Abstract

The present invention relates to an implantable medical device comprising a layer consisting of or comprising zirconia, and to a method for the preparation thereof.

IPC Classes  ?

• A61C 8/00 - Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
• A61C 13/00 - Dental prostheses; Making same
• C04B 35/48 - Shaped ceramic products characterised by their composition; Ceramic compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on zirconium or hafnium oxides or zirconates or hafnates

Abstract

The present invention relates to a virus-derived particle comprising one or more Cas protein(s), as well as to kits and methods using the same for altering a target nucleic acid.

IPC Classes  ?

• C07K 14/005 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
• C12N 7/00 - Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
• C12N 9/22 - Ribonucleases
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

The present invention relates to the use of a sequence chosen among Seq ID No 3, Seq ID No 1, Seq ID No 2, Seq ID No 4, Seq ID No 5, Seq ID No 6, Seq ID No 7, Seq ID No 8, and functional variants thereof, as an odorant binding protein (OBP).

IPC Classes  ?

• C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals
• G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor

Abstract

The electronic circuit performs binary computation operations and comprises word, bit and source lines, and memory cells organized in rows and columns. The electronic circuit performs binary computation operations and comprises word, bit and source lines, and memory cells organized in rows and columns. Each cell includes one pair of memristors and one pair of switches, each memristor being connected to a switch and linked to the same source line during each computation operation, each pair of memristors storing a binary value; the switches being linked to a word line and to a pair of complementary bit lines. The electronic circuit performs binary computation operations and comprises word, bit and source lines, and memory cells organized in rows and columns. Each cell includes one pair of memristors and one pair of switches, each memristor being connected to a switch and linked to the same source line during each computation operation, each pair of memristors storing a binary value; the switches being linked to a word line and to a pair of complementary bit lines. The circuit comprises a reading module including: a logic unit for each column, each comprising an input terminal connected to a source line to receive a column value, the logic unit toggling between values, depending on a comparison of the column value with a toggle threshold value; a modification unit for modifying, for at least one logic unit and depending on the computation operation, a difference between the column and threshold values.

IPC Classes  ?

• G11C 13/00 - Digital stores characterised by the use of storage elements not covered by groups , , or
• G11C 11/54 - Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using elements simulating biological cells, e.g. neuron

Abstract

A pressure-measuring device including an optical fibre with a thinned portion, a laser, called the heating laser, arranged to emit an optical wave, called the heating wave, into the thinned portion, a measuring means including a sensor that is arranged to measure a backscattered optical wave that is generated by an optical wave, called the interrogation wave, and that originates in the thinned portion of the optical fibre, and a processing unit arranged and/or programmed to measure a pressure of a fluid, preferably a gas, encircling the thinned portion, on the basis of the measurement of the backscattered wave.

IPC Classes  ?

• G01L 11/02 - Measuring steady or quasi-steady pressure of a fluid or a fluent solid material by means not provided for in group or by optical means
• G01L 21/00 - Vacuum gauges

Abstract

Systems and methods for managing an execution of an action strategy by an autonomous system are disclosed. The action strategy comprises a series of actions to be performed by the autonomous system to accomplish a corresponding active objective. The method comprises identifying, by a processor of the autonomous system, an active objective to be accomplished by the autonomous system, the active objective describing a hierarchy of actions to be performed to accomplish the corresponding active objective. The method comprises generating, by the processor, an action strategy from the hierarchy of actions of the active objective, the actions of the action strategy corresponding to the actions of the hierarchy of actions of the active objective and executing the action strategy. Upon completion of an execution of an action, the processor provides data comprising information relating to a state of completion of the action strategy.

IPC Classes  ?

• G06F 9/48 - Program initiating; Program switching, e.g. by interrupt

Abstract

Methods of and systems for knowledge-based reasoning to establish a list of active objectives by an autonomous system. The method comprises accessing a list of active objectives; accessing a first database populated with static environment properties, the static environment properties defining properties of entities, the entities defining an environment in which the autonomous system is configured to operate; accessing a second database populated with dynamic environment properties comprising third computer-readable instructions generated by the autonomous system based on events having been observed by the autonomous system. Upon observing a new event, a new dynamic environment property is generated based on the new event and coherence checking is executed to assess whether the new dynamic environment property conflicts with at least one of the static environment properties, and, if so, the new dynamic environment property being identified as incoherent.

IPC Classes  ?

• G06N 5/025 - Extracting rules from data

Abstract

The invention relates to variants of a DNA polymerase of the polX family capable of synthesizing a nucleic acid molecule without a template strand, or of a functional fragment of such a polymerase, comprising at least one mutation of a residue in at least one specific position, and to uses of said variants, in particular for the synthesis of nucleic acid molecules comprising 3′-OH modified nucleotides.

IPC Classes  ?

• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• C12N 15/70 - Vectors or expression systems specially adapted for E. coli
• C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides

Abstract

The present invention relates to the field of oncology. laboratory tools and methods, and especially anti-tumor DNA crosslinking agents. Most patients with advanced solid tumors develop resistance to chemotherapy due to the ability of cancer cells to repair or tolerate sustained DNA damages. The inventors showed that the compounds according to the present invention allow the detection and visualization of alkylated DNA damages induced by PBDs without altering their DNA crosslinking ability. This enables the study of the effect and properties of PBDs. In particular, the present invention relates new derivates of PBD molecules and their synthesis. The present invention also relates to a method for visualizing DNA crosslinking: to a method for assessing the resistance of a tumor to a crosslinking agent and to a method for identifying a molecule or treatment for improving the efficiency of a crosslinking agent.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• C07C 205/59 - Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
• C07D 207/22 - Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
• C07D 487/04 - Ortho-condensed systems
• C12Q 1/6841 - In situ hybridisation

Abstract

The present invention relates to a process for preparing a zeolite ZSM-5 presenting a Si/Al molar ratio comprised between 2 and 8, preferably between 3 and 8, comprising the following steps: a) mixing at least one silicon source, at least one aluminum source, at least one organic template and at least one aqueous solvent, in order to obtain a synthesis mixture in solution or gel form; b) ageing the mixture obtained in step a) at a temperature of between 20° C. and 200° C. during at least 30 minutes; and d) crystallizing the resulting mixture during at least 24 hours, wherein a step c) of adding wood lignin or oxidized wood lignin to the mixture is performed after step a) or after step b). It also relates to a zeolite which is obtainable by such a process, and to its use.

IPC Classes  ?

• C01B 39/40 - Type ZSM-5 using at least one organic template directing agent
• B01J 29/40 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of the pentasil type, e.g. types ZSM-5, ZSM-8 or ZSM-11
• B01J 35/61 - Surface area
• B01J 35/63 - Pore volume
• B01J 37/00 - Processes, in general, for preparing catalysts; Processes, in general, for activation of catalysts
• B01J 37/03 - Precipitation; Co-precipitation
• C07C 1/24 - Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only oxygen atoms as hetero atoms by elimination of water
• C07C 4/06 - Catalytic processes

Abstract

A system and a method for generating a navigation path for an autonomous system. The method comprises receiving data comprising characteristics of entities, the entities defining an environment in which the autonomous system is configured to operate; receiving first instructions causing the autonomous system to identify a destination in the environment; generating a navigation path comprising waypoints to be followed by the autonomous system to reach the destination, the waypoints being generated based on the characteristics of the entities and defining segmental paths; executing second instructions causing the autonomous system to navigate along the navigation path; and upon navigating from a first waypoint to a second waypoint: accessing updates of the characteristics of the entities located in a vicinity of a corresponding segmental path; generating a sub-path between the first waypoint and the second waypoint based on second information; and navigating along the sub-path to reach the second waypoint.

IPC Classes  ?

• G05D 1/229 - Command input data, e.g. waypoints
• B60W 60/00 - Drive control systems specially adapted for autonomous road vehicles
• G05D 1/656 - Interaction with payloads or external entities

Abstract

A quasi-optical beamformer includes a plurality N> 1 of power feeds (PF), each of the i∈[1; N] power feeds (PF) being configured to emit a respective radio-frequency beam denoted Ri, a radio-frequency transmission line (LT) fed at a first end by the power feeds and comprising at a second end a plurality of network ports (PR) that are configured to collect radio-frequency radiation, the transmission line (LT) comprising a radio-frequency waveguide (GO) that comprises at least two metal plates (PM) that are stacked so as to guide the radio-frequency beams Ri, i∈[1; N] towards the network ports (PR), the transmission line (LT) extending along a central main axis denoted axis x, a first reflector (M1) having a first centre (C1) centred on the axis x and a first effective radius of curvature and being configured to reflect the guided radio-frequency beams Ri, i∈[1; N], a second reflector (M2) having a second effective radius of curvature and being configured to reflect the radio-frequency beams (RFi) reflected by the first reflector so as to direct them towards the network ports so as to form output radio-frequency beams (RSi), the first and second effective radii of curvature and an arrangement of the power feeds (PF) with respect to the first reflector being configured so that: each of the output radio-frequency beams (RSi) is a plane wave, and a transverse amplitude distribution Ai, on the network ports (PR), of each output radio-frequency beam (RSi), is substantially identical.

IPC Classes  ?

• H01Q 19/06 - Combinations of primary active antenna elements and units with secondary devices, e.g. with quasi-optical devices, for giving the antenna a desired directional characteristic using refracting or diffracting devices, e.g. lens
• H01Q 9/04 - Resonant antennas
• H01Q 23/00 - Antennas with active circuits or circuit elements integrated within them or attached to them
• H04B 7/06 - Diversity systems; Multi-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas at the transmitting station

Abstract

The present invention relates to antibodies having specificity for BTN2 and uses thereof, in particular for the treatment of cancer.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants

Abstract

The present invention relates to a compound of the following general formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, for use as drug for inhibiting ferroptosis. The present invention relates to a compound of the following general formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, for use as drug for inhibiting ferroptosis.

IPC Classes  ?

• C07D 471/04 - Ortho-condensed systems
• A61K 31/404 - Indoles, e.g. pindolol
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• A61K 31/444 - Non-condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
• A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61P 39/06 - Free radical scavengers or antioxidants
• C07D 209/12 - Radicals substituted by oxygen atoms

Abstract

Bile salts are steroid acids derived from cholesterol in the liver, are released into the gastrointestinal tract to aid in digestion and are thoroughly modified by the resident gut microbiota. Bile acids act as versatile signaling molecules with a variety In of endocrine functions and are linked to several diseases. In particular, serum and urinary bile salts represent biomarkers for early diagnostics of liver dysfunction, yet their current detection methods are impractical and hard to scale. Here the inventors engineered engineered synthetic bile salt receptors using VtrA as sensing domains connected to E. coli CadC system which activates transcription upon dimerization. The performance of the system was assayed for various selection of promoters and they can show that fine tunable response that may be reached by changing expression levels of the bile salt receptor. By performing multiple rounds of directed evolution of the VtrA sensor the inventors obtained a collection of variants with a lower limit of detection and a higher sensitivity. Finally, they show that their bactosensor can detect pathological bile-salt concentrations in samples from patients with liver dysfunction. The present invention thus relates to bile salts bactosensor and use thereof for diagnostic and therapeutic purposes.

IPC Classes  ?

• C07K 14/195 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
• C12N 15/70 - Vectors or expression systems specially adapted for E. coli
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Abstract

The present invention relates to new dendrimers with thiophosphoramidate units and derivatives, their preparation method and their use.

IPC Classes  ?

• C07F 9/6593 - 1,3,5-Triaza-2,4,6-triphosphorines
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

The present invention provides SOCE inhibitors that are useful as therapeutic agents in a variety of applications. The present invention also relates to pharmaceutical compositions, products and kits comprising such SOCE inhibitors, and methods of using the SOCE inhibitors in the treatment of a variety of diseases.

IPC Classes  ?

• C07D 235/04 - Benzimidazoles; Hydrogenated benzimidazoles
• A61P 35/00 - Antineoplastic agents

Abstract

A method for the servo control of an optical device includes a cavity exhibiting resonance around a center frequency ƒc, a laser and a phase modulator, the method being designed to servo-control the cavity to the laser or vice versa and to compensate for an amplitude modulation introduced by the phase modulator, the method comprising, inter alia, the following steps: A. varying a difference δν between the optical frequency of the laser radiation and the center frequency, such that the optical frequency scans the resonance, the difference being controlled by a parameter of an element of the device, and for each difference δνi i. modulating, at a modulation frequency ƒmod, a phase of the laser radiation, through a modulation phase ϕmod, with the phase modulator, ii. injecting the phase-modulated radiation into the cavity, iii. using a photodiode to detect radiation reflected or transmitted by the cavity and generating an electrical signal (St, Sr) representative of the intensity of the detected radiation, iv. demodulating the electrical signal at the modulation frequency ƒmod by synchronously generating a first demodulated signal and a second demodulated signal representative of the demodulated electrical signal, respectively at a first demodulation phase ϕdem,1 and at a second modulation phase ϕdem,2ϕdem,2≈ϕdem,1k, where k∈[0; 2π] is different from the first phase, and by filtering the first and the second signal so as to retain only a DC component of the first demodulated signal Vϵ1, called error signal 1, and of the second demodulated signal Vϵ2, called error signal 2.

IPC Classes  ?

• H01S 3/00 - Lasers, i.e. devices using stimulated emission of electromagnetic radiation in the infrared, visible or ultraviolet wave range
• H01S 3/137 - Stabilisation of laser output parameters, e.g. frequency or amplitude by controlling devices placed within the cavity for stabilising of frequency
• H01S 3/139 - Stabilisation of laser output parameters, e.g. frequency or amplitude by controlling the mutual position or the reflecting properties of the reflectors of the cavity

Abstract

A process for preparing a catalyst material, includes: (a) providing a support material having surface hydroxyl (OH) groups, the support material is ceria (CeO2), zirconia (ZrO2) or a combination, and the support material contains between 0.3 and 2.0 mmol OH groups/g of the support material; (b) reacting the support material with at least one of: (b1) a compound containing at least one alkoxy or phenoxy group bound though its oxygen atom to a metal element from Group 5 (V, Nb, Ta) or Group 6 (Cr, Mo, W); (b2) a compound containing at least one hydrocarbon group bound though a carbon atom to a metal element from Group 5 or 6; (b3) a compound containing at least one hydrocarbon group bound though a carbon atom to a metal element which is copper (Cu); and (c) calcining the product obtained in step (b).

IPC Classes  ?

• B01J 37/02 - Impregnation, coating or precipitation
• B01D 53/94 - Chemical or biological purification of waste gases of engine exhaust gases by catalytic processes
• B01J 21/06 - Silicon, titanium, zirconium or hafnium; Oxides or hydroxides thereof
• B01J 23/10 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of rare earths
• B01J 23/20 - Vanadium, niobium or tantalum
• B01J 23/22 - Vanadium
• B01J 23/28 - Molybdenum
• B01J 23/30 - Tungsten
• B01J 23/72 - Copper
• B01J 31/02 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
• B01J 31/16 - Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
• B01J 31/22 - Organic complexes
• B01J 37/08 - Heat treatment

Abstract

A catalytic system based on at least one rare-earth metallocene and an organomagnesium reagent as co-catalyst of formula RB—(Mg—RA)m—Mg—RB is provided. According to the formula, RB comprises a benzene nucleus substituted with the magnesium atom. One of the carbon atoms of the benzene nucleus ortho to the magnesium is substituted with a methyl, an ethyl or an isopropyl or forms a ring with the carbon atom which is its closest neighbour and which is meta to the magnesium. The other carbon atom of the benzene nucleus ortho to the magnesium is substituted with a methyl, an ethyl or an isopropyl. RA is a divalent aliphatic hydrocarbon-based chain, optionally interrupted with one or more oxygen or sulfur atoms or with one or more arylene groups. The m is a number greater than or equal to 1, preferably 1. The catalytic system allows the synthesis of dienic and/or ethylenic telechelic polymers.

IPC Classes  ?

• C08F 4/54 - Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors selected from light metals, zinc, cadmium, mercury, copper, silver, gold, boron, gallium, indium, thallium, rare earths, or actinides together with other compounds thereof
• C08F 10/02 - Ethene

Abstract

The invention relates to a cell culture comprising a placental cell and a culture medium consisting of minimal essential nutriments and a low amount of serum. The invention also relates to a method using the cell culture for identifying endocrine disruptor.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
• C12N 5/073 - Embryonic cells or tissues; Foetal cells or tissues
• G01N 33/74 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones

Abstract

A method for recognizing a pattern in an image including a training phase of an oscillatory neuron network, the oscillatory neuron network being adapted to output a pattern when an image is inputted, the oscillatory neuron network being implemented by a circuitry comprising oscillators linked by interconnections including at least one coupling resistance having a coupling resistance value, the oscillators being coupled by a sub-harmonic injection technique and coding the output by their relative phase difference, the coupling resistance values being learnt during the training phase by using Hebbian learning rules, and an operating phase wherein the trained oscillatory neuron network is used to recognize a pattern in an image, at least one of the training phase and the operating phase being computer-implemented.

IPC Classes  ?

• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
• G06V 10/94 - Hardware or software architectures specially adapted for image or video understanding

Abstract

The present invention relates to a device for measuring and/or modifying a surface of a sample, including a sample holder, including a first area configured to receive the sample fixedly mounted relative to the first area, a support, a first probe configured to detect a first parameter at a point of the surface and to generate a first measurement signal representative of the first parameter, and a second probe configured to detect a second parameter at a point of the surface, and to generate a second measurement signal representative of the second parameter, the first parameter being different from the second parameter, or one of the first probe and the second probe being configured to modify a third parameter of the surface at the point of the surface.

IPC Classes  ?

• G01Q 60/04 - STM [Scanning Tunnelling Microscopy] combined with AFM [Atomic Force Microscopy]
• G01Q 20/00 - Monitoring the movement or position of the probe
• G01Q 30/14 - Liquid environment
• G01Q 40/00 - Calibration, e.g. of probes
• G01Q 60/16 - Probes, their manufacture or their related instrumentation, e.g. holders
• G01Q 60/38 - Probes, their manufacture or their related instrumentation, e.g. holders

Abstract

An electromagnetic waveguide, such as an optical fibre, including a hollow central core surrounded by a microstructured sheath formed by an assembly of elementary cells, the microstructured sheath also including at least two elementary cells, at least one intermediate element connecting the elementary cells, the intermediate element having a cross-section with an area less than or equal to 50% of the cross-sectional area of each of the cells that it connects, the intermediate element having a refractive index less than or equal to the refractive index of each of the elementary cells that it connects.

IPC Classes  ?

• G02B 6/032 - Optical fibres with cladding with non-solid core or cladding

Abstract

An optical structure comprising at least one stack having a central filter (1) and two sandwiching optical elements (2,3) between which the central filter (1) is interposed, wherein the central filter (1) is in a matrix material. The matrix material being doped with at least one doping agent, the central filter (1) and the two optical elements (2,3) on either side thereof being assembled by bonding layers (4a, 4b) of a material based on the same matrix material as that of the central filter, the optical elements (2,3) on either side of the central filter (1) and the bonding layers (4a, 4b) each having a refractive index equal to that of the material of the central filter or only differing from this refractive index within a range of plus or minus 0.05, preferably within a range of plus or minus 0.02.

IPC Classes  ?

• G02B 5/28 - Interference filters
• G02B 1/11 - Anti-reflection coatings
• G02F 1/35 - Non-linear optics

Abstract

The invention relates to a process for treating, with a plasma, a composition comprising at least a first compound and a second compound, characterized in that said process comprises at least: generating, within an enclosure, a non-equilibrium plasma flow from a gas present in said enclosure, and treating the composition contained in said enclosure with said non-equilibrium plasma flow so as to extract at least a portion of said first compound.

IPC Classes  ?

• C22B 4/00 - Electrothermal treatment of ores or metallurgical products for obtaining metals or alloys
• C22B 7/00 - Working-up raw materials other than ores, e.g. scrap, to produce non-ferrous metals or compounds thereof
• H05H 1/46 - Generating plasma using applied electromagnetic fields, e.g. high frequency or microwave energy

Abstract

A novel method for synthesizing NCA compounds. Also, a new use of a peptide coupling agent. The method makes it possible to obtain NCA compounds from α-amino-acids, under mild and non-racemic reaction conditions, and in the absence of constraining reagents of use, such as phosgene, which may lead to the formation of undesirable by-products.

IPC Classes  ?

• C07D 413/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 263/06 - Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
• C07D 498/04 - Ortho-condensed systems

Abstract

The present invention relates to a virus-derived particle comprising one or more Cas protein(s), as well as to kits and methods using the same for altering a target nucleic acid.

IPC Classes  ?

• C07K 14/005 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
• C12N 7/00 - Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
• C12N 9/22 - Ribonucleases
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

The invention relates to a method of directional self-assembly lithography, said method comprising a step of depositing a block copolymer film on a layer (20) neutral with respect the block copolymer, said block copolymer film being for use as a lithography mask, said method being characterized in that it comprises the following steps of: depositing said neutral layer (20) on a surface of a substrate (10), said neutral layer (20) being of the carbon or fluoro-carbon type deposited to a thickness greater than 1.5 times the thickness of the block copolymer film (40), crosslinking said neutral layer, depositing said block copolymer film, comprising at least one silylated block, on said crosslinked neutral layer (30), subjecting the stack to an assembly temperature in order to nanostructure said block copolymer, removing (G1) at least one of the nano-domains (41, 42) from the nanostructured block copolymer film (40), in order to create a pattern intended to be transferred by etching (G2, G3, G4) into the thickness of the substrate (10).

IPC Classes  ?

• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfaces; Materials therefor, e.g. comprising photoresists; Apparatus specially adapted therefor

Abstract

The present invention relates to a method for identifying potentially relevant markers in cancer diagnosis, prognosis and/or therapy, comprising an analysis approach which is based on the detection of variations in methylation of ribosomal RNAs in a biological sample. The present invention also relates to several applications of this analysis approach for determining the cancer subtype and/or the prognosis of a patient suffering from cancer, for estimating or assessing the benefit of a treatment in such patient, but also for selecting one or more therapeutic drug(s) targeting ribosomes useful for treating cancers.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

The present invention relates to an isolated double stranded DNA polynucleotide that forms triplex with sequence 5′-GGUGGCAGCAAGAGAAAAAUGAGGAAGAAGCAAAAGCGGAAA-3′ (SEQ ID NO: 1) of the long non-coding RNA ANRIL (Antisense Non-coding RNA in the INK4 Locus). It also relates to a vector comprising the double stranded DNA polynucleotide, and to a pharmaceutical composition comprising the double stranded DNA polynucleotide or the vector. The present invention relates as well to the isolated double stranded DNA polynucleotide for use in the treatment of myocardial infarction, aneurysms, stenosis, myocardial infarction, aneurysms, cancers, eye diseases or type 2 diabetes.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61P 9/00 - Drugs for disorders of the cardiovascular system
• A61P 35/00 - Antineoplastic agents
• C12N 15/63 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression

Abstract

A system for characterizing a pulse of electromagnetic radiation by time-resolved optical gating, which includes an interference-forming device which is adapted for superimposing four parts of the pulse. The system also includes a matrix image sensor which selectively captures, based on two-photon absorptions, an interference pattern formed by the pulse. The system allows obtaining the pulse shape completely and accurately, and is particularly suitable for characterizing ultrashort pulses. Also, the two-photon absorption can be produced in the matrix image sensor, or replaced by optical frequency doubling which is produced by an SHG crystal plate.

IPC Classes  ?

• G01J 11/00 - Measuring the characteristics of individual optical pulses or of optical pulse trains
• G02B 5/20 - Filters
• H04N 23/12 - Cameras or camera modules comprising electronic image sensors; Control thereof for generating image signals from different wavelengths with one sensor only

Abstract

An electrode including a storage film. The storage film includes a layer of a support material including at least one inclusion in which a compound of interest is stored and a wall of permeable sealing material sealing the at least one inclusion. The storage film further includes a porous layer covering, at least in part, the wall of sealing material, at least a portion of a surface of the porous layer constituting an active surface of the electrode.

IPC Classes  ?

• H01M 8/16 - Biochemical fuel cells, i.e. cells in which microorganisms function as catalysts

Abstract

The present invention relates to a synergistic combination of an FXR agonist and interferon for the treatment of hepatitis B.

IPC Classes  ?

• A61K 38/21 - Interferons
• A61K 31/4162 - 1,2-Diazoles condensed with heterocyclic ring systems
• A61K 31/42 - Oxazoles
• A61K 31/46 - 8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
• A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• A61P 31/20 - Antivirals for DNA viruses

Abstract

Radically polymerizable dental material, which includes a catalyst paste and a base paste, wherein the catalyst pastes includes an oxidizing agent, preferably a peroxide or hydroperoxide, a radically polymerizable monomer and/or oligomer with acid group and a polyfunctional radically polymerizable monomer, and the base paste comprises a polyfunctional radically polymerizable monomer without an acid group and a dihydropyridine derivative of Formula (1) Radically polymerizable dental material, which includes a catalyst paste and a base paste, wherein the catalyst pastes includes an oxidizing agent, preferably a peroxide or hydroperoxide, a radically polymerizable monomer and/or oligomer with acid group and a polyfunctional radically polymerizable monomer, and the base paste comprises a polyfunctional radically polymerizable monomer without an acid group and a dihydropyridine derivative of Formula (1) Radically polymerizable dental material, which includes a catalyst paste and a base paste, wherein the catalyst pastes includes an oxidizing agent, preferably a peroxide or hydroperoxide, a radically polymerizable monomer and/or oligomer with acid group and a polyfunctional radically polymerizable monomer, and the base paste comprises a polyfunctional radically polymerizable monomer without an acid group and a dihydropyridine derivative of Formula (1) The material has good mechanical properties and does not exhibit a bitter taste.

IPC Classes  ?

• A61K 6/891 - Compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• A61K 6/61 - Cationic, anionic or redox initiators
• A61K 6/62 - Photochemical radical initiators
• A61K 6/77 - Glass

Abstract

A method for monitoring a hadron beam during hadron-therapy treatment of a subject including tumour cells labelled with a radiopharmaceutical product, in which the hadron beam includes a plurality of discrete hadron bursts, the method including the following steps: when a burst impacts on the subject, detecting the prompt gamma generated by the interaction of the hadrons of the burst with the tissues of the subject using a Compton telescope and reconstructing an image of the interaction volume; when no burst impacts on the subject, extracting the position of the tumour cells labelled with the radiopharmaceutical product using the Compton telescope and reconstructing an image of the total volume of the tumour; comparing the image of the interaction volume and the image of the total volume of the tumour so as to locate the measured interaction volume relative to the measured total volume of the tumour.

IPC Classes  ?

• A61N 5/10 - X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy

Abstract

A chimeric antigen receptor including: a binding domain, the full DAP 10 protein, the full DAP 12 protein, or a functional variant thereof, and a hook binding domain. Also, a vector system comprising one or more vector including: a nucleic acid comprising a nucleic acid sequence encoding a chimeric antigen receptor and optionally a nucleic acid encoding a hook fusion protein, preferably having a streptavidin core; wherein the nucleic acids are located on the same or on different vectors. Further, a lentiviral vector particles system, host cell and kit including the nucleic acids or vector system, and their use as a medicament, notably for immunotherapy.

IPC Classes  ?

• C07K 14/435 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans
• C07K 14/705 - Receptors; Cell surface antigens; Cell surface determinants
• C07K 16/12 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from bacteria
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• C12N 7/00 - Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
• C12N 15/86 - Viral vectors

Abstract

A system to localize a micro-device inside a target body part, including: a micro-device remotely steered and controlled from outside the target body part, a control unit including a memory for storing one ultrasound image of the target body part, one probe being brought in contact with a securing body part of the patient, and at least one tracker connected to the micro-device. The probe and the tracker communicate with ultrasounds, the control unit being thus able to localize, in real time, the tracker within an internal referential defined with regards to the probe, and the control unit displays, on a screen, the ultrasound image and displays, in real time, the localization of the micro-device on the ultrasound image.

IPC Classes  ?

• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
• A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
• A61B 8/08 - Detecting organic movements or changes, e.g. tumours, cysts, swellings
• A61B 34/20 - Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
• A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets

Abstract

Glycosylphosphatidylinositol (GPI) is a glycolipid that anchors more than 150 proteins to the cell surface. Pathogenic variants in several genes that participate in GPI biosynthesis cause inherited GPI deficiency (IGD) disorders. Here, the inventors reported that homozygous null alleles of PIGG, a gene involved in GPI modification, are responsible for the rare Emm-negative blood phenotype. Using a panel of K562 cells defective in both the GPI-transamidase and GPI remodeling pathways, they demonstrate that the Emm antigen, whose molecular basis has remained unknown for decades, is carried only by free GPI and that its epitope is composed of the second and third ethanolamine of the GPI backbone. Importantly, the inventors show that the decrease in Emm expression in several IGD patients is indicative of GPI defects. Overall, our findings establish Emm as a novel blood group system and have important implications for understanding the biological function of human free GPI.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
• G01N 33/80 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types

Abstract

The present invention relates to a conjugated compound comprising a marker M pharmaceutically acceptable, and a peptide or pseudo-peptide P having at most 30 amino acid residues and able to bind the Low-Density Lipoprotein Receptor (LDLR) and to its use in a method of labelling and/or detecting and/or treating cancerous cells in a subject by administration of the conjugated compound to the subject an analysis of the presence and/or the amount of marker.

IPC Classes  ?

• A61K 51/08 - Peptides, e.g. proteins
• A61K 51/04 - Organic compounds
• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• G01N 33/574 - Immunoassay; Biospecific binding assay; Materials therefor for cancer
• G01N 33/60 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
• G01N 33/92 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol

Abstract

The invention relates to a measuring device (10) for measuring physical characteristics of cells. The device (10) comprises: a microfluidic chip (20) provided with a flow channel (22) for allowing cells to flow through; a manipulator (24) configured to apply deformation force to a cell in a continuous flow; and a sensor (26) configured to sense a physical characteristic of the cell. The manipulator (24) and the sensor (26) are configured to define a width (W2) of the flow channel (22) as a gap formed between them. The manipulator (24) is configured to apply the deformation force to the cell by compressing the cell against the sensor (26).

IPC Classes  ?

• G01N 15/14 - Electro-optical investigation
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
• G01N 15/10 - Investigating individual particles
• G01N 33/487 - Physical analysis of biological material of liquid biological material

Abstract

Positive electrodes based on organic active material, including molecules of thianthrene as the active material, substituted at specific positions. The electrodes have electrochemical properties enabling their use in a battery, in particular a recyclable battery. The electrodes thus replace the electrodes based on mineral salts that are conventionally used in batteries.

IPC Classes  ?

• H01M 4/60 - Selection of substances as active materials, active masses, active liquids of organic compounds
• H01M 4/04 - Processes of manufacture in general
• H01M 4/139 - Processes of manufacture
• H01M 10/052 - Li-accumulators
• H01M 10/0568 - Liquid materials characterised by the solutes
• H01M 10/0569 - Liquid materials characterised by the solvents

Abstract

A method for isolating a mammalian genomic DNA replication origin, the method including: isolating the genomic DNA molecules; identifying 500 bp windows within the DNA molecules; isolating from the genomic DNA molecules the fragments that have a size from 500 pb up 6000 pb; selecting a DNA replication origin that is able, when contained in the DNA of an Eukaryotic cell, to produce nascent DNA, and to initiate DNA replication; and isolating the origin.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

Abstract

A signal tracking system including: one fixation element to be secured to a rigid body part of the patient surrounding a target body part, the fixation element further including a mapping element, one tracker element to be secured to the fixation element to track, in real time, the internal tracker, and a control unit including a memory to store an internal referential and one image displaying the target body part and one fixation element. The control unit is designed to define, inside the internal referential, at least one 3D frame position attached to the at least one fixation element, and to precisely locate each point of the target body part, the control unit is further designed to precisely localize, in real time, the internal tracker inside the target body part.

IPC Classes  ?

• A61B 5/06 - Devices, other than using radiation, for detecting or locating foreign bodies
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
• A61B 34/20 - Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis

Abstract

The invention relates to recombinant measles virus expressing Immunodeficiency virus (IV) or HTLV polypeptides, and concerns in particular immunogenic immunodeficiency virus particles expressed by a measles virus and/or virus like particles (VLPs) that contain proteins of at least one immunodeficiency virus or Human T-lymphotropic virus. These particles may be recombinant infectious particles able to replicate in a host after an administration. The invention provides means, in particular nucleic acid constructs, vectors, cells and rescue systems to produce these recombinant infectious particles. The invention also relates to the use of these recombinant infectious particles, in particular under the form of a composition, more particularly in a vaccine formulation, for the treatment or prevention of an infection by HIV or HTLV.

IPC Classes  ?

• C12N 15/86 - Viral vectors
• A61P 31/18 - Antivirals for RNA viruses for HIV
• C07K 14/15 - Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
• C12N 7/00 - Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof

Abstract

A method for the detection of polycyclic aromatic hydrocarbons including: a) a step of contacting an aqueous solution including at least one polycyclic aromatic hydrocarbon with a catalyst for the oxidation of polycyclic aromatic hydrocarbons and with an electrode made of a conductive porous material, and b) a step of detecting the anthraquinone that is formed during the previous step through the oxidation of the polycyclic aromatic hydrocarbons.

IPC Classes  ?

• C12Q 1/26 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
• C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions

Abstract

The invention relates to a substrate coated with a coating consisting of molybdenum (Mo), sulfur (S), tantalum (Ta) and oxygen (O) atoms present in the form of one or several compound(s) selected from among the compounds of formula (I): The invention relates to a substrate coated with a coating consisting of molybdenum (Mo), sulfur (S), tantalum (Ta) and oxygen (O) atoms present in the form of one or several compound(s) selected from among the compounds of formula (I): MowSxTayOz  (I) wherein w is equal to 0 or 1; x varies from 0 to 2; y varies from 0 to 1 and z varies from 0 to 3; said coating comprising at least 5% at of oxygen and said coating having a dense compact microstructure.

IPC Classes  ?

• C10M 103/06 - Metal compounds
• C01G 39/00 - Compounds of molybdenum
• C23C 14/06 - Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the coating material
• C23C 14/35 - Sputtering by application of a magnetic field, e.g. magnetron sputtering

Abstract

The present invention relates to an expression cassette allowing expression of a functional LRIT3 protein in mammal eyes; said expression cassette is inserted in an expression vector, preferably an adeno-associated virus (AAV); accordingly, the present invention further relates to a recombinant adeno-associated virus (AAV) vector carrying a nucleic acid sequence encoding a normal LRIT3 gene, or fragment thereof, under the control of regulatory sequences which express the product of the gene in the ocular cells, a pharmaceutically acceptable composition comprising such a recombinant AAV vector and to its use for the treatment of congenital stationary night blindness

IPC Classes  ?

• C07K 14/705 - Receptors; Cell surface antigens; Cell surface determinants
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• A61P 27/02 - Ophthalmic agents
• C12N 15/86 - Viral vectors

Abstract

An optomechanical transducer, including a tuning fork made of piezoelectric material including two arms, at least one photoactive film partially deposited on at least one part of at least one of the arms of the tuning fork, the at least one photoactive film including photo-switchable molecules, suitable for molecular switching between a first molecular configuration and a second molecular configuration in response to the absorption of light at a defined, so-called photo-isomerisation wavelength, so that the photoactive film undergoes a shape change that induces a change in the stiffness coefficient of the tuning fork is disclosed. A probe is also provided for a frequency modulation atomic force microscope and to such a microscope.

IPC Classes  ?

• G01Q 10/04 - Fine scanning or positioning
• C09J 4/00 - Adhesives based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond
• G01Q 60/32 - AC mode
• G01Q 70/14 - Particular materials

Abstract

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, for use as a drug, especially as an antibiotic. The present invention also relates to a pharmaceutical composition comprising said compound of formula (I) and at least one pharmaceutically acceptable excipient. The present invention further concerns a method of preparation of a compound of formula (I′). The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, for use as a drug, especially as an antibiotic. The present invention also relates to a pharmaceutical composition comprising said compound of formula (I) and at least one pharmaceutically acceptable excipient. The present invention further concerns a method of preparation of a compound of formula (I′).

IPC Classes  ?

• C07C 49/747 - Unsaturated compounds containing a keto group being part of a ring containing hydroxy groups containing six-membered aromatic rings
• A61P 31/04 - Antibacterial agents
• C07C 45/59 - Preparation of compounds having C=O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only hetero atom in five-membered rings
• C07C 49/753 - Unsaturated compounds containing a keto group being part of a ring containing ether groups, groups, groups, or groups
• C07C 69/738 - Esters of keto-carboxylic acids
• C07D 317/54 - Radicals substituted by oxygen atoms

Abstract

The present invention relates to an in vitro method for preparing a composition comprising mesenchymal stem cells (MSCs) intended for treating ischemia-reperfusion injury, comprising: a) providing MSCs; b) cultivating MSCs in a culture medium comprising a PPARβ/δ agonist; c) removing the culture medium and washing the MSCs; and d) collecting MSCs in a pharmaceutically acceptable carrier, wherein the pharmaceutically acceptable carrier does not contain a PPARβ/δ agonist. It further relates to MSCs obtained using the method of the invention, as well as their use as a medicament, preferably in the treatment or prevention of ischemia-reperfusion injury, wherein the method of treatment or prevention does not comprise administering a PPARβ/δ agonist to the subject.

IPC Classes  ?

• A61K 35/28 - Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
• C12N 5/0775 - Mesenchymal stem cells; Adipose-tissue derived stem cells

Abstract

The invention relates to an isolated non-naturally occurring protein comprising the amino acid sequence as set forth in SEQ ID NO: 1, and wherein the amino acid in position 8, 47, 209 and/or 354 is substituted by any amino acid different from the amino acid indicated at that position in said sequence SEQ ID NO: 1.

IPC Classes  ?

• C07K 14/005 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
• C12N 7/00 - Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof

Abstract

The present invention relates to a polynucleotide comprising a gene encoding a hook protein and a gene encoding a protein of interest, said protein of interest being either a secretory protein or a cell membrane-anchored protein, wherein: said gene encoding the hook protein is under the control of a first transcription-activating signal, said gene encoding the protein of interest is under the control of a second transcription-activating signal, said second transcription-activating signal allowing a lower rate or frequency of transcription initiation than the first transcription-activating signal, said hook protein is fused to a cellular compartment-retention peptide, and said protein of interest is fused to a hook protein-binding domain The present invention relates to a polynucleotide comprising a gene encoding a hook protein and a gene encoding a protein of interest, said protein of interest being either a secretory protein or a cell membrane-anchored protein, wherein: said gene encoding the hook protein is under the control of a first transcription-activating signal, said gene encoding the protein of interest is under the control of a second transcription-activating signal, said second transcription-activating signal allowing a lower rate or frequency of transcription initiation than the first transcription-activating signal, said hook protein is fused to a cellular compartment-retention peptide, and said protein of interest is fused to a hook protein-binding domain It also related to vectors comprising the polynucleotide, cells comprising the polynucleotide or the vector and compositions comprising the same. It further relates to methods and uses for modulating the secretion or cell membrane-anchorage of a protein of interest, or for preventing and/or treating a disease in a subject in need thereof.

IPC Classes  ?

• C12P 21/00 - Preparation of peptides or proteins
• C07K 14/36 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptomyces (G)
• C07K 14/54 - Interleukins (IL)
• C07K 14/55 - IL-2
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

Abstract

Disclosed is a compound having the following formula (I): Disclosed is a compound having the following formula (I): as well as to the use of such as a dye sensitizer. Disclosed is a compound having the following formula (I): as well as to the use of such as a dye sensitizer. Also disclosed is a dye sensitized solar cell including at least one compound of formula (I) as dye sensitizer.

IPC Classes  ?

• C07F 5/02 - Boron compounds
• B01J 21/06 - Silicon, titanium, zirconium or hafnium; Oxides or hydroxides thereof
• B01J 31/38 - Catalysts comprising hydrides, coordination complexes or organic compounds containing in addition, inorganic metal compounds not provided for in groups of titanium, zirconium or hafnium
• B01J 35/00 - Catalysts, in general, characterised by their form or physical properties
• C09B 23/01 - Methine or polymethine dyes, e.g. cyanine dyes characterised by the methine chain
• H01G 9/20 - Light-sensitive devices

Abstract

The present disclosure relates to a time client device comprising a network interface for communicating over a communication network, the time client device being configured to: receive, over the communication network from an authentication server (AS), a first key, and a first value containing the first key in encrypted form; generate a second value using the first key; and during a time synchronization phase, transmit to a time server (TS) the first and second values.

IPC Classes  ?

• H04L 9/32 - Arrangements for secret or secure communications; Network security protocols including means for verifying the identity or authority of a user of the system

Abstract

Disclosed is a pharmaceutical composition that contains at least one compound with the following formula (I) as active ingredient: in which R1 is chosen from H, SO3−, R2 is chosen from H and COCH3, R3 is chosen from H, Disclosed is a pharmaceutical composition that contains at least one compound with the following formula (I) as active ingredient: in which R1 is chosen from H, SO3−, R2 is chosen from H and COCH3, R3 is chosen from H, COCH3, benzyl, SO3− and pharmaceutically acceptable salts of the compounds—with the exception of the compound of formula (I) in which R1=SO3− and R2=COCH3 and R3=H and of the sodium salt of the compound—and at least one pharmaceutically acceptable excipient. Also disclosed are an associated kit including a biocompatible medium and methods for treatment.

IPC Classes  ?

• C07H 5/06 - Aminosugars
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 47/02 - Inorganic compounds
• A61P 19/08 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease

Abstract

A microfluidic device comprising: —a first wall comprising a first substrate on which a plurality of closed patterns is grafted, —a second wall, facing the first wall, comprising a second substrate, —a plurality of nucleic acids grafted either on the first substrate or on the second substrate, wherein each nucleic acid comprises a barcode that encodes the position of the nucleic acid on said first or second substrate, wherein at least the plurality of closed patterns or the second substrate is made of an actuatable hydrogel which is swellable between a retracted state and a swollen state in which the closed patterns and the second substrate come into contact.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

Abstract

Nanostructured surface coating (1) configured to generate visual appearances in a visible spectrum range, comprising: —a first layer comprising a random distribution of nanoparticles (2); —a substrate (3), on which the first layer is arranged; —the nanoparticles having an optical refraction index npart having a value suitable for each individually diffusing the incident light; —the nanoparticles being arranged so that the mean distance between two adjacent particles d is defined in accordance with the following relationship so as to produce interference between the light diffused by the particles: 2 R≤d≤max (λ/np), where R is the smallest geometric radius of a circle surrounding the particle, λ is the greatest wavelength of the visible spectrum, and np is the optical refractive index of the medium in which the nanoparticles are dispersed.

IPC Classes  ?

• G02B 5/02 - Diffusing elements; Afocal elements

Abstract

A method for stripping U(VI) and an An(IV) from an organic solution including tri-n-butyl phosphate in an organic diluent, the solution containing U(VI) and the An(IV) present as U(VI) nitrate and An(IV) nitrate at concentrations such that the U(VI) nitrate concentration is higher than the An(IV) nitrate concentration, and the sum of the U(VI) nitrate and An(IV) nitrate concentrations is ≥55 g/L. The method includes contacting the organic solution and an aqueous solution of nitric and oxalic acids, the oxalic acid concentration in the aqueous solution and the O/A volume ratio selected so that the oxalic acid is deficient with respect to the stoichiometric conditions of a complete precipitation of U(VI) and actinide(IV), to obtain a precipitate containing the actinide(IV) in oxalate form and a fraction of the U(VI) in oxalate form with a U(VI)/actinide(IV) mass ratio of between 0.5 and 5; and separating the precipitate from the organic and aqueous solutions.

IPC Classes  ?

• G21F 9/12 - Processing by ion-exchange

Abstract

Disclosed is a mixing device including a chamber defining a circulation zone, the circulation zone including at least one base liquid and a mixing fluid, the mixing fluid being less paramagnetic than the base liquid, the mixing fluid including and/or consisting of at least one first fluid, the mixing device including at least one magnetic element which generates a magnetic field in the circulation zone so that the mixing fluid flows into the base liquid, the chamber including at least one first injection point of the first fluid into the circulation zone, the first injection point opening into the base liquid.

IPC Classes  ?

• B01F 25/31 - Injector mixers in conduits or tubes through which the main component flows
• B01F 25/314 - Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced at the circumference of the conduit
• B01F 33/451 - Magnetic mixers; Mixers with magnetically driven stirrers wherein the mixture is directly exposed to an electromagnetic field without use of a stirrer, e.g. for material comprising ferromagnetic particles or for molten metal

Abstract

Compositions containing micropeptides capable of modulating the accumulation of miRs involved in certain pathologies, and the use of these micropeptides for treating the certain pathologies. Also, methods of identifying these micropeptides modulating the accumulation of miRs involved in pathologies. Further, nuclei acids encoding those micropeptides that modulate the accumulation of miRs involved in pathologies.

IPC Classes  ?

• A61K 38/17 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 19/08 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
• A61P 31/14 - Antivirals for RNA viruses
• A61P 35/00 - Antineoplastic agents
• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

A process for manufacturing by moulding an optical component includes at least the following steps: a step of providing at least one mould, during which a glass profile is provided, said glass profile including a doping according to a predetermined geometry and having a refractive index profile depending on said doping and including at least an end including at least a structuring obtained by chemically etching of said doping, said structuring forming said at least one mould, and a moulding step, during which at least a moulding material suitable for forming at least an optical component is provided and arranged in said mould in order to shape said optical component.

IPC Classes  ?

• B29D 11/00 - Producing optical elements, e.g. lenses or prisms

Abstract

An inlaid timepiece component (1) including a body (10) made of a metallic and/or ceramic material including at least one hollow (11) forming the impression of a decoration (12). The at least one hollow is completely filled with successive strata (13, 14, 15) formed by an agglomeration of particles (16) via a cold metallisation in order to form a timepiece component (1) inlaid with at least one decoration (12).

IPC Classes  ?

• G04B 45/00 - Time-pieces of which the indicating means or cases provoke special effects, e.g. aesthetic effect
• G04B 19/18 - Graduations on the crystal or glass, on the bezel, or on the rim

Abstract

A method for executing a machine code with a computer, including constructing a signature for a current instruction on the basis of signals generated by a stage of a hardware processing path, this stage being a decoder or a stage following the decoder in the hardware processing path, and on the basis of the preceding signature constructed for an instruction which precedes it, then checking the integrity of the executed machine code by comparing the signature constructed for the current instruction with a prestored reference signature, then only when the integrity of the current instruction has been checked successfully, decrypting a cryptogram of the following instruction using the signature constructed for the current instruction.

IPC Classes  ?

• G06F 9/30 - Arrangements for executing machine instructions, e.g. instruction decode
• H04L 9/08 - Key distribution
• H04L 9/32 - Arrangements for secret or secure communications; Network security protocols including means for verifying the identity or authority of a user of the system

Abstract

The invention relates to a device for measuring the dose delivered through a radiosensitive film under exposure to ionizing radiations, to a system comprising such device and to the use of such device. More particularly, the device comprises a reflection film; at least one light source; a radiosensitive film; and an optical sensor system comprising a 2-D array of one or more photoresistor units and/or semiconductor units. The present invention also relates to a system comprising the device previously described; a readout integrated circuit unit connected to the optical sensor system of the device; and a processing unit connected to the readout integrated circuit. The present invention also relates to the use of a device as previously described.

IPC Classes  ?

• G01T 1/04 - Chemical dosimeters
• G01T 1/105 - Read-out devices

Abstract

A device for modifying at least the direction of magnetization of a magnetic layer, the modifying device including a ferroelectric layer having a ferroelectric polarization, arranged on or under the magnetic layer so as to define a stack including at least the magnetic layer and the ferroelectric layer, a generator apt to inject an electric current into the stack along a direction parallel to the plane of the layers of the stack, and a modification unit apt to modify the ferroelectric polarization of the ferroelectric layer, for modifying, with the generator, the direction of magnetization of the magnetic layer.

IPC Classes  ?

• G11C 11/16 - Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using magnetic elements using elements in which the storage effect is based on magnetic spin effect
• G11C 19/08 - Digital stores in which the information is moved stepwise, e.g. shift registers using magnetic elements using thin films in plane structure
• H10B 61/00 - Magnetic memory devices, e.g. magnetoresistive RAM [MRAM] devices
• H10N 50/80 - Constructional details
• H10N 52/00 - Hall-effect devices

Abstract

Method for determining tissue positions using an array, which comprise location sequences, the location sequences bind to the tissue samples via ligands. The tissue section which allows localisation tags to be assigned to areas of the tissue comprising a single or plurality of cells or organelles, e.g. about two to ten cells. By triangulation of the localisation tags it is possible to assign a unique relative position in the tissue per cell or organelle.

IPC Classes  ?

• C12Q 1/6841 - In situ hybridisation

Abstract

The method comprises an optimization step involving calculating a figure of merit representative of the sensitivity of the selected response to first sequence variations in first design variables and second sequence variations in second design variables of the spaces and substructures, then calculating a gradient of the figure of merit, subsequently modifying first or second design variables of at least one of the first and second sequences depending on said gradient in order to improve the figure of merit, and repeating the optimization step as long as the figure of merit does not represent a set objective and/or is lower than a selected value, wherein the first P+S design variables of the first sequence and the second P+S design variables of the second sequence are substructure (3p) or space (4s) widths between substructures (3p), which widths are defined in one of three different directions of a three-dimensional space.

IPC Classes  ?

• G06F 30/20 - Design optimisation, verification or simulation

Abstract

The invention relates to a method for recovering organic molecules (10) from a complex matrix (20) said method (100) comprising the steps of: Providing (110) the complex matrix (20); Contacting (120) the complex matrix (20) with biogenic nanoparticles (30), for an adsorption of the organic molecules (10) on biogenic nanoparticles (30); Separating (140) biogenic nanoparticles enriched (35) with the organic molecules (10) from a depleted complex matrix (22); and Using (150) the organic molecules (10) that were adsorbed to the biogenic nanoparticles (30) in a chemical process or in a chemical device.

IPC Classes  ?

• C10G 25/12 - Recovery of used adsorbent
• B01J 20/28 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
• B01J 20/34 - Regenerating or reactivating

Abstract

A modular comb element for a machine for automatically cutting a mat of sheets of material. The cutting machine includes a plurality of cutting supports. The comb element includes a plate forming a support from which a first and a second row of teeth extend longitudinally. The teeth of the first row alternate with the teeth of the second row, and a free end of the teeth of the first row are farther from a downstream edge of the support than a free end of the teeth of the second row of teeth. A ramp is mounted on the downstream edge of the support and inclined with respect to the latter so as to limit the contact surface between the mat of sheets and the comb element. Air injection means are at a downstream edge of the ramp over an entire width thereof.

IPC Classes  ?

• B26D 7/20 - Cutting beds
• B26D 7/01 - Means for holding or positioning work
• B26D 7/06 - Arrangements for feeding or delivering work of other than sheet, web, or filamentary form
• B26D 7/32 - Means for performing other operations combined with cutting for conveying or stacking cut product

Abstract

The present invention relates to an aqueous lubricant composition for lubricating moving parts in a mechanical system, comprising at least water, glycerol; and hypericin. The present invention relates to an aqueous lubricant composition for lubricating moving parts in a mechanical system, comprising at least water, glycerol; and hypericin. It also relates to the use of this aqueous lubricant composition for lubricating moving parts in a mechanical system, in particular in a vehicle propulsion system.

IPC Classes  ?

• C10M 173/02 - Lubricating compositions containing more than 10% water not containing mineral or fatty oils

Abstract

The present invention relates to the radiolabelled compound of enantiomer (R,R) of 5-fluoro-3-4(-phenylpiperidin-1-yl)-1,2,3,4-tetrahydronaphthalen-2-ol, and to this compound for use thereof in an in vivo diagnosis method, in particular of a cholinergic neurodegenerative disease selected for example from the group formed by Alzheimer's disease, dysmnesia, learning disability, schizophrenia, cognitive dysfunction, hyperactivity disorder, anxiety neurosis, depression, analgesia and Parkinson's disease.

IPC Classes  ?

• A61K 51/04 - Organic compounds
• C07D 211/14 - Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
• C07F 5/02 - Boron compounds

Abstract

An ultrasound probe holding device configured to attach to the head of an infant for transfontanellar imaging is disclosed, including a head pad configured to be in contact with the head of the infant and including a central opening, wherein the head pad is configured to receive an ultrasound probe; a pad squeezer, including a central opening and configured to cooperate with the head pad to allow an axial guidance of the head pad along a guidance axis substantially perpendicular to a surface tangent to the head of the infant; a device holder configured to be attached to the head of the infant and exert a downward force on the pad squeezer, along said guidance axis; and a repellent configured to exert a repellent force between the pad squeezer and the head pad when the device holder exerts the downward force on the pad squeezer.

IPC Classes  ?

• A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
• A61B 8/08 - Detecting organic movements or changes, e.g. tumours, cysts, swellings
• A61B 5/256 - Wearable electrodes, e.g. having straps or bands
• A61B 5/291 - Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]

Abstract

A stretch film for use in the cosmetic or agri-food packaging sectors comprises konjac and carrageenan in a mass ratio of between 20/80 and 60/40. A stretch film according to the present disclosure has advantageous properties for use as a biodegradable stretch cling film and cosmetic mask.

IPC Classes  ?

• A61K 8/9717 - Rhodophycota or Rhodophyta [red algae], e.g. Porphyra
• A61K 8/9794 - Liliopsida [monocotyledons]
• A61Q 19/00 - Preparations for care of the skin
• B65D 65/46 - Applications of disintegrable, dissolvable or edible materials
• A61K 8/02 - Cosmetics or similar toiletry preparations characterised by special physical form
• A45D 44/00 - Other cosmetic or toiletry articles, e.g. for hairdressers' rooms
• C08J 5/18 - Manufacture of films or sheets

Abstract

A method—for printing a 3D object, defined by a 3D image having multiple illuminated points, in a photoreactive composition volume—includes extracting from the image a mosaic sequence. Each mosaic includes multiple solid areas, each including illuminated point(s). The mosaic sequence is projected in an axial direction, inside the volume, to form—from each projected mosaic—multiple light areas, each corresponding to a solid area of the projected mosaic. In the solid area of a mosaic, a number of illuminated points and the distribution of the illuminated points are adjusted so, when projecting the mosaic is into the volume, the light area corresponding to the solid area causes a photoreaction in an associated composition block with a desired axial resolution. In the same mosaic, the solid areas are distributed such that, when projecting the mosaic into the volume, the composition does not react between the light areas associated with the multiple solid areas.

IPC Classes  ?

• B29C 64/393 - Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
• B33Y 10/00 - Processes of additive manufacturing
• B29C 64/129 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified characterised by the energy source therefor, e.g. by global irradiation combined with a mask
• B33Y 50/02 - Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
• B29C 64/264 - Arrangements for irradiation

Abstract

The present invention relates to trimeprazine derivatives of formula (I) for use for treating a neuropsychiatric disorder chosen among an intellectual disability (ID), preferably fragile X syndrome (FXS), autism spectrum disorders (ASD), and attention deficit hyperactivity disorder (ADID). The invention also relates to pharmaceutical compositions for use comprising such derivatives.

IPC Classes  ?

• A61K 31/5415 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61P 25/00 - Drugs for disorders of the nervous system

Abstract

Control system (1) for a state of a quantum harmonic oscillator, comprising:—a harmonic oscillator (3) in a Schrodinger's cat type state,—a stabilisation device (10) with a predetermined parity of a number of bosons of the state, which device is configured to use first and second frequency combs each comprising at least as many rays as a mean number of bosons in the state, and—a multiphonic dissipation device (20) which is suitable for removing at least one pair of bosons simultaneously from the oscillator, the dissipation device being activated only between two successive time peaks of the frequency combs over a time period greater than the inverse of the product of the mean number and the inverse of the characteristic time of the multiphonic dissipation, a time period separating two activation periods being less than a characteristic loss time of a boson.

IPC Classes  ?

• G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control
• G06N 10/70 - Quantum error correction, detection or prevention, e.g. surface codes or magic state distillation

Abstract

A process for producing a protein isolate from an oilseed meal, and the isolate thus obtained, said isolate comprising proteins and an amount of 4 wt % or less of phytic acid, said amount of phytic acid being by weight of proteins in said isolate. The process may comprise the following steps: a) providing an oilseed meal; b) mixing the oilseed meal with a first aqueous solvent to form a slurry at a pH ranging from 6 to 7.8, said slurry having a solid phase; c) separating said solid phase from said slurry, d) mixing said separated solid phase with a second aqueous solvent at a pH ranging from 1 to 3.5, preferably from 2 to 3, to form a mixture said mixture having a liquid phase; e) separating said liquid phase from said mixture formed in step d); f) f1) mixing the separated liquid phase to a phytase at a temperature and a pH suitable for phytase activity to obtain a mixture having a liquid phase and a solid phase; and/or f2) mixing the separated liquid to a salt, to obtain a resulting liquid composition having a molar concentration of said salt ranging from 0.05 M to 0.5 M, at a temperature ranging from 40° C. to 70° C., to obtain a mixture having a liquid phase and a solid phase; g) precipitating a solid phase from the liquid of step f) for example by a cooling down step of the mixture to a temperature of 30° C. or less; h) separating said solid precipitate from the liquid of step g) said liquid comprising a water-rich liquid phase and an oil-rich liquid phase; i) separating said water-rich liquid phase from said oil-rich liquid phase, j) subjecting said water-rich liquid phase obtained in step i) to one or several membrane filtration(s) to obtain a protein isolate; and k) optionally, drying said protein isolate to obtain a dry protein isolate.

IPC Classes  ?

• A23J 1/14 - Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from press-cake or oil-bearing seeds
• C07K 1/34 - Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis

Abstract

The invention relates to an inhibitor of FXYD2 wherein said inhibitor reduces the expression and/or activity of FXYD2 in a subject in need thereof and targets at least the region comprising or consisting of the nucleotides 219-229 of SEQ ID NO: 3. Inventors have shown that targeting a region of FXYD2 can be used to inhibit and/or reduce the expression and/or activity of FXYD2. They have designed and synthesized an antisense oligonucleotide (SEQ ID NO: 4) targeting the rat and human FXYD2 gene. The have performed intrathecal injection of FXYD2 optimized ASO in two rat models of pain (neuropathic and inflammatory pain). They have shown that FXYD2 ASO efficiently reduces its expression in rat Dorsal root ganglion (DRG). The have demonstrated that FXYD2 ASO dramatically reduces neuropathic pain in the Spinal Nerve Ligation (SNL) rat model and analgesic effect of FXYD2 ASO on neuropathic pain is greater than that of Ziconotide, the current market leader. They also have shown that FXYD2 ASO dramatically reduces inflammatory pain in Complete Freund's Adjuvant (CFA)-induced rat model.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61P 25/04 - Centrally acting analgesics, e.g. opioids

Abstract

Method for processing a plurality of X-ray tomography volume images each associated with a part, the plurality of volume images comprising a reference volume image, including: a step of correlating volume images to obtain a displacement field between each image and the reference image, to obtain a plurality of displacement fields minimizing the difference between the volume images, a processing by a dimensionality reduction method of the plurality of the image displacement fields to express them according to eigenmodes, and a statistical analysis of the fields expressed according to the eigenmodes.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G06T 7/60 - Analysis of geometric attributes
• G06T 15/00 - 3D [Three Dimensional] image rendering

Abstract

A device for non-invasively evaluating or monitoring an intra-abdominal pressure and/or abdominal wall deformations and/or a risk of incisional hernia of a subject at a preventive stage and/or a pre-operative stage and/or a post-operative stage, the device includes an adjustable and flexible frame, the frame comprising a central area, a left lateral area and a right lateral area; a network of main sensors suitable for measuring local deformations and/or local forces on the surface of the abdomen of the subject, the network of main sensors being assembled to the frame, wherein at least one main sensor is located in each area of the frame; connecting means adapted for connecting the network of main sensors to a treatment unit; and possibly positioning means adapted for positioning the device on the abdomen and/or adjustment means adapted for adjusting the device on the abdomen. The invention also relates to a system comprising a device and a treatment unit, and to a method for determining the abdominal wall dynamic biomechanical behavior of a subject, using a device or a system.

IPC Classes  ?

• A61B 5/03 - Measuring fluid pressure within the body other than blood pressure, e.g. cerebral pressure
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons

Abstract

The invention relates, in particular, to a quantum-enabled server (S) comprising an enclave (SE), a qubit source (SS), and quantum-computing means (SM), this enclave comprising means for: receiving information from a remote client through a secured communication channel; determining transformation data from said information; transforming at least one qubit received from said qubit source, according to transformation data; providing the at least one transformed qubits to said quantum-computing means.

IPC Classes  ?

• G06N 10/80 - Quantum programming, e.g. interfaces, languages or software-development kits for creating or handling programs capable of running on quantum computers; Platforms for simulating or accessing quantum computers, e.g. cloud-based quantum computing
• G06N 10/20 - Models of quantum computing, e.g. quantum circuits or universal quantum computers

Abstract

The present invention relates to a polypeptide X1X2-RK-X3X4-KK-X5X6X7X8X9X10-KR-X11X12 SEQ ID NO: 1 able to bind selectively to cells expressing proteoglycans comprising glycosaminoglycans as heparin or heparan sulfate. The linkage of said polypeptide to an internalization peptide enables the polypeptide to be internalized. The present invention relates to a polypeptide X1X2-RK-X3X4-KK-X5X6X7X8X9X10-KR-X11X12 SEQ ID NO: 1 able to bind selectively to cells expressing proteoglycans comprising glycosaminoglycans as heparin or heparan sulfate. The linkage of said polypeptide to an internalization peptide enables the polypeptide to be internalized. The present invention further relates to a conjugated polypeptide comprising said polypeptide and a biomarker, to a cell penetrating polypeptide comprising said polypeptide, optionally a linker and a cell internalization peptide and a chimeric polypeptide comprising said cell penetrating polypeptide and one or more biological cargos.

IPC Classes  ?

• G01N 33/574 - Immunoassay; Biospecific binding assay; Materials therefor for cancer
• C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals

Abstract

The present disclosure relates to a system (10) for measuring the mechanical properties of a skin sample (3) ex vivo or in vitro, comprising a measuring device comprising at least one mechanical stress module (20, 40) capable of applying a tensile force to the skin in a direction parallel to the surface of the skin sample (3), the at least one mechanical stress module (20, 40) comprising: —a traction means (30, 50) which is translatably movable in a direction parallel to the surface of the skin sample (3); — a translating arm (21, 41) connected, on the one hand, to the traction means (30, 50) and, on the other hand, to an axial displacement means; — one end of the traction means being provided with an attachment head (31, 51) capable of being attached to a region of the skin sample (3) so as to cause deformation of the skin sample by axially displacing the region of the skin sample— a control unit (202) configured to control the displacement means according to a stress frequency of between 0.1 mHz and 1 Hz, and— a calculation unit (203) configured to receive the signals transmitted by the measuring device and calculate the mechanical properties of the skin from the signals.

IPC Classes  ?

• G01N 3/08 - Investigating strength properties of solid materials by application of mechanical stress by applying steady tensile or compressive forces
• G01N 33/483 - Physical analysis of biological material
• G01N 3/06 - Special adaptations of indicating or recording means

Abstract

An electroactive material suitable for electrochemical cell electrode wherein the electroactive material includes a chalcogen oligomer that can reversibly deintercalate/reintercalate an anion of the chalcogen, such as La2O2S2, and the electrochemical electrodes and cells containing the electroactive material.

IPC Classes  ?

• H01M 4/58 - Selection of substances as active materials, active masses, active liquids of polyanionic structures, e.g. phosphates, silicates or borates
• H01M 4/04 - Processes of manufacture in general
• H01M 4/66 - Selection of materials
• H01M 10/0565 - Polymeric materials, e.g. gel-type or solid-type
• H01M 4/02 - Electrodes composed of, or comprising, active material

Abstract

The invention concerns a system for controlling the temperature of a microfluidic chip comprising a Peltier module (10) having a cold face (10a) and a hot face (10b) and connected to a power generator (11), a thermal regulation device (12) having a thermal regulated face (12a) applied against one of the faces of the Peltier module, at least one temperature sensor (17) being applied on the other face of the Peltier module and being intended to be applied against one of the main faces of a microfluidic chip and control means (18) configured to control the power generator (11) of the Peltier module depending on a temperature of the face of the Peltier module provided with said at least one temperature sensor and at least one temperature setting information selected from a target temperature and a target temporal temperature profile to regulate a temperature of the face of the Peltier module to said temperature setting information.

IPC Classes  ?

• B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
• B01L 9/00 - Supporting devices; Holding devices

Abstract

A correction device for correcting a radio frequency magnetic field in magnetic resonance imaging, the device intended to be positioned on an area of a patient's body during a magnetic resonance imaging examination and including a substrate and at least one conductor track on the substrate, the at least one conductor track having at least two segments that are connected to each other by at least one reactive electrical component.

IPC Classes  ?

• G01R 33/565 - Correction of image distortions, e.g. due to magnetic field inhomogeneities
• G01R 33/28 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance - Details of apparatus provided for in groups

Abstract

A triblock polymer of formula B-A-B is provided. According to the formula, the symbol A represents a “central” block which is a statistical copolymer comprising units of a 1,3-diene and more than 50 mol % of ethylene units. The symbols B each represent an “end” block which is a polyethylene with a melting point of greater than 90° C. and a number-average molar mass of greater than or equal to 2000 g/mol and less than or equal to 10 000 g/mol. The polymer has improved rheological properties relative to a statistical copolymer based on ethylene and 1,3-diene of the same microstructure without changing its mechanical and dynamic or thermal properties.

IPC Classes  ?

• C08F 297/08 - Macromolecular compounds obtained by successively polymerising different monomer systems using a catalyst of the ionic or coordination type without deactivating the intermediate polymer using a catalyst of the coordination type polymerising mono-olefins

Abstract

A device for measuring a particle beam, includes front and rear faces, a first central portion including a device for forming a space charge region through which a particle beam to be measured passes, charge carriers of a first and second type being generated by the beam when the latter passes through the space charge region, a second peripheral portion including a device for collecting at least one type of charge carrier from the first or second type of charge carriers generated in the space charge region, the central portion having a maximum thickness less than or equal to that of the peripheral portion, the peripheral portion surrounding the central portion such that a particle beam can pass through the central portion without passing through the peripheral portion. The device includes, in a region of the central portion leading to the rear face, a layer of a porous material.

IPC Classes  ?

• H01L 31/115 - Devices sensitive to very short wavelength, e.g. X-rays, gamma-rays or corpuscular radiation
• H01L 31/18 - Processes or apparatus specially adapted for the manufacture or treatment of these devices or of parts thereof
• H01L 31/0352 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by their semiconductor bodies characterised by their shape or by the shapes, relative sizes or disposition of the semiconductor regions

Abstract

The invention relates to a device (5) comprising: —an optical surface (10); —a cleaning unit (15) for cleaning the optical surface, comprising at least one wave transducer (70) acoustically coupled to the optical surface, the wave transducer having a piezoelectric layer (80) and electrodes (85) of opposite polarity in contact with the piezoelectric layer, and being configured to generate at least one surface ultrasonic wave (WS) or a Lamb wave (WL) propagating in the optical surface; —the optical surface having at least one region of optical interest (100) not superposed on the wave transducer, the device comprising an apparatus (20) configured to sense and/or to emit radiation (R) through the region of optical interest (100).

IPC Classes  ?

• G02B 27/00 - Optical systems or apparatus not provided for by any of the groups ,
• B08B 7/02 - Cleaning by methods not provided for in a single other subclass or a single group in this subclass by distortion, beating, or vibration of the surface to be cleaned
• B60S 1/56 - Cleaning windscreens, windows, or optical devices specially adapted for cleaning other parts or devices than front windows or windscreens
• G01S 7/497 - Means for monitoring or calibrating

Abstract

Disclosed is a device (5) for cleaning an optical surface, which device comprises: —a transparent optical surface (10); —a cleaning unit (15) for cleaning the optical surface, having a piezoelectric layer (20) and at least two wave transducers (45), each wave transducer having electrodes (40) of opposite polarity in contact with the piezoelectric layer and being acoustically coupled to the optical surface so as to generate at least one surface ultrasonic wave (Ws) or a Lamb wave (WL) propagating in the optical surface, the transducers being further arranged on the periphery of the optical surface.

IPC Classes  ?

• B60S 1/56 - Cleaning windscreens, windows, or optical devices specially adapted for cleaning other parts or devices than front windows or windscreens
• B08B 7/02 - Cleaning by methods not provided for in a single other subclass or a single group in this subclass by distortion, beating, or vibration of the surface to be cleaned

Abstract

A system for treating a target by laser shock in a regime of confinement in a liquid, the system includes a pulsed laser generating a beam having a pulse duration of between 1 ns and 30 ns and a wavelength, a concentrating optical device having a focal length and configured to concentrate the beam on the surface of the target, the incident laser beam on the concentrating device having a diameter, a tank filled with the liquid having a refractive index n, a desired value of the diameter of the beam on a surface of the target being predetermined and named Dst, a thickness of liquid passed through by the beam before reaching the surface of the target being chosen such that a laser intensity on the surface of the liquid (Isl) is less than or equal to a laser intensity on the surface of the target (Ist) divided by 2.

IPC Classes  ?

• B23K 26/122 - Working by laser beam, e.g. welding, cutting or boring in a special environment or atmosphere, e.g. in an enclosure in a liquid, e.g. underwater
• B23K 26/356 - Working by laser beam, e.g. welding, cutting or boring for surface treatment by shock processing
• B23K 26/0622 - Shaping the laser beam, e.g. by masks or multi-focusing by direct control of the laser beam by shaping pulses
• B23K 26/064 - Shaping the laser beam, e.g. by masks or multi-focusing by means of optical elements, e.g. lenses, mirrors or prisms

Abstract

The disclosure relates to a method for characterizing biological particles in aerosol form, such as suspended in an ambient gas, by laser-induced breakdown spectrometry and an associated system.

IPC Classes  ?

• G01N 15/14 - Electro-optical investigation
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Abstract

A device tracking system for monitoring a target body structure and localizing a device inside the target body structure. The device tracking system includes: a control unit, a device having one steering element to be handled outside the target body structure and one steerable element to be introduced inside the target body structure, one probe to be removably secured to the patient, and one tracker to be secured to the steerable element. The control unit stores one ultrasound image of the target body structure. The probe and the tracker communicate, and the control unit is able to localize, in real time, the steerable element. The control unit displays, the stored ultrasound image and displays, in real time, the localisation of the at steerable element on the at least one ultrasound image.

IPC Classes  ?

• A61B 8/08 - Detecting organic movements or changes, e.g. tumours, cysts, swellings
• A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves

Abstract

A method for the selective cleavage of a compound comprising an aromatic ring and a C—O—C linkage in the presence of a heterogeneous catalyst is provided. The heterogenous catalyst may be a supported noble metal catalyst doped with a halogen selected from the group consisting of chlorine and bromine. By using this method, it is possible to increase the selectivity and/or yield (preferably both) of aromatic compounds.

IPC Classes  ?

• C08H 7/00 - Lignin; Modified lignin; High-molecular-weight products derived therefrom
• B01J 23/46 - Ruthenium, rhodium, osmium or iridium
• B01J 21/18 - Carbon
• B01J 27/13 - Platinum group metals
• B01J 21/08 - Silica
• B01J 23/44 - Palladium
• C07C 37/54 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions decreasing the number of carbon atoms by splitting polyaromatic compounds, e.g. polyphenolalkanes by hydrolysis of lignin or sulfite waste liquor
• C07C 1/22 - Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only oxygen atoms as hetero atoms by reduction

Abstract

A polymer of hyaluronic acid modified by the grafting thereto of at least one of the functions —SO3− and aromatic rings may be used as dopant for a polymer formed from one or monomers chosen from EDOT, ProDOT, and derivatives thereof. An aqueous suspension, or ink, and materials, in particular hydrogels, based on at least one PEDOT and/or PProDOT polymer may be doped by at least one such modified hyaluronic acid polymer. Such modified hyaluronic acid polymers may be used in bioelectronic or biosensor devices.

IPC Classes  ?

• C08B 37/08 - Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
• C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules
• C08L 65/00 - Compositions of macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain; Compositions of derivatives of such polymers
• C09D 11/52 - Electrically conductive inks
• C09D 11/102 - Printing inks based on artificial resins containing macromolecular compounds obtained by reactions other than those only involving unsaturated carbon-to-carbon bonds
• C08J 3/075 - Macromolecular gels

Abstract

A method for producing a vertical component comprising with the basis of a III-N material, comprising providing platelets made of the III-N material obtained by epitaxy on pads, the platelets comprise at least first and second layers doped and stacked on one another in a vertical direction. The method further includes the production of a first electrode and the production of a second electrode located on the platelet and configured such that a current passing from one electrode to the other passes through at least the second layer in all of its thickness, the thickness being taken in the vertical direction.

IPC Classes  ?

• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
• H01L 21/78 - Manufacture or treatment of devices consisting of a plurality of solid state components or integrated circuits formed in, or on, a common substrate with subsequent division of the substrate into plural individual devices
• H01L 29/78 - Field-effect transistors with field effect produced by an insulated gate
• H01L 29/66 - Types of semiconductor device
• H01L 29/872 - Schottky diodes
• H01L 29/868 - PIN diodes
• H01L 21/8252 - Manufacture or treatment of devices consisting of a plurality of solid state components or integrated circuits formed in, or on, a common substrate with subsequent division of the substrate into plural individual devices to produce devices, e.g. integrated circuits, each consisting of a plurality of components the substrate being a semiconductor, using III-V technology
• H01L 27/08 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including integrated passive circuit elements with at least one potential-jump barrier or surface barrier the substrate being a semiconductor body including only semiconductor components of a single kind
• H01L 27/085 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including integrated passive circuit elements with at least one potential-jump barrier or surface barrier the substrate being a semiconductor body including only semiconductor components of a single kind including field-effect components only

Abstract

A telecommunication cable including a core with a plurality of optical fibres, an inner reinforcement radially arranged around the core, the inner reinforcement having a plurality of steel wires, an intermediate sheath arranged radially between the core and the inner reinforcement, and a protective sheath made of polymer material arranged radially around the inner reinforcement. The cable further includes at least one optical fibre sensor arranged between the core and the protective sheath.

IPC Classes  ?

• G02B 6/44 - Mechanical structures for providing tensile strength and external protection for fibres, e.g. optical transmission cables
• G01B 11/16 - Measuring arrangements characterised by the use of optical techniques for measuring the deformation in a solid, e.g. optical strain gauge
• G01D 5/353 - Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable using optical means, i.e. using infrared, visible or ultraviolet light with attenuation or whole or partial obturation of beams of light the beams of light being detected by photocells influencing the transmission properties of an optical fibre

Abstract

A scanning confocal photon-reassignment microscope is configured to operate in a coherent (reflectance or transmission) imaging mode and having a confocal pinhole the diameter of which is between 2 and 4 Airy units. The microscope can be used to observe viral particles in suspension.

IPC Classes  ?

• G02B 21/00 - Microscopes
• G02B 21/33 - Immersion oils

Abstract

The present invention relates to the use of a multimeric protein of the peroxiredoxin family as a scaffold protein, characterized in that one or more proteins(s) of interest are linked to one or two N- and C-terminal end(s) of one or more monomers(s) of the peroxiredoxin, said peroxiredoxin having no redox activity.

IPC Classes  ?

• C12N 11/06 - Enzymes or microbial cells immobilised on or in an organic carrier attached to the carrier via a bridging agent
• C12N 9/08 - Oxidoreductases (1.), e.g. luciferase acting on hydrogen peroxide as acceptor (1.11)
• C12N 15/70 - Vectors or expression systems specially adapted for E. coli