Abstract

Chiral redox-polymers that have been enabled for electrochemically-controlled enantioselective interactions. Supramolecular chirality was leveraged for enhancing recognition toward target enantiomers. Chiral redox-metallopolymers were synthesized based on Ugi's amine-inspired chiral monomers, and their enantioselective recognition toward ionic enantiomers, such as tryptophan and naproxen, is demonstrated, with higher enhancement provided by a chiral redox-polymer over a single-site, chiral building block. 2D nuclear magnetic resonance spectroscopy and solid-state circular dichroism support supramolecular chirality resulting from the intramolecular interaction between the ferrocene and the alkyl group in the backbone. The chiral redox-metallopolymers can be used as a platform for electrochemically-modulated enantioselective interactions toward a range of amino acids and pharmaceutical carboxylates.

IPC Classes  ?

• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials

Abstract

Methods are provided herein for training and using models to generate semantically representative continuous vectors for input mathematical expressions. These methods result in models that output continuous vectors that are nearby in an embedding space for equations that are mathematically equivalent but differently written. Such continuous vectors can be used to facilitate indexing and searching of databases of mathematical equations, e.g., to facilitate semantically-aware searching of databases of mathematical texts for equations that are mathematically equivalent to, or mathematically similar to, input query expressions. These training methods include training an encoder together with a decoder to predict pairs of mathematically equivalent but different training expressions, with the output of the encoder being the continuous vector that represents the semantic mathematical content of the pair of training expressions. Also provided are methods for efficiently generating such pairs of mathematically equivalent but different training expressions.

IPC Classes  ?

• G06N 3/0455 - Auto-encoder networks; Encoder-decoder networks
• G06N 3/044 - Recurrent networks, e.g. Hopfield networks
• G06N 3/0475 - Generative networks
• G06N 3/048 - Activation functions

Abstract

New synthetic methods to provide access to previously unexplored functionality at the C8 position of substituted imidazo[5,1-d][1,2,3,5]tetrazines of Formula I. Through synthesis and evaluation of a suite of compounds with a range of aqueous stabilities (from 0.5 to 40 hours), a predictive model for imidazotetrazine hydrolytic stability based on the Hammett constant of the C8 substituent was derived. Promising compounds were identified that possess activity against a panel of GBM cell lines, appropriate hydrolytic and metabolic stability, and brain-to-serum ratios dramatically elevated relative to TMZ, leading to lower hematological toxicity profiles and superior activity to TMZ in a mouse model of GBM. New synthetic methods to provide access to previously unexplored functionality at the C8 position of substituted imidazo[5,1-d][1,2,3,5]tetrazines of Formula I. Through synthesis and evaluation of a suite of compounds with a range of aqueous stabilities (from 0.5 to 40 hours), a predictive model for imidazotetrazine hydrolytic stability based on the Hammett constant of the C8 substituent was derived. Promising compounds were identified that possess activity against a panel of GBM cell lines, appropriate hydrolytic and metabolic stability, and brain-to-serum ratios dramatically elevated relative to TMZ, leading to lower hematological toxicity profiles and superior activity to TMZ in a mouse model of GBM.

IPC Classes  ?

• C07D 487/04 - Ortho-condensed systems
• A61K 9/20 - Pills, lozenges or tablets
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61K 31/495 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
• A61K 47/02 - Inorganic compounds
• A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
• A61K 47/36 - Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

Abstract

The present disclosure provides a system for monitoring unstructured environments. A predetermined path can be determined according to an assignment of geolocations to one or more agronomically anomalous target areas, where the one or more agronomically anomalous target areas are determined according to an analysis of a plurality of first images that automatically identifies a target area that deviates from a determination of an average of the plurality of first images that represents an anomalous place within a predetermined area, where the plurality of first images of the predetermined area are captured by a camera during a flight over the predetermined area. A camera of an unmanned vehicle can capture at least one second image of the one or more agronomically anomalous target areas as the unmanned vehicle travels along the predetermined path.

IPC Classes  ?

• G05D 1/00 - Control of position, course, altitude, or attitude of land, water, air, or space vehicles, e.g. automatic pilot
• G06F 16/29 - Geographical information databases
• G06F 18/21 - Design or setup of recognition systems or techniques; Extraction of features in feature space; Blind source separation
• G06V 10/22 - Image preprocessing by selection of a specific region containing or referencing a pattern; Locating or processing of specific regions to guide the detection or recognition
• G06V 10/762 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using clustering, e.g. of similar faces in social networks
• G06V 10/778 - Active pattern-learning, e.g. online learning of image or video features
• G06V 20/10 - Terrestrial scenes
• G06V 20/17 - Terrestrial scenes taken from planes or by drones
• G08G 5/00 - Traffic control systems for aircraft

Abstract

An electrochemical method of recycling and regenerating transition metal oxides includes heating a mixture of salts to obtain a molten salt solution, and immersing a working electrode, a counter electrode and optionally a reference electrode into the molten salt solution, where the working electrode is electrically connected to a cathode material comprising a transition metal oxide. A voltage is applied to the working electrode, such that electrodissolution of the transition metal oxide occurs and an alkali metal species comprising lithium or sodium ions and a transition metal species comprising transition metal ions are produced in the molten salt solution. During application of the voltage and dissolution of the transition metal oxide, a regenerated transition metal oxide is concurrently electrochemically produced, e.g., in the form of a film or a powder.

IPC Classes  ?

• C01D 15/02 - Oxides; Hydroxides
• C25B 3/25 - Reduction
• H01M 10/54 - Reclaiming serviceable parts of waste accumulators

Abstract

Disclosed herein are antibacterial compounds that accumulate in Gram-negative bacteria, methods of preparing the compounds, and methods of using the compounds to inhibit or kill microbes, and methods of treating microbial infections, such as Gram-negative bacterial infections. Compounds selected for conversion to potential Gram-negative antibacterial compounds were identified based on compounds having low globularity and low flexibility. Amine substituents were then strategically added to the selected compounds to provide compounds having antibacterial activity against Gram-negative bacteria.

IPC Classes  ?

• C07D 409/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
• A61P 31/04 - Antibacterial agents
• C07D 471/04 - Ortho-condensed systems
• C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or

Abstract

The present invention is a multivalent immunogenic composition for immunizing an animal against filariasis. In some aspects, the antigens of the multivalent immunogenic composition are protein-based, DNA-based, or a combination thereof. This invention also provides a method and kit for detecting a filarial nematode and determining vaccine efficacy.

IPC Classes  ?

• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61P 33/00 - Antiparasitic agents
• C07K 14/435 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans

Abstract

Compositions and methods for eliciting an immune response in a subject (such as against Shigella) are provided. In examples, the compositions can include fusion proteins including one or more epitopes from Shigella or E. coli. In examples, the methods can include administering a disclosed fusion protein to a subject.

IPC Classes  ?

• A61K 39/112 - Salmonella; Shigella
• A61K 39/108 - Escherichia; Klebsiella
• A61P 31/04 - Antibacterial agents
• C07K 14/245 - Escherichia (G)
• C07K 14/25 - Shigella (G)

Abstract

Novel Fusidic Acid (FA) based compounds that have equivalent potency against clinical isolates of Staphylococcus aureus (S. aureus) and Enterococcus faecium (E. faecium) as well as an improved resistance profile in vitro when compared to FA. Importantly, the new compounds display efficacy against a FA-resistant strain of Staphylococcus aureus in a soft-tissue murine infection model. This disclosure delineates the structural features of FA necessary for potent antibiotic activity and demonstrates that the resistance profile can be improved for this scaffold and target.

IPC Classes  ?

• C07J 13/00 - Normal steroids containing carbon, hydrogen, halogen, or oxygen, having a carbon-to-carbon double bond from or to position 17
• A61P 31/04 - Antibacterial agents
• C07J 41/00 - Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring

Abstract

Described herein are systems and methods which utilize an array of wells to rapidly detect target analytes from whole blood samples, even at very low concentrations. The provided systems and methods dry the blood sample to ensure a fluidic network forms in one or more dry blood sample islands and liquid with reagents useful for detecting nucleic acid sequences from a target analyte, including by amplification reactions that are bi-phasic because of the interaction between the solid dried blood sample phase and the liquid phases, including liquid having reagents that are able to fluidically and diffusively exchange with the fluidic network within the dried blood sample phase.

IPC Classes  ?

• C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12Q 1/6895 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
• G01N 1/44 - Sample treatment involving radiation, e.g. heat

Abstract

Disclosed are deuterated derivatives of tropolone useful for the treatment of diseases or disorders, e.g., involving deficiencies in iron transport.

Abstract

Disclosed is a method of treating a disease or condition characterized by neurodegeneration via administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of hinokitiol, hinokitiol derivatives, and iron-transporting tropolones.

Abstract

A device includes a porous scaffold characterized by a scaffold refractive index. An optically written optic is embedded in the porous scaffold. A coating forms a surface of the porous scaffold. The coating includes the surface and a transition region. The surface is characterized by a surface refractive index. The transition region is characterized by a refractive index gradient that transitions between the surface refractive index and the scaffold refractive index

IPC Classes  ?

• G02B 1/10 - Optical coatings produced by application to, or surface treatment of, optical elements
• G02B 6/02 - Optical fibres with cladding

Abstract

Aspects provide an intelligent direct input/output (IDIO) architecture for facilitating movement of data between processor cores and memories. A data packet is received at a network interface and classified based on its association with an application being processed by one or more cores of a processor. The disclosed IDIO architecture may determine to steer the data packet to a cache memory (e.g., a last level cache (LLC) or middle level cache (MLC)) or random access memory in response to receiving the data packet. The determination to steer the data packet to a particular memory may be based on characteristics of the data packet, the application, or other metrics. Where the data packet is steered to the MLC, the data packet may first be steered to the LLC and then prefetched to the MLC. The application may provide control information to invalidate a cacheline associated with the data packet one used.

IPC Classes  ?

• H04L 67/568 - Storing data temporarily at an intermediate stage, e.g. caching
• G06F 11/30 - Monitoring
• G06F 12/00 - Accessing, addressing or allocating within memory systems or architectures

Abstract

A method of maintaining lateral lane position of a vehicle traveling on a roadway includes detecting a magnetic field from a surface of the roadway, where the surface includes a magnetic or magnetized material, and adjusting a lateral position of the vehicle on the roadway such that the magnetic field has a maximum signal at a predetermined location on the vehicle, e.g., at or near a centerline of the vehicle. The magnetic or magnetized material may be localized to a longitudinal segment of the surface approximately centered between lane lines or at another desired location. Detection of the magnetic field may take place continuously while the vehicle is moving.

IPC Classes  ?

• B60W 30/12 - Lane keeping

Abstract

The disclosure provides an example Full Duplex-based ISAC optimization system. The system includes: (a) a Full Duplex (FD) massive MIMO Base Station (BS) node configured to operate at mmWave frequencies and having a plurality of transmitter antenna elements and a plurality of receiver antenna elements configured to communicate in a DownLink (DL) direction with a plurality of mobile users that each have a plurality of antenna receiver elements, where the plurality of RX antenna elements of the FD massive MIMO BS node are configured to receive DL signals reflected by a plurality of radar targets, and (b) at least one processor detects the plurality of radar targets randomly distributed within a communication environment based on the reflected DL signals, where the processor determines an estimation of a Direction of Arrival (DoA), a range, and a relative velocity for radar targets while optimizing a DL communication rate to the mobile users.

IPC Classes  ?

• H04B 7/0452 - Multi-user MIMO systems
• G01S 3/00 - Direction-finders for determining the direction from which infrasonic, sonic, ultrasonic, or electromagnetic waves, or particle emission, not having a directional significance, are being received
• G01S 13/00 - Systems using the reflection or reradiation of radio waves, e.g. radar systems; Analogous systems using reflection or reradiation of waves whose nature or wavelength is irrelevant or unspecified
• H04B 7/0456 - Selection of precoding matrices or codebooks, e.g. using matrices for antenna weighting

Abstract

Systems and methods for hardware-based asynchronous logging include: initiating first and second atomic regions on first and second cores of a central processing unit (CPU); and asynchronously logging data for the first atomic region and the second atomic region using the CPU by: asynchronously performing log persist operations (LPOs) to log an old data value from each atomic region; updating the old data value to a new data value from each atomic region; tracking dependencies between the first atomic region and the second atomic region using a memory controller; asynchronously performing data persist operations (DPOs) to persist the new data value for each atomic region; and committing the first atomic region and the second atomic region based on the dependencies using the memory controller of the CPU.

IPC Classes  ?

• G06F 3/06 - Digital input from, or digital output to, record carriers

Abstract

Disclosed herein are methods and systems that use a photonic crystal (PC) for interference scattering microscopy. Incident light is directed onto a surface of the PC and couples into a photonic crystal guided resonance (PCGR) mode of the PC such that less than 1% of the incident light is transmitted through the PC as transmitted light. One or more particles adjacent to the surface of the PC scatter a portion of the light coupled into the PCGR mode as scattered light. An image comprising a pattern of constructive and destructive interference between the transmitted light and the scattered light is formed, and an image sensor may capture one or more image frames of the image Imaging processing of the one or more image frames can be used to identify at least one scattering center corresponding to at least one particle of the one or more particles.

IPC Classes  ?

• G02B 21/00 - Microscopes

Abstract

An imaging substrate is provided to facilitate wide field photothermal infrared spectroscopic imaging of samples disposed thereon. The substrate includes at least two reflective layers and at least one spacer layer disposed therebetween which, together, form an optical cavity. The spacer layer(s) exhibit expansion and/or refractive index change as a function of heating by incident infrared illumination. Such localized heating results in a localized change in the effective reflectivity of the substrate by locally tuning/detuning the optical cavity. Thus, the pattern of effective reflectivity of the substrate can be made to correspond to the pattern of infrared absorptivity of a sample mounted on the substrate by illuminating the sample and the substrate with infrared illumination. The pattern of effective reflectivity can then be imaged, from the opposite side of the substrate from the sample and the incident infrared illumination, using a wide field microscope or other imaging

IPC Classes  ?

• G01N 21/35 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light

Abstract

Provided herein are systems that provide a genetic program to control bacterial life cycle and function execution, thereby conferring programmable microbial transition between planktonic and biofilm states and facilitating the development of cellular functions across physiological domains.

IPC Classes  ?

• C12N 15/63 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
• C12N 1/20 - Bacteria; Culture media therefor
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C12N 9/22 - Ribonucleases
• C12N 9/28 - Alpha-amylase from microbial source, e.g. bacterial amylase
• C12N 9/38 - Hydrolases (3.) acting on glycosyl compounds (3.2) acting on beta-galactose-glycoside bonds, e.g. beta-galactosidase
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof
• C12N 15/74 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora

Abstract

The current disclosure provides an improved sensitivity assay for detecting and quantifying nucleic acids in a sample. The assay utilizes target recycling amplification process (TRAP) for the digital detection of nucleic acids in tandem with photonic resonator absorption microscopy (PRAM) and utilizes toehold-mediated DNA strand displacement reactions. The disclosure also provides a system and method for use of the assay.

IPC Classes  ?

• C12Q 1/686 - Polymerase chain reaction [PCR]

Abstract

The neural network includes layers, and the layers each include a plurality of units, the plurality of units each have a weight coefficient associated with each input to a unit, and an importance parameter indicating importance of the weight coefficient. The method includes: in learning of a task, adjusting a first weight coefficient based on the importance parameter of the first weight coefficient and a first gradient of the first weight coefficient determined using a training set; and after the learning has been completed, determining, based on the training set, respective second gradients of a plurality of second weight coefficients included in a first layer including the first weight coefficient, and calculating the importance parameter of the first weight coefficient to be used in learning of a next task based on the respective second gradients.

IPC Classes  ?

• G06N 3/04 - Architecture, e.g. interconnection topology
• G06N 3/08 - Learning methods

Abstract

Compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods of use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells. The disclosed drug combinations can have lower neurotoxicity effects than other cancer therapies that achieve the same or similar therapeutic effect.

IPC Classes  ?

• A61K 31/495 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/20 - Pills, lozenges or tablets
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61K 31/4188 - 1,3-Diazoles condensed with heterocyclic ring systems, e.g. biotin, sorbinil
• A61K 31/53 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
• A61K 47/10 - Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers

Abstract

Magnetic resonance imaging systems and methods are provided for time-efficiently producing a plurality of image contrasts, the plurality of image contrasts including a first contrast being coupled with a second contrast and acquired over a plurality of key parameters that govern the second contrast to which the first contrast is coupled. In addition, the plurality of image contrasts is used to simultaneously map the first contrast, the second contrast, and additional contrasts.

IPC Classes  ?

• G01R 33/563 - Image enhancement or correction, e.g. subtraction or averaging techniques of moving material, e.g. flow-contrast angiography
• G01R 33/50 - NMR imaging systems based on the determination of relaxation times
• G01R 33/561 - Image enhancement or correction, e.g. subtraction or averaging techniques by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences

Abstract

The invention relates to FcRn polypeptides, to antibodies and related fragments thereof containing the FcRn polypeptides, to production of said antibodies and fragments and to use of said antibodies and fragments for therapy of various conditions.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 35/74 - Bacteria

Abstract

Herein is described the development of NIR-nanogels for NIR light-mediated cargo delivery. NIR-nanogels feature a photolabile cyanine crosslinker that can cleave via dioxetane chemistry when irradiated. This photochemical process results in the formation of two carbonyl fragments and concomitant NIR-nanogel degradation to facilitate cargo release. In contrast to studies where cyanines are utilized as photocages, our approach does not require direct chemical attachment to the cargo, thus expanding our ability to deliver molecules that cannot be covalently modified. We showcase this feature by encapsulating a palette of small-molecule chemotherapeutics that feature structurally diverse chemical architecture.

IPC Classes  ?

• A61B 6/00 - Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
• A61K 49/04 - X-ray contrast preparations
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons

Abstract

A method of measuring temperature includes positioning an optical fiber in contact with an object or in an environment having a temperature to be determined, where the optical fiber comprises a core surrounded by a cladding; the core comprises an alkaline-earth fluorosilicate glass including defects, and the cladding comprises a silica glass. Infrared light is supplied to the optical fiber, thereby electronically exciting the defects. Green light emitted from the defects is detected, and an intensity value of the green light is obtained and converted to a temperature value for the optical fiber, whereby the temperature of the object or environment is determined. The green light may be detected along a length of the optical fiber, and a plurality of intensity values may be converted to a plurality of temperature values along the fiber length, thereby obtaining a distributed measurement of the temperature of the object or environment.

IPC Classes  ?

• G01K 11/3213 - Measuring temperature based on physical or chemical changes not covered by group , , , or using changes in transmittance, scattering or luminescence in optical fibres at discrete locations in the fibre, e.g. using Bragg scattering using changes in luminescence, e.g. at the distal end of the fibres

Abstract

The current disclosure provides a simple single-step room temperature Activate Cleave and Count (ACC) assay coupled to Photonic Resonator Absorption Microscopy (PRAM) in an amplification-free approach. The assay, and associated system and method disclosed herein allow for detection of viral and bacterial pathogens as well disease such as cancer at the point of care.

IPC Classes  ?

• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
• C12Q 1/6818 - Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer

Abstract

The attachment of glucose to drugs and imaging agents enables cancer cell targeting via interactions with GLUT1 overexpressed on the cell surface. The present technology describes a biomimetic approach for the design of a multivalent glucose moiety (mvGlu). We showcase the utility of this new group by developing aza-BODIPY-based contrast agents boasting a significant PA signal enhancement greater than 11-fold after spectral unmixing. Moreover, when applied to targeting cancer cells, effective staining could be achieved with ultra-low dye concentrations (50 nM) and compared to a non-targeted analog, the signal intensity was >1000-fold higher. Also, we employed the mvGlu technology to develop a logic-gated acoustogenic probe to detect intratumoral Cu(I), which is an emerging cancer biomarker, in a murine model of breast tumor. This application was not possible using other acoustogenic probes previously developed for copper sensing.

IPC Classes  ?

• A61K 31/395 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
• A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
• A61K 31/44 - Non-condensed pyridines; Hydrogenated derivatives thereof
• A61K 31/69 - Boron compounds
• A61K 31/4192 - 1,2,3-Triazoles

Abstract

Systems and methods for phase-sensitive optical coherence tomography (“OCT”) and/or optical coherence microscopy (“OCM”) include imparting multiple phase shifts to the object beam, the reference beam, or both in an interferometer. Phase shifts can be imparted to the S-polarization and/or P-polarization modes of the object and/or reference beams. As an example, phase shifts can be imparted to the reference beam in the reference arm using a waveplate or other phase shifter. A non-polarizing beamsplitter can provide additional phase shifts to light reflected by the beamsplitter. Full field OCM can be provided by imaging the phase-shifted channels using an image sensor.

IPC Classes  ?

• G02B 21/00 - Microscopes
• G01B 9/02091 - Tomographic interferometers, e.g. based on optical coherence

Abstract

A plasma lamp is provided that employs excitation transfer between two atomic or molecular species so as to preferentially produce light at a specific atomic or molecular emission wavelength. The lamp includes a lamp body. The lamp body includes a top portion, a middle portion having an internal hollow space filled with an energy-donor chemical gas and an energy-acceptor chemical element, and a bottom portion. The lamp body further includes an array of a plurality of cavities connected to the internal hollow space. The internal hollow space and the array of the plurality of cavities are spaced apart from outer surfaces of the lamp body. The plasma lamp is configured to excite the energy-donor chemical gas by an ignition of a low-temperature plasma within the internal hollow space and the array of the plurality of cavities to cause an excitation transfer from the excited energy-donor chemical gas to the energy-acceptor chemical element, thereby emitting radiation having a wavelength of about 194 nm when mercury (Hg) is the energy-acceptor chemical element and helium (He) serves as the donor. Other wavelengths in the ultraviolet (UV) and vacuum ultraviolet (VUV) spectral regions are generated when other donor and acceptor atoms or molecules are employed. These lamps are well-suited as optical drivers for atomic clocks (such as the 40.5 GHz Hg ion clock), photochemical processing of materials, disinfection of water, air, and surfaces, as well as other applications requiring UV or VUV light.

IPC Classes  ?

• H01J 61/20 - Selection of substances for gas fillings; Specified operating pressure or temperature having a metallic vapour as the principal constituent mercury vapour
• H01J 61/06 - Main electrodes
• H01J 61/16 - Selection of substances for gas fillings; Specified operating pressure or temperature having helium, argon, neon, krypton, or xenon as the principle constituent
• H01J 61/35 - Vessels; Containers provided with coatings on the walls thereof; Selection of materials for the coatings

Abstract

Embodiments of compositions and methods for the treatment of blood disorders and malignancies in a subject are described herein. In one embodiment, a composition for the treatment of a blood disorder or a malignancy in a subject comprises decitabine, tetrahydrouridine, and an excipient. In another embodiment, a method for the treatment of a blood disorder or a malignancy in a subject comprises the oral administration of a composition comprising decitabine and tetrahydrouridine. In some examples, the composition may be administered 1-3 times weekly.

IPC Classes  ?

• A61K 31/7068 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

Aspects of the subject disclosure may include, for example, obtaining video data from a single monocular camera, wherein the video data comprises a plurality of frames, wherein the camera is attached to a mobile robot that is travelling along a lane defined by a row of crops, wherein the row of crops comprises a first plant stem, and wherein the plurality of frames include a depiction of the first plant stem; obtaining robot velocity data from encoder(s), wherein the encoder(s) are attached to the robot; performing foreground extraction on each of the plurality of frames of the video data, wherein the foreground extraction results in a plurality of foreground images; and determining, based upon the plurality of foreground images and based upon the robot velocity data, an estimated width of the first plant stem. Additional embodiments are disclosed.

IPC Classes  ?

• G05D 1/02 - Control of position or course in two dimensions
• H04W 4/40 - Services specially adapted for particular environments, situations or purposes for vehicles, e.g. vehicle-to-pedestrians [V2P]
• G06N 20/10 - Machine learning using kernel methods, e.g. support vector machines [SVM]
• G06V 20/10 - Terrestrial scenes
• G06V 20/40 - Scenes; Scene-specific elements in video content
• G06F 18/214 - Generating training patterns; Bootstrap methods, e.g. bagging or boosting

Abstract

The disclosure includes a multiplexed telecommunication-band quantum network that utilizes atomic arrays in optical cavities. An example quantum networking system includes at least one quantum repeater node. The quantum repeater node includes an array of neutral atoms disposed in an optical cavity and a fiber-optic switch (FOS). The FOS is optically coupled to the optical cavity. The quantum repeater node also includes at least one beamsplitter. The at least one beamsplitter is optically coupled to the FOS.

IPC Classes  ?

• H04Q 11/00 - Selecting arrangements for multiplex systems
• H04B 10/70 - Photonic quantum communication

Abstract

A structural component for a vehicle includes a component including an interior surface defining a first hollow passage and a structural reinforcement contacting the interior surface of the component. The structural reinforcement and component define a cross-section and the structural reinforcement partially fills the cross-section. A process for forming the structural component including inserting a bladder into the first hollow passage defined by the interior surface of the component and inflating the bladder in the first hollow passage, forming a cavity between the bladder and the interior surface, filling the cavity with a polymer resin, and foaming the polymer resin. A system for forming a structural component for a vehicle includes a component including a first hollow passage defined by an interior surface of the component, a bladder insertable into the first hollow passage of the component, and a supply line connected to an interior of the bladder.

IPC Classes  ?

• B62D 25/04 - Door pillars
• B29C 44/58 - Moulds
• B29C 44/18 - Filling preformed cavities

Abstract

A structural component for a vehicle and a process and system for forming the structural component. A first cavity is formed in a first hollow passage between a first bladder and an interior surface of a component forming the structural component. A first structural reinforcement layer is formed in the first cavity by filling the first cavity with a first polymer resin and foaming the first polymer resin to form a first polymer resin foam. A second cavity is formed in the first hollow passage and a second structural reinforcement layer is formed in the second cavity by filling the second cavity with a second polymer resin and foaming the second polymer resin to form a second polymer resin foam.

IPC Classes  ?

• B32B 5/32 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by the presence of two or more layers which comprise fibres, filaments, granules, or powder, or are foamed or specifically porous both layers being foamed or specifically porous
• B32B 5/20 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by features of a layer containing foamed or specifically porous material foamed in situ
• B32B 7/12 - Interconnection of layers using interposed adhesives or interposed materials with bonding properties
• B32B 1/08 - Tubular products
• B32B 37/00 - Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding
• B32B 37/15 - Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by the properties of the layers with at least one layer being manufactured and immediately laminated before reaching its stable state, e.g. in which a layer is extruded and laminated while in semi-molten state
• B29C 44/18 - Filling preformed cavities
• B29C 44/34 - Component parts, details or accessories; Auxiliary operations

Abstract

An example embodiment may involve obtaining text-based, ground truth electronic health records (EHRs), wherein the ground truth EHRs specify a sequence of medical visits involving a plurality of modalities, and wherein each of the medical visits specifies tokens representing at least one of the modalities; generating a training data set by perturbing the ground truth EHRs, wherein perturbing the ground truth EHRs involves deleting or shuffling some of the tokens in the ground truth EHRs; and iteratively applying a machine learning trainer application to the training data set, wherein the machine learning trainer application includes: (i) a bidirectional language model encoder that takes EHRs within the training data set and produces vector embeddings therefrom, (ii) an autoregressive language model decoder that takes the vector embeddings and infers predicted EHRs therefrom, and (iii) a loss function that compares the predicted EHRs to their corresponding ground truth EHRs.

IPC Classes  ?

• G06F 21/62 - Protecting access to data via a platform, e.g. using keys or access control rules
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records

Abstract

The present disclosure provides systems and methods that can provide portable, real-time accessible DNA memories. An example DNA-based data storage system includes a loading region configured to receive a plurality of DNA-based data storage elements in a suspension fluid and a plurality of microtubes disposed in a capture/release region. The microtubes are configured to capture and release the DNA-based data storage elements. The DNA-based data storage system also includes a linearization region configured to linearize the DNA-based data storage elements and a readout region with a readout device configured to provide information indicative of the respective DNA-based data storage elements.

IPC Classes  ?

• G06N 3/123 - DNA computing
• C12N 7/00 - Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof

Abstract

Methods of RNA-guided DNA endonuclease-mediated genome editing in Bacteria and Archaea are provided.

IPC Classes  ?

• C12N 15/90 - Stable introduction of foreign DNA into chromosome
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• C12N 15/63 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression

Abstract

Systems and methods for ultrafast imaging include: a memory having stored thereon a delay profile matrix and a field programmable gate array (FPGA) coupled with the memory. The delay profile matrix comprises a two-dimensional matrix in which each row corresponds to a delay profile at a particular depth. The FPGA is configured to: acquire radio frequency (RF) ultrasound data from a subject; load a delay profile from the delay profile matrix to a memory buffer of the FPGA, wherein the delay profile corresponds to a particular depth; read a first row of the RF ultrasound data based on a first delay value of the delay profile; generate beamformed data at the particular depth by beamforming the first row of RF ultrasound data; and generate an image of the subject based on the beamformed data.

IPC Classes  ?

• G01S 7/52 - RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES - Details of systems according to groups , , of systems according to group
• G01S 15/89 - Sonar systems specially adapted for specific applications for mapping or imaging

Abstract

Disclosed are prodrugs of MYC inhibitors and methods making and using same.

IPC Classes  ?

• C07D 231/12 - Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
• A61K 31/415 - 1,2-Diazoles
• A61P 35/00 - Antineoplastic agents

Abstract

In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, the disclosure, in one aspect, relates to compounds that are inhibitors for thioredoxin glutathione reductase (TGR), which is key for the survival of parasitic worms. In one aspect, the compounds described herein treat diseases produced by parasitic worms such as, for example, praziquantel-resistant worms.

IPC Classes  ?

• C07D 209/14 - Radicals substituted by nitrogen atoms, not forming part of a nitro radical
• C07D 213/38 - Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
• C07C 233/78 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
• C07D 231/12 - Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
• C07D 231/38 - Nitrogen atoms
• C07D 235/12 - Radicals substituted by oxygen atoms
• C07D 235/14 - Radicals substituted by nitrogen atoms
• C07D 235/16 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• C07D 235/24 - Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
• C07D 261/08 - Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
• C07D 261/18 - Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
• C07D 261/20 - Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
• C07D 263/32 - Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
• C07D 263/34 - Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
• C07D 263/56 - Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
• C07D 271/06 - 1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
• C07D 271/10 - 1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
• C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 401/10 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
• C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
• C07D 403/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 405/04 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 413/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 471/04 - Ortho-condensed systems
• A61P 33/12 - Schistosomicides
• A61K 31/421 - 1,3-Oxazoles, e.g. pemoline, trimethadione
• A61K 31/422 - Oxazoles not condensed and containing further heterocyclic rings
• A61K 31/4245 - Oxadiazoles
• A61K 31/415 - 1,2-Diazoles
• A61K 31/4439 - Non-condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61K 31/42 - Oxazoles

Abstract

Disclosed herein are compositions comprising: 4-phenylbutyrate (PBA) or a pharmaceutically acceptable salt thereof in an effective concentration as a therapeutic or prophylactic agent against viral infections, e.g., herpes simplex vims (HSV) infections. Also provided are methods for treating a disease or disorder in a subject, such as a viral infection (e.g., HSV infection), comprising administering to the subject a therapeutically or prophylactically effective amount of 4-phenylbutyrate (PBA) or a pharmaceutically acceptable salt thereof.

IPC Classes  ?

• A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
• A61P 31/22 - Antivirals for DNA viruses for herpes viruses
• A61K 31/522 - Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
• A61K 31/7072 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

A solution-phase processed vertical Schottky diode comprises a stack of films on a substrate, where the stack of films includes: a first electrode film comprising a noble metal; a first semiconducting film on the first electrode film, where the first semiconducting film comprises zinc oxide doped with an electron donor metal at a first dopant concentration; a second semiconducting film on the first semiconducting film, where the second semiconducting film comprises zinc oxide doped with the electron donor metal at a second dopant concentration higher than the first dopant concentration; and a second electrode film on the second semiconducting film, where the second electrode film comprises a noble metal.

IPC Classes  ?

• H01L 29/66 - Types of semiconductor device
• H01L 29/872 - Schottky diodes

Abstract

A system for redox polymer electrodialysis includes: a first electrode; a second electrode positioned in opposition to the first electrode; a pair of size-exclusion membranes positioned between the first and second electrodes; an ion exchange membrane positioned between the pair of size-exclusion membranes, the ion exchange membrane defining a feed channel and an accumulating channel between the size-exclusion membranes; and a redox channel containing the first and second electrodes and being separated from the feed and/or accumulating channels by the pair of size-exclusion membranes.

IPC Classes  ?

• C02F 1/469 - Treatment of water, waste water, or sewage by electrochemical methods by electrochemical separation, e.g. by electro-osmosis, electrodialysis, electrophoresis
• B01D 61/46 - Apparatus therefor
• B01D 61/02 - Reverse osmosis; Hyperfiltration
• B01D 71/10 - Cellulose; Modified cellulose
• B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
• C02F 1/44 - Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis

Abstract

An osmotically-active closed-cell composite comprises a closed-cell structure including fluid-filled cells separated by cell walls, where the fluid-filled cells comprise water and a solute, and the cell walls comprise a polymer permeable to water and impermeable to the solute. The closed-cell structure is configured to undergo osmotically-induced swelling during exposure to an aqueous environment having a different chemical potential from the fluid-filled cells.

IPC Classes  ?

• C12N 5/04 - Plant cells or tissues

Abstract

The present disclosure describes compositions of matter comprising a ribonucleoprotein complex comprising a nucleic acid-guided nuclease and a guide RNA, and further comprising and a blocking nucleic acid molecule represented by Formula IV, wherein Formula IV in the 5′-to-3′ direction comprises: T-D-M-A-Lp-C; wherein T is 17-31 nucleotides in length; D is 0-15 nucleotides in length; M is 1-25 nucleotides in length; A is 0-15 nucleotides in length and comprises a sequence complementary to D; and L is 3-25 nucleotides in length; p is 0 or 1; C is 4-15 nucleotides in length and comprises a sequence complementary to T; and wherein the blocking nucleic acid molecule comprises a sequence complementary to a gRNA.

IPC Classes  ?

• C12Q 1/6823 - Release of bound markers
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
• C12Q 1/682 - Signal amplification
• C12N 9/22 - Ribonucleases

Abstract

A methodology is used to quantify implications and/or footprints of carbon, water, and/or nutrients of a particular crop in a region on a large scale and at field-level. A methodology is used to quantify, calculate, and/or visualize cover crop traits, tillage practices, and/or their outcomes at large scale. A methodology is used to accurately derive, estimate, and/or predict large-scale, long-term, and field-level cover crop adoption and biomass information using remote sensing time series.

IPC Classes  ?

• G06Q 10/0637 - Strategic management or analysis, e.g. setting a goal or target of an organisation; Planning actions based on goals; Analysis or evaluation of effectiveness of goals
• G06Q 50/02 - Agriculture; Fishing; Mining

Abstract

The present disclosure provides prime editors, editor systems and methods of uses thereof. Specifically, the disclosure provides methods of use of split prime editors for editing genomic DNA.

IPC Classes  ?

• C12N 15/90 - Stable introduction of foreign DNA into chromosome
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof
• C12N 9/22 - Ribonucleases
• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)

Abstract

A unique class of perfluorocarbon-free Dextran-based oxygen nanobubbles (DONBs) and formulations thereof. The critical components in the formulation are chosen among the U.S. Food, and Drug Administration's (FDA) approved compounds, which provide a biocompatible environment for incorporating pharmaceutical agents. Moreover, the nanobubbles are fabricated with simple sonication and homogenization method that easily fulfills the current good manufacturing practices (cGMP) requirements, which will promote scaleup production for commercial manufacturing. The formulated DONBs release oxygen over an extended period to keep the partial pressure of oxygen within the inner retina high and thus preserve retinal tissue from ischemia.

IPC Classes  ?

• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61P 27/02 - Ophthalmic agents
• A61K 9/51 - Nanocapsules

Abstract

A method of spontaneously patterning a polymer during frontal polymerization includes activating an initiation region of a monomer solution to reaction to initiate a polymerization reaction. A polymerization front is generated and propagates through the monomer solution in a radial or longitudinal direction away from the initiation region. The monomer solution is spontaneously heated downstream of the polymerization front by thermal transport away from the polymerization reaction. Once a localized region of the monomer solution reaches a temperature sufficient for spontaneous initiation of another polymerization reaction, a new polymerization front is generated and propagates through the monomer solution in a circumferential or transverse direction. The spontaneous heating of the monomer solution downstream of the polymerization front and the initiation of another polymerization reaction occurs cyclically, producing multiple new polymerization fronts and spatial variations in reaction temperature across the monomer solution. Once polymerization is complete, a spontaneously patterned polymer is formed.

IPC Classes  ?

• C08G 61/08 - Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes only aliphatic carbon atoms prepared by ring-opening of carbocyclic compounds of carbocyclic compounds containing one or more carbon-to-carbon double bonds in the ring

Abstract

Disclosed are isolated nanoparticles composed of an extracellular matrix which comprises at least one heparin binding domain and nucleic acid or polyphosphate, as well as compositions comprising the nanoparticles and methods of treating tissue Injury.

IPC Classes  ?

• C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin (CIG)
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 38/00 - Medicinal preparations containing peptides
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof

Abstract

Herein is disclosed amphiphilic small molecules with different hydrophobic and hydrophilic fragments that show high binding affinity to both Aβ plaques and oligomers, and selectively binding Aβ oligomers. These amphiphilic compounds can also label the Aβ species in the brain sections of transgenic AD mice, as shown by immunostaining with an Aβ antibody. Certain amphiphilic compounds were found to alleviate the Cu2+-Aβ induced toxicity in cell viability assays. Additionally, two compounds, ZY-15-MT and ZY-15-OMe, were found to disrupt the interactions between Aβ oligomers and human neuroblastoma SH-SY5Y cell membranes. These studies show compounds with amphiphilic properties that target Aβ oligomers and modulate the Aβ oligomer-cell membrane interactions can be effective as small molecule AD therapeutics. Also, the disclosed amphiphilic dicyanomethylene compounds that can emit in the near-infrared region and chelate copper can be used as early diagnostic agents for AD.

IPC Classes  ?

• C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
• A61K 49/00 - Preparations for testing in vivo
• A61K 51/04 - Organic compounds
• C07D 403/10 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing aromatic rings
• C07D 409/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

An isolated nucleic acid that includes an open reading frame encoding a lanthipeptide protease polypeptide for scarless tag removal from a polypeptide is presented. Reagents, expression constructs and methods are also provided for preparing a scarless tag polypeptide product from a tagged polypeptide precursor containing a lanthipeptide protease cleavage site. The reagents are directed to novel lanthipeptide proteases and expression constructs and polypeptide precursors that include highly specific lanthipeptide protease substrate recognition sequence. Methods are provided that enable scarless tag removal from a cognate lanthipeptide, a non-cognate lanthipeptide or a heterologous polypeptide that includes extraneous amino acid sequences, such as leader peptides and tags.

IPC Classes  ?

• C12N 9/52 - Proteinases derived from bacteria
• C07K 14/195 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
• C07K 14/315 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
• C07K 14/32 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
• C12P 21/06 - Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
• C12P 21/02 - Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
• C07K 14/31 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
• C12N 15/62 - DNA sequences coding for fusion proteins

Abstract

The disclosure provides an example charging nest for wireless power transfer to drones is disclosed. The charging nest includes (a) a housing having an opening at a first end, (b) a plurality of antennas arranged around a periphery of the housing with each antenna aperture arranged facing a center of the housing, where each of the plurality of antennas has a director, an exciter, and a plurality of reflectors, and (c) a plurality of transmitters or transceivers each electrically coupled to a corresponding exciter of the plurality of antennas.

IPC Classes  ?

• B60L 53/30 - Constructional details of charging stations
• B60L 53/12 - Inductive energy transfer
• H02J 50/20 - Circuit arrangements or systems for wireless supply or distribution of electric power using microwaves or radio frequency waves
• H02J 50/40 - Circuit arrangements or systems for wireless supply or distribution of electric power using two or more transmitting or receiving devices
• B64C 39/02 - Aircraft not otherwise provided for characterised by special use

Abstract

The present disclosure provides assay containers, sets of containers, portable diagnostic devices, methods of detecting target nucleic acid molecules in a sample, and methods of diagnosing infections, such as COVID-19 infections, in a subject.

IPC Classes  ?

• C12Q 1/6844 - Nucleic acid amplification reactions
• C07K 14/195 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

Abstract

Provided herein are compositions and methods for the fermentative production of 2,3-butanediol (2,3-BDO), compositions and methods for making methyl ethyl ketone (MEK), and methods of inducing drought tolerance in plants.

IPC Classes  ?

• C12P 7/04 - Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
• C12N 9/04 - Oxidoreductases (1.), e.g. luciferase acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• C12N 9/16 - Hydrolases (3.) acting on ester bonds (3.1)
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C12N 9/88 - Lyases (4.)
• A01N 63/32 - Yeast
• A01P 21/00 - Plant growth regulators

Abstract

Disclosed are polypeptides and methods of glycosylating the C19 hydroxyl group of AmdeB (i.e., amphotericin B lacking the sugar moiety) comprising contacting AmdeB with a saccharide in the presence of one of the polypeptides. The methods access compounds that are analogues of amphotericin B with a modified sugar moiety that have an improved therapeutic index, such as C2'epiAmB. Also disclosed are pharmaceutical compositions comprising the compounds and a pharmaceutically acceptable carrier.

IPC Classes  ?

• C07H 17/08 - Hetero rings containing eight or more ring members, e.g. erythromycins
• C12P 19/62 - Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin

Abstract

A generator-rectifier system and grid interface includes an active rectifier configured to accept an input from one of a plurality of ac ports of a multi-port permanent magnet synchronous generator. Passive rectifiers are connected to the others of the plurality of ac ports. Connections provide outputs of the active rectifier and the passive rectifiers. A first converter is controlled at a fixed duty ratio driven by the outputs to interface with a dc grid or at a low grid frequency switching waveform to create a grid frequency ac output to interface with an ac grid. A second converter is connected the output of the active rectifier, the second converter being controlled at a variable duty ratio to interface with the dc grid or an above grid frequency switching waveform to create an above grid frequency ac waveform to interface with an ac grid. Connections provide a serial stack of outputs of the first and second converters.

IPC Classes  ?

• H02J 3/38 - Arrangements for parallelly feeding a single network by two or more generators, converters or transformers
• H02M 7/219 - Conversion of ac power input into dc power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only in a bridge configuration
• H02M 3/335 - Conversion of dc power input into dc power output with intermediate conversion into ac by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate ac using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only
• H02M 1/00 - APPARATUS FOR CONVERSION BETWEEN AC AND AC, BETWEEN AC AND DC, OR BETWEEN DC AND DC, AND FOR USE WITH MAINS OR SIMILAR POWER SUPPLY SYSTEMS; CONVERSION OF DC OR AC INPUT POWER INTO SURGE OUTPUT POWER; CONTROL OR REGULATION THEREOF - Details of apparatus for conversion

Abstract

An energetic composition and a method of unzipping polymer binders are disclosed, which includes localizing a heat feedback just near the reaction front by unzipping polymer binders employed to a nanothermite. The energetic composition includes an unzipping polymer binder employed to high load fuel and oxidizer particles.

IPC Classes  ?

• C06B 33/02 - Compositions containing particulate metal, alloy, boron, silicon, selenium or tellurium with at least one oxygen supplying material which is either a metal oxide or a salt, organic or inorganic, capable of yielding a metal oxide with an organic non-explosive or an organic non-thermic component
• C06B 47/02 - Compositions in which the components are separately stored until the moment of burning or explosion, e.g. "Sprengel"-type explosives; Suspensions of solid component in a normally non-explosive liquid phase, including a thickened aqueous phase the components comprising a binary propellant
• C06B 23/00 - Compositions characterised by non-explosive or non-thermic constituents

Abstract

Miscanthus x giganteus is a widely recognized bioenergy crop that finds potential applications in a biorefinery for the production of a wide range of biofuels and biochemicals. This disclosure focuses upon the quantification of the total anthocyanin concentration in miscanthus. Hydrothermal pretreatment was studied for recovering anthocyanins in the pretreatment liquor. The optimized pretreatment conditions (170° C., 10 min) led to a recovery of 94.3±1.5% w/w of the total anthocyanin concentration and also improved the enzymatic digestibility of the biomass, allowing recovery of 70.6±0.5% w/w of glucose at the end of 72 h of enzymatic saccharification. The sugar monomers obtained after the enzymatic hydrolysis of the pretreated biomass could be used for the production of biofuels or biochemicals in an integrated biorefinery.

IPC Classes  ?

• B01D 11/02 - Solvent extraction of solids
• C13K 1/02 - Glucose; Glucose-containing syrups obtained by saccharification of cellulosic materials
• C12N 9/42 - Hydrolases (3.) acting on glycosyl compounds (3.2) acting on beta-1, 4-glucosidic bonds, e.g. cellulase

Abstract

P. aeruginosa E. coliP. aeruginosa E. coliP. aeruginosaP. aeruginosaP. aeruginosaP. aeruginosa P. aeruginosa including dozens of clinical isolates.

IPC Classes  ?

• A61K 31/56 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
• A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
• C07J 41/00 - Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring

Abstract

The present disclosure relates generally to data storage using DNA sequences comprising synthetic nucleotides. In particular, the disclosure provides for a DNA data storage system comprising a covalently linked sequence of nucleotides, wherein the sequence of nucleotides comprises a modification region, wherein the nucleotides comprise synthetic nucleotides.

IPC Classes  ?

• G11C 13/02 - Digital stores characterised by the use of storage elements not covered by groups , , or using elements whose operation depends upon chemical change
• G16B 50/30 - Data warehousing; Computing architectures
• G16B 40/00 - ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
• G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids
• C12Q 1/6869 - Methods for sequencing

Abstract

A robotic surgical station is disclosed having a wheeled base, a partial-ring shaped structure slidably coupled to the based to be rotatable relative to the base about a horizontal roll axis passing through a center of the ring shape, a patient's bed restrained to a first arcuate segment of the partial-ring shaped structure at a first mount, a plurality of robotic arms restrained to a second arcuate segment of the partial-ring shaped structure at a second mount, and a remote control unit to command one or more of the plurality of robotic arms. The second arcuate segment is rotatable sideways with respect to the first arcuate segment to allow full access to the patient's bed by a surgeon.

IPC Classes  ?

• A61B 34/37 - Master-slave robots
• A61B 90/50 - Supports for surgical instruments, e.g. articulated arms
• B25J 9/16 - Programme controls

Abstract

A non-contact clinical Raman spectroscopy guided probe includes at least one first fiber operably coupled with a first light source and having a working end for delivering excitation light emitted from the first light source to the target site; at least one second fiber operably coupled with a detector and having a working end for collecting Raman scattering light scattered from the target site in response to excitation by the excitation light to the detector; and a lens positioned between the working ends of the at least one first fiber and the at least one second fiber and the target site for focusing the excitation light onto the target site and retrieving collection efficiency of the Raman scattering light. The probe is also guided during device positioning to provide the user with feedback on orientation in the lateral and axial directions to repeatably measure specific locations on the target site.

IPC Classes  ?

• G01N 21/65 - Raman scattering
• G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers
• G01J 3/44 - Raman spectrometry; Scattering spectrometry
• G01J 3/02 - Spectrometry; Spectrophotometry; Monochromators; Measuring colours - Details

Abstract

The present disclosure relates to polynucleotide nanostructures and techniques that use polynucleotide nanostructures as biomolecular recognition entities for detecting viral infections, e.g. Covid-19, and other disease. For example, an artificial biopolymer complex can include a network of polynucleotides including structural units connected to one another via a series of arms and junctions, e.g. in the form of a DNA Star. Intersections of three or more arms form the junctions at a predetermined distance from one another. The artificial biopolymer complex further includes binders, e.g. aptamers, attached to the network of polynucleotides that can bind to antigens of a target analyte. The binders are attached at loci on one or more of the arms forming the junctions. The loci are separated by predetermined inter¬binder distances such that the binders are positioned on the network of polynucleotides in a predetermined two-dimensional or three-dimensional spatial pattern that matches a two-dimensional or three-dimensional spatial pattern of the antigens on the target analyte. The nucleic acid oligonucleotides, e.g. the aptamers, from which the nanostructure is formed may be labelled with fluorophores and/or quenchers to detect the binding to a target.

IPC Classes  ?

• G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
• G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

Disclosed are compositions comprising a lipid polymer excipient and AmB or an AmB derivative. The lipid polymer excipient can form micelles when formulated with AmB or the AmB derivative and can solubilize and stabilize the drug. Also disclosed are methods of treating a fungal infection comprising administering to a subject in need thereof a therapeutically effective amount of a composition.

IPC Classes  ?

• A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• A61K 47/10 - Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
• C07H 17/08 - Hetero rings containing eight or more ring members, e.g. erythromycins
• A61P 31/10 - Antimycotics

Abstract

Plasma-Activated liquids and methods of using the same are described. In one aspect, a method of manufacturing an integrated circuit includes activating a photolithography liquid with a plasma; and treating a device component with the activated photolithography liquid. In one example, the photolithography liquid is a photoresist. Activating the photoresist liquid may impart reactive species to the photoresist.

IPC Classes  ?

• G03F 7/42 - Stripping or agents therefor
• G03F 7/32 - Liquid compositions therefor, e.g. developers
• H01L 21/027 - Making masks on semiconductor bodies for further photolithographic processing, not provided for in group or
• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
• H01L 21/311 - Etching the insulating layers

Abstract

This disclosure relates to processes for converting saturated polyethylene to at least an alkene product. The processes comprise contacting the saturated polyethylene with three or more catalyst components in a reactor, the reactor comprising an alkene reactant. The three or more catalyst components comprise a metathesis catalyst component, an isomerization catalyst component, and a dehydrogenation catalyst component. Contacting causes at least a portion of the saturated polyethylene to undergo dehydrogenation reactions to form unsaturated polyethylene and at least a portion of the unsaturated polyethylene, or products derived therefrom, to undergo metathesis reactions and isomerization reactions to produce an effluent comprising at least the alkene product.

IPC Classes  ?

• C07C 6/04 - Metathesis reactions at an unsaturated carbon-to-carbon bond at a carbon-to-carbon double bond
• C07C 11/06 - Propene
• C07C 11/04 - Ethene
• C07C 11/02 - Alkenes
• C07C 4/08 - Preparation of hydrocarbons from hydrocarbons containing a larger number of carbon atoms by splitting-off an aliphatic or cycloaliphatic part from the molecule
• C07C 5/373 - Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms by dehydrogenation with formation of free hydrogen with simultaneous isomerisation
• B01J 21/12 - Silica and alumina
• C07C 6/00 - Preparation of hydrocarbons from hydrocarbons containing a different number of carbon atoms by redistribution reactions

Abstract

This disclosure relates to processes for converting unsaturated polyethylene to at least an alkene product. The processes comprise contacting the unsaturated polyethylene with two or more catalyst components in a reactor comprising an alkene reactant. The two or more catalyst components comprise a metathesis catalyst component and an isomerization catalyst component. Contacting causes at least a portion of the unsaturated polyethylene, or products derived therefrom, to undergo metathesis reactions and isomerization reactions to produce an effluent comprising at least the alkene product.

IPC Classes  ?

• C07C 6/04 - Metathesis reactions at an unsaturated carbon-to-carbon bond at a carbon-to-carbon double bond
• C07C 11/06 - Propene
• C07C 11/04 - Ethene
• C07C 11/02 - Alkenes
• C07C 4/08 - Preparation of hydrocarbons from hydrocarbons containing a larger number of carbon atoms by splitting-off an aliphatic or cycloaliphatic part from the molecule
• B01J 32/00 - Catalyst carriers in general
• B01J 21/04 - Alumina
• B01J 27/10 - Chlorides
• B01J 31/12 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides

Abstract

Provided herein are compositions and methods for producing pyridine-based macrocyclic peptides.

IPC Classes  ?

• C07K 1/107 - General processes for the preparation of peptides by chemical modification of precursor peptides
• C07K 14/00 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
• C12N 9/50 - Proteinases
• C12N 9/88 - Lyases (4.)
• C12P 21/04 - Cyclic or bridged peptides or polypeptides, e.g. bacitracin
• C12P 21/02 - Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Abstract

The disclosure provides an example electrosurgical system and methods for use thereof. The electrosurgical system includes a high-frequency inverter (“HFI”) having a full bridge and a control system electrically coupled to the HFI. The control system controls output parameters including one or more of an output power Pout(t) and an output voltage or current by varying power reference Pref(t) or switch states of the HFI. The control system causes a power adaptation ΔP(t) to a preset power set Pset based on receiving at least one of impedance feedback and thermal feedback according to the following relationship: Pref(t)=Pset+ΔP(t).

IPC Classes  ?

• A61B 18/12 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
• A61B 18/14 - Probes or electrodes therefor
• A61B 18/16 - Indifferent or passive electrodes for grounding

Abstract

A hydrophobic, self-healing coating includes a vitrimer film having a silicone polymer network crosslinked with dynamic covalent bonds including a boronic ester, where the vitrimer film has a thickness of less than 1000 nm, and where the dynamic covalent bonds provide a mechanism for self-healing of the vitrimer film.

IPC Classes  ?

• C09D 183/04 - Polysiloxanes
• C09D 5/16 - Anti-fouling paints; Underwater paints
• C09D 7/20 - Diluents or solvents
• C09D 7/61 - Additives non-macromolecular inorganic
• C08G 77/398 - Polysiloxanes modified by chemical after-treatment containing atoms other than carbon, hydrogen, oxygen or silicon containing boron or metal atoms

Abstract

The present disclosure describes compositions of matter comprising a ribonucleoprotein complex comprising a nucleic acid-guided nuclease and a guide RNA, and further comprising and a blocking nucleic acid molecule represented by Formula III in the 5′-to-3′ direction comprises: T-D-M-A-(B-L)J-C; wherein T is 17-135 nucleotides in length; D is 0-10 nucleotides in length; M is 1-25 nucleotides in length or is absent, wherein if M is absent then T-D and A-(B-L)J-C are separate nucleic acid strands; A is 0-15 nucleotides in length and comprises at least 50% sequence complementarity to D; B is 4-12 nucleotides in length and comprises at least 50% sequence complementarity to T; L is 3-25 nucleotides in length; J is an integer between 1 and 10; C is 4-15 nucleotides in length; and wherein the blocking nucleic acid molecule comprises a sequence complementary to a gRNA.

IPC Classes  ?

• C12Q 1/6823 - Release of bound markers
• C12Q 1/682 - Signal amplification
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof
• C12N 9/22 - Ribonucleases
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

Abstract

A system for selective electrodeposition for metal recycling includes an electrochemical cell comprising: a fluid including first and second transition metals and a salt at a molar concentration of greater than 1 M; a working electrode in contact with the fluid, where the working electrode has a surface coated with a positively charged polyelectrolyte; and a counter electrode in contact with the fluid and spaced apart from the working electrode. The system also includes a power supply electrically connected to the working and counter electrodes.

IPC Classes  ?

• C25B 15/08 - Supplying or removing reactants or electrolytes; Regeneration of electrolytes
• C22B 3/04 - Extraction of metal compounds from ores or concentrates by wet processes by leaching
• C22B 7/006 -
• C25B 9/65 - Means for supplying current; Electrode connections; Electric inter-cell connections
• C25C 1/08 - Electrolytic production, recovery or refining of metals by electrolysis of solutions of iron group metals, refractory metals or manganese of nickel or cobalt
• C25C 7/02 - Electrodes; Connections thereof
• C25D 17/10 - Electrodes
• C22B 3/10 - Hydrochloric acid
• H01M 10/052 - Li-accumulators
• H01M 10/54 - Reclaiming serviceable parts of waste accumulators
• H01M 4/52 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of nickel, cobalt or iron

Abstract

The disclosure provides for methods of detecting target polynucleotides in a biological sample from a subject including the steps of extracting the target polynucleotides from the biological sample and subjecting the biological sample to conditions that amplify the target polynucleotides in the biological sample using a polymerase chain reaction (PCR) and detecting the target polynucleotides in biological sample. The methods may be used to detect Human Papilloma Virus (HPV) mediated squamous cell carcinoma or non-HPV mediated squamous cell carcinoma.

IPC Classes  ?

• C12Q 1/6851 - Quantitative amplification
• C12Q 1/6809 - Methods for determination or identification of nucleic acids involving differential detection
• C12Q 1/686 - Polymerase chain reaction [PCR]
• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• G01N 33/574 - Immunoassay; Biospecific binding assay; Materials therefor for cancer

Abstract

Small molecule ERα biomodulators that kill therapy-resistant ERa positive breast, ovarian, and endometrial cancer cells are disclosed. In one embodiment, the small molecule biomodulator has increased therapeutic utility because of an increased ability to kill therapy-resistant cancer cells compared to BHPI and other conventional therapies (endocrine therapies, tamoxifen, and fulvestrant/ICI). The small molecule biomodulators not only inhibit proliferation of the cancer cells but kills them, which prevents reactivation of tumors years later. Compounds of the invention, such as ErSO-DFP, are effective for treating ERa positive cancers such as breast cancer, ovarian cancer, uterine cancer, cervical carcinoma, endometrial cancer, and the like.

IPC Classes  ?

• C07D 209/34 - Oxygen atoms in position 2
• C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
• A61P 35/00 - Antineoplastic agents

Abstract

Provided are fluorescent nanoparticle and related methods of using the fluorescent nanoparticles for imaging tumors. The fluorescent nanoparticle comprises a gelatin matrix; and a fluorophore encapsulated within the gelatin matrix and ionically-bound to the gelatin matrix. The encapsulated fluorophore has an encapsulation concentration selected to provide: quenching of fluorophore encapsulated within the gelatin matrix and a substantial fluorescence for the fluorophore released from the gelatin matrix.

IPC Classes  ?

• A61K 9/50 - Microcapsules
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61L 27/48 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
• G01N 21/64 - Fluorescence; Phosphorescence

Abstract

Thermoset resin compositions including a compound of formula (I) having a working life and/or a pot life of at least 1 hour are provided. Copolymers prepared from the thermoset resin compositions are further provided. Methods of preparing and polymerizing the thermoset resin compositions are further provided. Delivery devices for preparing thermoset resin compositions are further provided.

IPC Classes  ?

• C08G 61/08 - Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes only aliphatic carbon atoms prepared by ring-opening of carbocyclic compounds of carbocyclic compounds containing one or more carbon-to-carbon double bonds in the ring
• C08L 65/00 - Compositions of macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain; Compositions of derivatives of such polymers

Abstract

Thermoset resin compositions including a compound of formula (I) having a working life and/or a pot life of at least 1 hour are provided. Copolymers prepared from the thermoset resin compositions are further provided. Methods of preparing and polymerizing the thermoset resin compositions are further provided. Delivery devices for preparing thermoset resin compositions are further provided.

IPC Classes  ?

• C08F 234/02 - Copolymers of cyclic compounds having no unsaturated aliphatic radicals in a side chain and having one or more carbon-to-carbon double bonds in a heterocyclic ring in a ring containing oxygen
• C08F 4/80 - Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors selected from metals not provided for in group selected from iron group metals or platinum group metals
• C08K 3/36 - Silica
• C08F 2/44 - Polymerisation in the presence of compounding ingredients, e.g. plasticisers, dyestuffs, fillers
• C08L 45/00 - Compositions of homopolymers or copolymers of compounds having no unsaturated aliphatic radicals in a side chain, and having one or more carbon-to-carbon double bonds in a carbocyclic or in a heterocyclic ring system; Compositions of derivatives of such polymers

Abstract

In one aspect, the disclosure relates to relates to substituted benzothiophene analogs which are useful as selective degraders of estrogen receptor, methods of making same, pharmaceutical compositions comprising same, and methods of treating one or more clinical conditions associated with estrogen receptor, such as a cancer, including breast cancer, or osteoporosis. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

IPC Classes  ?

• A61K 31/397 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
• A61K 31/138 - Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
• A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• A61K 31/277 - Nitriles; Isonitriles having a ring, e.g. verapamil
• A61K 31/4025 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
• A61K 31/4196 - 1,2,4-Triazoles
• A61K 31/4535 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
• A61K 31/565 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol
• A61K 31/566 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol having an oxo group in position 17, e.g. oestrone
• A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
• A61K 38/09 - Luteinising hormone-releasing hormone [LHRH]; Related peptides
• A61K 39/395 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• C07D 409/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, the disclosure, in one aspect, relates to compounds (I) that are inhibitors for spleen tyrosine kinase (Syk), which is a key signaling protein in hematologic cells and implicated in multiple hematopoietic malignancies, cancer (e.g., chronic lymphoid leukemia (CLL) or acute myeloid leukemia (AML) ), diabetes, and immune disorders. In one aspect, the compounds described herein drug resistance, which renders current ATP- competitive Syk inhibitors ineffective.

IPC Classes  ?

• C07D 213/74 - Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
• C07D 239/42 - One nitrogen atom
• C07D 403/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 409/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
• A61P 35/02 - Antineoplastic agents specific for leukemia
• A61K 31/497 - Non-condensed pyrazines containing further heterocyclic rings
• A61K 31/506 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings

Abstract

The present invention provides use of amphiphilic amine-terminated poly(amidoamine) (PAMAM) dendrimers and bola-amphiphilic amine-terminated PAMAM dendrimer and particles formed by said dendrimers as antipathogenic agents. Specifically, antibacterial use of compositions comprising these dendrimers is presented. Provided also particles formed by said dendrimers encapsulating antibacterial agents and use of such loaded particles for treatments of pathogenic infections such as bacterial infections.

IPC Classes  ?

• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
• A61P 31/04 - Antibacterial agents
• A61K 31/546 - Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula , e.g. cephalosporins, cefaclor, cephalexine containing further heterocyclic rings, e.g. cephalothin
• A61K 31/65 - Tetracyclines
• A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
• A61K 31/7052 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 31/711 - Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
• A61K 38/14 - Peptides containing saccharide radicals; Derivatives thereof
• A61K 9/51 - Nanocapsules
• A61K 47/30 - Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
• C08G 73/02 - Polyamines
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 31/00 - Medicinal preparations containing organic active ingredients
• A61K 31/785 - Polymers containing nitrogen
• A61K 31/787 - Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
• A61K 9/00 - Medicinal preparations characterised by special physical form

Abstract

Herein is described an oxygen nanobubbles-embedded hydrogel (ONB-G) with carbopol for oxygenation of wounds to accelerate the wound healing process. We integrate carbopol hydrogel and dextran-based ONBs, to prepare ONB-G that can hold oxygen and release it to accelerate wound healing. Oxygen release tests showed that the proposed ONB-G could maintain oxygen in the hydrogels for up to 34 days. Also, fluorescence studies indicated that the ONB-G could maintain the high oxygen levels for up to 8 weeks. Histological evaluation of tissues with a pig model with incision and punch wounds showed that treatment with ONB-G exhibited improved healing compared with hydrogel without ONBs or treated without gel. Our studies show that dextran-shell ONBs embedded in a gel (ONB-G) has the potential to accelerate wound healing given its oxygen holding capacity and release properties.

IPC Classes  ?

• A61L 26/00 - Chemical aspects of, or use of materials for, liquid bandages

Abstract

Aspects of the subject disclosure may include, for example, performing, by a processing system, image fusion using two or more groups of images to generate predicted images, wherein each group of the two or more groups has one of a different resolution, a different frequency temporal pattern or a combination thereof than another of the two or more groups. Gap filling can be performed by the processing system to correct images of the two or more groups. Additional embodiments are disclosed.

IPC Classes  ?

• G06T 5/00 - Image enhancement or restoration
• G06V 10/26 - Segmentation of patterns in the image field; Cutting or merging of image elements to establish the pattern region, e.g. clustering-based techniques; Detection of occlusion
• G06V 20/13 - Satellite images
• G06V 10/80 - Fusion, i.e. combining data from various sources at the sensor level, preprocessing level, feature extraction level or classification level
• G06T 7/10 - Segmentation; Edge detection
• G06T 5/50 - Image enhancement or restoration by the use of more than one image, e.g. averaging, subtraction

Abstract

In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, the disclosure, in one aspect, relates to compounds that increase the amount of nicotinamide adenine dinucleotide (NAD+) in a subject. By raising the amount of nicotinamide adenine dinucleotide in a subject, diseases associated with reduced levels of nicotinamide adenine dinucleotide can be treated or prevented. In one aspect, raising the amount of NAD+ in a subject can reduce or ameliorate one or more symptoms of Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, multiple sclerosis, amylotrophic lateral sclerosis, AIDS-induced dementia, or epilepsy.

IPC Classes  ?

• C07D 309/06 - Radicals substituted by oxygen atoms
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• C07D 407/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
• C07D 413/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 409/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Provided herein are genetically modified Issatchenkia yeast and fermentation methods for producing succinic acid.

IPC Classes  ?

• C12P 7/46 - Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
• C12N 15/81 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
• C12N 15/52 - Genes encoding for enzymes or proenzymes
• C12N 9/04 - Oxidoreductases (1.), e.g. luciferase acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C12N 9/26 - Hydrolases (3.) acting on glycosyl compounds (3.2) acting on alpha-1, 4-glucosidic bonds, e.g. hyaluronidase, invertase, amylase
• C12N 9/88 - Lyases (4.)
• C12N 9/00 - Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes

Abstract

Methods of preparing oligomers including heating a mixture of an amount of a functionalized cycloalkene, an amount of a chain transfer agent, a phosphite ester, and a catalyst, a degree of polymerization of the oligomers controllable by a molar ratio of the amount of the functionalized cycloalkene to the amount of the chain transfer agent, are provided herein. Methods of preparing polymers including heating the oligomers and a second amount of the functionalized cycloalkene, a phosphite ester, and a catalyst are further provided. Compositions of oligomers and functionalized cycloalkenes are further provided.

IPC Classes  ?

• C08G 61/08 - Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes only aliphatic carbon atoms prepared by ring-opening of carbocyclic compounds of carbocyclic compounds containing one or more carbon-to-carbon double bonds in the ring
• C07C 2/04 - Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms by addition between unsaturated hydrocarbons by oligomerisation of well-defined unsaturated hydrocarbons without ring formation
• C07C 29/44 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by addition reactions, i.e. reactions involving at least one carbon-to-carbon double or triple bond
• C07C 67/08 - Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds

Abstract

Staphylococcus nepalensis releases corisin, a peptide conserved in diverse Staphylococci, that induces apoptosis of lung epithelial cells. Therefore, methods and apparatus for detecting the presence of corisin in a biological sample of a patient are disclosed, as well as pharmaceutical compositions, such as antibodies, and methods for treating patents having or suspected of having fibrosis.

IPC Classes  ?

• C07K 16/12 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from bacteria
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
• A61P 11/00 - Drugs for disorders of the respiratory system

Abstract

Disclosed are C16 amide derivatives of C2′-epi-amphotericin B (C2′epiAmB) and salts thereof, characterized by improved clinical efficacy with reduced toxicity compared to AmB. Also disclosed are pharmaceutical compositions, comprising any of the disclosed compounds or salts thereof, as well as methods of treatment and therapeutic uses of the same.

IPC Classes  ?

• C07H 17/08 - Hetero rings containing eight or more ring members, e.g. erythromycins
• A61P 31/10 - Antimycotics

Abstract

Here we show that P. ananatis produces at least three phosphonates, two of which were purified and structurally characterized. The first, designated pantaphos, was shown to be 2-(hydroxy(phosphono)methyl)maleate; the second, a probable biosynthetic precursor, was shown to be 2-(phosphonomethyl)maleate. Purified pantaphos is both necessary and sufficient for the hallmark lesions of onion center rot. Moreover, when tested against mustard seedlings, the phytotoxic activity of pantaphos was comparable to the widely used herbicides glyphosate and phosphinothricin. Pantaphos was also active against a variety of human cell lines.

IPC Classes  ?

• C07F 9/38 - Phosphonic acids (R—P(:O)(OH)2); Thiophosphonic acids
• A01N 57/20 - Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-carbon bonds containing acyclic or cycloaliphatic radicals

Abstract

4-Hydroxyphenyl-2H-indazol-5-ol compounds are estrogen receptor beta ligands that have immunomodulatory properties and increase oligodendrocyte survival, differentiation, and remyelination. The compounds, compositions, and kits are useful in the treatment of multiple sclerosis and endometriosis.

IPC Classes  ?

• C07D 231/56 - Benzopyrazoles; Hydrogenated benzopyrazoles
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• C07D 409/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 409/10 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Abstract

Compounds of formula (I) are provided. Polymers including monomers of formula (II) are further provided. Methods of releasing controlled amounts of a small molecule from the polymers are further provided. Devices for releasing controlled amounts of a small molecule are further provided. Compounds of formula (I) are provided. Polymers including monomers of formula (II) are further provided. Methods of releasing controlled amounts of a small molecule from the polymers are further provided. Devices for releasing controlled amounts of a small molecule are further provided.

IPC Classes  ?

• C08F 24/00 - Homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a heterocyclic ring containing oxygen
• A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests

Abstract

Methods of preparing oligomers including heating a mixture of an amount of a functionalized cycloalkene, an amount of a chain transfer agent, a phosphite ester, and a catalyst, a degree of polymerization of the oligomers controllable by a molar ratio of the amount of the functionalized cycloalkene to the amount of the chain transfer agent, are provided herein. Methods of preparing polymers including heating the oligomers and a second amount of the functionalized cycloalkene, a phosphite ester, and a catalyst are further provided. Compositions of oligomers and functionalized cycloalkenes are further provided.

IPC Classes  ?

• C08G 61/08 - Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes only aliphatic carbon atoms prepared by ring-opening of carbocyclic compounds of carbocyclic compounds containing one or more carbon-to-carbon double bonds in the ring
• C08L 65/00 - Compositions of macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain; Compositions of derivatives of such polymers
• C09D 165/00 - Coating compositions based on macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain; Coating compositions based on derivatives of such polymers

Abstract

Methods for recycling oligomeric units derived from a first polymer into a second polymer are provided herein. Methods of preparing oligomeric macromonomers from oligomeric units are further provided. Methods of polymerizing oligomeric macromonomers are further provided.

IPC Classes  ?

• C08J 11/10 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation
• C08G 61/00 - Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule

Abstract

A microscope mounting system includes a sample holder shaped and configured to fit a particular horizontal microscope stage and fix one end of a soft material sample. A blade holder configured to position a cutting blade and connect directly or eventually to the particular microscope or a frame of the particular microscope. A load measurement device is configured to determine a load applied to the cutting blade. A precision adjustment assembly sets positioning of the cutting blade in the horizontal x-y plane and the z vertical plane such that a cutting edge of the cutting blade can be positioned at a focal point of the particular microscope. At least two grips are configured to grip a second end of the soft material sample at at least two discrete locations on opposite sides of the cutting blade when the blade contacts the soft material sample at the focal point. A tension mechanism can apply tension in the x-y plane to each of the at least two grips.

IPC Classes  ?

• G01N 1/28 - Preparing specimens for investigation
• G01N 3/58 - Investigating machinability by cutting tools; Investigating the cutting ability of tools
• G01N 1/36 - Embedding or analogous mounting of samples

Abstract

A catalyst for hydrosilylation is disclosed. The catalyst comprises a complex having a certain formula. A redox-switchable catalyst system for preparing the catalyst is also disclosed. The redox-switchable catalyst system comprises a redox-switchable catalyst and a reducing compound. The reducing compound reduces a formal oxidation state of the redox-switchable catalyst to give the catalyst, where the former is generally inactive in catalyzing hydrosilylation and the latter is catalytically active. A composition comprising the catalyst and/or the redox-switchable catalyst system, and a hydrosilylation reaction product, are also disclosed.

IPC Classes  ?

• B01J 31/24 - Phosphines

Abstract

Methods for recycling oligomeric units derived from a first polymer into a second polymer are provided herein. Methods of preparing oligomeric macromonomers from oligomeric units are further provided. Methods of polymerizing oligomeric macromonomers are further provided.

IPC Classes  ?

• C08J 11/20 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation by treatment with organic material by treatment with hydrocarbons or halogenated hydrocarbons

Abstract

The present disclosure provides an example method for using an MRI system electrically coupled to a computing device. The method includes generating, via the MRI system, an echo-shifted echo- planar imaging with blip up/down acquisition ("esEPI-BUDA") pulse sequence including a first radiofrequency ("RF") pulse and a second RF pulse, the first RF pulse followed by a first echo- train that is interleaved with the first and the second RF pulses, and the second RF pulse followed by a second echo-train such that the first and the second echo-trains have opposite phase-encoding blip gradient polarities to traverse echo planar imaging ("EPI") k-space in a reversed order. In response to the pulse sequence being generated, the MRI system acquires two k-space datasets within a single shot and corrects image distortion, via the MRI system, based on the two acquired k-space datasets.

IPC Classes  ?

• G01R 33/565 - Correction of image distortions, e.g. due to magnetic field inhomogeneities
• G01R 33/48 - NMR imaging systems
• G01R 33/561 - Image enhancement or correction, e.g. subtraction or averaging techniques by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences
• G01R 33/24 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance for measuring direction or magnitude of magnetic fields or magnetic flux

Abstract

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IPC Classes  ?

• C25B 15/00 - Operating or servicing cells
• C25B 11/047 - Ceramics
• C25B 11/046 - Alloys
• C25B 11/03 - Electrodes; Manufacture thereof not otherwise provided for characterised by shape or form perforated or foraminous
• C25B 9/19 - Cells comprising dimensionally-stable non-movable electrodes; Assemblies of constructional parts thereof with diaphragms
• C25B 3/26 - Reduction of carbon dioxide
• C25B 3/07 - Oxygen containing compounds
• C25B 3/03 - Acyclic or carbocyclic hydrocarbons
• C25B 1/23 - Carbon monoxide or syngas
• B01D 53/86 - Catalytic processes
• B01D 53/78 - Liquid phase processes with gas-liquid contact
• B01D 53/73 - After-treatment of removed components
• B01D 53/32 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by electrical effects other than those provided for in group
• B01D 53/24 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by centrifugal force
• B01D 53/62 - Carbon oxides