Abstract

Chiral redox-polymers that have been enabled for electrochemically-controlled enantioselective interactions. Supramolecular chirality was leveraged for enhancing recognition toward target enantiomers. Chiral redox-metallopolymers were synthesized based on Ugi's amine-inspired chiral monomers, and their enantioselective recognition toward ionic enantiomers, such as tryptophan and naproxen, is demonstrated, with higher enhancement provided by a chiral redox-polymer over a single-site, chiral building block. 2D nuclear magnetic resonance spectroscopy and solid-state circular dichroism support supramolecular chirality resulting from the intramolecular interaction between the ferrocene and the alkyl group in the backbone. The chiral redox-metallopolymers can be used as a platform for electrochemically-modulated enantioselective interactions toward a range of amino acids and pharmaceutical carboxylates.

IPC Classes  ?

• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials

Abstract

Methods are provided herein for training and using models to generate semantically representative continuous vectors for input mathematical expressions. These methods result in models that output continuous vectors that are nearby in an embedding space for equations that are mathematically equivalent but differently written. Such continuous vectors can be used to facilitate indexing and searching of databases of mathematical equations, e.g., to facilitate semantically-aware searching of databases of mathematical texts for equations that are mathematically equivalent to, or mathematically similar to, input query expressions. These training methods include training an encoder together with a decoder to predict pairs of mathematically equivalent but different training expressions, with the output of the encoder being the continuous vector that represents the semantic mathematical content of the pair of training expressions. Also provided are methods for efficiently generating such pairs of mathematically equivalent but different training expressions.

IPC Classes  ?

• G06N 3/0455 - Auto-encoder networks; Encoder-decoder networks
• G06N 3/044 - Recurrent networks, e.g. Hopfield networks
• G06N 3/0475 - Generative networks
• G06N 3/048 - Activation functions

Abstract

New synthetic methods to provide access to previously unexplored functionality at the C8 position of substituted imidazo[5,1-d][1,2,3,5]tetrazines of Formula I. Through synthesis and evaluation of a suite of compounds with a range of aqueous stabilities (from 0.5 to 40 hours), a predictive model for imidazotetrazine hydrolytic stability based on the Hammett constant of the C8 substituent was derived. Promising compounds were identified that possess activity against a panel of GBM cell lines, appropriate hydrolytic and metabolic stability, and brain-to-serum ratios dramatically elevated relative to TMZ, leading to lower hematological toxicity profiles and superior activity to TMZ in a mouse model of GBM. New synthetic methods to provide access to previously unexplored functionality at the C8 position of substituted imidazo[5,1-d][1,2,3,5]tetrazines of Formula I. Through synthesis and evaluation of a suite of compounds with a range of aqueous stabilities (from 0.5 to 40 hours), a predictive model for imidazotetrazine hydrolytic stability based on the Hammett constant of the C8 substituent was derived. Promising compounds were identified that possess activity against a panel of GBM cell lines, appropriate hydrolytic and metabolic stability, and brain-to-serum ratios dramatically elevated relative to TMZ, leading to lower hematological toxicity profiles and superior activity to TMZ in a mouse model of GBM.

IPC Classes  ?

• C07D 487/04 - Ortho-condensed systems
• A61K 9/20 - Pills, lozenges or tablets
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61K 31/495 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
• A61K 47/02 - Inorganic compounds
• A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
• A61K 47/36 - Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

Abstract

The present disclosure provides a system for monitoring unstructured environments. A predetermined path can be determined according to an assignment of geolocations to one or more agronomically anomalous target areas, where the one or more agronomically anomalous target areas are determined according to an analysis of a plurality of first images that automatically identifies a target area that deviates from a determination of an average of the plurality of first images that represents an anomalous place within a predetermined area, where the plurality of first images of the predetermined area are captured by a camera during a flight over the predetermined area. A camera of an unmanned vehicle can capture at least one second image of the one or more agronomically anomalous target areas as the unmanned vehicle travels along the predetermined path.

IPC Classes  ?

• G05D 1/00 - Control of position, course, altitude, or attitude of land, water, air, or space vehicles, e.g. automatic pilot
• G06F 16/29 - Geographical information databases
• G06F 18/21 - Design or setup of recognition systems or techniques; Extraction of features in feature space; Blind source separation
• G06V 10/22 - Image preprocessing by selection of a specific region containing or referencing a pattern; Locating or processing of specific regions to guide the detection or recognition
• G06V 10/762 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using clustering, e.g. of similar faces in social networks
• G06V 10/778 - Active pattern-learning, e.g. online learning of image or video features
• G06V 20/10 - Terrestrial scenes
• G06V 20/17 - Terrestrial scenes taken from planes or by drones
• G08G 5/00 - Traffic control systems for aircraft

Abstract

Disclosed herein are antibacterial compounds that accumulate in Gram-negative bacteria, methods of preparing the compounds, and methods of using the compounds to inhibit or kill microbes, and methods of treating microbial infections, such as Gram-negative bacterial infections. Compounds selected for conversion to potential Gram-negative antibacterial compounds were identified based on compounds having low globularity and low flexibility. Amine substituents were then strategically added to the selected compounds to provide compounds having antibacterial activity against Gram-negative bacteria.

IPC Classes  ?

• C07D 409/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
• A61P 31/04 - Antibacterial agents
• C07D 471/04 - Ortho-condensed systems
• C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or

Abstract

The present invention is a multivalent immunogenic composition for immunizing an animal against filariasis. In some aspects, the antigens of the multivalent immunogenic composition are protein-based, DNA-based, or a combination thereof. This invention also provides a method and kit for detecting a filarial nematode and determining vaccine efficacy.

IPC Classes  ?

• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61P 33/00 - Antiparasitic agents
• C07K 14/435 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans

Abstract

Compositions and methods for eliciting an immune response in a subject (such as against Shigella) are provided. In examples, the compositions can include fusion proteins including one or more epitopes from Shigella or E. coli. In examples, the methods can include administering a disclosed fusion protein to a subject.

IPC Classes  ?

• A61K 39/112 - Salmonella; Shigella
• A61K 39/108 - Escherichia; Klebsiella
• A61P 31/04 - Antibacterial agents
• C07K 14/245 - Escherichia (G)
• C07K 14/25 - Shigella (G)

Abstract

Novel Fusidic Acid (FA) based compounds that have equivalent potency against clinical isolates of Staphylococcus aureus (S. aureus) and Enterococcus faecium (E. faecium) as well as an improved resistance profile in vitro when compared to FA. Importantly, the new compounds display efficacy against a FA-resistant strain of Staphylococcus aureus in a soft-tissue murine infection model. This disclosure delineates the structural features of FA necessary for potent antibiotic activity and demonstrates that the resistance profile can be improved for this scaffold and target.

IPC Classes  ?

• C07J 13/00 - Normal steroids containing carbon, hydrogen, halogen, or oxygen, having a carbon-to-carbon double bond from or to position 17
• A61P 31/04 - Antibacterial agents
• C07J 41/00 - Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring

Abstract

Described herein are systems and methods which utilize an array of wells to rapidly detect target analytes from whole blood samples, even at very low concentrations. The provided systems and methods dry the blood sample to ensure a fluidic network forms in one or more dry blood sample islands and liquid with reagents useful for detecting nucleic acid sequences from a target analyte, including by amplification reactions that are bi-phasic because of the interaction between the solid dried blood sample phase and the liquid phases, including liquid having reagents that are able to fluidically and diffusively exchange with the fluidic network within the dried blood sample phase.

IPC Classes  ?

• C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12Q 1/6895 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
• G01N 1/44 - Sample treatment involving radiation, e.g. heat

Abstract

A method of maintaining lateral lane position of a vehicle traveling on a roadway includes detecting a magnetic field from a surface of the roadway, where the surface includes a magnetic or magnetized material, and adjusting a lateral position of the vehicle on the roadway such that the magnetic field has a maximum signal at a predetermined location on the vehicle, e.g., at or near a centerline of the vehicle. The magnetic or magnetized material may be localized to a longitudinal segment of the surface approximately centered between lane lines or at another desired location. Detection of the magnetic field may take place continuously while the vehicle is moving.

IPC Classes  ?

• B60W 30/12 - Lane keeping

Abstract

Systems and methods for hardware-based asynchronous logging include: initiating first and second atomic regions on first and second cores of a central processing unit (CPU); and asynchronously logging data for the first atomic region and the second atomic region using the CPU by: asynchronously performing log persist operations (LPOs) to log an old data value from each atomic region; updating the old data value to a new data value from each atomic region; tracking dependencies between the first atomic region and the second atomic region using a memory controller; asynchronously performing data persist operations (DPOs) to persist the new data value for each atomic region; and committing the first atomic region and the second atomic region based on the dependencies using the memory controller of the CPU.

IPC Classes  ?

• G06F 3/06 - Digital input from, or digital output to, record carriers

Abstract

Disclosed herein are methods and systems that use a photonic crystal (PC) for interference scattering microscopy. Incident light is directed onto a surface of the PC and couples into a photonic crystal guided resonance (PCGR) mode of the PC such that less than 1% of the incident light is transmitted through the PC as transmitted light. One or more particles adjacent to the surface of the PC scatter a portion of the light coupled into the PCGR mode as scattered light. An image comprising a pattern of constructive and destructive interference between the transmitted light and the scattered light is formed, and an image sensor may capture one or more image frames of the image Imaging processing of the one or more image frames can be used to identify at least one scattering center corresponding to at least one particle of the one or more particles.

IPC Classes  ?

• G02B 21/00 - Microscopes

Abstract

An imaging substrate is provided to facilitate wide field photothermal infrared spectroscopic imaging of samples disposed thereon. The substrate includes at least two reflective layers and at least one spacer layer disposed therebetween which, together, form an optical cavity. The spacer layer(s) exhibit expansion and/or refractive index change as a function of heating by incident infrared illumination. Such localized heating results in a localized change in the effective reflectivity of the substrate by locally tuning/detuning the optical cavity. Thus, the pattern of effective reflectivity of the substrate can be made to correspond to the pattern of infrared absorptivity of a sample mounted on the substrate by illuminating the sample and the substrate with infrared illumination. The pattern of effective reflectivity can then be imaged, from the opposite side of the substrate from the sample and the incident infrared illumination, using a wide field microscope or other imaging

IPC Classes  ?

• G01N 21/35 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light

Abstract

Provided herein are systems that provide a genetic program to control bacterial life cycle and function execution, thereby conferring programmable microbial transition between planktonic and biofilm states and facilitating the development of cellular functions across physiological domains.

IPC Classes  ?

• C12N 15/63 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
• C12N 1/20 - Bacteria; Culture media therefor
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C12N 9/22 - Ribonucleases
• C12N 9/28 - Alpha-amylase from microbial source, e.g. bacterial amylase
• C12N 9/38 - Hydrolases (3.) acting on glycosyl compounds (3.2) acting on beta-galactose-glycoside bonds, e.g. beta-galactosidase
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof
• C12N 15/74 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora

Abstract

The neural network includes layers, and the layers each include a plurality of units, the plurality of units each have a weight coefficient associated with each input to a unit, and an importance parameter indicating importance of the weight coefficient. The method includes: in learning of a task, adjusting a first weight coefficient based on the importance parameter of the first weight coefficient and a first gradient of the first weight coefficient determined using a training set; and after the learning has been completed, determining, based on the training set, respective second gradients of a plurality of second weight coefficients included in a first layer including the first weight coefficient, and calculating the importance parameter of the first weight coefficient to be used in learning of a next task based on the respective second gradients.

IPC Classes  ?

• G06N 3/04 - Architecture, e.g. interconnection topology
• G06N 3/08 - Learning methods

Abstract

Compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods of use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells. The disclosed drug combinations can have lower neurotoxicity effects than other cancer therapies that achieve the same or similar therapeutic effect.

IPC Classes  ?

• A61K 31/495 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/20 - Pills, lozenges or tablets
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61K 31/4188 - 1,3-Diazoles condensed with heterocyclic ring systems, e.g. biotin, sorbinil
• A61K 31/53 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
• A61K 47/10 - Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers

Abstract

Magnetic resonance imaging systems and methods are provided for time-efficiently producing a plurality of image contrasts, the plurality of image contrasts including a first contrast being coupled with a second contrast and acquired over a plurality of key parameters that govern the second contrast to which the first contrast is coupled. In addition, the plurality of image contrasts is used to simultaneously map the first contrast, the second contrast, and additional contrasts.

IPC Classes  ?

• G01R 33/563 - Image enhancement or correction, e.g. subtraction or averaging techniques of moving material, e.g. flow-contrast angiography
• G01R 33/50 - NMR imaging systems based on the determination of relaxation times
• G01R 33/561 - Image enhancement or correction, e.g. subtraction or averaging techniques by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences

Abstract

The invention relates to FcRn polypeptides, to antibodies and related fragments thereof containing the FcRn polypeptides, to production of said antibodies and fragments and to use of said antibodies and fragments for therapy of various conditions.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 35/74 - Bacteria

Abstract

A method of measuring temperature includes positioning an optical fiber in contact with an object or in an environment having a temperature to be determined, where the optical fiber comprises a core surrounded by a cladding; the core comprises an alkaline-earth fluorosilicate glass including defects, and the cladding comprises a silica glass. Infrared light is supplied to the optical fiber, thereby electronically exciting the defects. Green light emitted from the defects is detected, and an intensity value of the green light is obtained and converted to a temperature value for the optical fiber, whereby the temperature of the object or environment is determined. The green light may be detected along a length of the optical fiber, and a plurality of intensity values may be converted to a plurality of temperature values along the fiber length, thereby obtaining a distributed measurement of the temperature of the object or environment.

IPC Classes  ?

• G01K 11/3213 - Measuring temperature based on physical or chemical changes not covered by group , , , or using changes in transmittance, scattering or luminescence in optical fibres at discrete locations in the fibre, e.g. using Bragg scattering using changes in luminescence, e.g. at the distal end of the fibres

Abstract

The current disclosure provides a simple single-step room temperature Activate Cleave and Count (ACC) assay coupled to Photonic Resonator Absorption Microscopy (PRAM) in an amplification-free approach. The assay, and associated system and method disclosed herein allow for detection of viral and bacterial pathogens as well disease such as cancer at the point of care.

IPC Classes  ?

• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
• C12Q 1/6818 - Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer

Abstract

Systems and methods for phase-sensitive optical coherence tomography (“OCT”) and/or optical coherence microscopy (“OCM”) include imparting multiple phase shifts to the object beam, the reference beam, or both in an interferometer. Phase shifts can be imparted to the S-polarization and/or P-polarization modes of the object and/or reference beams. As an example, phase shifts can be imparted to the reference beam in the reference arm using a waveplate or other phase shifter. A non-polarizing beamsplitter can provide additional phase shifts to light reflected by the beamsplitter. Full field OCM can be provided by imaging the phase-shifted channels using an image sensor.

IPC Classes  ?

• G02B 21/00 - Microscopes
• G01B 9/02091 - Tomographic interferometers, e.g. based on optical coherence

Abstract

A plasma lamp is provided that employs excitation transfer between two atomic or molecular species so as to preferentially produce light at a specific atomic or molecular emission wavelength. The lamp includes a lamp body. The lamp body includes a top portion, a middle portion having an internal hollow space filled with an energy-donor chemical gas and an energy-acceptor chemical element, and a bottom portion. The lamp body further includes an array of a plurality of cavities connected to the internal hollow space. The internal hollow space and the array of the plurality of cavities are spaced apart from outer surfaces of the lamp body. The plasma lamp is configured to excite the energy-donor chemical gas by an ignition of a low-temperature plasma within the internal hollow space and the array of the plurality of cavities to cause an excitation transfer from the excited energy-donor chemical gas to the energy-acceptor chemical element, thereby emitting radiation having a wavelength of about 194 nm when mercury (Hg) is the energy-acceptor chemical element and helium (He) serves as the donor. Other wavelengths in the ultraviolet (UV) and vacuum ultraviolet (VUV) spectral regions are generated when other donor and acceptor atoms or molecules are employed. These lamps are well-suited as optical drivers for atomic clocks (such as the 40.5 GHz Hg ion clock), photochemical processing of materials, disinfection of water, air, and surfaces, as well as other applications requiring UV or VUV light.

IPC Classes  ?

• H01J 61/20 - Selection of substances for gas fillings; Specified operating pressure or temperature having a metallic vapour as the principal constituent mercury vapour
• H01J 61/06 - Main electrodes
• H01J 61/16 - Selection of substances for gas fillings; Specified operating pressure or temperature having helium, argon, neon, krypton, or xenon as the principle constituent
• H01J 61/35 - Vessels; Containers provided with coatings on the walls thereof; Selection of materials for the coatings

Abstract

Embodiments of compositions and methods for the treatment of blood disorders and malignancies in a subject are described herein. In one embodiment, a composition for the treatment of a blood disorder or a malignancy in a subject comprises decitabine, tetrahydrouridine, and an excipient. In another embodiment, a method for the treatment of a blood disorder or a malignancy in a subject comprises the oral administration of a composition comprising decitabine and tetrahydrouridine. In some examples, the composition may be administered 1-3 times weekly.

IPC Classes  ?

• A61K 31/7068 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

Aspects of the subject disclosure may include, for example, obtaining video data from a single monocular camera, wherein the video data comprises a plurality of frames, wherein the camera is attached to a mobile robot that is travelling along a lane defined by a row of crops, wherein the row of crops comprises a first plant stem, and wherein the plurality of frames include a depiction of the first plant stem; obtaining robot velocity data from encoder(s), wherein the encoder(s) are attached to the robot; performing foreground extraction on each of the plurality of frames of the video data, wherein the foreground extraction results in a plurality of foreground images; and determining, based upon the plurality of foreground images and based upon the robot velocity data, an estimated width of the first plant stem. Additional embodiments are disclosed.

IPC Classes  ?

• G05D 1/02 - Control of position or course in two dimensions
• H04W 4/40 - Services specially adapted for particular environments, situations or purposes for vehicles, e.g. vehicle-to-pedestrians [V2P]
• G06N 20/10 - Machine learning using kernel methods, e.g. support vector machines [SVM]
• G06V 20/10 - Terrestrial scenes
• G06V 20/40 - Scenes; Scene-specific elements in video content
• G06F 18/214 - Generating training patterns; Bootstrap methods, e.g. bagging or boosting

Abstract

The disclosure includes a multiplexed telecommunication-band quantum network that utilizes atomic arrays in optical cavities. An example quantum networking system includes at least one quantum repeater node. The quantum repeater node includes an array of neutral atoms disposed in an optical cavity and a fiber-optic switch (FOS). The FOS is optically coupled to the optical cavity. The quantum repeater node also includes at least one beamsplitter. The at least one beamsplitter is optically coupled to the FOS.

IPC Classes  ?

• H04Q 11/00 - Selecting arrangements for multiplex systems
• H04B 10/70 - Photonic quantum communication

Abstract

A structural component for a vehicle includes a component including an interior surface defining a first hollow passage and a structural reinforcement contacting the interior surface of the component. The structural reinforcement and component define a cross-section and the structural reinforcement partially fills the cross-section. A process for forming the structural component including inserting a bladder into the first hollow passage defined by the interior surface of the component and inflating the bladder in the first hollow passage, forming a cavity between the bladder and the interior surface, filling the cavity with a polymer resin, and foaming the polymer resin. A system for forming a structural component for a vehicle includes a component including a first hollow passage defined by an interior surface of the component, a bladder insertable into the first hollow passage of the component, and a supply line connected to an interior of the bladder.

IPC Classes  ?

• B62D 25/04 - Door pillars
• B29C 44/58 - Moulds
• B29C 44/18 - Filling preformed cavities

Abstract

A structural component for a vehicle and a process and system for forming the structural component. A first cavity is formed in a first hollow passage between a first bladder and an interior surface of a component forming the structural component. A first structural reinforcement layer is formed in the first cavity by filling the first cavity with a first polymer resin and foaming the first polymer resin to form a first polymer resin foam. A second cavity is formed in the first hollow passage and a second structural reinforcement layer is formed in the second cavity by filling the second cavity with a second polymer resin and foaming the second polymer resin to form a second polymer resin foam.

IPC Classes  ?

• B32B 5/32 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by the presence of two or more layers which comprise fibres, filaments, granules, or powder, or are foamed or specifically porous both layers being foamed or specifically porous
• B32B 5/20 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by features of a layer containing foamed or specifically porous material foamed in situ
• B32B 7/12 - Interconnection of layers using interposed adhesives or interposed materials with bonding properties
• B32B 1/08 - Tubular products
• B32B 37/00 - Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding
• B32B 37/15 - Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by the properties of the layers with at least one layer being manufactured and immediately laminated before reaching its stable state, e.g. in which a layer is extruded and laminated while in semi-molten state
• B29C 44/18 - Filling preformed cavities
• B29C 44/34 - Component parts, details or accessories; Auxiliary operations

Abstract

An example embodiment may involve obtaining text-based, ground truth electronic health records (EHRs), wherein the ground truth EHRs specify a sequence of medical visits involving a plurality of modalities, and wherein each of the medical visits specifies tokens representing at least one of the modalities; generating a training data set by perturbing the ground truth EHRs, wherein perturbing the ground truth EHRs involves deleting or shuffling some of the tokens in the ground truth EHRs; and iteratively applying a machine learning trainer application to the training data set, wherein the machine learning trainer application includes: (i) a bidirectional language model encoder that takes EHRs within the training data set and produces vector embeddings therefrom, (ii) an autoregressive language model decoder that takes the vector embeddings and infers predicted EHRs therefrom, and (iii) a loss function that compares the predicted EHRs to their corresponding ground truth EHRs.

IPC Classes  ?

• G06F 21/62 - Protecting access to data via a platform, e.g. using keys or access control rules
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records

Abstract

The present disclosure provides systems and methods that can provide portable, real-time accessible DNA memories. An example DNA-based data storage system includes a loading region configured to receive a plurality of DNA-based data storage elements in a suspension fluid and a plurality of microtubes disposed in a capture/release region. The microtubes are configured to capture and release the DNA-based data storage elements. The DNA-based data storage system also includes a linearization region configured to linearize the DNA-based data storage elements and a readout region with a readout device configured to provide information indicative of the respective DNA-based data storage elements.

IPC Classes  ?

• G06N 3/123 - DNA computing
• C12N 7/00 - Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof

Abstract

Methods of RNA-guided DNA endonuclease-mediated genome editing in Bacteria and Archaea are provided.

IPC Classes  ?

• C12N 15/90 - Stable introduction of foreign DNA into chromosome
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• C12N 15/63 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression

Abstract

Systems and methods for ultrafast imaging include: a memory having stored thereon a delay profile matrix and a field programmable gate array (FPGA) coupled with the memory. The delay profile matrix comprises a two-dimensional matrix in which each row corresponds to a delay profile at a particular depth. The FPGA is configured to: acquire radio frequency (RF) ultrasound data from a subject; load a delay profile from the delay profile matrix to a memory buffer of the FPGA, wherein the delay profile corresponds to a particular depth; read a first row of the RF ultrasound data based on a first delay value of the delay profile; generate beamformed data at the particular depth by beamforming the first row of RF ultrasound data; and generate an image of the subject based on the beamformed data.

IPC Classes  ?

• G01S 7/52 - RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES - Details of systems according to groups , , of systems according to group
• G01S 15/89 - Sonar systems specially adapted for specific applications for mapping or imaging

Abstract

Disclosed herein are compositions comprising: 4-phenylbutyrate (PBA) or a pharmaceutically acceptable salt thereof in an effective concentration as a therapeutic or prophylactic agent against viral infections, e.g., herpes simplex vims (HSV) infections. Also provided are methods for treating a disease or disorder in a subject, such as a viral infection (e.g., HSV infection), comprising administering to the subject a therapeutically or prophylactically effective amount of 4-phenylbutyrate (PBA) or a pharmaceutically acceptable salt thereof.

IPC Classes  ?

• A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
• A61P 31/22 - Antivirals for DNA viruses for herpes viruses
• A61K 31/522 - Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
• A61K 31/7072 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

A solution-phase processed vertical Schottky diode comprises a stack of films on a substrate, where the stack of films includes: a first electrode film comprising a noble metal; a first semiconducting film on the first electrode film, where the first semiconducting film comprises zinc oxide doped with an electron donor metal at a first dopant concentration; a second semiconducting film on the first semiconducting film, where the second semiconducting film comprises zinc oxide doped with the electron donor metal at a second dopant concentration higher than the first dopant concentration; and a second electrode film on the second semiconducting film, where the second electrode film comprises a noble metal.

IPC Classes  ?

• H01L 29/66 - Types of semiconductor device
• H01L 29/872 - Schottky diodes

Abstract

A system for redox polymer electrodialysis includes: a first electrode; a second electrode positioned in opposition to the first electrode; a pair of size-exclusion membranes positioned between the first and second electrodes; an ion exchange membrane positioned between the pair of size-exclusion membranes, the ion exchange membrane defining a feed channel and an accumulating channel between the size-exclusion membranes; and a redox channel containing the first and second electrodes and being separated from the feed and/or accumulating channels by the pair of size-exclusion membranes.

IPC Classes  ?

• C02F 1/469 - Treatment of water, waste water, or sewage by electrochemical methods by electrochemical separation, e.g. by electro-osmosis, electrodialysis, electrophoresis
• B01D 61/46 - Apparatus therefor
• B01D 61/02 - Reverse osmosis; Hyperfiltration
• B01D 71/10 - Cellulose; Modified cellulose
• B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
• C02F 1/44 - Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis

Abstract

An osmotically-active closed-cell composite comprises a closed-cell structure including fluid-filled cells separated by cell walls, where the fluid-filled cells comprise water and a solute, and the cell walls comprise a polymer permeable to water and impermeable to the solute. The closed-cell structure is configured to undergo osmotically-induced swelling during exposure to an aqueous environment having a different chemical potential from the fluid-filled cells.

IPC Classes  ?

• C12N 5/04 - Plant cells or tissues

Abstract

The present disclosure describes compositions of matter comprising a ribonucleoprotein complex comprising a nucleic acid-guided nuclease and a guide RNA, and further comprising and a blocking nucleic acid molecule represented by Formula IV, wherein Formula IV in the 5′-to-3′ direction comprises: T-D-M-A-Lp-C; wherein T is 17-31 nucleotides in length; D is 0-15 nucleotides in length; M is 1-25 nucleotides in length; A is 0-15 nucleotides in length and comprises a sequence complementary to D; and L is 3-25 nucleotides in length; p is 0 or 1; C is 4-15 nucleotides in length and comprises a sequence complementary to T; and wherein the blocking nucleic acid molecule comprises a sequence complementary to a gRNA.

IPC Classes  ?

• C12Q 1/6823 - Release of bound markers
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
• C12Q 1/682 - Signal amplification
• C12N 9/22 - Ribonucleases

Abstract

The present disclosure provides prime editors, editor systems and methods of uses thereof. Specifically, the disclosure provides methods of use of split prime editors for editing genomic DNA.

IPC Classes  ?

• C12N 15/90 - Stable introduction of foreign DNA into chromosome
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof
• C12N 9/22 - Ribonucleases
• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)

Abstract

A unique class of perfluorocarbon-free Dextran-based oxygen nanobubbles (DONBs) and formulations thereof. The critical components in the formulation are chosen among the U.S. Food, and Drug Administration's (FDA) approved compounds, which provide a biocompatible environment for incorporating pharmaceutical agents. Moreover, the nanobubbles are fabricated with simple sonication and homogenization method that easily fulfills the current good manufacturing practices (cGMP) requirements, which will promote scaleup production for commercial manufacturing. The formulated DONBs release oxygen over an extended period to keep the partial pressure of oxygen within the inner retina high and thus preserve retinal tissue from ischemia.

IPC Classes  ?

• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61P 27/02 - Ophthalmic agents
• A61K 9/51 - Nanocapsules

Abstract

A method of spontaneously patterning a polymer during frontal polymerization includes activating an initiation region of a monomer solution to reaction to initiate a polymerization reaction. A polymerization front is generated and propagates through the monomer solution in a radial or longitudinal direction away from the initiation region. The monomer solution is spontaneously heated downstream of the polymerization front by thermal transport away from the polymerization reaction. Once a localized region of the monomer solution reaches a temperature sufficient for spontaneous initiation of another polymerization reaction, a new polymerization front is generated and propagates through the monomer solution in a circumferential or transverse direction. The spontaneous heating of the monomer solution downstream of the polymerization front and the initiation of another polymerization reaction occurs cyclically, producing multiple new polymerization fronts and spatial variations in reaction temperature across the monomer solution. Once polymerization is complete, a spontaneously patterned polymer is formed.

IPC Classes  ?

• C08G 61/08 - Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes only aliphatic carbon atoms prepared by ring-opening of carbocyclic compounds of carbocyclic compounds containing one or more carbon-to-carbon double bonds in the ring

Abstract

An isolated nucleic acid that includes an open reading frame encoding a lanthipeptide protease polypeptide for scarless tag removal from a polypeptide is presented. Reagents, expression constructs and methods are also provided for preparing a scarless tag polypeptide product from a tagged polypeptide precursor containing a lanthipeptide protease cleavage site. The reagents are directed to novel lanthipeptide proteases and expression constructs and polypeptide precursors that include highly specific lanthipeptide protease substrate recognition sequence. Methods are provided that enable scarless tag removal from a cognate lanthipeptide, a non-cognate lanthipeptide or a heterologous polypeptide that includes extraneous amino acid sequences, such as leader peptides and tags.

IPC Classes  ?

• C12N 9/52 - Proteinases derived from bacteria
• C07K 14/195 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
• C07K 14/315 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
• C07K 14/32 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
• C12P 21/06 - Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
• C12P 21/02 - Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
• C07K 14/31 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
• C12N 15/62 - DNA sequences coding for fusion proteins

Abstract

The present disclosure provides assay containers, sets of containers, portable diagnostic devices, methods of detecting target nucleic acid molecules in a sample, and methods of diagnosing infections, such as COVID-19 infections, in a subject.

IPC Classes  ?

• C12Q 1/6844 - Nucleic acid amplification reactions
• C07K 14/195 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

Abstract

Provided herein are compositions and methods for the fermentative production of 2,3-butanediol (2,3-BDO), compositions and methods for making methyl ethyl ketone (MEK), and methods of inducing drought tolerance in plants.

IPC Classes  ?

• C12P 7/04 - Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
• C12N 9/04 - Oxidoreductases (1.), e.g. luciferase acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• C12N 9/16 - Hydrolases (3.) acting on ester bonds (3.1)
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C12N 9/88 - Lyases (4.)
• A01N 63/32 - Yeast
• A01P 21/00 - Plant growth regulators

Abstract

A generator-rectifier system and grid interface includes an active rectifier configured to accept an input from one of a plurality of ac ports of a multi-port permanent magnet synchronous generator. Passive rectifiers are connected to the others of the plurality of ac ports. Connections provide outputs of the active rectifier and the passive rectifiers. A first converter is controlled at a fixed duty ratio driven by the outputs to interface with a dc grid or at a low grid frequency switching waveform to create a grid frequency ac output to interface with an ac grid. A second converter is connected the output of the active rectifier, the second converter being controlled at a variable duty ratio to interface with the dc grid or an above grid frequency switching waveform to create an above grid frequency ac waveform to interface with an ac grid. Connections provide a serial stack of outputs of the first and second converters.

IPC Classes  ?

• H02J 3/38 - Arrangements for parallelly feeding a single network by two or more generators, converters or transformers
• H02M 7/219 - Conversion of ac power input into dc power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only in a bridge configuration
• H02M 3/335 - Conversion of dc power input into dc power output with intermediate conversion into ac by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate ac using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only
• H02M 1/00 - APPARATUS FOR CONVERSION BETWEEN AC AND AC, BETWEEN AC AND DC, OR BETWEEN DC AND DC, AND FOR USE WITH MAINS OR SIMILAR POWER SUPPLY SYSTEMS; CONVERSION OF DC OR AC INPUT POWER INTO SURGE OUTPUT POWER; CONTROL OR REGULATION THEREOF - Details of apparatus for conversion

Abstract

An energetic composition and a method of unzipping polymer binders are disclosed, which includes localizing a heat feedback just near the reaction front by unzipping polymer binders employed to a nanothermite. The energetic composition includes an unzipping polymer binder employed to high load fuel and oxidizer particles.

IPC Classes  ?

• C06B 33/02 - Compositions containing particulate metal, alloy, boron, silicon, selenium or tellurium with at least one oxygen supplying material which is either a metal oxide or a salt, organic or inorganic, capable of yielding a metal oxide with an organic non-explosive or an organic non-thermic component
• C06B 47/02 - Compositions in which the components are separately stored until the moment of burning or explosion, e.g. "Sprengel"-type explosives; Suspensions of solid component in a normally non-explosive liquid phase, including a thickened aqueous phase the components comprising a binary propellant
• C06B 23/00 - Compositions characterised by non-explosive or non-thermic constituents

Abstract

Miscanthus x giganteus is a widely recognized bioenergy crop that finds potential applications in a biorefinery for the production of a wide range of biofuels and biochemicals. This disclosure focuses upon the quantification of the total anthocyanin concentration in miscanthus. Hydrothermal pretreatment was studied for recovering anthocyanins in the pretreatment liquor. The optimized pretreatment conditions (170° C., 10 min) led to a recovery of 94.3±1.5% w/w of the total anthocyanin concentration and also improved the enzymatic digestibility of the biomass, allowing recovery of 70.6±0.5% w/w of glucose at the end of 72 h of enzymatic saccharification. The sugar monomers obtained after the enzymatic hydrolysis of the pretreated biomass could be used for the production of biofuels or biochemicals in an integrated biorefinery.

IPC Classes  ?

• B01D 11/02 - Solvent extraction of solids
• C13K 1/02 - Glucose; Glucose-containing syrups obtained by saccharification of cellulosic materials
• C12N 9/42 - Hydrolases (3.) acting on glycosyl compounds (3.2) acting on beta-1, 4-glucosidic bonds, e.g. cellulase

Abstract

The present disclosure relates generally to data storage using DNA sequences comprising synthetic nucleotides. In particular, the disclosure provides for a DNA data storage system comprising a covalently linked sequence of nucleotides, wherein the sequence of nucleotides comprises a modification region, wherein the nucleotides comprise synthetic nucleotides.

IPC Classes  ?

• G11C 13/02 - Digital stores characterised by the use of storage elements not covered by groups , , or using elements whose operation depends upon chemical change
• G16B 50/30 - Data warehousing; Computing architectures
• G16B 40/00 - ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
• G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids
• C12Q 1/6869 - Methods for sequencing

Abstract

A robotic surgical station is disclosed having a wheeled base, a partial-ring shaped structure slidably coupled to the based to be rotatable relative to the base about a horizontal roll axis passing through a center of the ring shape, a patient's bed restrained to a first arcuate segment of the partial-ring shaped structure at a first mount, a plurality of robotic arms restrained to a second arcuate segment of the partial-ring shaped structure at a second mount, and a remote control unit to command one or more of the plurality of robotic arms. The second arcuate segment is rotatable sideways with respect to the first arcuate segment to allow full access to the patient's bed by a surgeon.

IPC Classes  ?

• A61B 34/37 - Master-slave robots
• A61B 90/50 - Supports for surgical instruments, e.g. articulated arms
• B25J 9/16 - Programme controls

Abstract

The present disclosure relates to polynucleotide nanostructures and techniques that use polynucleotide nanostructures as biomolecular recognition entities for detecting viral infections, e.g. Covid-19, and other disease. For example, an artificial biopolymer complex can include a network of polynucleotides including structural units connected to one another via a series of arms and junctions, e.g. in the form of a DNA Star. Intersections of three or more arms form the junctions at a predetermined distance from one another. The artificial biopolymer complex further includes binders, e.g. aptamers, attached to the network of polynucleotides that can bind to antigens of a target analyte. The binders are attached at loci on one or more of the arms forming the junctions. The loci are separated by predetermined inter¬binder distances such that the binders are positioned on the network of polynucleotides in a predetermined two-dimensional or three-dimensional spatial pattern that matches a two-dimensional or three-dimensional spatial pattern of the antigens on the target analyte. The nucleic acid oligonucleotides, e.g. the aptamers, from which the nanostructure is formed may be labelled with fluorophores and/or quenchers to detect the binding to a target.

IPC Classes  ?

• G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
• G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

Plasma-Activated liquids and methods of using the same are described. In one aspect, a method of manufacturing an integrated circuit includes activating a photolithography liquid with a plasma; and treating a device component with the activated photolithography liquid. In one example, the photolithography liquid is a photoresist. Activating the photoresist liquid may impart reactive species to the photoresist.

IPC Classes  ?

• G03F 7/42 - Stripping or agents therefor
• G03F 7/32 - Liquid compositions therefor, e.g. developers
• H01L 21/027 - Making masks on semiconductor bodies for further photolithographic processing, not provided for in group or
• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
• H01L 21/311 - Etching the insulating layers

Abstract

The disclosure provides an example electrosurgical system and methods for use thereof. The electrosurgical system includes a high-frequency inverter (“HFI”) having a full bridge and a control system electrically coupled to the HFI. The control system controls output parameters including one or more of an output power Pout(t) and an output voltage or current by varying power reference Pref(t) or switch states of the HFI. The control system causes a power adaptation ΔP(t) to a preset power set Pset based on receiving at least one of impedance feedback and thermal feedback according to the following relationship: Pref(t)=Pset+ΔP(t).

IPC Classes  ?

• A61B 18/12 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
• A61B 18/14 - Probes or electrodes therefor
• A61B 18/16 - Indifferent or passive electrodes for grounding

Abstract

A hydrophobic, self-healing coating includes a vitrimer film having a silicone polymer network crosslinked with dynamic covalent bonds including a boronic ester, where the vitrimer film has a thickness of less than 1000 nm, and where the dynamic covalent bonds provide a mechanism for self-healing of the vitrimer film.

IPC Classes  ?

• C09D 183/04 - Polysiloxanes
• C09D 5/16 - Anti-fouling paints; Underwater paints
• C09D 7/20 - Diluents or solvents
• C09D 7/61 - Additives non-macromolecular inorganic
• C08G 77/398 - Polysiloxanes modified by chemical after-treatment containing atoms other than carbon, hydrogen, oxygen or silicon containing boron or metal atoms

Abstract

The present disclosure describes compositions of matter comprising a ribonucleoprotein complex comprising a nucleic acid-guided nuclease and a guide RNA, and further comprising and a blocking nucleic acid molecule represented by Formula III in the 5′-to-3′ direction comprises: T-D-M-A-(B-L)J-C; wherein T is 17-135 nucleotides in length; D is 0-10 nucleotides in length; M is 1-25 nucleotides in length or is absent, wherein if M is absent then T-D and A-(B-L)J-C are separate nucleic acid strands; A is 0-15 nucleotides in length and comprises at least 50% sequence complementarity to D; B is 4-12 nucleotides in length and comprises at least 50% sequence complementarity to T; L is 3-25 nucleotides in length; J is an integer between 1 and 10; C is 4-15 nucleotides in length; and wherein the blocking nucleic acid molecule comprises a sequence complementary to a gRNA.

IPC Classes  ?

• C12Q 1/6823 - Release of bound markers
• C12Q 1/682 - Signal amplification
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof
• C12N 9/22 - Ribonucleases
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

Abstract

Small molecule ERα biomodulators that kill therapy-resistant ERa positive breast, ovarian, and endometrial cancer cells are disclosed. In one embodiment, the small molecule biomodulator has increased therapeutic utility because of an increased ability to kill therapy-resistant cancer cells compared to BHPI and other conventional therapies (endocrine therapies, tamoxifen, and fulvestrant/ICI). The small molecule biomodulators not only inhibit proliferation of the cancer cells but kills them, which prevents reactivation of tumors years later. Compounds of the invention, such as ErSO-DFP, are effective for treating ERa positive cancers such as breast cancer, ovarian cancer, uterine cancer, cervical carcinoma, endometrial cancer, and the like.

IPC Classes  ?

• C07D 209/34 - Oxygen atoms in position 2
• C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
• A61P 35/00 - Antineoplastic agents

Abstract

Thermoset resin compositions including a compound of formula (I) having a working life and/or a pot life of at least 1 hour are provided. Copolymers prepared from the thermoset resin compositions are further provided. Methods of preparing and polymerizing the thermoset resin compositions are further provided. Delivery devices for preparing thermoset resin compositions are further provided.

IPC Classes  ?

• C08F 234/02 - Copolymers of cyclic compounds having no unsaturated aliphatic radicals in a side chain and having one or more carbon-to-carbon double bonds in a heterocyclic ring in a ring containing oxygen
• C08F 4/80 - Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors selected from metals not provided for in group selected from iron group metals or platinum group metals
• C08K 3/36 - Silica
• C08F 2/44 - Polymerisation in the presence of compounding ingredients, e.g. plasticisers, dyestuffs, fillers
• C08L 45/00 - Compositions of homopolymers or copolymers of compounds having no unsaturated aliphatic radicals in a side chain, and having one or more carbon-to-carbon double bonds in a carbocyclic or in a heterocyclic ring system; Compositions of derivatives of such polymers

Abstract

In one aspect, the disclosure relates to relates to substituted benzothiophene analogs which are useful as selective degraders of estrogen receptor, methods of making same, pharmaceutical compositions comprising same, and methods of treating one or more clinical conditions associated with estrogen receptor, such as a cancer, including breast cancer, or osteoporosis. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

IPC Classes  ?

• A61K 31/397 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
• A61K 31/138 - Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
• A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• A61K 31/277 - Nitriles; Isonitriles having a ring, e.g. verapamil
• A61K 31/4025 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
• A61K 31/4196 - 1,2,4-Triazoles
• A61K 31/4535 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
• A61K 31/565 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol
• A61K 31/566 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol having an oxo group in position 17, e.g. oestrone
• A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
• A61K 38/09 - Luteinising hormone-releasing hormone [LHRH]; Related peptides
• A61K 39/395 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• C07D 409/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Herein is described an oxygen nanobubbles-embedded hydrogel (ONB-G) with carbopol for oxygenation of wounds to accelerate the wound healing process. We integrate carbopol hydrogel and dextran-based ONBs, to prepare ONB-G that can hold oxygen and release it to accelerate wound healing. Oxygen release tests showed that the proposed ONB-G could maintain oxygen in the hydrogels for up to 34 days. Also, fluorescence studies indicated that the ONB-G could maintain the high oxygen levels for up to 8 weeks. Histological evaluation of tissues with a pig model with incision and punch wounds showed that treatment with ONB-G exhibited improved healing compared with hydrogel without ONBs or treated without gel. Our studies show that dextran-shell ONBs embedded in a gel (ONB-G) has the potential to accelerate wound healing given its oxygen holding capacity and release properties.

IPC Classes  ?

• A61L 26/00 - Chemical aspects of, or use of materials for, liquid bandages

Abstract

Aspects of the subject disclosure may include, for example, performing, by a processing system, image fusion using two or more groups of images to generate predicted images, wherein each group of the two or more groups has one of a different resolution, a different frequency temporal pattern or a combination thereof than another of the two or more groups. Gap filling can be performed by the processing system to correct images of the two or more groups. Additional embodiments are disclosed.

IPC Classes  ?

• G06T 5/00 - Image enhancement or restoration
• G06V 10/26 - Segmentation of patterns in the image field; Cutting or merging of image elements to establish the pattern region, e.g. clustering-based techniques; Detection of occlusion
• G06V 20/13 - Satellite images
• G06V 10/80 - Fusion, i.e. combining data from various sources at the sensor level, preprocessing level, feature extraction level or classification level
• G06T 7/10 - Segmentation; Edge detection
• G06T 5/50 - Image enhancement or restoration by the use of more than one image, e.g. averaging, subtraction

Abstract

In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, the disclosure, in one aspect, relates to compounds that increase the amount of nicotinamide adenine dinucleotide (NAD+) in a subject. By raising the amount of nicotinamide adenine dinucleotide in a subject, diseases associated with reduced levels of nicotinamide adenine dinucleotide can be treated or prevented. In one aspect, raising the amount of NAD+ in a subject can reduce or ameliorate one or more symptoms of Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, multiple sclerosis, amylotrophic lateral sclerosis, AIDS-induced dementia, or epilepsy.

IPC Classes  ?

• C07D 309/06 - Radicals substituted by oxygen atoms
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• C07D 407/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
• C07D 413/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 409/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Provided herein are genetically modified Issatchenkia yeast and fermentation methods for producing succinic acid.

IPC Classes  ?

• C12P 7/46 - Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
• C12N 15/81 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
• C12N 15/52 - Genes encoding for enzymes or proenzymes
• C12N 9/04 - Oxidoreductases (1.), e.g. luciferase acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C12N 9/26 - Hydrolases (3.) acting on glycosyl compounds (3.2) acting on alpha-1, 4-glucosidic bonds, e.g. hyaluronidase, invertase, amylase
• C12N 9/88 - Lyases (4.)
• C12N 9/00 - Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes

Abstract

Methods of preparing oligomers including heating a mixture of an amount of a functionalized cycloalkene, an amount of a chain transfer agent, a phosphite ester, and a catalyst, a degree of polymerization of the oligomers controllable by a molar ratio of the amount of the functionalized cycloalkene to the amount of the chain transfer agent, are provided herein. Methods of preparing polymers including heating the oligomers and a second amount of the functionalized cycloalkene, a phosphite ester, and a catalyst are further provided. Compositions of oligomers and functionalized cycloalkenes are further provided.

IPC Classes  ?

• C08G 61/08 - Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes only aliphatic carbon atoms prepared by ring-opening of carbocyclic compounds of carbocyclic compounds containing one or more carbon-to-carbon double bonds in the ring
• C07C 2/04 - Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms by addition between unsaturated hydrocarbons by oligomerisation of well-defined unsaturated hydrocarbons without ring formation
• C07C 29/44 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by addition reactions, i.e. reactions involving at least one carbon-to-carbon double or triple bond
• C07C 67/08 - Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds

Abstract

Staphylococcus nepalensis releases corisin, a peptide conserved in diverse Staphylococci, that induces apoptosis of lung epithelial cells. Therefore, methods and apparatus for detecting the presence of corisin in a biological sample of a patient are disclosed, as well as pharmaceutical compositions, such as antibodies, and methods for treating patents having or suspected of having fibrosis.

IPC Classes  ?

• C07K 16/12 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from bacteria
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
• A61P 11/00 - Drugs for disorders of the respiratory system

Abstract

Disclosed are C16 amide derivatives of C2′-epi-amphotericin B (C2′epiAmB) and salts thereof, characterized by improved clinical efficacy with reduced toxicity compared to AmB. Also disclosed are pharmaceutical compositions, comprising any of the disclosed compounds or salts thereof, as well as methods of treatment and therapeutic uses of the same.

IPC Classes  ?

• C07H 17/08 - Hetero rings containing eight or more ring members, e.g. erythromycins
• A61P 31/10 - Antimycotics

Abstract

Here we show that P. ananatis produces at least three phosphonates, two of which were purified and structurally characterized. The first, designated pantaphos, was shown to be 2-(hydroxy(phosphono)methyl)maleate; the second, a probable biosynthetic precursor, was shown to be 2-(phosphonomethyl)maleate. Purified pantaphos is both necessary and sufficient for the hallmark lesions of onion center rot. Moreover, when tested against mustard seedlings, the phytotoxic activity of pantaphos was comparable to the widely used herbicides glyphosate and phosphinothricin. Pantaphos was also active against a variety of human cell lines.

IPC Classes  ?

• C07F 9/38 - Phosphonic acids (R—P(:O)(OH)2); Thiophosphonic acids
• A01N 57/20 - Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-carbon bonds containing acyclic or cycloaliphatic radicals

Abstract

4-Hydroxyphenyl-2H-indazol-5-ol compounds are estrogen receptor beta ligands that have immunomodulatory properties and increase oligodendrocyte survival, differentiation, and remyelination. The compounds, compositions, and kits are useful in the treatment of multiple sclerosis and endometriosis.

IPC Classes  ?

• C07D 231/56 - Benzopyrazoles; Hydrogenated benzopyrazoles
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• C07D 409/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 409/10 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Abstract

Compounds of formula (I) are provided. Polymers including monomers of formula (II) are further provided. Methods of releasing controlled amounts of a small molecule from the polymers are further provided. Devices for releasing controlled amounts of a small molecule are further provided. Compounds of formula (I) are provided. Polymers including monomers of formula (II) are further provided. Methods of releasing controlled amounts of a small molecule from the polymers are further provided. Devices for releasing controlled amounts of a small molecule are further provided.

IPC Classes  ?

• C08F 24/00 - Homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a heterocyclic ring containing oxygen
• A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests

Abstract

A microscope mounting system includes a sample holder shaped and configured to fit a particular horizontal microscope stage and fix one end of a soft material sample. A blade holder configured to position a cutting blade and connect directly or eventually to the particular microscope or a frame of the particular microscope. A load measurement device is configured to determine a load applied to the cutting blade. A precision adjustment assembly sets positioning of the cutting blade in the horizontal x-y plane and the z vertical plane such that a cutting edge of the cutting blade can be positioned at a focal point of the particular microscope. At least two grips are configured to grip a second end of the soft material sample at at least two discrete locations on opposite sides of the cutting blade when the blade contacts the soft material sample at the focal point. A tension mechanism can apply tension in the x-y plane to each of the at least two grips.

IPC Classes  ?

• G01N 1/28 - Preparing specimens for investigation
• G01N 3/58 - Investigating machinability by cutting tools; Investigating the cutting ability of tools
• G01N 1/36 - Embedding or analogous mounting of samples

Abstract

A catalyst for hydrosilylation is disclosed. The catalyst comprises a complex having a certain formula. A redox-switchable catalyst system for preparing the catalyst is also disclosed. The redox-switchable catalyst system comprises a redox-switchable catalyst and a reducing compound. The reducing compound reduces a formal oxidation state of the redox-switchable catalyst to give the catalyst, where the former is generally inactive in catalyzing hydrosilylation and the latter is catalytically active. A composition comprising the catalyst and/or the redox-switchable catalyst system, and a hydrosilylation reaction product, are also disclosed.

IPC Classes  ?

• B01J 31/24 - Phosphines

Abstract

Methods for recycling oligomeric units derived from a first polymer into a second polymer are provided herein. Methods of preparing oligomeric macromonomers from oligomeric units are further provided. Methods of polymerizing oligomeric macromonomers are further provided.

IPC Classes  ?

• C08J 11/20 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation by treatment with organic material by treatment with hydrocarbons or halogenated hydrocarbons

Abstract

This invention relates to chimeric polypeptides comprising OX40L and Jagged-1 polypeptides and fragments thereof and their uses for treatment of autoimmune diseases.

IPC Classes  ?

• C12N 5/0783 - T cells; NK cells; Progenitors of T or NK cells
• C07K 14/705 - Receptors; Cell surface antigens; Cell surface determinants

Abstract

The disclosure relates to units, systems and methods for producing ammonia from a nitrogen-containing feedstock from sources like wastewater, ammonium nitrate solution, or an input gas containing one or more nitrogen-containing species, which can advantageously reduce carbon dioxide emissions, and energy consumption, as well as balance the nitrogen cycle.

IPC Classes  ?

• C25B 1/27 - Ammonia
• C25B 9/70 - Assemblies comprising two or more cells
• C25B 11/031 - Porous electrodes
• C25B 11/075 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound
• C25B 9/19 - Cells comprising dimensionally-stable non-movable electrodes; Assemblies of constructional parts thereof with diaphragms
• C25B 11/052 - Electrodes comprising one or more electrocatalytic coatings on a substrate
• C25B 11/065 - Carbon

Abstract

J-C and T-D are separate nucleic acid strands; T is 17-135 nucleotides in length and comprises at least 50% sequence complementarity to B and C; D is 0-10 nucleotides in length and comprises at least 50% sequence complementarity to A; and wherein the blocking nucleic acid molecule comprises a sequence complementary to a gRNA.

IPC Classes  ?

• C12Q 1/6823 - Release of bound markers
• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
• C12Q 1/682 - Signal amplification

Abstract

Wick-free vapor chambers and hybrid vapor chambers are described. An example wick-free vapor chamber includes a wettability-patterned condenser configured to control vapor condensation along patterned domains formed on the wettability-patterned condenser; and a wettability-patterned evaporator. The wettability patterned evaporator is configured to: i) accept condensate from the wettability-patterned condenser and ii) transport the condensate along patterned domains formed on the wettability-patterned evaporator to one or more hot domain portions of the wettability-patterned evaporator. An example hybrid vapor chamber includes a wettability patterned condenser configured to control vapor condensation along patterned domains formed on the wettability-patterned condenser; and an evaporator configured to accept condensate from the wettability -patterned condenser.

IPC Classes  ?

• F28D 15/04 - Heat-exchange apparatus with the intermediate heat-transfer medium in closed tubes passing into or through the conduit walls in which the medium condenses and evaporates, e.g. heat-pipes with tubes having a capillary structure

Abstract

This invention provides a cross-linked alginate hydrogel layer encapsulating single mesenchymal stromal cells or progenitor cells, as well as compositions including the encapsulated cells and to methods of using the same to promote osteogenesis and fibrotic tissue repair in a subject.

IPC Classes  ?

• A61K 35/28 - Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• C12N 5/0775 - Mesenchymal stem cells; Adipose-tissue derived stem cells
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
• A61K 38/18 - Growth factors; Growth regulators
• A61K 47/36 - Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61K 38/19 - Cytokines; Lymphokines; Interferons
• A61K 9/06 - Ointments; Bases therefor
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor

Abstract

A cooling system includes a container having a water-based fluid in which are immersed printed circuit boards (PCBs). One or more high-thermal electrical components are disposed on the PCBs. A condenser causes water vapor generated by the one or more high-thermal electrical components to condense and passively return to the water-based fluid. A nano-engineered coating is deposited over the one or more high-thermal electrical components that includes an electrical insulation coating of between two to 25 microns in thickness deposited on the one or more high-thermal electrical components. A metallic nano-layer comprising a porous metallic nano-structure deposited on the electrical insulation coating.

IPC Classes  ?

• C23C 16/56 - After-treatment
• C23C 16/46 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition (CVD) processes characterised by the method of coating characterised by the method used for heating the substrate
• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
• C23C 16/40 - Oxides

Abstract

A dataflow-based general-purpose processor architecture and its method are disclosed. A circuit for the dataflow-based general-purpose processor architecture includes multiple processing elements (PEs) corresponding to multiple assigned central processing unit (CPU) instructions in program order, a register file, and multiple feedforward register lanes configured to map each of the multiple assigned CPU instructions on the multiple PEs to the register file or another PE of the multiple PEs to construct a hardware datapath corresponding to a dataflow graph of the multiple assigned CPU instructions. Other aspects, embodiments, and features are also claimed and described.

IPC Classes  ?

• G06F 9/30 - Arrangements for executing machine instructions, e.g. instruction decode

Abstract

The ability to scale data can provide numerous advantages, especially with regard to agricultural information. For example, agroecosystems include land and data associated with the land, such as physical traits and information. This can include, for example, information related to the soil, crops, other vegetation, and other information related to the land. In order to be able to quickly and accurately know such information and traits, ground truth data can be scaled using aerial and/or satellite imagery. Models and other machine learning can utilize ground truth data to scale limited field area data (e.g., 0.1-1 km) and accurately apply the same to large swaths of land (e.g., >100 km2) with accuracy for the field traits and/or characteristics.

IPC Classes  ?

• G06V 20/13 - Satellite images
• G06V 20/10 - Terrestrial scenes

Abstract

A catheter includes a bifurcated shaft body and a tip coupled to the bifurcated shaft body. The tip is configured to dissect a portion of a tissue in a controlled navigation for targeted delivery of a payload to an area of or within the tissue. In addition, the tip is adapted to bend along a shape of the area of the tissue.

IPC Classes  ?

• A61F 9/00 - Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
• A61F 9/007 - Methods or devices for eye surgery

Abstract

A method of fabricating a power semiconductor device includes forming a bi layer mask on a semiconductor substrate, where the bilayer mask comprises a first dielectric layer on the semiconductor substrate and a second dielectric layer on the first dielectric layer. The first and second dielectric layers are through-etched to define an exposed portion of the semiconductor substrate. The first dielectric layer is selectively etched to form an undercut region of the bi layer mask. A crystalline semiconductor material is epitaxially grown on the exposed portion of the semiconductor substrate, and a polycrystalline semiconductor material is deposited on the second dielectric layer of the bilayer mask. After the epitaxial growth, the bilayer mask and the polycrystalline semiconductor material are removed from the semiconductor substrate, leaving behind a mesa comprising the crystalline semiconductor material on the semiconductor substrate. Advantageously, a sidewall of the mesa is substantially smooth and/or defect-free.

IPC Classes  ?

• H01L 29/868 - PIN diodes
• H01L 29/06 - Semiconductor bodies characterised by the shapes, relative sizes, or dispositions of the semiconductor regions
• H01L 21/033 - Making masks on semiconductor bodies for further photolithographic processing, not provided for in group or comprising inorganic layers
• H01L 29/872 - Schottky diodes
• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
• H01L 29/20 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only AIIIBV compounds

Abstract

An in situ cell bioreactor and delivery system is provided. The system is composed of toroidal-spiral particles, which encapsulate cells therein and can further provide one or more active agents. Methods for using the system in cell-based therapies are also provided.

IPC Classes  ?

• C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
• C12M 1/42 - Apparatus for the treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic wave
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances

Abstract

A high efficiency grating coupler design includes a grating region formed of a first material on an optics substrate. A side reflector formed of the first material is disposed on the optics substrate adjacent the grating region. A high contrast overlay is on the grating region, but is not disposed on the side reflector. The grating region includes teeth formed of the first material and the high contrast overlay, wherein the teeth have independently apodized fill factor, etch depth, and heights The first material and a material of the high contrast overlay can be selected to correspond to a particular laser type, wavelength of the laser, properties of the laser beam, and material of the laser. In addition, the teeth of the grating region, along with the side reflector teeth, can be apodized for optimized optical coupling efficiency with respect to the laser.

IPC Classes  ?

• G02B 6/34 - Optical coupling means utilising prism or grating
• G02B 27/00 - Optical systems or apparatus not provided for by any of the groups ,

Abstract

Light emitting diode (LED) structures formed by metal-assisted chemical etching for microLED device applications include heterostructure micropillars on a substrate, where each heterostructure micropillar comprises a stack of semiconductor layers separated by heterojunctions. Sidewalls of the heterostructure micropillars are completely or substantially devoid of ion-induced defects. A method of forming an array of LED structures comprises: providing a sample to be etched, where the sample includes a heterostructure stack with metal catalyst regions on a top surface thereof, the heterostructure stack including a plurality of semiconductor layers separated by heterojunctions; exposing the sample to an etching solution or vapor; during the exposure to the etching solution or vapor, optionally illuminating the sample with above-gap radiation; and etching the semiconductor layers in a thickness direction between the metal catalyst regions, thereby forming an array of heterostructure micropillars, each covered with one of the metal catalyst regions.

IPC Classes  ?

• H01L 33/00 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof
• H01L 33/32 - Materials of the light emitting region containing only elements of group III and group V of the periodic system containing nitrogen
• H01L 33/06 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by the semiconductor bodies with a quantum effect structure or superlattice, e.g. tunnel junction within the light emitting region, e.g. quantum confinement structure or tunnel barrier
• H01L 27/15 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components with at least one potential-jump barrier or surface barrier, specially adapted for light emission

Abstract

The disclosure provides an example implant, surgical systems, and methods for closing a tissue opening. The implant includes a barbed suture having a first end and a second end. A first disc statically coupled to the first end of the barbed suture at a center of the first disc. And a second disc having a through-hole arranged in a center of the second disc, where the second disc is moveably coupled to the barbed suture via the through-hole.

IPC Classes  ?

• A61B 17/04 - Surgical instruments, devices or methods, e.g. tourniquets for closing wounds, or holding wounds closed, e.g. surgical staples; Accessories for use therewith for suturing wounds; Holders or packages for needles or suture materials

Abstract

A listening system includes one or more remote signal sources that generate one or more electronic signals, which correspond to sound in an ambient environment. A first ear microphone detects a first combination of audio signals including ambient sound and one or more propagated audio signals, corresponding to the one or more electronic signals, received at a first ear of a listener. The system includes first ear playback device and a processing device to apply a first set of audio filters including an audio filter to process a respective electronic signal of the one or more electronic signals with a first error signal, which is based on an output of the first ear microphone, to generate a first output signal to the first ear playback device, wherein acoustic cue components of the first output signal match corresponding acoustic cue components of the first combination of audio signals.

IPC Classes  ?

• H04R 25/00 - Deaf-aid sets

Abstract

A listening system includes a first microphone device and a second microphone device that generate a first electronic signal and a second electronic signal corresponding to sound within audio detection range. Control logic of the first microphone device detects a crosstalk audio signal from a direction of the second microphone device that matches the second electronic signal. The first electronic signal includes a mixture that includes the crosstalk audio signal. An ear playback device is associated with the second microphone device. A processing device receives the first electronic signal and the second electronic signal, removes the second electronic signal from the first electronic signal to generate a cleansed first electronic signal, and processes the cleansed first electronic signal to integrate the cleansed first electronic signal into an output signal to the ear playback device.

IPC Classes  ?

• H04R 25/00 - Deaf-aid sets
• G10K 11/178 - Methods or devices for protecting against, or for damping, noise or other acoustic waves in general using interference effects; Masking sound by electro-acoustically regenerating the original acoustic waves in anti-phase

Abstract

The disclosure provides example shunt apparatus and methods for deploying the apparatus. The apparatus includes (a) an inner catheter having first and second ends, where the inner catheter has a plurality of fenestrations extending along a portion of the inner catheter, (b) an outer catheter, where the inner catheter is positioned at least partially within a lumen of the outer catheter, (c) a deployment wire moveably arranged in a lumen of a conduit that is coupled to the outer catheter, and (d) a mesh arranged surrounding at least the first end of the inner catheter, where the mesh has a first end coupled to the inner catheter and the mesh has a second end coupled to the deployment wire, where the mesh is configured to move between a first position in an unexpanded condition having the form of a sheath to a second position in an expanded condition.

IPC Classes  ?

• A61M 27/00 - Drainage appliances for wounds, or the like
• A61F 2/966 - Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod

Abstract

Abstract: Disclosed are methods, systems, components, and compositions for synthesis of sequence defined polymers. The methods, systems, components, and compositions may be utilized for incorporating novel substrates that include non-standard amino acid monomers and non-amino acid monomers into sequence defined polymers. As disclosed herein, the novel substrates may be utilized for acylation of tRNA via flexizyme catalyzed reactions. The tRNAs thus acylated with the novel substrates may be utilized in synthesis platforms for incorporating the novel substrates into a sequence defined polymer.

IPC Classes  ?

• C12N 15/11 - DNA or RNA fragments; Modified forms thereof
• C12Q 1/6869 - Methods for sequencing

Abstract

A catalyst for hydrosilylation is provided. The catalyst comprises a nanoparticle having a surface and a plurality of ligands are tethered to the surface of the nanoparticle. Each ligand includes an independently selected cyclic aliphatic hydrocarbon group having one unsaturated moiety. Platinum is bonded to the unsaturated moiety the cyclic aliphatic hydrocarbon group in the catalyst. A method of preparing the catalyst is also provided. The method comprises mixing a ligand functionalized nanoparticle and a platinum mixture to give the catalyst.

IPC Classes  ?

• C08F 255/00 - Macromolecular compounds obtained by polymerising monomers on to polymers of hydrocarbons as defined in group

Abstract

An integrated multi-port generator-rectifier device includes multiple passive output ports provided from a plurality of passive-rectifier windings on a common, single magnetic structure. The passive-rectifier windings interact with a plurality of magnetic poles. Coils in the passive rectifier windings are serially connected. Each of the passive rectifier windings has a pitch as that is a fraction of magnet pole pitch and a pattern to magnetically decouple back emf phases of the separate rectifiers. The device further includes an active port provided by an active rectifier.

IPC Classes  ?

• H02M 1/14 - Arrangements for reducing ripples from dc input or output
• H02J 3/01 - Arrangements for reducing harmonics or ripples

Abstract

A method and microfluidic device for increasing the production of extracellular vesicles are provided which include the use of a cell-adhesive substrate for culturing extracellular-vesicle-producing cells, wherein the cell-adhesive substrate is a hydrogel having a Young's modulus of about 0.1 kPa to about 5 kPa and the hydrogel is functionalized with one or more cell adhesive peptides.

IPC Classes  ?

• C12N 11/10 - Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
• C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means
• C12N 5/0775 - Mesenchymal stem cells; Adipose-tissue derived stem cells
• C12M 1/00 - Apparatus for enzymology or microbiology

Abstract

A process for producing an ether including treating (a) an ester with (b) hydrogen in the presence of (c) a heterogeneous catalyst to reduce the ester by hydrogenation to form an ether product.

IPC Classes  ?

• C07C 41/01 - Preparation of ethers

Abstract

An active CO2 capture unit for capturing CO2 from a dilute source of CO2 input gas can include an inlet through which an input gas is introduced into the unit and a non-aqueous region comprising a non-aqueous CO2 binding organic liquid containing OH− arranged to be in contact with the input gas to chemisorb CO2 from the input gas and convert the chemisorbed CO2 into HCO3− by reacting with OH−. The unit also includes an aqueous region arranged downstream of the non-aqueous region, wherein at an aqueous region interface, the HCO3− interacts with H2O and decomposes to CO2 and CO32−. An anion exchange membrane is disposed between the non-aqueous region and the aqueous region to facilitate HCO3− diffusion and migration from the non-aqueous region to the aqueous region. A captured CO2 outlet is disposed downstream of the aqueous region.

IPC Classes  ?

• B01D 53/14 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by absorption
• B01D 53/22 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
• B01D 71/28 - Polymers of vinyl aromatic compounds
• B01D 53/78 - Liquid phase processes with gas-liquid contact
• B01D 53/86 - Catalytic processes
• B01D 53/62 - Carbon oxides
• C25B 3/26 - Reduction of carbon dioxide
• C25B 3/03 - Acyclic or carbocyclic hydrocarbons
• C25B 3/07 - Oxygen containing compounds
• C25B 1/23 - Carbon monoxide or syngas
• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 11/075 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound
• C25B 11/052 - Electrodes comprising one or more electrocatalytic coatings on a substrate
• C25B 11/03 - Electrodes; Manufacture thereof not otherwise provided for characterised by shape or form perforated or foraminous
• C25B 9/19 - Cells comprising dimensionally-stable non-movable electrodes; Assemblies of constructional parts thereof with diaphragms

Abstract

The use of DNA or other charged biomolecules for data storage can include the use of devices to manipulate the biomolecules in solution, e.g., to store and later to selectively read out selected samples of stored biomolecules. Systems and methods provided herein facilitate the electrical manipulation of DNA or other charged biomolecules for data storage or other applications by applying voltages to sets of electrodes arranged along the length of channels of microfluidic devices. The magnitudes and signs of the applied voltages can be controlled to collect DNA into a channel, to retain the collected DNA in the channel for later use, and then to expel the DNA from the channel for readout (e.g., by a pore sequencer integrated into the same microfluidic device as the channel). Such storage channels can have rectangular cross-sections or otherwise include electrodes having substantially planar geometry.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

Abstract

A method of compositional feature representation learning for video understanding is described. The method includes individually processing a sequence of video frames received as an input of a feature map network to generate a plurality of feature maps. The method also includes binding the plurality of feature maps to a fixed set of slot variables using an attention model according to a motion segmentation signal. The method further includes combining slot states corresponding to the fixed set of slot variables into a combined feature map. The method also includes decoding the combined feature map to form a reconstructed sequence of video frames, in which objects discovered in the reconstructed sequence of video frames are identified.

IPC Classes  ?

• G06V 20/58 - Recognition of moving objects or obstacles, e.g. vehicles or pedestrians; Recognition of traffic objects, e.g. traffic signs, traffic lights or roads
• G06T 7/215 - Motion-based segmentation
• G06T 7/246 - Analysis of motion using feature-based methods, e.g. the tracking of corners or segments
• G06V 10/774 - Generating sets of training patterns; Bootstrap methods, e.g. bagging or boosting
• G06V 10/77 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using data integration or data reduction, e.g. principal component analysis [PCA] or independent component analysis [ICA] or self-organising maps [SOM]; Blind source separation

Abstract

The present disclosure provides methods, pharmaceutical compositions, and kits comprising histone deacetylase (HD AC) inhibitors of formula I, or a pharmaceutically acceptable salt thereof, wherein R1, R2, L1, L2, m, n, p, X, Y, and Z are as defined in the specification, including methods of increasing the sensitivity of cancer cells to the cytotoxic effects of radiotherapy and/or chemotherapy in a subject. The present disclosure provides methods, pharmaceutical compositions, and kits comprising histone deacetylase (HD AC) inhibitors of formula I, or a pharmaceutically acceptable salt thereof, wherein R1, R2, L1, L2, m, n, p, X, Y, and Z are as defined in the specification, including methods of increasing the sensitivity of cancer cells to the cytotoxic effects of radiotherapy and/or chemotherapy in a subject.

IPC Classes  ?

• C07C 275/40 - Derivatives of urea, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
• C07F 5/02 - Boron compounds
• A61K 39/395 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
• A61P 35/00 - Antineoplastic agents
• A61K 31/17 - Amides, e.g. hydroxamic acids having the group N—C(O)—N or N—C(S)—N, e.g. urea, thiourea, carmustine
• A61K 31/69 - Boron compounds

Abstract

The present disclosure involves a process to identify a patient likely to have OSCC by taking a sample containing miRNA from epithelial cells from the patient's oral cavity and determining the relative level of expression of miRNA sequences which have different levels of expression in epithelial cell OSCC tissue than in benign tissue. The epithelial cells are those that form the mucosal epithelium that consists mainly of keratinocytes with some immune cells. It involves determining the relative level of expression of at least miRNA sequences hsa-miR-130-3p, hsa-miR-7-5p, hsa-miR-101-3p and hsa-miR-146b-5p. It also involves discriminating between benign oral lesions and OSCC using a sample of epithelial cells of the lesion and determining the relative level of expression of miRNA sequences which have different levels of expression in epithelial cell OSCC tissue than in benign tissue. It uses the relative level of expression of at least miRNA sequences hsa-miR-196a-5p and hsa-miR-873-5p.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

In accordance with the principles herein, a co-design approach for compute-in-memory inference for deep neural networks (DNN) is set forth. Multiplication-free function approximators are employed along with a co-adapted processing array and compute flow. Resulting methods, systems, devices, and algorithms in accordance with the principles herein overcome many deficiencies in the currently available in—methods, systems, devices, and algorithms (in-SRAM) DNN processing devices. Systems, devices, and algorithms constructed in accordance with the co-adapted implementation herein seamlessly extends to multi-bit precision weights, eliminates the need for DACs, and easily extends to higher vector-scale parallelism. Additionally, a SRAM-immersed successive approximation ADC (SA-ADC) can be constructed, where the parasitic capacitance of bit lines of SRAM array can be exploited as a capacitive DAC. The dominant area overhead in SA-ADC, due to its capacitive DAC, can allow low area implementation of within-SRAM SA-ADC.

IPC Classes  ?

• G06N 3/02 - Neural networks

Abstract

A passive thermal regulation system includes a substrate and a coating. The coating is positioned to encapsulate at least a portion of the substrate. The coating includes a first hydrogel layer and a second hydrogel layer. The first hydrogel layer has a plurality of carbon materials configured to absorb a solar radiation. The second hydrogel layer includes a hydrogel that is different from the first hydrogel layer. The coating, at a first temperature, causes the passive thermal regulation system to passively switch from a solar reflective state to solar absorber state to permit the plurality of carbon materials to absorb the solar radiation. At a second temperature, the coating causes the system to passively switch from the solar absorber state to the solar reflective state where the hydrogel of the second hydrogel layer inhibits the solar radiation from absorption. The second temperature is greater than the first temperature.

IPC Classes  ?

• F24S 70/225 - SOLAR HEAT COLLECTORS; SOLAR HEAT SYSTEMS - Details of absorbing elements characterised by surface treatment for increasing absorption for spectrally selective absorption
• F24S 80/52 - Transparent coverings; Elements for transmitting incoming solar rays and preventing outgoing heat radiation characterised by the material
• C09D 5/26 - Thermosensitive paints
• C09D 5/32 - Radiation-absorbing paints

Abstract

A wafer includes a buried substrate; a first layer of silicon (100) disposed on the buried substrate that includes silicon sidewalls (111) at an angle to the buried substrate and that form a bottom of each of multiple U-shaped grooves; a second layer of patterned oxide disposed on the silicon (100) that provides vertical sidewalls of each U-shaped groove formed within the first and second layers; a third layer of a buffer covering the first layer and partially covering the second layer partway up the vertical sidewalls; and multiple gallium nitride (GaN)-based structures disposed within the multiple U-shaped grooves, the multiple GaN-based structures each including cubic gallium nitride (c-GaN) formed at merged growth fronts of hexagonal gallium nitride (h-GaN) that extend from the silicon sidewalls (111).

IPC Classes  ?

• C30B 29/40 - AIIIBV compounds
• C30B 25/16 - Controlling or regulating
• C30B 25/18 - Epitaxial-layer growth characterised by the substrate

Abstract

A wafer includes a buried substrate; a layer of silicon (100) disposed on the buried substrate and forming multiple U-shaped grooves, wherein each U-shaped groove comprises a bottom portion and silicon sidewalls (111) at an angle to the buried substrate; a buffer layer disposed within the multiple U-shaped grooves; and multiple gallium nitride (GaN)-based structures having vertical sidewalls disposed within and protruding above the multiple U-shaped grooves, the multiple GaN-based structures each including cubic gallium nitride (c-GaN) formed at merged growth fronts of hexagonal gallium nitride (h-GaN) that extend from the silicon sidewalls (111).

IPC Classes  ?

• H01L 21/311 - Etching the insulating layers
• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
• H01L 21/3213 - Physical or chemical etching of the layers, e.g. to produce a patterned layer from a pre-deposited extensive layer
• H01L 33/00 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof

Abstract

Super-resolution label-free microscopy is provided using multiplexed, temporally modulated acquisition patterns of emission point spread functions (“PSFs”). Supercontinuum ultrafast pulses can be used to enhance nonlinear processes, such as autofluorescence and harmonic generation, in order to provide super-resolution imaging of nonlinear label-free signals. Images can be reconstructed using various reconstruction techniques, including pixel reassignment, wavelet reconstruction, and deep learning model-based reconstructions.

IPC Classes  ?

• G06T 3/40 - Scaling of a whole image or part thereof
• G06T 5/50 - Image enhancement or restoration by the use of more than one image, e.g. averaging, subtraction