data associated with the user; and a computing device configured to generate, based on the brain activity data and the sleep tracking data, sleep routine data representative of a target sleep routine for the user.
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/291 - Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
A61B 5/245 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetoencephalographic [MEG] signals
A61B 5/16 - Devices for psychotechnics; Testing reaction times
An illustrative system includes a brain interface system configured to be worn by a user and to output brain activity data representative of brain activity of the user while the user concurrently plays an electronic game and a computing device configured to obtain the brain activity data and modify, based on the brain activity data, an attribute of the electronic game.
A63F 13/212 - Input arrangements for video game devices characterised by their sensors, purposes or types using sensors worn by the player, e.g. for measuring heart beat or leg activity
A61B 5/16 - Devices for psychotechnics; Testing reaction times
A63F 13/24 - Constructional details thereof, e.g. game controllers with detachable joystick handles
A63F 13/67 - Generating or modifying game content before or while executing the game program, e.g. authoring tools specially adapted for game development or game-integrated level editor adaptively or by learning from player actions, e.g. skill level adjustment or by storing successful combat sequences for re-use
A63F 13/69 - Generating or modifying game content before or while executing the game program, e.g. authoring tools specially adapted for game development or game-integrated level editor by enabling or updating specific game elements, e.g. unlocking hidden features, items, levels or versions
10.
DEVICES, SYSTEMS, AND METHODS USING WEARABLE TIME DOMAIN-BASED ACTIVITY TRACKER
An illustrative optical measurement device includes a light source configured to emit light pulses directed at a target. The optical measurement device further includes a detector configured to detect arrival times for photons of the light pulses after the photons are scattered by the target. The optical measurement device further includes a processing unit configured to generate, based on the arrival times of the photons at the detector, histogram data associated with the target. The processing unit is further configured to determine, based on the histogram data, an absolute optical property associated with the target. The processing unit is further configured to determine, based on the absolute optical property, a blood oxygenation level of the user, and perform an operation based on the blood oxygenation level.
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
An illustrative system may include an extended reality system and a brain interface system configured to be concurrently worn by a user. The extended reality system may be configured to provide the user with an extended reality experience (e.g., an immersive virtual reality experience or a non-immersive augmented reality experience). The brain interface system may be configured to acquire one or more brain activity measurements while the extended reality experience is being provided to the user.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
12.
MAINTAINING CONSISTENT PHOTODETECTOR SENSITIVITY IN AN OPTICAL MEASUREMENT SYSTEM
An illustrative optical measurement system includes a light source configured to emit a light pulse directed at a target. The optical measurement system further includes a plurality of photodetectors configured to operate in accordance with an input bias voltage. The optical measurement system further includes a control circuit configured to identify a photodetector subset included in the plurality of photodetectors and that detects, while the input bias voltage has a first value, photons of the light pulse after the light pulse is scattered by the target. The control circuit is further configured to determine, based on the identifying of the photodetector subset, an overvoltage associated with the photodetector subset. The control circuit is further configured to update, based on the overvoltage, the input bias voltage for the plurality of photodetectors to have a second value.
A shielding arrangement for a magnetoencephalography (MEG) system includes a passively shielded enclosure having a plurality of walls defining the passively shielded enclosure, each of the plurality of walls including passive magnetic shielding material to reduce an ambient background magnetic field within the passively shielded enclosure; a vestibular wall extending from a first vertical wall to define, and at least partially separate, a vestibular area of the passively shielded enclosure adjacent the doorway and a user area of the passively shielded enclosure; and active shield coils distributed within the passively shielded enclosure and configured to further reduce the ambient background magnetic field within the user area of the passively shielded enclosure.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/245 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetoencephalographic [MEG] signals
A magnetocardiography (MCG) system includes a passively shielded enclosure having walls defining the passively shielded enclosure, each of the walls including passive magnetic shielding material to reduce an ambient background magnetic field within the passively shielded enclosure; an MCG measurement device including optically pumped magnetometers (OPMs); and active shield coils within the passively shielded enclosure and stationary relative to the passively shielded enclosure and the MCG measurement device, wherein the active shield coils are configured to further reduce the ambient background magnetic field within a user area of the passively shielded enclosure.
A61B 5/243 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetocardiographic [MCG] signals
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
An exemplary optical measurement system includes a light source configured to emit light directed at a target. The optical measurement system further includes a photodetector configured to detect a photon of the light after the light is scattered by the target. The optical measurement system further includes a control circuit configured to receive a first input voltage that is a temperature-dependent voltage. The control circuit is further configured to receive a second input voltage that is a temperature-invariant voltage. The control circuit is further configured to output, based on a combination of the first input voltage and the second input voltage, a bias voltage for the photodetector, wherein the combination of the first and second input voltages is configured to cause the bias voltage to vary based on temperature.
An exemplary system includes a photodetector configured to generate a photodetector output pulse when the photodetector detects a photon from a light pulse having a light pulse time period, a TDC configured to monitor for the occurrence of the photodetector output pulse during a measurement time window that is within and shorter in duration than the light pulse time period, a PLL circuit for the TDC, and a precision timing circuit connected to the PLL circuit and configured to adjust, based on at least one signal generated within the PLL circuit, a temporal position of the measurement time window within the light pulse time period.
An exemplary system includes a photodetector configured to generate a plurality of photodetector output pulses over time as a plurality of light pulses are applied to and scattered by a target, a TPSF generation circuit configured to generate, based on the photodetector output pulses, a TPSF representative of a light pulse response of the target, and a control circuit configured to direct the TPSF generation circuit to selectively operate in different resolution modes.
An exemplary optical measurement system described herein includes a control circuit configured to output a global bias voltage and a module communicatively coupled to the control circuit. The module includes a light source configured to emit light directed at a target. The module further includes a plurality of detectors configured to detect arrival times for photons of the light after the light is scattered by the target. The module further includes a module control circuit configured to receive the global bias voltage and output a plurality of detector bias voltages based on the global bias voltage. The plurality of detector bias voltages include a respective detector bias voltage for each detector of the plurality of detectors.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G01S 7/4861 - Circuits for detection, sampling, integration or read-out
G01S 17/02 - Systems using the reflection of electromagnetic waves other than radio waves
H01L 31/107 - Devices sensitive to infrared, visible or ultraviolet radiation characterised by only one potential barrier or surface barrier the potential barrier working in avalanche mode, e.g. avalanche photodiode
19.
PHOTODETECTOR CALIBRATION OF AN OPTICAL MEASUREMENT SYSTEM
An illustrative optical measurement system includes a light source configured to emit light directed at a target, an array of photodetectors configured to detect photons of the light after the light is scattered by the target, and a processing unit. The processing unit is configured to measure a noise level of a photodetector included in the array of photodetectors and determine that the noise level meets a predetermined threshold. The processing unit is further configured to prevent, based on the determining that the noise level meets the predetermined threshold, an output of the photodetector from being used in generating a histogram based on a temporal distribution of photons detected by the array of photodetectors.
An authentication system comprises a brain-computer interface (BCI) configured for detecting neural activity in a brain of a subject in response to the subject performing a repeatable mental task, and outputting neural data representative of the detected neural activity. The authentication system further comprises a computer configured for acquiring the neural data output by the BCI while the subject is performing the repeatable mental task, and generating an authorization request containing the neural data. The authentication system further comprises an authentication processor configured for acquiring the authorization request containing the neural data from the computer, authenticating the subject based on the acquired authorization request, and sending an authorization token to the computer.
An illustrative optical measurement system may include a wearable assembly configured to be worn by a user and comprising a plurality of light sources each configured to emit light directed at a target and a plurality of detectors configured to detect arrival times for photons of the light after the light is scattered by the target, wherein a ratio of a total number of the detectors to a total number of the light sources is at least two to one.
An illustrative optical measurement system includes a light source configured to emit, during a measurement session time period, a sequence of light pulses towards a target; a plurality of photodetectors configured to remain in an armed state during an entire duration of the measurement session time period, and detect, while in the armed state, photons of the light pulses after the light pulses are scattered by the target; and a plurality of time-to-digital converters (TDCs) comprising a different TDC for each photodetector of the plurality of photodetectors, the TDCs configured to record timestamp symbols representative of when the photons are detected by the photodetectors.
A system for training a neurome that emulates a brain of a user comprises a non-invasive brain interface assembly configured for detecting neural activity of the user in response to analog instances of a plurality of stimuli peripherally input into the brain of the user from at least one source of content, memory configured for storing a neurome configured for outputting a plurality of determined brain states of an avatar in response to inputs of the digital instances of the plurality of stimuli, and a neurome training processor configured for determining a plurality of brain states of the user based on the detected neural activity of the user, and modifying the neurome based on the plurality of determined brain states of the user and the plurality of determined brain states of the avatar.
An illustrative multimodal measurement system includes a wearable assembly configured to be worn by a user and comprising a plurality of light sources each configured to emit light directed at a target within the user, a plurality of detectors configured to detect arrival times for photons of the light after the light is scattered by the target, and a plurality of electrodes configured to be external to the user and detect electrical activity of the target.
An optical measurement system includes a wearable module assembly configured to be worn on a body of a user. The wearable module assembly includes a plurality of wearable modules and a connecting assembly. Each wearable module includes a light source configured to emit a light pulse toward a target within the body of the user and a plurality of detectors configured to receive photons included in the light pulse after the photons are scattered by the target. The connecting assembly physically and flexibly connects the plurality of wearable modules such that the wearable module assembly is conformable to a three-dimensional (3D) surface of the body of the user when the wearable module assembly is worn on the body of the user.
An optical measurement system includes a wearable module having at least one time-resolved single photon photodetector configured to detect photons from at least one light pulse after the at least one light pulse is scattered by a target within a body of a user; at least one light guide configured to receive the photons and guide the photons to the at least one photodetector; and a housing that houses both the at least one photodetector and at least a portion of the at least one light guide. The optical measurement system further includes a signal processing circuit configured to determine a temporal distribution of the photons detected by the at least one photodetector and generate a histogram based on the temporal distribution of the photons.
An illustrative research support computing system maintains subject data representative of attributes for research subjects included in a potential subject pool for potential research studies. The system receives, from a client device, an input dataset representative of: 1) a set of parameters defining a research study to be conducted with respect to a research subject group, and 2) a set of criteria for research subjects that are to be included in the research subject group. The system designates a research subject included in the potential subject pool for inclusion in the research subject group based on the set of criteria, and receives research data detected for the research subject in accordance with the set of parameters. The system also provides an output dataset generated based on the research data detected for the research subject in accordance with the set of parameters. Corresponding methods and systems are also disclosed.
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
28.
INTEGRATED LIGHT SOURCE ASSEMBLY WITH LASER COUPLING FOR A WEARABLE OPTICAL MEASUREMENT SYSTEM
A wearable module for use in an optical measurement system may include a first light source configured to emit a first light pulse in a first wavelength, a second light source configured to emit a second light pulse in a second wavelength that is different from the first wavelength, a light guide configured to guide the first light pulse and the second light pulse toward a target within a body of a user; an optical member configured to receive the first light pulse from the first light source and the second light pulse from the second light source and direct the first light pulse and the second light pulse to the light guide, and a housing that houses the first light source, the second light source, and the optical member.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/16 - Devices for psychotechnics; Testing reaction times
29.
WEARABLE DEVICES AND WEARABLE ASSEMBLIES WITH ADJUSTABLE POSITIONING FOR USE IN AN OPTICAL MEASUREMENT SYSTEM
An optical measurement system includes a wearable device including a support assembly configured to be worn on a body of a user and a wearable assembly supported by the support assembly. The wearable assembly includes a plurality of light sources configured to emit a plurality of light pulses toward a target within the body of the user and a plurality of detectors each configured to receive a set of photons included in a light pulse included in the plurality of light pulses after the set of photons is scattered by the target. A position of the wearable assembly on the support assembly is adjustable.
A method of making an array of vapor cells for an array of magnetometers includes providing a plurality of separate vapor cell elements, each vapor cell element including at least one vapor cell; arranging the vapor cell elements in an alignment jig to produce a selected arrangement of the vapor cells; attaching at least one alignment- maintaining film onto the vapor cell elements in the alignment jig; transferring the vapor cells elements and the at least one alignment-maintaining film from the alignment jig to a mold; injecting a bonding material into the mold and between the vapor cell elements to bond the vapor cell elements in the selected arrangement; removing the at least one alignment maintaining film from the vapor cell elements; and removing the bonded vapor cells elements in the selected arrangement from the mold to provide the array of vapor.
A method of operating an optically pumped magnetometer (OPM) includes directing a light beam through a vapor cell of the OPM including a vapor of atoms; applying RF excitation to cause spins of the atoms to precess; measuring a frequency of the precession; for each of a plurality of different axes relative to the vapor cell, directing a light beam through the vapor cell, applying a magnetic field through the vapor cell along the axis, applying RF excitation to cause spins of the atoms to precess, and measuring a frequency of the precession in the applied magnetic field; determining magnitude and components of an ambient background magnetic field along the axes using the measured frequencies; and applying a magnetic field based on the components around the vapor cell to counteract the ambient background magnetic field to facilitate operation of the OPM in a spin exchange relaxation free (SERF) mode.
G01N 24/00 - Investigating or analysing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
G01R 33/26 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance for measuring direction or magnitude of magnetic fields or magnetic flux using optical pumping
G01R 33/00 - Arrangements or instruments for measuring magnetic variables
A61B 5/04 - Measuring bioelectric signals of the body or parts thereof
32.
SYSTEMS AND METHODS HAVING AN OPTICAL MAGNETOMETER ARRAY WITH BEAM SPLITTERS
An array of optically pumped magnetometers includes an array of vapor cells; and an array of beam splitters. The array of beam splitters is arranged into columns, including a first column, and rows. Each row and each column includes at least two of the beam splitters. The array of beam splitters is configured to receive light into the first column of the array and to distribute that light from the first column into each of the rows and to distribute the light from each of the rows into a plurality of individual light beams directed toward the vapor cells.
G01R 33/032 - Measuring direction or magnitude of magnetic fields or magnetic flux using magneto-optic devices, e.g. Faraday
G01R 33/26 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance for measuring direction or magnitude of magnetic fields or magnetic flux using optical pumping
G01R 33/00 - Arrangements or instruments for measuring magnetic variables
33.
SYSTEMS AND METHODS FOR FREQUENCY AND WIDE-BAND TAGGING OF MAGNETOENCEPHALOGRAPY (MEG) SIGNALS
A biological signal detection system includes one or more magnetic field sensors for placement on a user and for detecting signals generated by biological magnetic field sources of the user; at least one memory; at least one processor coupled to the at least one memory and the one or more magnetic field sensors and configured to receive the detected signals of the one or more magnetic field sensors. The at least one processor is configured to perform actions including receiving the detected signals from the magnetic field sensors; determining whether the detected signals are modulated by a predetermined stimulus tag; and, in response to the determination, identifying which of the detected signals are modulated by the predetermined stimulus tag.
A non-invasive system and method are provided. Brain activity of a user is detected using a non-invasive brain interface when the user is exposed to an external stimulus. The user is determined to be negatively primed by the external stimulus based on the detected brain activity. An alert that the user is being negatively primed by the external stimulus is automatically provided. A tagged training session may be automatically provided to the user in response determining that the user has a negative mental state, thereby promoting a positive mental state of the user. A training session list containing the tagged training session may be automatically modified based on the determined mental state of the user.
A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
A61B 5/0482 - Electroencephalography using biofeedback
35.
PHOTODETECTOR SYSTEMS WITH LOW-POWER TIME-TO-DIGITAL CONVERTER ARCHITECTURES
An exemplary photodetector system includes a photodetector and a time-to-digital converter (TDC) coupled to the photodetector. The TDC is configured to receive, during a predetermined event detection time window that commences in response to an application of a light pulse to a target, a signal triggered by an event in which the photodetector detects a photon of the light pulse after the light pulse reflects from the target. The TDC is further configured to enable, in response to the receiving the signal, a gated ring oscillator (GRO) of the TDC, measure, using the GRO, a time interval between when the event occurred and an end of the predetermined event detection time window, and determine, based on the time interval and the predetermined event detection time window, an arrival time of the photon at the photodetector.
An exemplary system includes an array of photodetectors and a control system. Each photodetector of the array of photodetectors may include a single-photon avalanche diode (SPAD) and a fast-gating circuit configured to arm and disarm the SPAD. The control system is configured to control a current drawn by the array of photodetectors.
H04N 5/3745 - Addressed sensors, e.g. MOS or CMOS sensors having additional components embedded within a pixel or connected to a group of pixels within a sensor matrix, e.g. memories, A/D converters, pixel amplifiers, shared circuits or shared components
G01T 1/24 - Measuring radiation intensity with semiconductor detectors
An exemplary photodetector system includes a plurality of photodetectors connected in parallel and a processor communicatively coupled to the plurality of photodetectors. The processor is configured to receive an accumulated output from the plurality of photodetectors. The accumulated output represents an accumulation of respective outputs from each of the plurality of photodetectors detecting photons during a predetermined measurement time period that occurs in response to a light pulse being directed toward a target within a body. The processor is further configured to determine, based on the accumulated output, a temporal distribution of photons detected by the plurality of photodetectors, and generate, based on the temporal distribution of photons, a histogram representing a light pulse response of the target within the body.
A non-invasive product customization system and a method of customizing a product formulation is provided. Brain activity of a user is detected in response to an input of a product formulation into a brain of the user via a sensory nervous system of the user. A mental state of the user is detected based on the detected brain activity. The product formulation is modified based on the determined mental state of the user. The modified product formulation may be presented to the user in a manner that modulates the mental state of the user.
A magnetic field measurement system (300), non-transitory computer-readable medium or method can include instructions for, or performance of, actions including receiving output of multiple first magnetic field sensors (302) and multiple second magnetic field sensors (304); and demixing, using the output of the first (N) and second magnetic field sensors (M), at least one signal from at least one target source from signals from other magnetic field sources. The demixing may be performed using a model in which the output of the first magnetic field sensors (N) includes the at least one signal from the at least one target source and that the output of the second magnetic field sensors (M) does not include the at least one signal from the at least one target source.
G01R 33/00 - Arrangements or instruments for measuring magnetic variables
G01R 33/26 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance for measuring direction or magnitude of magnetic fields or magnetic flux using optical pumping
A61B 5/04 - Measuring bioelectric signals of the body or parts thereof
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
40.
INTEGRATED MAGNETOMETER ARRAYS FOR MAGNETOENCEPHALOGRAPHY (MEG) DETECTION SYSTEMS AND METHODS
An array of optically pumped magnetometers includes a vapor cell arrangement having a wafer defining one or more cavities and alkali metal atoms disposed in the cavities to provide an alkali metal vapor; an array of light sources, each of the light sources arranged to illuminate a different portion of the one or more cavities of the vapor cell arrangement with light; at least one mirror arranged to reflect the light from the array of light sources after the light passes through the one or more cavities of the vapor cell arrangement; and an array of detectors to receive light reflected by the at least one mirror, wherein each of the detectors is arranged to receive light originating from one of the light sources.
G01R 33/00 - Arrangements or instruments for measuring magnetic variables
A61B 5/04 - Measuring bioelectric signals of the body or parts thereof
G01N 24/00 - Investigating or analysing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
G01R 33/032 - Measuring direction or magnitude of magnetic fields or magnetic flux using magneto-optic devices, e.g. Faraday
G01R 33/26 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance for measuring direction or magnitude of magnetic fields or magnetic flux using optical pumping
41.
MODULATION OF MENTAL STATE OF A USER USING A NON-INVASIVE BRAIN INTERFACE SYSTEM AND METHOD
Brain activity of a user is detected, and a mental state of the user is determined. In one technique, life/work context is automatically presented to the user in a manner that modulates the mental state of the user. In another technique, an entertainment selection is presented to the user, and an entertainment selection list is automatically modified in response to the determined mental state of the user. In still another technique, the mental state that is determined is a negative emotional state, and life/work context is automatically presented to the user in a manner that promotes a cognitive state of the user in response to the determined emotional state of the user. In yet another technique, the wellness of the user is automatically tracked over a time period based on the determined mental state.
One embodiment is a magnetic field measurement system that includes at least one magnetometer having a vapor cell, a light source to direct light through the vapor cell, and a detector to receive light directed through the vapor cell; at least one magnetic field generator disposed adjacent the vapor cell; and a feedback circuit coupled to the at least one magnetic field generator and the detector of the at least one magnetometer. The feedback circuit includes at least one feedback loop that includes a first low pass filter with a first cutoff frequency. The feedback circuit is configured to compensate for magnetic field variations having a frequency lower than the first cutoff frequency. The first low pass filter rejects magnetic field variations having a frequency higher than the first cutoff frequency and provides the rejected magnetic field variations for measurement as an output of the feedback circuit.
G01R 33/00 - Arrangements or instruments for measuring magnetic variables
G01R 33/032 - Measuring direction or magnitude of magnetic fields or magnetic flux using magneto-optic devices, e.g. Faraday
G01R 33/26 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance for measuring direction or magnitude of magnetic fields or magnetic flux using optical pumping
A mental state awareness system (10) comprises a non-invasive brain interface assembly (14) configured for detecting brain activity of a user, a processor configured for determining a mental state of a user based on the detected brain activity, and a biofeedback device (18) configured for automatically providing biofeedback to the user indicative of the determined mental state of the user.
A magnetic field measurement system can include at least one magnetometer; and a ferrofluid shield disposed at least partially around the at least one magnetometer. For example, the ferrofluid shield can include a microfluid fabric and a ferrofluid disposed in or flowable into the microfluid fabric. As another example, the ferrofluid shield can include a ferrofluid and a controller configured to alter an arrangement of the ferrofluid within the ferrofluid shield.
A magnetic field measurement system that includes at least one magnetometer; at least one magnetic field generator; a processor coupled to the at least one magnetometer and the at least one magnetic field generator and configured to: measure an ambient background magnetic field using at least one of the at least one magnetometer in a first mode selected from a scalar mode or a vector mode; generate, in response to the measurement of the ambient background magnetic field, a compensation field using the at least one magnetic field generator; and measure a target magnetic field using at least one of the at least one magnetometer in a spin exchange relaxation free (SERF) mode which is different from the first mode.
G01R 33/00 - Arrangements or instruments for measuring magnetic variables
G01R 33/26 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance for measuring direction or magnitude of magnetic fields or magnetic flux using optical pumping
46.
MAGNETIC FIELD SHAPING COMPONENTS FOR MAGNETIC FIELD MEASUREMENT SYSTEMS AND METHODS FOR MAKING AND USING
A magnetic field measurement system includes at least one magnetometer; and at least one flux concentrator made of a high magnetic permeability material and configured to receive magnetic field signals from a source, to concentrate the magnetic field signals or reorient the magnetic field signals in a preselected direction, and to direct the concentrated or reoriented magnetic field signals toward at least one of the at least one magnetometer. In addition to, or as an alternative to, the flux concentrator, the system can include a passive shield made of the high magnetic permeability material. The system may also include active shielding.
A magnetometer can include a single, integrated, unitary structure that has a gas cell (570) defining a cavity having a vapor or vaporizable material disposed therein, a collimating element (578) coupled to the gas cell and configured for collimating light directed toward the gas cell, and a lens element (582) coupled the gas cell and configured for redirecting at least a portion of light that has passed through the gas cell. Additionally or alternatively, a gas cell of a magnetometer may be made of sapphire.
G01R 33/26 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance for measuring direction or magnitude of magnetic fields or magnetic flux using optical pumping
G01N 24/00 - Investigating or analysing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
48.
SYSTEMS AND METHODS TO REDUCE DATA AND COMPLEXITY IN NEURAL SIGNAL PROCESSING CHAIN
Described herein are systems and methods for reducing the size of data payloads delivered to downstream processing from a raw series of biological sensor recordings. In one variation, the system comprises a low-power hardware architecture that combines serially sampled neural signal data with a transformation matrix (TFM) using a novel systolic random-logic-macro (RLM) array.
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G06F 15/82 - Architectures of general purpose stored program computers data or demand driven
H04B 1/66 - TRANSMISSION - Details of transmission systems not characterised by the medium used for transmission for improving efficiency of transmission
49.
NON-INVASIVE SYSTEMS AND METHODS FOR DETECTING MENTAL IMPAIRMENT
A mental impairment detection system and non-invasive method of detecting mental impairment of a user are provided. A test (e.g., an inhibitory reflex test or a sustained attention test) is administered to the user, brain activity in a frontal lobe of the user is non-invasively detected while the test is administered to the user, and a level of mental impairment of the user is determined based on the brain activity detected in the frontal lobe of the user.
A magnetic field measurement system includes an array of magnetometers; at least one magnetic field generator with each of the at least one magnetic field generator configured to generate a first magnetic field at one or more of the magnetometers, wherein the generated first magnetic field combines with the ambient magnetic field to produce a directional magnetic field at the one or more of the magnetometers, where a magnitude and direction of the directional magnetic field is selectable using the at least one magnetic field generator; and a controller coupled to the magnetometers and the at least one magnetic field generator, the controller including a processor configured for receiving signals from the magnetometers, observing or measuring a magnetic field from the received signals, and controlling the at least one magnetic field generator to generate the first magnetic field and select the direction of the directional magnetic field.
G01R 33/26 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance for measuring direction or magnitude of magnetic fields or magnetic flux using optical pumping
A61B 5/04 - Measuring bioelectric signals of the body or parts thereof
G01R 33/032 - Measuring direction or magnitude of magnetic fields or magnetic flux using magneto-optic devices, e.g. Faraday
An exemplary photodetector includes a SPAD and a capacitor. The capacitor is configured to be charged, while the SPAD is in a disarmed state, with a bias voltage by a voltage source. The capacitor is further configured to supply, when the SPAD is put in an armed state, the bias voltage to an output node of the SPAD such that a voltage across the SPAD is greater than a breakdown voltage of the SPAD.
An exemplary non-invasive wearable brain interface system includes a headgear configured to be worn on a head of the user and a plurality of self-contained photodetector units configured to removably attach to the headgear. The photodetector units each include a plurality of photodetectors configured to detect photons of light after the photons reflect from a target within a brain of the user. The brain interface system further includes a master control unit communicatively coupled to each of the photodetector units by way of a plurality of wires and configured to control the photodetector units, the master control unit comprising an input power port configured to connect to a power cable that provides power from a power source for the master control unit and the photodetector units.
An exemplary stacked photodetector assembly includes a first wafer and a second wafer bonded to the first wafer. The first wafer includes a SPAD and has a thickness T1 configured to minimize absorption by the first wafer of photons included in light incident upon the first wafer while the SPAD is in a disarmed state. The second wafer has a thickness T2 configured to provide structural support for the first wafer. The stacked photodetector assembly includes a fast gating circuit electrically coupled to the SPAD and configured to arm and disarm the SPAD.
A non-invasive optical measurement system comprises a two-dimensional array of photonic integrated circuits (PICs) mechanically coupled to each other. Each PIC is configured for emitting sample light into an anatomical structure, such that the sample light is scattered by the anatomical structure, resulting in physiological-encoded signal light that exits the anatomical structure. Each PIC is further configured for detecting the signal light. The non-invasive optical measurement system further comprises processing circuitry configured for analyzing the detected signal light from each of the PICs, and based on this analysis, determining an occurrence and a three-dimensional spatial location of the physiological event in the anatomical structure.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
55.
ULTRASOUND MODULATING OPTICAL TOMOGRAPHY USING REDUCED LASER PULSE DURATION
Sample light is delivered into the anatomical structure having a target voxel, whereby a portion of the sample light passing through the target voxel is scattered by the anatomical structure as signal light, and another portion of the sample light not passing through the target voxel is scattered by the anatomical structure as background light that is combined with the signal light to create a sample light pattern. Reference light is combined with the sample light pattern to generate an interference light pattern, such that the signal light and the reference light are combined in a heterodyne manner. Ultrasound is delivered into the target voxel, such that the signal light is frequency shifted by the ultrasound. The ultrasound and the sample light are pulsed in synchrony, such that at least one pulse of the sample light has a combined duration less than a pulse width of the ultrasound.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
56.
SYSTEMS AND METHODS FOR QUASI-BALLISTIC PHOTON OPTICAL COHERENCE TOMOGRAPHY IN DIFFUSIVE SCATTERING MEDIA USING A LOCK-IN CAMERA DETECTOR
Described herein are systems and methods for noninvasive functional brain imaging using low-coherence interferometry (e.g., for the purpose of creating a brain computer interface with higher spatiotemporal resolution). One variation of a system and method comprises optical interference components and techniques using a lock-in camera. The system comprises a light source and a processor configured to rapidly phase-shift the reference light beam across a pre-selected set of phase shifts or offsets, to store a set of interference patterns associated with each of these pre-selected phase shifts, and to process these stored interference patterns to compute an estimate of the number of photons traveling between a light source and the lock-in camera detector for which the path length falls within a user-defined path length range.
A system and method of performing ultrasound modulated optical tomography. Ultrasound is delivered into a target voxel in an anatomical structure, and sample light is delivered into the anatomical structure. A portion of the sample light passing through the target voxel is scattered by the anatomical structure as signal light, and another portion of the sample light not passing through the target voxel is scattered by the anatomical structure as background light that combines with the signal light to create a sample light pattern. The ultrasound and the sample light are pulsed in synchrony, such that only the signal light is frequency shifted by the ultrasound. Reference light is combined with the sample light pattern to generate an interference light pattern, which is sequentially modulated to generate different interference light patterns. Spatial components of each different interference light pattern are simultaneously detected and stored in bins.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
58.
SYSTEM AND METHOD FOR SIMULTANEOUSLY DETECTING PHASE MODULATED OPTICAL SIGNALS
An optical detection method and system are provided. Sample light is delivered into an anatomical structure having a target voxel, whereby a portion of the sample light passing through the target voxel is scattered by the anatomical structure as signal light, and another portion of the sample light not passing through the target voxel is scattered by the anatomical structure as background light that is combined with the signal light to create a sample light pattern. The sample light pattern and the reference light having an M number of different phases are concurrently combined to respectively generate an M number of interference light patterns. The M number of interference light patterns are detected. M pluralities of values representative of spatial components of the respective M number of interference light patterns are generated, and a physiologically-dependent optical parameter of the target voxel is determined based on the M pluralities of values.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
Devices, systems, and methods herein relate to processing biosignal data. These systems and methods may obtain sensor data from a plurality of electrodes and may also be used to augment cortical function, treat neurological disease, and provide insight and analysis of biological processes and/or clinical therapeutic outcomes. An implantable biosignal processing system may comprise a lead having at least one biosignal sensor configured to transmit biosignal data based on electrophysiological activity of a subject. A first processing system may be coupled to the biosignal sensor and comprise a plurality of analog signal processing circuits configured to be selectively powered based on a selectable treatment mode. A second processing system in communication with the first processing system and may comprise a plurality of digital signal processing circuits configured to be selectively powered based on the treatment mode. A neurostimulator may stimulate tissue according to the set of biosignal characteristics.
patents
